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Moderate red wine consumption is associated with a lower prevalence of the metabolic syndrome in the PREDIMED population

  • Anna Tresserra-Rimbau (a1) (a2), Alexander Medina-Remón (a2) (a3), Rosa M. Lamuela-Raventós (a1) (a2), Monica Bulló (a2) (a4), Jordi Salas-Salvadó (a2) (a4), Dolores Corella (a2) (a5), Montserrat Fitó (a2) (a6), Alfredo Gea (a7), Enrique Gómez-Gracia (a2) (a8), José Lapetra (a2) (a9), Fernando Arós (a2) (a10), Miquel Fiol (a2) (a11), Emili Ros (a2) (a12), Luis Serra-Majem (a2) (a13), Xavier Pintó (a2) (a14), Miguel A. Muñoz (a15), Ramón Estruch (a2) (a3) and on behalf of the PREDIMED Study Investigators...

Previous studies on the association between alcohol intake and the development of the metabolic syndrome (MetS) have yielded inconsistent results. Besides, few studies have analysed the effects of red wine (RW) consumption on the prevalence of the MetS and its components. As moderate RW drinkers have a better lipid profile and lower incidence rates of diabetes, hypertension and abdominal obesity, all components of the MetS, it was hypothesised that moderate RW consumption could be associated with a lower prevalence of the MetS. In the present cross-sectional study of 5801 elderly participants at a high cardiovascular risk included in the PREDIMED (Prevención con Dieta Mediterránea) study, 3897 fulfilled the criteria of the MetS at baseline. RW intake was recorded using a validated 137-item FFQ. Multiple logistic regression analysis was carried out to estimate the association between RW intake and the prevalence of the MetS. Compared with non-drinkers, moderate RW drinkers ( ≥ 1 drink/d) were found to have a reduced risk of prevalent MetS (OR 0·56, 95 % CI 0·45, 0·68; P< 0·001), a lower risk of having an abnormal waist circumference (OR 0·59, 95 % CI 0·46, 0·77; P< 0·001), low HDL-cholesterol concentrations (OR 0·42, 95 % CI 0·32, 0·53; P< 0·001), high blood pressure (OR 0·28, 95 % CI 0·17, 0·45; P< 0·001) and high fasting plasma glucose concentrations (OR 0·67, 95 % CI 0·54, 0·82; P< 0·001) after adjusting for several confounders. This association was found to be stronger in female participants, in participants aged < 70 years and in participants who were former or current smokers. No significant association was found between RW intake ( ≥ 1 drink/d) and TAG concentrations. In conclusion, moderate RW consumption is associated with a lower prevalence of the MetS in an elderly Mediterranean population at a high cardiovascular risk.

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Corresponding author
*Corresponding author: Dr R. Estruch, fax +34 93 2279236, email
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1Eckel, RH, Grundy, SM & Zimmet, PZ (2005) The metabolic syndrome. Lancet 365, 14151428.
2Babio, N, Bulló, M, Basora, J, et al. (2009) Adherence to the Mediterranean diet and risk of metabolic syndrome and its components. Nutr Metab Cardiovasc Dis 19, 563570.
3Freiberg, MS, Cabral, HJ, Heeren, TC, et al. (2004) Alcohol consumption and the prevalence of the metabolic syndrome in the US: a cross-sectional analysis of data from the Third National Health and Nutrition Examination Survey. Diabetes Care 27, 29542959.
4Alkerwi, A, Boutsen, M, Vaillant, M, et al. (2009) Alcohol consumption and the prevalence of metabolic syndrome: a meta-analysis of observational studies. Atherosclerosis 204, 624635.
5Barrio-Lopez, MT, Bes-Rastrollo, M, Sayon-Orea, C, et al. (2013) Different types of alcoholic beverages and incidence of metabolic syndrome and its components in a Mediterranean cohort. Clin Nutr 32, 797804.
6Chiva-Blanch, G, Urpi-Sarda, M, Ros, E, et al. (2013) Effects of red wine polyphenols and alcohol on glucose metabolism and the lipid profile: a randomized clinical trial. Clin Nutr 32, 200206.
7Botden, IP, Draijer, R, Westerhof, BE, et al. (2012) Red wine polyphenols do not lower peripheral or central blood pressure in high normal blood pressure and hypertension. Am J Hypertens 25, 718723.
8Chiva-Blanch, G, Urpi-Sarda, M, Ros, E, et al. (2012) Dealcoholized red wine decreases systolic and diastolic blood pressure and increases plasma nitric oxide: short communication. Circ Res 111, 10651068.
9Baba, S, Osakabe, N, Kato, Y, et al. (2007) Continuous intake of polyphenolic compounds containing cocoa powder reduces LDL oxidative susceptibility and has beneficial effects on plasma HDL-cholesterol concentrations in humans. Am J Clin Nutr 85, 709717.
10Covas, MI, Nyyssönen, K, Poulsen, HE, et al. (2006) The effect of polyphenols in olive oil on heart disease risk factors: a randomized trial. Ann Intern Med 145, 333341.
11Monagas, M, Khan, N, Andres-Lacueva, C, et al. (2009) Effect of cocoa powder on the modulation of inflammatory biomarkers in patients at high risk of cardiovascular disease. Am J Clin Nutr 90, 11441150.
12Pfeuffer, M, Auinger, A, Bley, U, et al. (2013) Effect of quercetin on traits of the metabolic syndrome, endothelial function and inflammation in men with different APOE isoforms. Nutr Metab Cardiovasc Dis 23, 403409.
13Shin, HC, Kim, SH, Park, Y, et al. (2012) Effects of 12-week oral supplementation of Ecklonia cava polyphenols on anthropometric and blood lipid parameters in overweight Korean individuals: a double-blind randomized clinical trial. Phytother Res 26, 363368.
14Miyazaki, R, Kotani, K, Ayabe, M, et al. (2013) Minor effects of green tea catechin supplementation on cardiovascular risk markers in active older people: a randomized controlled trial. Geriatr Gerontol Int 13, 622629.
15Martínez-González, MA, Corella, D, Salas-Salvadó, J, et al. (2012) Cohort profile: design and methods of the PREDIMED study. Int J Epidemiol 41, 377385.
16Willett, WC, Howe, GR & Kushi, LH (1997) Adjustment for total energy intake in epidemiologic studies. Am J Clin Nutr 65, 1220S1228S, discussion 1229S–1231S.
17Fernández-Ballart, JD, Piñol, JL, Zazpe, I, et al. (2010) Relative validity of a semi-quantitative food-frequency questionnaire in an elderly Mediterranean population of Spain. Br J Nutr 103, 18081816.
18Martínez-González, MA, Fernández-Jarne, E, Serrano-Martínez, M, et al. (2004) Development of a short dietary intake questionnaire for the quantitative estimation of adherence to a cardioprotective Mediterranean diet. Eur J Clin Nutr 58, 15501552.
19Elosua, R, Marrugat, J, Molina, L, et al. (1994) Validation of the Minnesota Leisure Time Physical Activity Questionnaire in Spanish men. The MARATHOM Investigators. Am J Epidemiol 139, 11971209.
20O'Brien, E, Waeber, B, Parati, G, et al. (2001) Blood pressure measuring devices: recommendations of the European Society of Hypertension. BMJ 322, 531536.
21Warnick, GR, Knopp, RH, Fitzpatrick, V, et al. (1990) Estimating low-density lipoprotein cholesterol by the Friedewald equation is adequate for classifying patients on the basis of nationally recommended cutpoints. Clin Chem 36, 1519.
22Alberti, KG, Eckel, RH, Grundy, SM, et al. (2009) Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 120, 16401645.
23Fernandez-Sola, J, Estruch, R, Nicolas, JM, et al. (1997) Comparison of alcoholic cardiomyopathy in women versus men. Am J Cardiol 80, 481485.
24Gunzerath, L, Faden, V, Zakhari, S, et al. (2004) National Institute on Alcohol Abuse and Alcoholism report on moderate drinking. Alcohol Clin Exp Res 28, 829847.
25Di Castelnuovo, A, Costanzo, S, Bagnardi, V, et al. (2006) Alcohol dosing and total mortality in men and women: an updated meta-analysis of 34 prospective studies. Arch Intern Med 166, 24372445.
26Rumawas, ME, Meigs, JB, Dwyer, JT, et al. (2009) Mediterranean-style dietary pattern, reduced risk of metabolic syndrome traits, and incidence in the Framingham Offspring Cohort. Am J Clin Nutr 90, 16081614.
27Álvarez-León, EE, Henríquez, P & Serra-Majem, L (2006) Mediterranean diet and metabolic syndrome: a cross-sectional study in the Canary Islands. Public Health Nutr 9, 10891098.
28Kesse-Guyot, E, Ahluwalia, N, Lassale, C, et al. (2013) Adherence to Mediterranean diet reduces the risk of metabolic syndrome: a 6-year prospective study. Nutr Metab Cardiovasc Dis 23, 677683.
29Paletas, K, Athanasiadou, E, Sarigianni, M, et al. (2010) The protective role of the Mediterranean diet on the prevalence of metabolic syndrome in a population of Greek obese subjects. J Am Coll Nutr 29, 4145.
30Panagiotakos, DB, Pitsavos, C, Chrysohoou, C, et al. (2004) Impact of lifestyle habits on the prevalence of the metabolic syndrome among Greek adults from the ATTICA study. Am Heart J 147, 106112.
31Tortosa, A, Bes-Rastrollo, M, Sanchez-Villegas, A, et al. (2007) Mediterranean diet inversely associated with the incidence of metabolic syndrome: the SUN prospective cohort. Diabetes Care 30, 29572959.
32Kastorini, CM, Milionis, HJ, Esposito, K, et al. (2011) The effect of Mediterranean diet on metabolic syndrome and its components: a meta-analysis of 50 studies and 534,906 individuals. J Am Coll Cardiol 57, 12991313.
33Esposito, K, Marfella, R, Ciotola, M, et al. (2004) Effect of a Mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: a randomized trial. JAMA 292, 14401446.
34Salas-Salvado, J, Fernandez-Ballart, J, Ros, E, et al. (2008) Effect of a Mediterranean diet supplemented with nuts on metabolic syndrome status: one-year results of the PREDIMED randomized trial. Arch Intern Med 168, 24492458.
35Martínez-González, MA & Sánchez-Villegas, A (2004) The emerging role of Mediterranean diets in cardiovascular epidemiology: monounsaturated fats, olive oil, red wine or the whole pattern? Eur J Epidemiol 19, 913.
36Arranz, S, Chiva-Blanch, G, Valderas-Martínez, P, et al. (2012) Wine, beer, alcohol and polyphenols on cardiovascular disease and cancer. Nutrients 4, 759781.
37Zilkens, RR, Burke, V, Hodgson, JM, et al. (2005) Red wine and beer elevate blood pressure in normotensive men. Hypertension 45, 874879.
38Ellison, RC, Zhang, Y, Qureshi, MM, et al. (2004) Lifestyle determinants of high-density lipoprotein cholesterol: the National Heart, Lung, and Blood Institute Family Heart Study. Am Heart J 147, 529535.
39Klatsky, AL (2010) Alcohol and cardiovascular health. Physiol Behav 100, 7681.
40Rimm, EB, Williams, P, Fosher, K, et al. (1999) Moderate alcohol intake and lower risk of coronary heart disease: meta-analysis of effects on lipids and haemostatic factors. BMJ 319, 15231528.
41Schroder, H, Marrugat, J, Fito, M, et al. (2006) Alcohol consumption is directly associated with circulating oxidized low-density lipoprotein. Free Radic Biol Med 40, 14741481.
42Estruch, R, Sacanella, E, Mota, F, et al. (2011) Moderate consumption of red wine, but not gin, decreases erythrocyte superoxide dismutase activity: a randomised cross-over trial. Nutr Metab Cardiovasc Dis 21, 4653.
43Baliunas, DO, Taylor, BJ, Irving, H, et al. (2009) Alcohol as a risk factor for type 2 diabetes: a systematic review and meta-analysis. Diabetes Care 32, 21232132.
44Koppes, LL, Dekker, JM, Hendriks, HF, et al. (2005) Moderate alcohol consumption lowers the risk of type 2 diabetes: a meta-analysis of prospective observational studies. Diabetes Care 28, 719725.
45Davies, MJ, Baer, DJ, Judd, JT, et al. (2002) Effects of moderate alcohol intake on fasting insulin and glucose concentrations and insulin sensitivity in postmenopausal women: a randomized controlled trial. JAMA 287, 25592562.
46Fumeron, F, Lamri, A, Emery, N, et al. (2011) Dairy products and the metabolic syndrome in a prospective study, DESIR. J Am Coll Nutr 30, 454S463S.
47Wilsgaard, T & Jacobsen, BK (2007) Lifestyle factors and incident metabolic syndrome. The Tromsø Study 1979–2001. Diabetes Res Clin Pract 78, 217224.
48Kimokoti, RW & Brown, LS (2011) Dietary management of the metabolic syndrome. Clin Pharmacol Ther 90, 184187.
49Dandona, P, Aljada, A, Chaudhuri, A, et al. (2005) Metabolic syndrome: a comprehensive perspective based on interactions between obesity, diabetes, and inflammation. Circulation 111, 14481454.
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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
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