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Minerals and vitamins in bone health: the potential value of dietary enhancement

  • Jean-Philippe Bonjour (a1), Léon Guéguen (a2), Cristina Palacios (a3), Martin J. Shearer (a4) and Connie M. Weaver (a5)...

Abstract

Nutrition is important to bone health, and a number of minerals and vitamins have been identified as playing a potential role in the prevention of bone diseases, particularly osteoporosis. Despite this, there is currently no consensus on maximum levels to allow in food or as dietary supplements. The benefits of supplementation of populations at risk of osteoporosis with Ca and vitamin D are well established. Prolonged supplementation of Ca and vitamin D in elderly has been shown to prevent bone loss, and in some intervention studies to prevent fragility fractures. Although P is essential to bone health, the average intake is considered to be more than sufficient and supplementation could raise intake to adverse levels. The role of vitamin K in bone health is less well defined, though it may enhance the actions of Ca and vitamin D. Sr administered in pharmacological doses as the ranelate salt was shown to prevent fragility fractures in postmenopausal osteoporosis. However, there is no hard evidence that supplementation with Sr salts would be beneficial in the general population. Mg is a nutrient implicated in bone quality, but the benefit of supplementation via foodstuffs remains to be established. A consensus on dietary supplementation for bone health should balance the risks, for example, exposure of vulnerable populations to values close to maximal tolerated doses, against evidence for benefits from randomised clinical trials, such as those for Ca and vitamin D. Feedback from community studies should direct further investigations and help formulate a consensus on dietary supplementation for bone health.

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Corresponding author

*Corresponding author: Professor Jean-Philippe Bonjour, fax +41 223829973, email jean-philippe.bonjour@unige.ch

References

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1World Health Organization (2003) Diet, Nutrition and the Prevention of Chronic Diseases. Joint WHO/FAO Expert Consultation. WHO Technical Report Series no. 916. Geneva: WHO.
2International Osteoporosis Foundation (on Behalf of the European Parliament Osteoporosis Interest Group and EU Osteoporosis Consultation Panel) (2005) Osteoporosis in Europe: Indicators in Progress. Nyon, Switzerland: IOF.
3Kanis, JA & Johnell, O (2005) Requirements for DXA for the management of osteoporosis in Europe. Osteoporos Int 16, 229238.
4World Health Organization (2007) Assessment of Osteoporosis at the Primary Health Care Level. Report of a WHO Scientific Group. Geneva: WHO.
5World Health Organization (1994) Assessment of Fracture Risk and its Application to Screening for Postmenopausal Osteoporosis. Report of a WHO Study Group. WHO Technical Report Series no. 843. Geneva: WHO.
6Melton, LJ III, Gabriel, SE, Crowson, CS, et al. (2003) Cost-equivalence of different osteoporotic fractures. Osteoporos Int 14, 383388.
7World Health Organization (2003) Prevention and Management of Osteoporosis. Report of a Scientific Group. WHO Technical Report Series no. 921. Geneva: WHO.
8Barrett-Connor, E, Siris, ES, Wehren, LE, et al. (2005) Osteoporosis and fracture risk in women of different ethnic groups. J Bone Miner Res 20, 185194.
9Nevitt, MC, Cummings, SR, Stone, KL, et al. (2005) Risk factors for a first-incident radiographic vertebral fracture in women > or = 65 years of age: the study of osteoporotic fractures. J Bone Miner Res 20, 131140.
10Nguyen, TV, Kelly, PJ, Sambrook, PN, et al. (1994) Lifestyle factors and bone density in the elderly: implications for osteoporosis prevention. J Bone Miner Res 9, 13391346.
11Law, MR & Hackshaw, AK (1997) A meta-analysis of cigarette smoking, bone mineral density and risk of hip fracture: recognition of a major effect. BMJ 315, 841846.
12Prentice, A, Schoenmakers, I, Laskey, MA, et al. (2006) Nutrition and bone growth and development. Proc Nutr Soc 65, 348360.
13Favus, MJ (2006) Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 6th ed.Washington, DC: The American Society for Bone and Mineral Research.
14Riaz, S, Alam, M & Umer, M (2006) Frequency of osteomalacia in elderly patients with hip fractures. J Pak Med Assoc 56, 273276.
15Huang, Z, Himes, JH & McGovern, PG (1996) Nutrition and subsequent hip fracture risk among a national cohort of white women. Am J Epidemiol 144, 124134.
16Bonjour, JP, Chevalley, T, Rizzoli, R, et al. (2007) Gene–environment interactions in the skeletal response to nutrition and exercise during growth. Med Sport Sci 51, 6480.
17Barr, SI (2006) Introduction to dietary reference intakes. Appl Physiol Nutr Metab 31, 6165.
18North American Menopause Society (2006) The role of calcium in peri- and postmenopausal women: 2006 position statement of the North American Menopause Society. Menopause 13, 862877.
19Chapuy, MC, Arlot, ME, Duboeuf, F, et al. (1992) Vitamin D3 and calcium to prevent hip fractures in the elderly women. N Engl J Med 327, 16371642.
20Dawson-Hughes, B, Harris, SS, Krall, EA, et al. (1997) Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. N Engl J Med 337, 670676.
21Prince, RL, Devine, A, Dhaliwal, SS, et al. (2006) Effects of calcium supplementation on clinical fracture and bone structure: results of a 5-year, double-blind, placebo-controlled trial in elderly women. Arch Intern Med 166, 869875.
22Jackson, RD, LaCroix, AZ, Gass, M, et al. (2006) Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med 354, 669683.
23Grant, AM, Avenell, A, Campbell, MK, et al. (2005) Oral vitamin D3 and calcium for secondary prevention of low-trauma fractures in elderly people (Randomised Evaluation of Calcium Or vitamin D, RECORD): a randomised placebo-controlled trial. Lancet 365, 16211628.
24Boonen, S, Lips, P, Bouillon, R, et al. (2007) Need for additional calcium to reduce the risk of hip fracture with vitamin D supplementation: evidence from a comparative metaanalysis of randomized controlled trials. J Clin Endocrinol Metab 92, 14151423.
25Tang, BM, Eslick, GD, Nowson, C, et al. (2007) Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 years and older: a meta-analysis. Lancet 370, 657666.
26Institute of Medicine Food and Nutrition Board (1997) Dietary Reference Intakes for Calcium, Phosphorus, Magnesium, Vitamin D and Fluoride. Washington, DC: National Academy Press.
27Commitee on Medical Aspects of Food and Nutrition Policy (COMA) (1998) Nutrition and Bone Health: with Particular Reference to Calcium and Vitamin D. London: The Stationery Office.
28Guéguen, L (2001) Calcium, phosphore (Calcium, phosphorus). In Apports Nutritionnels Conseillés pour la Population Française (Recommended Nutritional Intakes for the French Population), pp. 131146 [Martin, A, editor]. Paris: Tech & Doc.
29Pointillart, A & Guéguen, L (2006) Le lait est-il indispensable pour satisfaire les ANC en calcium? (Is milk essential to satisfy the ANC for calcium?). Sci Aliments 26, 509515.
30Miller, DD (1989) Calcium in the diet: food sources, recommended intakes, and nutritional bioavailability. Adv Food Nutr Res 33, 103156.
31Scientific Committee on Food of the European Commission (2003) Opinion of the Scientific Committee on Food on the tolerable upper intake level of calcium. Tolerable upper intake levels for vitamins and minerals. http://www.efsa.europa.eu (accessed 20 September 2007).
32Whiting, SJ & Wood, RJ (1997) Adverse effects of high-calcium diets in humans. Nutr Rev 55, 19.
33Expert Group on Vitamins and Minerals (2003) Safe Upper Levels for Vitamins and Minerals. London: Food Standards Agency.
34Food Standards Agency UK (2007) Vitamins and minerals in food supplements and fortified foods. Update on stakeholder engagement on the EC discussion document. Agenda Item 3.1. 13 July 2006. http://www.foodstandards.gov.uk (accessed 20 September 2007).
35Heaney, RP, Recker, RR & Weaver, CM (1990) Absorbability of calcium sources: the limited role of solubility. Calcif Tissue Int 46, 300304.
36Allen, LH (1982) Calcium bioavailability and absorption: a review. Am J Clin Nutr 35, 783808.
37Recker, RR, Bammi, A, Barger-Lux, MJ, et al. (1988) Calcium absorbability from milk products, an imitation milk, and calcium carbonate. Am J Clin Nutr 47, 9395.
38Ekman, M, Reizenstein, P, Teigen, SW, et al. (1991) Comparative absorption of calcium from carbonate tablets, lactogluconate/carbonate effervescent tablet, and chloride solution. Bone 12, 9397.
39Hansen, C, Werner, E, Erbes, HJ, et al. (1996) Intestinal calcium absorption from different calcium preparations: influence of anion and solubility. Osteoporos Int 6, 386393.
40Mortensen, L & Charles, P (1996) Bioavailability of calcium supplements and the effect of vitamin D: comparisons between milk, calcium carbonate, and calcium carbonate plus vitamin D. Am J Clin Nutr 63, 354357.
41Guéguen, L & Pointillart, A (2000) The bioavailability of dietary calcium. J Am Coll Nutr 19, 119S136S.
42Zhao, Y, Martin, BR & Weaver, CM (2005) Calcium bioavailability of calcium carbonate fortified soymilk is equivalent to cow's milk in young women. J Nutr 135, 23792382.
43European Parliament and the Council of the European Union (2002) Directive 2002/46/EC on the approximation of the laws of the member states relating to food supplementation. http://eurlex.europa.eu (accessed 28 March 2007).
44Smith, KT, Heaney, RP, Flora, L, et al. (1987) Calcium absorption from a new calcium delivery system (CCM). Calcif Tissue Int 41, 351352.
45Martin, BR, Weaver, CM, Heaney, RP, et al. (2002) Calcium absorption from three salts and CaSO(4)-fortified bread in premenopausal women. J Agric Food Chem 50, 38743876.
46Brandolini, M, Guéguen, L, Boirie, Y, et al. (2005) Higher calcium urinary loss induced by a calcium sulphate-rich mineral water intake than by milk in young women. Br J Nutr 93, 225231.
47Florin, THJ, Neale, G, Goretski, S, et al. (1993) The sulphate content of foods and beverages. J Food Composition Anal 6, 140151.
48European Food Safety Authority (2004) Opinion of the AFC panel related to calcium sulphate as a mineral substance in food intended for the general population. Question EFSA-Q-2003-237. http://www.efsa.europa.eu (accessed 28 March 2007).
49Calvo, MS & Park, YK (1996) Changing phosphorus content of the U.S. diet: potential for adverse effects on bone. J Nutr 126, 1168S1180S.
50Calvo, MS, Kumar, R & Heath, H (1990) Persistently elevated parathyroid hormone secretion and action in young women after four weeks of ingesting high phosphorus, low calcium diets. J Clin Endocrinol Metab 70, 13341340.
51Brixen, K, Nielsen, HK, Charles, P, et al. (1992) Effects of a short course of oral phosphate treatment on serum parathyroid hormone(1-84) and biochemical markers of bone turnover: a dose–response study. Calcif Tissue Int 51, 276281.
52Calvo, MS, Whiting, SJ & Barton, CN (2005) Vitamin D intake: a global perspective of current status. J Nutr 135, 310316.
53Heaney, RP & Recker, RR (1987) Calcium supplements: anion effects. Bone Miner 2, 433439.
54Bizik, BK, Ding, W & Cerklewski, FL (1996) Evidence that bone resorption of young men is not increased by high dietary phosphorus obtained from milk and cheese. Nutr Res 16, 11431146.
55Karkkainen, M & Lamberg-Allardt, C (1996) An acute intake of phosphate increases parathyroid hormone secretion and inhibits bone formation in young women. J Bone Miner Res 11, 19051912.
56European Food Safety Authority (2005) Opinion of the Scientific Panel on Dietary Products, Nutrition, and Allergies on a request of the Commission related to the Tolerable Upper Intake Levels of Phosphorus. http://www.efsa.europa.eu (accessed 20 September 2007).
57Whybro, A, Jagger, H, Barker, M, et al. (1998) Phosphate supplementation in young men: lack of effect on calcium homeostasis and bone turnover. Eur J Clin Nutr 52, 2933.
58Grimm, M, Muller, A, Hein, G, et al. (2001) High phosphorus intake only slightly affects serum minerals, urinary pyridinium crosslinks and renal function in young women. Eur J Clin Nutr 55, 153161.
59Dhingra, R, Sullivan, LM, Fox, CS, et al. (2007) Relations of serum phosphorus and calcium levels to the incidence of cardiovascular disease in the community. Arch Intern Med 167, 879885.
60Heaney, RP & Weaver, CM (2003) Calcium and vitamin D. Endocrinol Metab Clin North Am 32, 181194, vii–viii.
61Barger-Lux, MJ, Heaney, RP, Lanspa, SJ, et al. (1995) An investigation of sources of variation in calcium absorption efficiency. J Clin Endocrinol Metab 80, 406411.
62Devine, A, Wilson, SG, Dick, IM, et al. (2002) Effects of vitamin D metabolites on intestinal calcium absorption and bone turnover in elderly women. Am J Clin Nutr 75, 283288.
63Heaney, RP (2004) Functional indices of vitamin D status and ramifications of vitamin D deficiency. Am J Clin Nutr 80, 1706S1709S.
64Abrams, SA, Griffin, IJ, Hawthorne, KM, et al. (2005) Relationships among vitamin D levels, parathyroid hormone, and calcium absorption in young adolescents. J Clin Endocrinol Metab 90, 55765581.
65Thomas, MK, Lloyd-Jones, DM, Thadhani, RI, et al. (1998) Hypovitaminosis D in medical inpatients. N Engl J Med 338, 777783.
66Guillemant, J, Taupin, P, Le, HT, et al. (1999) Vitamin D status during puberty in French healthy male adolescents. Osteoporos Int 10, 222225.
67Gordon, CM, DePeter, KC, Feldman, HA, et al. (2004) Prevalence of vitamin D deficiency among healthy adolescents. Arch Pediatr Adolesc Med 158, 531537.
68Lehtonen-Veromaa, MK, Mottonen, TT, Nuotio, IO, et al. (2002) Vitamin D and attainment of peak bone mass among peripubertal Finnish girls: a 3-y prospective study. Am J Clin Nutr 76, 14461453.
69Cheng, S, Tylavsky, F, Kroger, H, et al. (2003) Association of low 25-hydroxyvitamin D concentrations with elevated parathyroid hormone concentrations and low cortical bone density in early pubertal and prepubertal Finnish girls. Am J Clin Nutr 78, 485492.
70El-Hajj Fuleihan, G, Nabulsi, M, Tamim, H, et al. (2006) Effect of vitamin D replacement on musculoskeletal parameters in school children: a randomized controlled trial. J Clin Endocrinol Metab 91, 405412.
71Viljakainen, HT, Natri, AM, Karkkainen, M, et al. (2006) A positive dose–response effect of vitamin D supplementation on site-specific bone mineral augmentation in adolescent girls: a double-blinded randomized placebo-controlled 1-year intervention. J Bone Miner Res 21, 836844.
72Andersen, R, Molgaard, C, Skovgaard, LT, et al. (2008) Effect of vitamin D supplementation on bone and vitamin D status among Pakistani immigrants in Denmark: a randomised double-blinded placebo-controlled intervention study. Br J Nutr 100, 197207.
73Bischoff-Ferrari, HA, Dietrich, T, Orav, EJ, et al. (2004) Positive association between 25-hydroxy vitamin D levels and bone mineral density: a population-based study of younger and older adults. Am J Med 116, 634639.
74Bischoff-Ferrari, HA, Willett, WC, Wong, JB, et al. (2005) Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. JAMA 293, 22572264.
75Porthouse, J, Cockayne, S, King, C, et al. (2005) Randomised controlled trial of calcium and supplementation with cholecalciferol (vitamin D3) for prevention of fractures in primary care. BMJ 330, 1003.
76Avenell, A, Gillespie, WJ & Gillespie, LD, et al. (2005) Vitamin D and vitamin D analogues for preventing fractures associated with involutional and post-menopausal osteoporosis. The Cochrane Database of Systematic Reviews, issue 3, CD000227. http://www.mrw.interscience.wiley.com/cochrane/clsysrev/articles/CD000227/frame.html.
77Bischoff-Ferrari, HA, Dawson-Hughes, B, Willett, WC, et al. (2004) Effect of vitamin D on falls: a meta-analysis. JAMA 291, 19992006.
78Bischoff-Ferrari, HA, Orav, EJ & Dawson-Hughes, B (2006) Effect of cholecalciferol plus calcium on falling in ambulatory older men and women: a 3-year randomized controlled trial. Arch Intern Med 166, 424430.
79Boland, R (1986) Role of vitamin D in skeletal muscle function. Endocr Rev 7, 434448.
80Visser, M, Deeg, DJ & Lips, P (2003) Low vitamin D and high parathyroid hormone levels as determinants of loss of muscle strength and muscle mass (sarcopenia): the Longitudinal Aging Study Amsterdam. J Clin Endocrinol Metab 88, 57665772.
81Bischoff, HA, Borchers, M, Gudat, F, et al. (2001) In situ detection of 1,25-dihydroxyvitamin D3 receptor in human skeletal muscle tissue. Histochem J 33, 1924.
82Zehnder, D, Bland, R, Williams, MC, et al. (2001) Extrarenal expression of 25-hydroxyvitamin D(3)-1 α-hydroxylase. J Clin Endocrinol Metab 86, 888894.
83Moore, C, Murphy, MM, Keast, DR, et al. (2004) Vitamin D intake in the United States. J Am Diet Assoc 104, 980983.
84Weaver, CM & Fleet, JC (2004) Vitamin D requirements: current and future. Am J Clin Nutr 80, 1735S1739S.
85Chen, TC, Shao, A, Heath, H III, et al. (1993) An update on the vitamin D content of fortified milk from the United States and Canada. N Engl J Med 329, 1507.
86Lips, P, Duong, T, Oleksik, A, et al. (2001) A global study of vitamin D status and parathyroid function in postmenopausal women with osteoporosis: baseline data from the Multiple Outcomes of Raloxifene Evaluation clinical trial. J Clin Endocrinol Metab 86, 12121221.
87Dawson-Hughes, B, Heaney, RP, Holick, MF, et al. (2005) Estimates of optimal vitamin D status. Osteoporos Int 16, 713716.
88Grant, WB & Holick, MF (2005) Benefits and requirements of vitamin D for optimal health: a review. Altern Med Rev 10, 94111.
89Vieth, R, Bischoff-Ferrari, H, Boucher, BJ, et al. (2007) The urgent need to recommend an intake of vitamin D that is effective. Am J Clin Nutr 85, 649650.
90Hathcock, JN, Shao, A, Vieth, R, et al. (2007) Risk assessment for vitamin D. Am J Clin Nutr 85, 618.
91Weaver, CM (2003) 2003 W. O. Atwater Memorial Lecture: Defining nutrient requirements from a perspective of bone-related nutrients. J Nutr 133, 40634066.
92Calvo, MS, Whiting, SJ & Barton, CN (2004) Vitamin D fortification in the United States and Canada: current status and data needs. Am J Clin Nutr 80, 1710S1716S.
93Chee, WS, Suriah, AR, Chan, SP, et al. (2003) The effect of milk supplementation on bone mineral density in postmenopausal Chinese women in Malaysia. Osteoporos Int 14, 828834.
94Du, X, Zhu, K, Trube, A, et al. (2004) School-milk intervention trial enhances growth and bone mineral accretion in Chinese girls aged 10–12 years in Beijing. Br J Nutr 92, 159168.
95Shearer, MJ (1995) Vitamin K. Lancet 345, 229234.
96Boskey, AL, Gadaleta, S, Gundberg, C, et al. (1998) Fourier transform infrared microspectroscopic analysis of bones of osteocalcin-deficient mice provides insight into the function of osteocalcin. Bone 23, 187196.
97Shearer, MJ (2000) Role of vitamin K and Gla proteins in the pathophysiology of osteoporosis and vascular calcification. Curr Opin Clin Nutr Metab Care 3, 433438.
98Coutu, DL, Wu, JH, Monette, A, et al. (2008) Periostin, a member of a novel family of vitamin K-dependent proteins, is expressed by mesenchymal stromal cells. J Biol Chem 283, 1799118001.
99Berkner, KL & Runge, KW (2004) The physiology of vitamin K nutriture and vitamin K-dependent protein function in atherosclerosis. J Thromb Haemost 2, 21182132.
100Vermeer, C, Shearer, MJ, Zittermann, A, et al. (2004) Beyond deficiency: potential benefits of increased intakes of vitamin K for bone and vascular health. Eur J Nutr 43, 325335.
101Thijssen, HH, Vervoort, LM, Schurgers, LJ, et al. (2006) Menadione is a metabolite of oral vitamin K. Br J Nutr 95, 260266.
102Schurgers, LJ, Teunissen, KJ, Hamulyak, K, et al. (2007) Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7. Blood 109, 32793283.
103Schurgers, LJ, Geleijnse, JM, Grobbee, DE, et al. (1999) Nutritional intake of vitamin K1 (phylloquinone) and K2 (menaquinone) in The Netherlands. J Nutr Environ Med 9, 115122.
104Booth, SL & Suttie, JW (1998) Dietary intake and adequacy of vitamin K. J Nutr 128, 785788.
105Thane, CW, Paul, AA, Bates, CJ, et al. (2002) Intake and sources of phylloquinone (vitamin K1): variation with socio-demographic and lifestyle factors in a national sample of British elderly people. Br J Nutr 87, 605613.
106Thane, CW, Bolton-Smith, C & Coward, WA (2006) Comparative dietary intake and sources of phylloquinone (vitamin K1) among British adults in 1986–7 and 2000–1. Br J Nutr 96, 11051115.
107Institute of Medicine Food and Nutrition Board (2001) Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Manganese, Molybdenum, Nickel, Silicon, Vanadium and Zinc. Washington, DC: National Academy Press.
108Feskanich, D, Weber, P, Willett, WC, et al. (1999) Vitamin K intake and hip fractures in women: a prospective study. Am J Clin Nutr 69, 7479.
109Booth, SL, Tucker, KL, Chen, H, et al. (2000) Dietary vitamin K intakes are associated with hip fracture but not with bone mineral density in elderly men and women. Am J Clin Nutr 71, 12011208.
110Booth, SL, Broe, KE, Gagnon, DR, et al. (2003) Vitamin K intake and bone mineral density in women and men. Am J Clin Nutr 77, 512516.
111Booth, SL, Broe, KE, Peterson, JW, et al. (2004) Associations between vitamin K biochemical measures and bone mineral density in men and women. J Clin Endocrinol Metab 89, 49044909.
112Kalkwarf, HJ, Khoury, JC, Bean, J, et al. (2004) Vitamin K, bone turnover, and bone mass in girls. Am J Clin Nutr 80, 10751080.
113Szulc, P, Chapuy, MC, Meunier, PJ, et al. (1996) Serum undercarboxylated osteocalcin is a marker of the risk of hip fracture: a three year follow-up study. Bone 18, 487488.
114Vergnaud, P, Garnero, P, Meunier, PJ, et al. (1997) Undercarboxylated osteocalcin measured with a specific immunoassay predicts hip fracture in elderly women: the EPIDOS Study. J Clin Endocrinol Metab 82, 719724.
115Luukinen, H, Kakonen, SM, Pettersson, K, et al. (2000) Strong prediction of fractures among older adults by the ratio of carboxylated to total serum osteocalcin. J Bone Miner Res 15, 24732478.
116Szulc, P, Arlot, M, Chapuy, MC, et al. (1994) Serum undercarboxylated osteocalcin correlates with hip bone mineral density in elderly women. J Bone Miner Res 9, 15911595.
117Knapen, MH, Nieuwenhuijzen Kruseman, AC, Wouters, RS, et al. (1998) Correlation of serum osteocalcin fractions with bone mineral density in women during the first 10 years after menopause. Calcif Tissue Int 63, 375379.
118Cockayne, S, Adamson, J, Lanham-New, S, et al. (2006) Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials. Arch Intern Med 166, 12561261.
119Braam, LA, Knapen, MH, Geusens, P, et al. (2003) Vitamin K1 supplementation retards bone loss in postmenopausal women between 50 and 60 years of age. Calcif Tissue Int 73, 2126.
120Bolton-Smith, C, McMurdo, ME, Paterson, CR, et al. (2007) Two-year randomized controlled trial of vitamin K1 (phylloquinone) and vitamin D3 plus calcium on the bone health of older women. J Bone Miner Res 22, 509519.
121Booth, SL, Dallal, G, Shea, MK, et al. (2008) Effect of vitamin K supplementation on bone loss in elderly men and women. J Clin Endocrinol Metab 93, 12171223.
122Caraballo, PJ, Gabriel, SE, Castro, MR, et al. (1999) Changes in bone density after exposure to oral anticoagulants: a meta-analysis. Osteoporos Int 9, 441448.
123Ducy, P, Desbois, C, Boyce, B, et al. (1996) Increased bone formation in osteocalcin-deficient mice. Nature 382, 448452.
124Liu, G & Peacock, M (1998) Age-related changes in serum undercarboxylated osteocalcin and its relationships with bone density, bone quality, and hip fracture. Calcif Tissue Int 62, 286289.
125Kaptoge, S, Dalzell, N, Welch, A, et al. (2005) Vitamin K and fracture risk: an effect on bone width not BMD? J Bone Miner Res 20, 1293.
126Knapen, MH, Schurgers, LJ & Vermeer, C (2007) Vitamin K2 supplementation improves hip bone geometry and bone strength indices in postmenopausal women. Osteoporos Int 18, 963972.
127Schurgers, LJ, Shearer, MJ, Hamulyak, K, et al. (2004) Effect of vitamin K intake on the stability of oral anticoagulant treatment: dose–response relationships in healthy subjects. Blood 104, 26822689.
128Sconce, E, Avery, P, Wynne, H, et al. (2007) Vitamin K supplementation can improve stability of anticoagulation for patients with unexplained variability in response to warfarin. Blood 109, 24192423.
129Lehnerdt, F (1910) On the question of the substitution of calcium in the bones by strontium. II. Report. Strontium feeding in suckling animals, the influence of strontium on the bone system of suckled young animals. Beitr Pathol Anat 47, 215247.
130Shorr, E & Carter, AC (1952) The usefulness of strontium as an adjuvant to calcium in the remineralization of the skeleton in man. Bull Hosp Joint Dis 13, 5966.
131McCaslin, FE & Jane, JM (1959) The effect of strontium lactate in the treatment of osteoporosis. Proc Staff Meetings Mayo Clin 34, 329334.
132Grynpas, MD, Hamilton, E, Cheung, R, et al. (1996) Strontium increases vertebral bone volume in rats at a low dose that does not induce detectable mineralization defect. Bone 18, 253259.
133Marie, PJ (1996) Effects of strontium on bone tissue and bone cells. In Therapeutic Uses of Trace Elements, pp. 277282 [Nève, J, Chappuis, P and Lamand, M, editors]. New York: Springer Verlag.
134Marie, PJ, Garba, MT, Hott, M, et al. (1985) Effect of low doses of stable strontium on bone metabolism in rats. Miner Electrolyte Metab 11, 513.
135Marie, PJ & Hott, M (1986) Short-term effects of fluoride and strontium on bone formation and resorption in the mouse. Metabolism 35, 547551.
136Skoryna, SC & Fuskova, M (1981) Effect of stable strontium supplementation. In Handbook of Stable Strontium, pp. 593617 [Skoryna, SC, editor]. New York: Plenum Press.
137Marie, PJ, Ammann, P, Boivin, G, et al. (2001) Mechanisms of action and therapeutic potential of strontium in bone. Calcif Tissue Int 69, 121129.
138Meunier, PJ, Roux, C, Seeman, E, et al. (2004) The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis. N Engl J Med 350, 459468.
139Reginster, JY, Seeman, E, De Vernejoul, MC, et al. (2005) Strontium ranelate reduces the risk of nonvertebral fractures in postmenopausal women with osteoporosis: Treatment of Peripheral Osteoporosis (TROPOS) study. J Clin Endocrinol Metab 90, 28162822.
140Reginster, JY, Felsenberg, D, Boonen, S, et al. (2008) Effects of long-term strontium ranelate treatment on the risk of nonvertebral and vertebral fractures in postmenopausal osteoporosis: results of a five-year, randomized, placebo-controlled trial. Arthritis Rheum 58, 16871695.
141Nakamura, T (2007) Therapeutic agents for disorders of bone and calcium metabolism. Osteoporotic fracture prevention by strontium ranelate (article in Japanese). Clin Calcium 17, 8087.
142Venugopal, B & Luckey, TD (1978) Metal Toxicity in Mammals. New York: Plenum Press.
143Pennington, JA & Jones, JW (1987) Molybdenum, nickel, cobalt, vanadium, and strontium in total diets. J Am Diet Assoc 87, 16441650.
144Ozgur, S, Sumer, H & Kocoglu, G (1996) Rickets and soil strontium. Arch Dis Child 75, 524526.
145Office of Health and Environmental Assessment (1990) Drinking Water Criteria Document for Stable Strontium. Washington, DC: Office of Drinking Water.
146Ministry of Agriculture, Fisheries and Food (1997) 1994 Total Diet Study: Metal and Other Elements, Food Safety Agency, Food Surveillance Information Sheets. London: MAFF.
147Varo, P, Saari, E, Paaso, A, et al. (1982) Strontium in Finnish foods. Int J Vitam Nutr Res 52, 342350.
148Agency for Toxic Substances and Disease Registry (2004) Toxicological Profile of Strontium. Washington, DC: US Department of Health and Human Services, Public Health Service.
149Martin, AD (2001) Apports Nutritonnels Conseillés pour la Population Française (Recommended Nutritional Intakes for the French Population), 3rd ed.Paris: TEC&DOC.
150Kshirsagar, SG (1985) Effect of age on strontium–calcium discrimination by rat tissues. Indian J Exp Biol 23, 366369.
151El Solh, N & Rousselet, F (1981) Effects of stable strontium administration on calcium metabolism with particular reference to low-calcium diet. In Handbook of Stable Strontium, pp. 515544 [Skoryna, SC, editor]. New York: Plenum Press.
152Morohashi, T, Sano, T & Yamada, S (1994) Effects of strontium on calcium metabolism in rats. I. A distinction between the pharmacological and toxic doses. Jpn J Pharmacol 64, 155162.
153Storey, E (1961) Strontium ‘rickets’: bone, calcium and strontium changes. Australas Ann Med 10, 213222.
154Rousselet, F, El Solh, N, Maurat, JP, et al. (1975) Strontium et metabolisme calcique: interaction strontium–vitamine D (Strontium and calcium metabolism: strontium–vitamin D interaction). Comp Rend Séances Soc Biol 169, 322329.
155Svensson, O, Reinholt, FP, Engfeldt, B, et al. (1987) The parathyroid gland in metal rickets. A stereological study. Acta Pathol Microbiol Immunol Scand 95, 309314.
156Marcus, CS & Wasserman, RH (1965) Comparison of intestinal discrimination between calcium 47, strontium 85, and barium 133. Am J Physiol 209, 973977.
157Storey, E (1962) Intermittent bone changes and multiple cartilage defects in chronic strontium rickets in rats. J Bone Joint Surg Br 44-B, 194208.
158Browning, E (1969) Toxicity of Industrial Metals, 2nd ed.New York: Appleton-Century-Croft.
159Sugihira, N & Suzuki, KT (1991) Discrimination between strontium and calcium in suckling rats. Biol Trace Elem Res 29, 110.
160Schrooten, I, Cabrera, W, Goodman, WG, et al. (1998) Strontium causes osteomalacia in chronic renal failure rats. Kidney Int 54, 448456.
161Fatemi, S, Ryzen, E, Flores, J, et al. (1991) Effect of experimental human magnesium depletion on parathyroid hormone secretion and 1,25-dihydroxyvitamin D metabolism. J Clin Endocrinol Metab 73, 10671072.
162Tucker, KL, Hannan, MT, Chen, H, et al. (1999) Potassium, magnesium, and fruit and vegetable intakes are associated with greater bone mineral density in elderly men and women. Am J Clin Nutr 69, 727736.
163New, SA, Robins, SP, Campbell, MK, et al. (2000) Dietary influences on bone mass and bone metabolism: further evidence of a positive link between fruit and vegetable consumption and bone health? Am J Clin Nutr 71, 142151.
164New, SA (2003) Intake of fruit and vegetables: implications for bone health. Proc Nutr Soc 62, 889899.
165Macdonald, HM, New, SA, Fraser, WD, et al. (2005) Low dietary potassium intakes and high dietary estimates of net endogenous acid production are associated with low bone mineral density in premenopausal women and increased markers of bone resorption in postmenopausal women. Am J Clin Nutr 81, 923933.
166Wang, MC, Moore, EC, Crawford, PB, et al. (1999) Influence of pre-adolescent diet on quantitative ultrasound measurements of the calcaneus in young adult women. Osteoporos Int 9, 532535.
167Angus, RM, Sambrook, PN, Pocock, NA, et al. (1988) Dietary intake and bone mineral density. Bone Miner 4, 265277.
168New, SA, Bolton-Smith, C, Grubb, DA, et al. (1997) Nutritional influences on bone mineral density: a cross-sectional study in premenopausal women. Am J Clin Nutr 65, 18311839.
169Ilich, JZ, Brownbill, RA & Tamborini, L (2003) Bone and nutrition in elderly women: protein, energy, and calcium as main determinants of bone mineral density. Eur J Clin Nutr 57, 554565.
170Tranquilli, AL, Lucino, E, Garzetti, GG, et al. (1994) Calcium, phosphorus and magnesium intakes correlate with bone mineral content in postmenopausal women. Gynecol Endocrinol 8, 5558.
171Ryder, KM, Shorr, RI, Bush, AJ, et al. (2005) Magnesium intake from food and supplements is associated with bone mineral density in healthy older white subjects. J Am Geriatr Soc 53, 18751880.
172Carpenter, TO, DeLucia, MC, Zhang, JH, et al. (2006) A randomized controlled study of effects of dietary magnesium oxide supplementation on bone mineral content in healthy girls. J Clin Endocrinol Metab 91, 48664872.
173Abraham, GE & Grewal, H (1990) A total dietary program emphasizing magnesium instead of calcium. Effect on the mineral density of calcaneous bone in postmenopausal women on hormonal therapy. J Reprod Med 35, 503507.
174Stendig-Lindberg, G, Tepper, R & Leichter, I (1993) Trabecular bone density in a two year controlled trial of peroral magnesium in osteoporosis. Magnes Res 6, 155163.
175Dimai, HP, Porta, S, Wirnsberger, G, et al. (1998) Daily oral magnesium supplementation suppresses bone turnover in young adult males. J Clin Endocrinol Metab 83, 27422748.
176Flynn, A, Moreiras, O, Stehle, P, et al. (2003) Vitamins and minerals: a model for safe addition to foods. Eur J Nutr 42, 118130.
177Ford, ES & Mokdad, AH (2003) Dietary magnesium intake in a national sample of US adults. J Nutr 133, 28792882.
178Elmadfa, I, Weichselbaum, E, König, J, et al. (2005) European nutrition and health report 2004. Forum Nutr 1220.
179Touvier, M, Boutron-Ruault, MC, Volatier, JL, et al. (2005) Efficacy and safety of regular vitamin and mineral supplement use in France: results from the ECCA study. Int J Vitam Nutr Res 75, 201209.
180Abdulla, M, Andersson, I, Asp, NG, et al. (1981) Nutrient intake and health status of vegans. Chemical analyses of diets using the duplicate portion sampling technique. Am J Clin Nutr 34, 24642477.
181Haddad, EH, Berk, LS, Kettering, JD, et al. (1999) Dietary intake and biochemical, hematologic, and immune status of vegans compared with nonvegetarians. Am J Clin Nutr 70, 586S593S.
182Clark, I & Belanger, L (1967) The effects of alterations in dietary magnesium on calcium, phosphate and skeletal metabolism. Calcif Tissue Res 1, 204218.
183Thurnher, H & Kresbach, E (1961) Contribution to the clinical aspects and treatment of magnesium sulfate poisoning (article in German). Wien Klin Wochenschr 73, 356357.
184Wallace, KL, Curry, SC, LoVecchio, F, et al. (1998) Effect of magnesium hydroxide on iron absorption following simulated mild iron overdose in human subjects. Acad Emerg Med 5, 961965.
185Sturniolo, GC, Montino, MC, Rossetto, L, et al. (1991) Inhibition of gastric acid secretion reduces zinc absorption in man. J Am Coll Nutr 10, 372375.
186Griffin, JP & D'Arcy, PF (1981) Handbuch der Arzneimittelinteraktionen (Handbook of Drug Interactions). Munich, Germany: Oldenburg-Verlag.
187Andon, MB, Ilich, JZ, Tzagournis, MA, et al. (1996) Magnesium balance in adolescent females consuming a low- or high-calcium diet. Am J Clin Nutr 63, 950953.
188Lewis, NM, Marcus, MS, Behling, AR, et al. (1989) Calcium supplements and milk: effects on acid–base balance and on retention of calcium, magnesium, and phosphorus. Am J Clin Nutr 49, 527533.
189Sojka, J, Wastney, M, Abrams, S, et al. (1997) Magnesium kinetics in adolescent girls determined using stable isotopes: effects of high and low calcium intake. Am J Physiol 273, R710R715.

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