Skip to main content Accesibility Help
×
×
Home

Oligosaccharides and glycoconjugates in bovine milk and colostrum

  • Pramod K. Gopal (a1) and H. S. Gill (a1) (a2)
Abstract

Oligosaccharides and glycoconjugates are some of the most important bioactive components in milk. A great deal of information is available on the biological function of the components from human milk. Their primary role seems to be in providing protection against pathogens by acting as competitive inhibitors for the binding sites on the epithelial surfaces of the intestine. Evidence is also available to support the role of some of these components as growth promoters for genera of beneficial microflora in the colon. Compared with human milk, levels of oligosaccharides in bovine milk are very low. Nevertheless, a number of neutral and acidic oligosaccharides have been isolated from bovine milk and characterised. The highest concentration of these molecules is found in early postparturition milk (colostrum). The chemical structure of the oligosaccharides and many of the glycoconjugates from bovine milk are similar to those in human milk. It is likely that bovine oligosaccharides and glycoconjugates can be used in milk products as bioactive components in human nutrition.

    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Oligosaccharides and glycoconjugates in bovine milk and colostrum
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Oligosaccharides and glycoconjugates in bovine milk and colostrum
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Oligosaccharides and glycoconjugates in bovine milk and colostrum
      Available formats
      ×
Copyright
Corresponding author
*Corresponding author: Dr P. K. Gopal, fax +64 6 354 1756, email pramod.gopal@nzdri.org.nz
References
Hide All
Andersson, B, Porras, O, Hanson, L, Lagergard, T, Svanborg-Eden, C (1986) Inhibition of attachment of Streptococcus pneumoniae and Haemophilus influenzae by human milk and receptor oligosaccharides. Journal of Infectious Diseases 153, 232237.
Brand Miller, J, McVeagh, P & Bull, S (1994) Biological function of oligosaccharides. Acta Paediatrica 83, 1051.
Brand Miller, J, McVeagh, P, McNeil, Y & Gillard, B (1995) Human milk oligosaccharides are not digested and absorbed in the small intestine of young infants. Proceedings of the Nutrition Society of Australia 19, 44.
Carlson, SE (1985) N-Acetylneuraminic acid concentrations in human milk oligosaccharides and glycoproteins during lactation. American Journal of Clinical Nutrition 41, 720726.
Cleary, T, Chambers, J & Pickering, L (1985) Protection of mice from heat stable enterotoxin of E. coli by infant formulas. Journal of Pediatric Gastroenteterology Nutrition 4, 125131.
Gibson, G & Roberfroid, M (1995) Dietary modulation of human colonic microbiota-introducing the concept of probiotics. Journal of Nutrition 125, 14011412.
Green, B, Merchant, J & Newgrain, K (1987) Milk composition in the eastern quoll, Dasyurus viverrinus (Marsupialia, Dasyuridae). Australian Journal of Biological Science 40, 379387.
Holmgren, J, Svennerholm, A & Lindbhad, M (1983) Receptor like glyco compounds in human milk that inhibit classical and E1 Tor Viberio cholera cell adhesion (haemagglutination). Infection and Immunity 39, 147154.
Jenness, R (1974) The composition of milk. In Lactation: A Comprehensive Treatise, pp. 3107. [Larson, BL and Smith, VR, editors]. New York: Academic Press.
Kanamaru, Y, Toyoki, T, Nagaoka, S, Kuzuya, Y & Niki, R (1993) High molecular weight mucin-like glycoprotein in bovine milk. Bioscience, Biotechnology and Biochemistry 57, 666667.
Kobata, A (1977) Milk glycoproteins and oligosaccharides The Glycoconjugates, Vol. I, 423 [Horowitz, M and Pigman, W, editors]. New York: Academic Press.
Korhonen, T, Valtonen, M, Parkkinen, J, Vaisanen-Rhen, V, Finne, J, Orskov, F, Orskov, I, Svenson, S & Makela, P (1985) Serotypes, hemolysin production, and receptor recognition of Escherichia coli strains associated with neonatal sepsis and meningitis. Infection and Immunity 48, 486491.
Kuhn, R & Brossmer, R (1956) Ueber o-acetyllactaminsaure-lactose aus Kuh-Colostrum und ihre Spaltbarkeit durch Influenza virus. Chemistry Berlin 89, 20132025.
Kulkarni, PR & Pimpale, NV (1989) Colostrum – a review. Indian Journal of Dairy Science 42, 216224.
Kunz, C & Rudloff, S (1993) Biological functions of oligosaccharides in human milk. Acta Paediatrica 82, 903912.
Kunz, C, Rodriguez-Palmero, M, Berthold, K & Jensen, R (1999) Nutritional and biochemical properties of human milk, part 1; general aspects, proteins and carbohydrates. Clinics in Perinatology 26, 307333.
McVeagh, P & Brand Miller, J (1997) Human milk oligosaccharides, only the breast. Journal of Paediatric Child Health 33, 281286.
Messer, M, Fitzgerald, P, Merchant, J & Green, B (1987) Changes in milk carbohydrates during lactation in the eastern quoll Dasyurus viverrinus (Marsupialia). Comparative Biochemistry and Physiology B 88, 10831086.
Montreuil, J (1994) The saga of human milk oligosaccharides New Perspectives in Infant Nutrition, pp. 311 [Renner, B, Sawatzki, G, editors] Thieme: Stuttgart.
Montreuil, J & Mullet, S (1960) Etude des variations des constituents glucidiques du lait de femme au cours de la lactation. Bulletin Societé de Chimie Biologique 42, 365373.
Neeser, J-R, Golliard, M & Vedovo, SD (1990) Quantitative determination of complex carbohydrates in bovine milk and in milk based infant formulas. Journal of Dairy Science 74, 28602871.
Newberg, D (1999) Human milk glycoconjugates that inhibit pathogens. Current Medicinal Chemistry 5, 117127.
Newberg, D & Neubauer, S (1995) Carbohydrates in milks, analysis, quantities, and significance Handbook of Milk Composition, pp. 273349 [Jensen, RG, editor]. New York: Academic Press.
Parkkinen, J & Finne, J (1985) Occurrence of N-acetylglucosamine 6-phosphate in complex carbohydrates. Characterisation of a phosphorylated sialyl oligosaccharide from bovine colostrum. Journal of Biological Chemistry 260, 1097110975.
Parkkinen, J & Finne, J (1987) Isolation of sialyl oligosaccharides and sialyl oligosaccharide phosphates from bovine colostrum and human urine. Methods in Enzymology 138, 289300.
Parkkinen, J, Finne, J, Achtman, M, Vaisanen, V & Korhonen, T (1983) Escherichia coli strains binding neuraminyl alpha 2–3 galactosides. Biochemical and Biophysical Research Communications 111, 456461.
Polonosky, M & Lespagnol, A (1933) Nouvelles acquisitions sur les composes glucidiques du lait de femme. Bulletin of the Society for Chemistry and Biology 15, 320349.
Saito, T, Itoh, T & Adachi, S (1984) Presence of two neutral disaccharides containing N-acetylhexosamine in bovine colostrum as free forms. Biochimica et Biophysica Acta 801, 147150.
Saito, T, Itoh, T & Adachi, S (1987) Chemical structure of three neutral trisaccharides isolated from bovine colostrum. Carbohydrate Research 165, 4351.
Sanchez-Diaz, A, Ruano, M, Lorente, F & Hueso, P (1997) A critical analysis of total sialic acid and sialoglycoconjugate content of bovine milk-based infant formulas. Journal of Pediatric Gastroenterology and Nutrition 24, 405410.
Schneir, M & Rafelson, M (1966) Isolation and characterisation of two structural isomers of N-acetylneuraminyl lactose from bovine colostrum. Biochimica et Biophysica Acta 130, 111.
Schroten, H, Lethen, A & Hanisch, R (1992) Inhibition of adhesion of S-fimbriated Escherichia coli to epithelial cells by muconium and faeces of breast-fed and formula-fed newborns. Mucins are the major inhibitory component. Journal of Pediatric Gastroenterology and Nutrition 15, 150155.
Shimazu, M, Yamauchi, K, Miyauchi, Y, Sakurai, T, Tokugawa, K & McIlhinney, AJ (1986) HighMr glycoprotein profiles in human milk serum and fat globular membrane. Biochemical Journal 233, 725730.
Simon, PM, Goodee, PL, Mobasseri, A & Zopf, D (1997) Inhibition of Helicobacter pylori binding to gastrointestinal epithelial cells by sialic acid-containing oligosaccharides. Infection and Immunity 65, 750757.
Takamizawa, K, Iwamori, M, Mutai, M & Nagai, Y (1986) Gangliosides of bovine butter milk. Isolation and characterization of a novel monosialoganglioside with a new branching structure. Journal of Biological Chemistry 261, 56255631.
Urashima, T, Saito, T, Ohmisya, K & Shimazaki, K (1991) Structural determination of three neutral oligosaccharides in bovine (Holstein–Friesian) colostrum, including novel trisaccharide; GalNAc α1–3 Gal β1–4 Glc. Biochimica et Biophysica Acta 1073, 225229.
Varki, A (1993) Biological roles of oligosaccharides; all of the theories are correct. Glycobiology 3, 97130.
Veh, RW, Michalski, J, Corfield, AP, Sander-wewer, M, Dagmar, G & Schauer, R (1981) New chromatographic system for the rapid analysis and preparation of colostrum sialyl oligosaccharides. Journal of Chromatography 212, 313322.
Yoshihama, M, Mochizuki, E, Mitsuhashi, S & Ahiko, K (1982) Studies on the application of galactosyl lactose for infant formula. III Effect of galactosyl lactose on intestinal bacterial flora of newborn infants. Yukijinushi Nyugyo Gijyutsu Kenkyushu, Hokoku 78, 3337.
Zopf, D & Roth, S (1996) Oligosaccharides anti-infection agents. Lancet 347, 10171021.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed