Skip to main content
×
×
Home

Nutritional genomics: food industry applications from farm to fork

  • Louise Brown (a1) and Frans van der Ouderaa (a1)
Abstract

Nutritional genomics is a new and promising science area which can broadly be defined as the application of high throughput genomics (transcriptomics, proteomics, metabolomics/metabonomics) and functional genomic technologies to the study of nutritional sciences and food technology. First utilised in the food industry by plant biotechnologists to manipulate plant biosynthetic pathways, the use of genomic technologies has now spread within the agriculture sector, unleashing a host of new applications (e.g. approaches for producing novel, non-transgenic plant varietals; identification of genetic markers to guide plant and animal breeding programmes; exploration of diet–gene interactions for enhancing product quality and plant/animal health). Beyond agriculture, genomic technologies are also contributing to the improvement of food processing, food safety and quality assurance as well as the development of functional food products and the evolution of new health management concepts such as ‘personalised nutrition’, an emerging paradigm in which the diet of an individual is customised, based on their own genomic information, to optimise health and prevent disease. In this review the relevance of nutritional genomics to the food industry will be considered and examples given on how this science area is starting to be leveraged for economic benefits and to improve human nutrition and health.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Nutritional genomics: food industry applications from farm to fork
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Nutritional genomics: food industry applications from farm to fork
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Nutritional genomics: food industry applications from farm to fork
      Available formats
      ×
Copyright
Corresponding author
*Corresponding author: Dr Louise Brown, fax +44 (0)1234 248010, email Louise.Brown@unilever.com
References
Hide All
Abee, T, van Schaik, W & Siezen, RJ (2004) Impact of genomics on microbial food safety. Trends Biotechnol 22, 653660.
Battershill, JM (2005) Toxicogenomics: regulatory perspective on current position. Hum Experimental Toxicol 24, 3540.
Bautista, MC & Engler, MM (2005) The Mediterranean diet: is it cardioprotective? Prog Cardiovasc Nurs 20, 7076.
Bonaa, KH, Njolstad, I, Ueland, PM, Schirmer, H, Tverdal, A, Steigen, T, Wang, H, Nordrehaug, JE, Arnesen, E & Rasmussen, K (2006) Homocysteine lowering and cardiovascular events after acute myocardial infarction. N Engl J Med 354, 15781588.
Bourre, JM (2005) Where to find omega-3 fatty acids and how feeding animals with diet enriched in omega-3 fatty acids to increase nutritional value of derived products for human: what is actually useful? J Nutr Health Aging 9, 232242.
Brindle, JT, Antti, H, Holmes, E, et al. (2002) Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics. Nat Med 8, 14391444.
Brindle, JT, Nicholson, JK, Schofield, PM, Grainger, DJ & Holmes, E (2003) Application of chemometrics to H-1 NMR spectroscopic data to investigate a relationship between human serum metabolic profiles and hypertension. Analyst 128, 3236.
Buchanan-Wollaston, V, Earl, S, Harrison, E, Mathas, E, Navabpour, S, Page, T & Pink, D (2003) The molecular analysis of leaf senescence – a genomics approach. Plant Biotechnol J 1, 322.
Chadwick, R (2004) Nutrigenomics, individualism and public health. Pro Nutr Soc 63, 161166.
Chen, LFO, Hwang, JY, Charng, YY, Sun, CW & Yang, SF (2001) Transformation of broccoli (Brassica oleracea var. italica) with isopentenyltransferase gene via Agrobacterium tumefaciens for post-harvest yellowing retardation. Mol Breeding 7, 243257.
Clarke, R (2005) Homocysteine-lowering trials for prevention of heart disease and stroke. Sem Vasc Med 5, 215222.
DellaPenna, D (1999) Nutritional genomics: manipulating plant micronutrients to improve human health. Science 285, 375379.
Enattah, NS, Sahi, T, Savilahti, E, Terwilliger, JD, Peltonen, L & Jarvela, I (2002) Identification of a variant associated with adult-type hypolactasia. Nat Genet 30, 233237.
Fisher, ND & Hollenberg, NK (2005) Flavanols for cardiovascular health: the science behind the sweetness. J Hypertens 23, 14531459.
Fuchs, D, Winkelmann, I, Johnson, IT, Mariman, E, Wenzel, U & Daniel, H (2005) Proteomics in nutrition research: principles, technologies and applications. Br J Nutr 94, 302314.
Gordon, ES, Gordish Dressman, HA & Hoffman, EP (2005) The genetics of muscle atrophy and growth: The impact and implications of polymorphisms in animals and humans. Int J Biochem Cell Biol 37, 20642074.
Hails, R & Kinderlerer, J (2003) The GM public debate: context and communication strategies. Nat Rev Genet 4, 819825.
Harlizius, B, van Wijk, R & Merks, JW (2004) Genomics for food safety and sustainable animal production. J Biotechnol 113, 3342.
Heijne, WH, Kienhuis, AS, van Ommen, B, Stierum, RH & Groten, JP (2005) Systems toxicology: applications of toxicogenomics, transcriptomics, proteomics and metabolomics in toxicology. Expert Rev Proteomics 2, 767780.
Hendriks, HF, Weststrate, JA, van Vliet, T & Meijer, GW (1999) Spreads enriched with three different levels of vegetable oil sterols and the degree of cholesterol lowering in normocholesterolaemic and mildly hypercholesterolaemic subjects. Eur J Clin Nutr 53, 319327.
Henzi, MX, Christey, MC & McNeil, DL (2000) Morphological characterisation and agronomic evaluation of transgenic broccoli (Brassica oleracea L. var. italica) containing an antisense ACC oxidase gene. Euphytica 113, 918.
Herman, WH, Hoerger, TJ, Brandle, M, Hicks, K, Sorensen, S, Zhang, P, Hamman, RF, Ackermann, RT, Engelgau, MM & Ratner, RE (2005) The cost-effectiveness of lifestyle modification or metformin in preventing type 2 diabetes in adults with impaired glucose tolerance. Ann Intern Med 142, 323332.
Hillier, LW, Miller, W, Birney, E, et al. (2004) Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution. Nature 432, 695716.
Hogenauer, C, Hammer, HF, Mellitzer, K, Renner, W, Krejs, GJ & Toplak, H (2005) Evaluation of a new DNA test compared with the lactose hydrogen breath test for the diagnosis of lactase non-persistence. Eur J Gastroenterol Hepatol 17, 371376.
Jain, S, Jain, RK & McCouch, SR (2004) Genetic analysis of Indian aromatic and quality rice (Oryza sativa L.) germplasm using panels of fluorescently-labeled microsatellite markers. Theor Appl Genet 109, 965977.
Jarvela, IE (2005) Molecular genetics of adult-type hypolactasia. Ann Med 37, 179185.
Jiang, RS, Xu, GY, Zhang, XQ & Yang, N (2005) Association of polymorphisms for prolactin and prolactin receptor genes with broody traits in chickens. Poult Sci 84, 839845.
Kaput, J, Ordovas, JM, Ferguson, L, et al. (2005) The case for strategic international alliances to harness nutritional genomics for public and personal health. Br J Nutr 94, 623632.
Knowler, WC, Barrett-Connor, E, Fowler, SE, Hamman, RF, Lachin, JM, Walker, EA & Nathan, DM (2002) Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 346, 393403.
Lewis, SJ, Ebrahim, S & Smith, GD (2005) Meta-analysis of MTHFR 677C →  T polymorphism and coronary heart disease: does totality of evidence support causal role for homocysteine and preventive potential of folate? Br Med J 331, 10531056A.
Li, G, Hu, Y, Yang, W, Jiang, Y, Wang, J, Xiao, J, Hu, Z, Pan, X, Howard, BV & Bennett, PH (2002) Effects of insulin resistance and insulin secretion on the efficacy of interventions to retard development of type 2 diabetes mellitus: the DA Qing IGT and Diabetes Study. Diabetes Res Clin Pract 58, 193200.
Lindon, JC, Keun, HC, Ebbels, TMD, Pearce, JMT, Holmes, E & Nicholson, JK (2005) The Consortium for Metabonomic Toxicology (COMET): aims, activities and achievements. Pharmacogenomics 6, 691699.
Lock, AL & Bauman, DE (2004) Modifying milk fat composition of dairy cows to enhance fatty acids beneficial to human health. Lipids 39, 11971206.
Lonn, E, Yusuf, S, Arnold, MJ, et al. (2006) Homocysteine lowering with folic acid and B vitamins in vascular disease. N Engl J Med 354, 15671577.
McCabe, MS, Garratt, LC, Schepers, F, Jordi, WJRM, Stoopen, GM, Davelaar, E, van Rhijn, JHA, Power, JB & Davey, MR (2001) Effects of P-SAG12-IPT gene expression on development and senescence in transgenic lettuce. Plant Physiology 127, 505516.
McMahon, JA, Green, TJ, Skeaff, CM, Knight, RG, Mann, JI & Williams, SM (2006) A controlled trial of homocysteine lowering and cognitive performance. N Engl J Med 354, 27642772.
Matthews, SB, Waud, JP, Roberts, AG & Campbell, AK (2005) Systemic lactose intolerance: a new perspective on an old problem. Postgrad Med J 81, 167173.
Miyaki, K, Murata, M, Kikuchi, H, Takei, I, Nakayama, T, Watanabe, K & Omae, K (2005) Assessment of tailor-made prevention of atherosclerosis with folic acid supplementation: randomized, double-blind, placebo-controlled trials in each MTHFR C677T genotype. J Hum Genet 50, 241248.
Muir, SR, Collins, GJ, Robinson, S, Hughes, S, Bovy, A, Ric, DV, van Tunen, AJ & Verhoeyen, ME (2001) Overexpression of petunia chalcone isomerase in tomato results in fruit containing increased levels of flavonols. Nat Biotechnol 19, 470474.
Nugent, AP (2005) LIPGENE: an EU project to tackle the metabolic syndrome. Biochimie 87, 129132.
Page, T, Griffiths, G & Buchanan-Wollaston, V (2001) Molecular and biochemical characterization of postharvest senescence in broccoli. Plant Physiol 125, 718727.
Paine, JA, Shipton, CA, Chaggar, S, et al. (2005) Improving the nutritional value of Golden Rice through increased pro-vitamin A content. Nat Biotechnol 23, 482487.
Pareek, CS, Czarnik, U, Zabolewicz, T, Pareek, RS & Walawski, K (2005) DGAT1 K232A quantitative trait nucleotide polymorphism in Polish Black-and-White cattle. J Appl Genet 46, 8587.
Rasinpera, H, Savilahti, E, Enattah, NS, Kuokkanen, M, Totterman, N, Lindahl, H, Jarvela, I & Kolho, KL (2004) A genetic test which can be used to diagnose adult-type hypolactasia in children. Gut 53, 15711576.
Reynolds, VL (2005) Applications of emerging technologies in toxicology and safety assessment. Int J Toxicol 24, 135137.
Roy, R, Ordovas, L, Zaragoza, P, Romero, A, Moreno, C, Altarriba, J & Rodellar, C (2006) Association of polymorphisms in the bovine FASN gene with milk-fat content. Anima Genet 37, 215218.
Saris, WH & Harper, A (2005) DiOGenes: a multidisciplinary offensive focused on the obesity epidemic. Obes Rev 6, 175176.
Saw, SM, Yuan, JM, Ong, CN, Arakawa, K, Lee, HP, Coetzee, GA & Yu, MC (2001) Genetic, dietary, and other lifestyle determinants of plasma homocysteine concentrations in middle-aged and older Chinese men and women in Singapore. Am J Clinic Nutr 73, 232239.
Schaefer, EJ, Lamon-Fava, S, Ausman, LM, Ordovas, JM, Clevidence, BA, Judd, JT, Goldin, BR, Woods, M, Gorbach, S & Lichtenstein, AH (1997) Individual variability in lipoprotein cholesterol response to National Cholesterol Education Program Step 2 diets. Am J Clin Nutr 65, 823830.
Seshadri, S (2006) Elevated plasma homocysteine levels: Risk factor or risk marker for the development of dementia and Alzheimer's disease? J Alzheimers D 9, 393398.
Sibley, E (2004) Carbohydrate intolerance. Curr Opin Gastroenterol 20, 162167.
Slade, AJ & Knauf, VC (2005) TILLING moves beyond functional genomics into crop improvement. Transgenic Res 14, 109115.
Solanky, KS, Bailey, JC, Beckwith-Hall, BM, Davis, A, Bingham, S, Holmes, E, Nicholson, JK & Cassidy, A (2003) Application of biofluid 1H nuclear magnetic resonance-based metabonomic techniques for the analysis of the biochemical effects of dietary isoflavones on human plasma profiles. Anal Biochem 323, 197204.
Solanky, KS, Bailey, NJ, Beckwith-Hall, BM, Bingham, S, Davis, A, Holmes, E, Nicholson, JK & Cassidy, A (2005) Biofluid H-1 NMR-based metabonomic techniques in nutrition research metabolic effects of dietary isoflavones in humans. J Nutr Biochem 16, 236244.
Steinhilber, SH (2005) Influence of strain and age of hen and dietary fat on the incorporation of omega-3-fatty acids into chicken eggs and on egg quality parameters. Archiv fur Geflugelkunde 69, 9495.
Stott, DJ, MacIntosh, G, Do Lowe, G, et al. (2005) Randomized controlled trial of homocysteine-lowering vitamin treatment in elderly patients with vascular disease. Am J Clin Nutr 82, 13201326.
Strain, JJ, Dowey, L, Ward, M, Pentieva, K & McNulty, H (2004) B-vitamins, homocysteine metabolism and CVD. Proc Nutr Soc 63, 597603.
Taboada, EN, Acedillo, RR, Carrillo, CD, Findlay, WA, Medeiros, DT, Mykytczuk, OL, Roberts, MJ, Valencia, CA, Farber, JM & Nash, JH (2004) Large-scale comparative genomics meta-analysis of Campylobacter jejuni isolates reveals low level of genome plasticity. J Clin Microbiol 42, 45664576.
Troen, A & Rosenberg, I (2006) Homocysteine and cognitive function. Sem Vasc Med 5, 209214.
Tuomilehto, J, Lindstrom, J, Eriksson, JG, et al. (2001) Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 344, 13431350.
Ulvik, A, Ueland, PM, Fredriksen, A, Meyer, K, Vollset, SE, Hoff, G & Schneede, J (2006) Functional inference of the methylenetetrahydrofolate reductase 677 C>T and 1298A>C polymorphisms from a large-scale epidemiological study. Hum Genet Published online: 18 Novemeber 2006. doi:10.1007/s00439-006-0290-2.
van der Werf, MJ, Schuren, FHJ, Bijlsma, S, Tas, AC & van Ommen, B (2001) Nutrigenomics: Application of genomics technologies in nutritional sciences and food technology. J Food Sci 66, 772780.
van Ommen, B & Groten, JP (2004) Nutrigenomics in efficacy and safety evaluation of food components. In Nutrigenetics and Nutrigenomics. World Rev Nutr Diet, vol. 93, pp. 134152 [Simpopoulos, AP and Ordovas, JM, editors]. Basel: Karger.
Wang, YL, Tang, HR, Nicholson, JK, Hylands, PJ, Sampson, J & Holmes, E (2005) A metabonomic strategy for the detection of the metabolic effects of chamomile (Matricaria recutita L.) ingestion. J Agri Food Chem 53, 191196.
Weikard, R, Kuhn, C, Goldammer, T, Freyer, G & Schwerin, M (2005) The bovine PPARGC1A gene: molecular characterization and association of an SNP with variation of milk fat synthesis. Physiol Genomics 21, 113.
Whitfield, PD, German, AJ & Noble, PJM (2004) Metabolomics: an emerging post-genomic tool for nutrition. Br J Nutr 92, 549555.
Wild, S, Roglic, G, Green, A, Sicree, R & King, H (2004) Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 27, 10471053.
Williams, R (2005) Gene tests served up to tell fine foods from fakes. Nature 434, 262.
Wong, GK, Liu, B, Wang, J, et al. (2004) A genetic variation map for chicken with 2·8 million single-nucleotide polymorphisms. Nature 432, 717722.
Woolfe, M & Primrose, S (2004) Food forensics: using DNA technology to combat misdescription and fraud. Trends Biotechnol 22, 222–226.
Ye, X, Al Babili, S, Kloti, A, Zhang, J, Lucca, P, Beyer, P & Potrykus, I (2000) Engineering the provitamin A (beta-carotene) biosynthetic pathway into (carotenoid-free) rice endosperm. Science 287, 303305.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords