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Microalgal docosahexaenoic acid decreases plasma triacylglycerol in normolipidaemic vegetarians: a randomised trial

  • Julia Geppert (a1), Veronika Kraft (a1), Hans Demmelmair (a1) and Berthold Koletzko (a1)
  • DOI: http://dx.doi.org/10.1079/BJN20051720
  • Published online: 01 March 2007
Abstract

Triacylglycerol (TG) lowering effects of n−3 long-chain PUFA (n−3 LCPUFA) have been repeatedly demonstrated, but studies investigating the individual effects of EPA or DHA on plasma TG and lipoproteins in man are rare. The effects of a new DHA-rich, almost EPA-free microalgae oil (Ulkenia sp.) on plasma lipids and several safety parameters were investigated in a double-blind, placebo-controlled, parallel design intervention study. Normolipidaemic vegetarians (eighty-seven females, twenty-seven males) consumed daily microalgae oil (0·94g DHA/d) or olive oil (as placebo) for 8 weeks. DHA supplementation decreased plasma TG by 23% from 1·08 (sem 0·07) to 0·83 (sem 0·04) mmol/l (p<0·001). Absolute TG decreases after DHA supplementation were inversely correlated to baseline TG concentrations (r −0·627, p<0·001). Plasma total, LDL and HDL cholesterol increased significantly in the DHA group, resulting in lower TG:HDL cholesterol and unchanged LDL:HDL and total cholesterol:HDL cholesterol ratios. The intake of DHA-rich microalgae oil did not result in any physiologically relevant changes of safety and haemostatic factors. In conclusion, DHA-rich oil from microalgae Ulkenia sp. was well tolerated and can be considered a suitable vegetarian source of n−3 LCPUFA. Although DHA supplementation improved some CHD risk factors (plasma TG, TG:HDL cholesterol ratio), LDL cholesterol increased. Therefore, the overall effects of this intervention on CHD risk deserve further investigation.

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Corresponding author
*Corresponding author: Professor Berthold Koletzko, fax +49 89 5160 3336, email Berthold.Koletzko@med.uni-muenchen.de
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M Abbey , P Clifton , M Kestin , B Belling & P Nestel Effect of fish oil on lipoproteins, lecithin:cholesterol acyltransferase, and lipid transfer protein activity in humans. Arteriosclerosis (1990) 10, 8594.

MA Austin , JE Hokanson & KL Edwards Hypertriglyceridemia as a cardiovascular risk factor. Am J Cardiol (1998) 81, 7B12B.

KH Bonaa , KS Bjerve , B Straume , IT Gram & D Thelle Effect of eicosapentaenoic and docosahexaenoic acids on blood pressure in hypertension. A population-based intervention trial from the Tromso study. N Engl J Med (1990) 322, 795801.

JM Gaziano , CH Hennekens , CJ O'Donnell , JL Breslow & JE Buring (1997) Fasting triglycerides, high-density lipoprotein, and risk of myocardial infarction. Circulation. 96 25202525

BA Griffin The effect of n-3 fatty acids on low density lipoprotein subfractions. Lipids (2001) 36 S91S97

SA Grover , L Coupal & XP Hu (1995) Identifying adults at increased risk of coronary disease. How well do the current cholesterol guidelines work?. JAMA. 274 801806

SA Grover , CS Palmer & L Coupal Serum lipid screening to identify high-risk individuals for coronary death. The results of the Lipid Research Clinics prevalence cohort. Arch Intern Med. (1994) 154 679684

HN Hodis (1999) Triglyceride-rich lipoprotein remnant particles and risk of atherosclerosis. Circulation. 99 28522854

JE Hokanson & MA Austin (1996) Plasma triglyceride level is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol level: a meta-analysis of population-based prospective studies. J Cardiovasc Risk. 3 213219

DR Illingworth , WS Harris & WE Connor (1984) Inhibition of low density lipoprotein synthesis by dietary omega-3 fatty acids in humans. Arteriosclerosis 4 270275

M Inagaki & WS Harris Changes in lipoprotein composition in hypertriglyceridemic patients taking cholesterol-free fish oil supplements. Atherosclerosis (1990) 82 237246

B Kinosian , H Glick & G Garland (1994) Cholesterol and coronary heart disease: predicting risks by levels and ratios. Ann Intern Med. 121 641647

HR Knapp & GA FitzGerald (1989) The antihypertensive effects of fish oil. A controlled study of polyunsaturated fatty acid supplements in essential hypertension. N Engl J Med. 320 10371043

G Lu , SL Windsor & WS Harris (1999) Omega-3 fatty acids alter lipoprotein subfraction distributions and the in vitro conversion of very low density lipoproteins to low density lipoproteins. J Nutr Biochem. 10 151158

YK Lungershausen , M Abbey , PJ Nestel & PRC Howe (1994) Reduction of blood pressure and plasma triglycerides by omega-3 fatty acids in treated hypertensives. J Hypertens. 12 10411045

GJ Nelson , PC Schmidt , GL Bartolini , DS Kelley & D Kyle (1997) The effect of dietary docosahexaenoic acid on plasma lipoproteins and tissue fatty acid composition in humans. Lipids 32 11371146

I Toft , KH Bonaa , OC Ingebretsen , A Nordoy & T Jenssen (1995) Effects of n-3 polyunsaturated fatty acids on glucose homeostasis and blood pressure in essential hypertension: a randomized, controlled trial. Ann Intern Med. 123 911918

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British Journal of Nutrition
  • ISSN: 0007-1145
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