1 Lattka, E, Illig, T, Heinrich, J, et al. (2010) Do FADS genotypes enhance our knowledge about fatty acid related phenotypes? Clin Nutr 29, 277–287.
2 Fekete, K, Marosvolgyi, T, Jakobik, V, et al. (2009) Methods of assessment of n-3 long-chain polyunsaturated fatty acid status in humans: a systematic review. Am J Clin Nutr 89, 2070S–2084S.
3 Hodson, L, Skeaff, CM & Fielding, BA (2008) Fatty acid composition of adipose tissue and blood in humans and its use as a biomarker of dietary intake. Prog Lipid Res 47, 348–380.
4 Siguel, EN, Chee, KM, Gong, JX, et al. (1987) Criteria for essential fatty acid deficiency in plasma as assessed by capillary column gas-liquid chromatography. Clin Chem 33, 1869–1873.
5 Al-Turkmani, MR, Freedman, SD & Laposata, M (2007) Fatty acid alterations and n-3 fatty acid supplementation in cystic fibrosis. Prostaglandins Leukot Essent Fatty Acids 77, 309–318.
6 Min, Y, Ghebremeskel, K, Lowy, C, et al. (2004) Adverse effect of obesity on red cell membrane arachidonic and docosahexaenoic acids in gestational diabetes. Diabetologia 47, 75–81.
7 Rise, P, Volpi, S, Colombo, C, et al. (2010) Whole blood fatty acid analysis with micromethod in cystic fibrosis und pulmonary disease. Journal of Cystic Fibrosis 9, 228–233.
8 Delgado-Noguera, MF, Calvache, JA & Bonfill Cosp, X (2011) Supplementation with long chain polyunsaturated fatty acids (LCPUFA) to breastfeeding mothers for improving child growth and development. Cochrane Database Syst Rev CD007901.
9 Agostoni, C, Buonocore, G, Carnielli, VP, et al. (2009) Enteral nutrient supply for preterm infants: commentary from the European Society of Paediatric Gastroenterology, Hepatology and Nutrition Committee on Nutrition. J Pediatr Gastroenterol Nutr 50, 85–91.
10 Schulzke, SM, Patole, SK & Simmer, K (2011) Longchain polyunsaturated fatty acid supplementation in preterm infants. Cochrane Database Syst Rev 2, CD000375.
11 Simmer, K, Patole, SK & Rao, SC (2008) Longchain polyunsaturated fatty acid supplementation in infants born at term. Cochrane Database Syst Rev CD000376.
12 Carlson, SE (2009) Docosahexaenoic acid supplementation in pregnancy and lactation. Am J Clin Nutr 89, 678S–684S.
13 Koletzko, B, Lien, E, Agostoni, C, et al. (2008) The roles of long-chain polyunsaturated fatty acids in pregnancy, lactation and infancy: review of current knowledge and consensus recommendations. J Perinat Med 36, 5–14.
14 Leung, BM, Wiens, K & Kaplan, BJ (2011) Does prenatal micronutrient supplementation improve children's mental development? A systematic review. BMC Pregnancy Childbirth 11, 12.
15 Raz, R & Gabis, L (2009) Essential fatty acids and attention-deficit-hyperactivity disorder: a systematic review. Dev Med Child Neurol 51, 580–592.
16 Hooper, L, Thompson, RL, Harrison, RA, et al. (2006) Risks and benefits of omega 3 fats for mortality, cardiovascular disease, and cancer: systematic review. BMJ 332, 752–760.
17 von Schacky, C & Harris, WS (2007) Cardiovascular benefits of omega-3 fatty acids. Cardiovasc Res 73, 310–315.
18 Dewey, A, Baughan, C, Dean, T, et al. (2007) Eicosapentaenoic acid (EPA, an omega-3 fatty acid from fish oils) for the treatment of cancer cachexia. Cochrane Database Syst Rev CD004597.
19 Funahashi, H, Satake, M, Hasan, S, et al. (2008) Opposing effects of n-6 and n-3 polyunsaturated fatty acids on pancreatic cancer growth. Pancreas 36, 353–362.
20 Kuriki, K, Hirose, K, Wakai, K, et al. (2007) Breast cancer risk and erythrocyte compositions of n-3 highly unsaturated fatty acids in Japanese. Int J Cancer 121, 377–385.
21 Leung, BMY & Kaplan, BJ (2009) Perinatal Depression: Prevalence, Risks, and the Nutrition Link–A Review of the Literature. Journal of the American Dietetic Association 109, 1566–1575.
22 Lin, P-Y, Huang, S-Y & Su, K-P (2011) A Meta-Analytic Review of Polyunsaturated Fatty Acid Compositions in Patients with Depression. Biological Psychiatry 68, 140–147.
23 Montgomery, P & Richardson, AJ (2008) Omega-3 fatty acids for bipolar disorder. Cochrane Database Syst Rev CD005169.
24 Ramakrishnan, U (2011) Fatty acid status and maternal mental health. Maternal, Child Nutrition 7, 99–111.
25 Turner, D, Shah, PS, Steinhart, AH, et al. (2011) Maintenance of remission in inflammatory bowel disease using omega-3 fatty acids (fish oil): a systematic review and meta-analyses. Inflamm Bowel Dis 17, 336–345.
26 Thien, FCK, De Luca, S, Woods, RK, et al. (2011) Cochrane Review: Dietary marine fatty acids (fish oil) for asthma in adults and children. Evidence-Based Child Health: A Cochrane Review Journal 6, 984–1012.
27 McKarney, C, Everard, M & N'Diaye, T (2007) Omega-3 fatty acids (from fish oils) for cystic fibrosis. Cochrane Database Syst Rev CD002201.
28 Cederholm, T & Palmblad, J (2011) Are omega-3 fatty acids options for prevention and treatment of cognitive decline and dementia? Current Opinion in Clinical Nutrition, Metabolic Care 13, 150–155, .
29 Milte, CM, Sinn, N & Howe, PR (2009) Polyunsaturated fatty acid status in attention deficit hyperactivity disorder, depression, and Alzheimer's disease: towards an omega-3 index for mental health? Nutr Rev 67, 573–590.
30 Lepage, G & Roy, CC (1986) Direct transesterification of all classes of lipids in a one-step reaction. J Lipid Res 27, 114–120.
31 Bligh, EG & Dyer, WJ (1959) A rapid method of total lipid extraction and purification. Can J Biochem Physiol 37, 911–917.
32 Folch, J, Lees, M & Sloane Stanley, GH (1957) A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 226, 497–509.
33 Rose, HG & Oklander, M (1965) Improved Procedure for the Extraction of Lipids from Human Erythrocytes. J Lipid Res 6, 428–431.
34 Carnielli, VP, Pederzini, F, Vittorangeli, R, et al. (1996) Plasma and red blood cell fatty acid of very low birth weight infants fed exclusively with expressed preterm human milk. Pediatr Res 39, 671–679.
35 Skipski, VP, Peterson, RF & Barclay, M (1964) Quantitative analysis of phospholipids by thin-layer chromatography. Biochem J 90, 374–378.
36 Agren, JJ, Julkunen, A & Penttila, I (1992) Rapid separation of serum lipids for fatty acid analysis by a single aminopropyl column. J Lipid Res 33, 1871–1876.
37 Burdge, GC, Wright, P, Jones, AE, et al. (2000) A method for separation of phosphatidylcholine, triacylglycerol, non-esterified fatty acids and cholesterol esters from plasma by solid-phase extraction. Br J Nutr 84, 781–787.
38 Hamilton, JG & Comai, K (1988) Rapid separation of neutral lipids, free fatty acids and polar lipids using prepacked silica Sep-Pak columns. Lipids 23, 1146–1149.
39 Kaluzny, MA, Duncan, LA, Merritt, MV, et al. (1985) Rapid separation of lipid classes in high yield and purity using bonded phase columns. J Lipid Res 26, 135–140.
40 Vorbeck, ML, Mattick, LR, Lee, FA, et al. (1961) Preparation of Methyl Esters of Fatty Acids for Gas-Liquid Chromatography. Quantitative Comparison of Methylation Techniques. Analytical Chemistry 33, 1512–1514.
41 Dodds, ED, McCoy, MR, Rea, LD, et al. (2005) Gas chromatographic quantification of fatty acid methyl esters: flame ionization detection vs. electron impact mass spectrometry. Lipids 40, 419–428.
42 Lepage, G, Levy, E, Ronco, N, et al. (1989) Direct transesterification of plasma fatty acids for the diagnosis of essential fatty acid deficiency in cystic fibrosis. J Lipid Res 30, 1483–1490.
43 Martinez, M, Mougan, I, Roig, M, et al. (1994) Blood polyunsaturated fatty acids in patients with peroxisomal disorders. A multicenter study. Lipids 29, 273–280.
44 Tiangson, CLP, Gavino, VC, Gavino, G, et al. (2003) Docosahexaenoic acid level of the breast milk of some Filipino women. International Journal of Food Sciences and Nutrition 54, 379–386.
45 Dacremont, G & Vincent, G (1995) Assay of plasmalogens and polyunsaturated fatty acids (PUFA) in erythrocytes and fibroblasts. J Inherit Metab Dis 18, Suppl. 1, 84–89.
46 Masood, A, Stark, KD & Salem, N Jr (2005) A simplified and efficient method for the analysis of fatty acid methyl esters suitable for large clinical studies. J Lipid Res 46, 2299–2305.
47 Masood, M & Salem, N (2008) High-Throughput Analysis of Plasma Fatty Acid Methyl Esters Employing Robotic Transesterification and Fast Gas Chromatography. Lipids 43, 171–180.
48 Garg, ML, Leitch, J, Blake, RJ, et al. (2006) Long-chain n-3 polyunsaturated fatty acid incorporation into human atrium following fish oil supplementation. Lipids 41, 1127–1132.
49 Akoto, L, Vreuls, RJ, Irth, H, et al. (2008) Fatty acid profiling of raw human plasma and whole blood using direct thermal desorption combined with gas chromatography-mass spectrometry. J Chromatogr A 1186, 365–371.
50 Glaser, C, Demmelmair, H & Koletzko, B (2010) High-throughput analysis of total plasma fatty acid composition with direct in situ transesterification. PLoS One 5, e12045.
51 Takemoto, Y, Suzuki, Y, Horibe, R, et al. (2003) Gas chromatography/mass spectrometry analysis of very long chain fatty acids, docosahexaenoic acid, phytanic acid and plasmalogen for the screening of peroxisomal disorders. Brain Dev 25, 481–487.
52 Armstrong, JM, Metherel, AH & Stark, KD (2008) Direct microwave transesterification of fingertip prick blood samples for fatty acid determinations. Lipids 43, 187–196.
53 Bailey-Hall, E, Nelson, EB & Ryan, AS (2008) Validation of a rapid measure of blood PUFA levels in humans. Lipids 43, 181–186.
54 Marangoni, F, Colombo, C & Galli, C (2005) A method for the direct evaluation of the fatty acid status in a drop of blood from a fingertip in humans. World Rev Nutr Diet 94, 139–143.
55 Agostoni, C, Marangoni, F, Stival, G, et al. (2008) Whole blood fatty acid composition differs in term versus mildly preterm infants: small versus matched appropriate for gestational age. Pediatr Res 64, 298–302.
56 Agostoni, C, Riva, E, Giovannini, M, et al. (2008) Maternal smoking habits are associated with differences in infants' long-chain polyunsaturated fatty acids in whole blood: a case-control study. Arch Dis Child 93, 414–418.
57 Ryan, AS & Nelson, EB (2008) Assessing the effect of docosahexaenoic acid on cognitive functions in healthy, preschool children: a randomized, placebo-controlled, double-blind study. Clin Pediatr (Phila) 47, 355–362.
58 Bicalho, B, David, F, Rumplel, K, et al. (2008) Creating a fatty acid methyl ester database for lipid profiling in a single drop of human blood using high resolution capillary gas chromatography and mass spectrometry. J Chromatogr A 1211, 120–128.
59 Min, Y, Ghebremeskel, K, Geppert, J, et al. (2011) Effect of storage temperature and length on fatty acid composition of fingertip blood collected on filter paper. Prostaglandins Leukot Essent Fatty Acids 84, 13–18.
60 Harris, WS & Von Schacky, C (2004) The Omega-3 Index: a new risk factor for death from coronary heart disease? Prev Med 39, 212–220.
61 Block, RC, Harris, WS, Reid, KJ, et al. (2008) EPA and DHA in blood cell membranes from acute coronary syndrome patients and controls. Atherosclerosis 197, 821–828.
62 Shearer, CS, Pottala, JV & Harris, WS (2010) .
63 Glaser, C, Demmelmair, H & Koletzko, B (2010) High-throughput analysis of fatty acid composition of plasma glycerophospholipids. J Lipid Res 51, 216–221.
64 GlaserCD, H CD, H & Koletzko, B (2009) High Throughput method for analyzing the fatty acid composition in palsma phosphoglycerides [LUDWIG-MAXIMILIANS-UNIVERSITÄT, , editor]. Germany.
65 Decsi, T & Koletzko, B (1994) Fatty acid composition of plasma lipid classes in healthy subjects from birth to young adulthood. Eur J Pediatr 153, 520–525.
66 Gronowitz, E, Mellstrom, D & Strandvik, B (2006) Serum phospholipid fatty acid pattern is associated with bone mineral density in children, but not adults, with cystic fibrosis. Br J Nutr 95, 1159–1165.
67 Guerra, A, Demmelmair, H, Toschke, AM, et al. (2007) Three-year tracking of fatty acid composition of plasma phospholipids in healthy children. Ann Nutr Metab 51, 433–438.
68 Hoyos, C, Almqvist, C, Garden, F, et al. (2008) Effect of omega 3 and omega 6 fatty acid intakes from diet and supplements on plasma fatty acid levels in the first 3 years of life. Asia Pac J Clin Nutr 17, 552–557.
69 Glaser, C, Demmelmair, H, Sausenthaler, S, et al. (2010) Fatty acid composition of serum glycerophospholipids in children. J Pediatr 157, 826–831 e821.
70 McMurchie, EJ, Margetts, BM, Beilin, LJ, et al. (1984) Dietary-induced changes in the fatty acid composition of human cheek cell phospholipids: correlation with changes in the dietary polyunsaturated/saturated fat ratio. Am J Clin Nutr 39, 975–980.
71 Connor, SL, Zhu, N, Anderson, GJ, et al. (2000) Cheek cell phospholipids in human infants: a marker of docosahexaenoic and arachidonic acids in the diet, plasma, and red blood cells. Am J Clin Nutr 71, 21–27.
72 Hoffman, DR, Birch, EE, Birch, DG, et al. (1999) Fatty acid profile of buccal cheek cell phospholipids as an index for dietary intake of docosahexaenoic acid in preterm infants. Lipids 34, 337–342.
73 Kirby, A, Woodward, A, Jackson, S, et al. (2010) A double-blind, placebo-controlled study investigating the effects of omega-3 supplementation in children aged 8-10 years from a mainstream school population. Res Dev Disabil 31, 718–730.
74 Koletzko, B, Knoppke, B, von Schenck, U, et al. (1999) Noninvasive assessment of essential fatty acid status in preterm infants by buccal mucosal cell phospholipid analysis. J Pediatr Gastroenterol Nutr 29, 467–474.
75 Laitinen, K, Sallinen, J, Linderborg, K, et al. (2006) Serum, cheek cell and breast milk fatty acid compositions in infants with atopic and non-atopic eczema. Clin Exp Allergy 36, 166–173.
76 Sampugna, J, Light, L, Enig, MG, et al. (1988) Cheek cell fatty acids as indicators of dietary lipids in humans. Lipids 23, 131–136.
77 Klingler, M, Demmelmair, H, Koletzko, B, et al. (2011) Fatty Acid status determination by cheek cell sampling combined with methanol-based ultrasound extraction of glycerophospholipids. Lipids 46, 981–990.
78 Kohn, G, van der Ploeg, P, Mobius, M, et al. (1996) Influence of the derivatization procedure on the results of the gaschromatographic fatty acid analysis of human milk and infant formulae. Z Ernahrungswiss 35, 226–234.
79 Morrison, WR & Smith, LM (1964) Preparation of Fatty Acid Methyl Esters and Dimethylacetals from Lipids with Boron Fluoride–Methanol. J Lipid Res 5, 600–608.
80 Ichihara, Ki, Waku, K, Yamaguchi, C, et al. (2002) A convenient method for determination of the C(20–22) PUFA composition of glycerolipids in blood and breast milk. Lipids 37, 523–526.