Skip to main content
×
×
Home

Multivitamin and dietary supplements, body weight and appetite: results from a cross-sectional and a randomised double-blind placebo-controlled study

  • Geneviève C. Major (a1), Eric Doucet (a2), Mélanie Jacqmain (a1), Myriam St-Onge (a1), Claude Bouchard (a3) and Angelo Tremblay (a1)...
Abstract

Two studies were conducted to compare characteristics of consumers and non-consumers of vitamin and/or dietary supplements (study 1) and to assess the effect of a multivitamin and mineral supplementation during a weight-reducing programme (study 2). Body weight and composition, energy expenditure, and Three-Factor Eating Questionnaire scores were compared between consumers and non-consumers of micronutrients and/or dietary supplements in the Québec Family Study (study 1). In study 2, these variables and appetite ratings (visual analogue scales) were measured in forty-five obese non-consumers of supplements randomly assigned to a double-blind 15-week energy restriction ( − 2930 kJ/d) combined with a placebo or with a multivitamin and mineral supplement. Compared with non-consumers, male consumers of vitamin and/or dietary supplements had a lower body weight (P < 0·01), fat mass (P < 0·05), BMI (P < 0·05), and a tendency for greater resting energy expenditure (P = 0·06). In women, the same differences were observed but not to a statistically significant extent. In addition, female supplements consumers had lower disinhibition and hunger scores (P < 0·05). In study 2, body weight was significantly decreased after the weight-loss intervention (P < 0·001) with no difference between treatment groups. However, fasting and postprandial appetite ratings were significantly reduced in multivitamin and mineral-supplemented women (P < 0·05). Usual vitamin and/or dietary supplements consumption and multivitamin and mineral supplementation during a weight-reducing programme seems to have an appetite-related effect in women. However, lower body weight and fat were more detectable in male than in female vitamin and/or dietary supplements consumers.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Multivitamin and dietary supplements, body weight and appetite: results from a cross-sectional and a randomised double-blind placebo-controlled study
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Multivitamin and dietary supplements, body weight and appetite: results from a cross-sectional and a randomised double-blind placebo-controlled study
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Multivitamin and dietary supplements, body weight and appetite: results from a cross-sectional and a randomised double-blind placebo-controlled study
      Available formats
      ×
Copyright
Corresponding author
*Corresponding author: Dr Angelo Tremblay, fax +1 418 656 3044, email Angelo.tremblay@kin.msp.ulaval.ca
References
Hide All
1Jacqmain, M, Doucet, E, Despres, JP, Bouchard, C & Tremblay, A (2003) Calcium intake, body composition, and lipoprotein-lipid concentrations in adults. Am J Clin Nutr 77, 14481452.
2Loos, RJ, Rankinen, T, Leon, AS, Skinner, JS, Wilmore, JH, Rao, DC & Bouchard, C (2004) Calcium intake is associated with adiposity in black and white men and white women of the HERITAGE Family Study. J Nutr 134, 17721778.
3Zemel, MB, Shi, H, Greer, B, Dirienzo, D & Zemel, PC (2000) Regulation of adiposity by dietary calcium. FASEB J 14, 11321138.
4Nachtigal, MC, Patterson, RE, Stratton, KL, Adams, LA, Shattuck, AL & White, E (2005) Dietary supplements and weight control in a middle-age population. J Altern Complement Med 11, 909915.
5Groff, JL & Gropper, SS (2000) Advanced Nutrition and Human Metabolism, 3rd ed.Belmont, CA: West/Wadsworth.
6Heisler, LK, Cowley, MA, Kishi, T, et al. (2003) Central serotonin and melanocortin pathways regulating energy homeostasis. Ann N Y Acad Sci 994, 169174.
7Anderson, GH & Johnston, JL (1983) Nutrient control of brain neurotransmitter synthesis and function. Can J Physiol Pharmacol 61, 271281.
8Singh, RB, Beegom, R, Rastogi, SS, Gaoli, Z & Shoumin, Z (1998) Association of low plasma concentrations of antioxidant vitamins, magnesium and zinc with high body fat per cent measured by bioelectrical impedance analysis in Indian men. Magnes Res 11, 310.
9Harnroongroj, T, Jintaridhi, P, Vudhivai, N, Pongpaew, P, Tungtrongchitr, R, Phonrat, B, Changbumrung, S & Schelp, FP (2002) B vitamins, vitamin C and hematological measurements in overweight and obese Thais in Bangkok. J Med Assoc Thai 85, 1725.
10Wortsman, J, Matsuoka, LY, Chen, TC, Lu, Z & Holick, MF (2000) Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr 72, 690693.
11Moor, DB, Wartanowicz, M & Ziemlanski, S (1992) Blood vitamin and lipid levels in overweight and obese women. Eur J Clin Nutr 46, 803808.
12Tungtrongchitr, R, Pongpaew, P, Tongboonchoo, C, Vudhivai, N, Changbumrung, S, Tungtrongchitr, A, Phonrat, B, Viroonudomphol, D, Pooudong, S & Schelp, FP (2003) Serum homocysteine, B12 and folic acid concentration in Thai overweight and obese subjects. Int J Vitam Nutr Res 73, 814.
13Martinez, JJ, Ruiz, FA & Candil, SD (2006) Baseline serum folate level may be a predictive factor of weight loss in a morbid-obesity-management programme. Br J Nutr 96, 956964.
14Johnston, CS (2005) Strategies for healthy weight loss: from vitamin C to the glycemic response. J Am Coll Nutr 24, 158165.
15Bahadori, B, Wallner, S, Schneider, H, Wascher, TC & Toplak, H (1997) Effect of chromium yeast and chromium picolinate on body composition of obese, non-diabetic patients during and after a formula diet (article in German). Acta Med Austriaca 24, 185187.
16Crawford, V, Scheckenbach, R & Preuss, HG (1999) Effects of niacin-bound chromium supplementation on body composition in overweight African-American women. Diabetes Obes Metab 1, 331337.
17Bouchard, C (1996) Genetic epidemiology, association and sib-pair linkage: results from the Québec Family Study. In Molecular and Genetic Aspects of Obesity, pp. 470481 [Bray, GA and Ryan, DH, editors]. Baton Rouge, LA: Louisiana State University Press.
18Tremblay, A, Sévigny, J, Leblanc, C & Bouchard, C (1983) The reproducibility of a three-day dietary record. Nutr Res 3, 819830.
19Government of Canada (1990) The Canadian Nutrient File. Ottawa: Health and Welfare Canada.
20Bouchard, C, Tremblay, A, Leblanc, C, Lortie, G, Savard, R & Thériault, G (1983) A method to assess energy expenditure in children and adults. Am J Clin Nutr 37, 461467.
21Stunkard, AJ & Messick, S (1985) The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger. J Psychosom Res 29, 7183.
22Lluch, A (1995) Identification des conduites alimentaires par approches nutritionnelles et psychométriques: implications thérapeutiques et préventives dans l'obésité humaine (Identification of food intake behaviours by nutritional and psychometric means: implications for prevention and treatment of human obesity). PhD Thesis, University of Nancy, France.
23Drapeau, V, Provencher, V, Lemieux, S, Despres, JP, Bouchard, C & Tremblay, A (2003) Do 6-y changes in eating behaviors predict changes in body weight? Results from the Quebec Family Study. Int J Obes Relat Metab Disord 27, 808814.
24Laessle, RG, Tuschl, RJ, Kotthaus, BC & Pirke, KM (1989) A comparison of the validity of three scales for the assessment of dietary restraint. J Abnorm Psychol 98, 504507.
25Behnke, AR & Wilmore, JH (1974) Evaluation and Regulation of Body Build and Composition. Englewood Cliffs, NJ: Prentice-Hall.
26Meneely, EA & Kaltreider, NL (1949) Volume of the lung determined by helium dilution. J Clin Invest 28, 129139.
27Siri, WE (1956) The gross composition of the body. Adv Biol Med Phys 4, 239280.
28Weir, JB (1949) New methods for calculating metabolic rate with special reference to protein metabolism. J Physiol 109, 19.
29Association Diabète Québec (1993) Plan d'Alimentation avec le Système d'Échanges (Plan of Food Exchange System). Montréal, Canada: Groupe Litho Graphique.
30Harrison, GG, Buskirk, ER, Carter, JEL, Johnston, FE, Lohman, TG, Pollock, ML, Roche, AF & Wilnor, J (1988) Skinfold thickness and measurement technique. In Anthropometric Standardization Reference Manual, pp. 3980 [Lohman, TG, Roche, AF and Martorell, R, editors]. Champaign, IL: Human Kinetics Books.
31Frayn, KN (1983) Calculation of substrate oxidation rates in vivo from gaseous exchange. J Appl Physiol 55, 628634.
32White, MD, Bouchard, G, Buemann, B, Almeras, N, Despres, JP, Bouchard, C & Tremblay, A (1996) Reproducibility of 24-h energy expenditure and macronutrient oxidation rates in an indirect calorimeter. J Appl Physiol 80, 133139.
33Day, DS, Gozansky, WS, Van Pelt, RE, Schwartz, RS & Kohrt, WM (2005) Sex hormone suppression reduces resting energy expenditure and β-adrenergic support of resting energy expenditure. J Clin Endocrinol Metab 90, 33123317.
34Drapeau, V, Blundell, J, Therrien, F, Lawton, C, Richard, D & Tremblay, A (2005) Appetite sensations as a marker of overall intake. Br J Nutr 93, 273280.
35Blundell, JE & Hill, AJ (1986) Paradoxical effects of an intense sweetener (aspartame) on appetite. Lancet i, 10921093.
36Doucet, E, St Pierre, S, Almeras, N & Tremblay, A (2003) Relation between appetite ratings before and after a standard meal and estimates of daily energy intake in obese and reduced obese individuals. Appetite 40, 137143.
37Arvaniti, K, Richard, D & Tremblay, A (2000) Reproducibility of energy and macronutrient intake and related substrate oxidation rates in a buffet-type meal. Br J Nutr 83, 489495.
38Grzybek, A, Klosiewicz-Latoszek, L & Targosz, U (2002) Changes in the intake of vitamins and minerals by men and women with hyperlipidemia and overweight during dietetic treatment. Eur J Clin Nutr 56, 11621168.
39Vasilaras, TH, Astrup, A & Raben, A (2004) Micronutrient intake in overweight subjects is not deficient on an ad libitum fat-reduced, high-simple carbohydrate diet. Eur J Clin Nutr 58, 326336.
40Doucet, E, Imbeault, P, St Pierre, S, Almeras, N, Mauriege, P, Richard, D & Tremblay, A (2000) Appetite after weight loss by energy restriction and a low-fat diet-exercise follow-up. Int J Obes Relat Metab Disord 24, 906914.
41Blundell, JE, Goodson, S & Halford, JC (2001) Regulation of appetite: role of leptin in signalling systems for drive and satiety. Int J Obes Relat Metab Disord 25, Suppl. 1, S29S34.
42Keim, NL, Stern, JS & Havel, PJ (1998) Relation between circulating leptin concentrations and appetite during a prolonged, moderate energy deficit in women. Am J Clin Nutr 68, 794801.
43Reeves, PG (2003) Patterns of food intake and self-selection of macronutrients in rats during short-term deprivation of dietary zinc. J Nutr Biochem 14, 232243.
44Friedman, MI, Tordoff, MG & Ramirez, I (1986) Integrated metabolic control of food intake. Brain Res Bull 17, 855859.
45Friedman, MI & Tordoff, MG (1986) Fatty acid oxidation and glucose utilization interact to control food intake in rats. Am J Physiol 251, R840R845.
46French, S & Castiglione, K (2002) Recent advances in the physiology of eating. Proc Nutr Soc 61, 489496.
47Kahler, A, Zimmermann, M & Langhans, W (1999) Suppression of hepatic fatty acid oxidation and food intake in men. Nutrition 15, 819828.
48Anderson, GH, Catherine, NL, Woodend, DM & Wolever, TM (2002) Inverse association between the effect of carbohydrates on blood glucose and subsequent short-term food intake in young men. Am J Clin Nutr 76, 10231030.
49Campfield, LA, Smith, FJ, Rosenbaum, M & Hirsch, J (1996) Human eating: evidence for a physiological basis using a modified paradigm. Neurosci Biobehav Rev 20, 133137.
50Ames, BN (2004) A role for supplements in optimizing health: the metabolic tune-up. Arch Biochem Biophys 423, 227234.
51McCaughey, SA & Tordoff, MG (2002) Magnesium appetite in the rat. Appetite 38, 2938.
52Paradis, S & Cabanac, M (2005) Calcium deficiency cannot induce obesity in rats. Physiol Behav 85, 259264.
53Tordoff, MG (2001) Calcium: taste, intake, and appetite. Physiol Rev 81, 15671597.
54Zuberbuehler, CA, Messikommer, RE & Wenk, C (2002) Choice feeding of selenium-deficient laying hens affects diet selection, selenium intake and body weight. J Nutr 132, 34113417.
55Barkeling, B, Rossner, S & Sjoberg, A (1995) Methodological studies on single meal food intake characteristics in normal weight and obese men and women. Int J Obes Relat Metab Disord 19, 284290.
56Flint, A, Raben, A, Blundell, JE & Astrup, A (2000) Reproducibility, power and validity of visual analogue scales in assessment of appetite sensations in single test meal studies. Int J Obes Relat Metab Disord 24, 3848.
57Carmody, TP, Brunner, RL & St Jeor, ST (1995) Dietary helplessness and disinhibition in weight cyclers and maintainers. Int J Eat Disord 18, 247256.
58Volpe, SL, Huang, HW, Larpadisorn, K & Lesser, II (2001) Effect of chromium supplementation and exercise on body composition, resting metabolic rate and selected biochemical parameters in moderately obese women following an exercise program. J Am Coll Nutr 20, 293306.
59Provencher, V, Drapeau, V, Tremblay, A, Despres, JP & Lemieux, S (2003) Eating behaviors and indexes of body composition in men and women from the Quebec Family Study. Obes Res 11, 783792.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed