Hostname: page-component-6b989bf9dc-jks4b Total loading time: 0 Render date: 2024-04-13T02:24:23.816Z Has data issue: false hasContentIssue false

Oligosaccharides and glycoconjugates in bovine milk and colostrum

Published online by Cambridge University Press:  09 March 2007

Pramod K. Gopal*
Affiliation:
New Zealand Dairy Research Institute, Massey University, Palmerston North, New Zealand
H. S. Gill
Affiliation:
New Zealand Dairy Research Institute, Massey University, Palmerston North, New Zealand Milk and Health Research Centre, Massey University, Palmerston North, New Zealand
*
*Corresponding author: Dr P. K. Gopal, fax +64 6 354 1756, email pramod.gopal@nzdri.org.nz
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Oligosaccharides and glycoconjugates are some of the most important bioactive components in milk. A great deal of information is available on the biological function of the components from human milk. Their primary role seems to be in providing protection against pathogens by acting as competitive inhibitors for the binding sites on the epithelial surfaces of the intestine. Evidence is also available to support the role of some of these components as growth promoters for genera of beneficial microflora in the colon. Compared with human milk, levels of oligosaccharides in bovine milk are very low. Nevertheless, a number of neutral and acidic oligosaccharides have been isolated from bovine milk and characterised. The highest concentration of these molecules is found in early postparturition milk (colostrum). The chemical structure of the oligosaccharides and many of the glycoconjugates from bovine milk are similar to those in human milk. It is likely that bovine oligosaccharides and glycoconjugates can be used in milk products as bioactive components in human nutrition.

Type
Research Article
Copyright
Copyright © The Nutrition Society 2000

References

Andersson, B, Porras, O, Hanson, L, Lagergard, T, Svanborg-Eden, C (1986) Inhibition of attachment of Streptococcus pneumoniae and Haemophilus influenzae by human milk and receptor oligosaccharides. Journal of Infectious Diseases 153, 232237.CrossRefGoogle ScholarPubMed
Brand Miller, J, McVeagh, P & Bull, S (1994) Biological function of oligosaccharides. Acta Paediatrica 83, 1051.Google Scholar
Brand Miller, J, McVeagh, P, McNeil, Y & Gillard, B (1995) Human milk oligosaccharides are not digested and absorbed in the small intestine of young infants. Proceedings of the Nutrition Society of Australia 19, 44.Google Scholar
Carlson, SE (1985) N-Acetylneuraminic acid concentrations in human milk oligosaccharides and glycoproteins during lactation. American Journal of Clinical Nutrition 41, 720726.CrossRefGoogle ScholarPubMed
Cleary, T, Chambers, J & Pickering, L (1985) Protection of mice from heat stable enterotoxin of E. coli by infant formulas. Journal of Pediatric Gastroenteterology Nutrition 4, 125131.Google ScholarPubMed
Gibson, G & Roberfroid, M (1995) Dietary modulation of human colonic microbiota-introducing the concept of probiotics. Journal of Nutrition 125, 14011412.CrossRefGoogle Scholar
Green, B, Merchant, J & Newgrain, K (1987) Milk composition in the eastern quoll, Dasyurus viverrinus (Marsupialia, Dasyuridae). Australian Journal of Biological Science 40, 379387.CrossRefGoogle ScholarPubMed
Holmgren, J, Svennerholm, A & Lindbhad, M (1983) Receptor like glyco compounds in human milk that inhibit classical and E1 Tor Viberio cholera cell adhesion (haemagglutination). Infection and Immunity 39, 147154.CrossRefGoogle Scholar
Jenness, R (1974) The composition of milk. In Lactation: A Comprehensive Treatise, pp. 3107. [Larson, BL and Smith, VR, editors]. New York: Academic Press.Google Scholar
Kanamaru, Y, Toyoki, T, Nagaoka, S, Kuzuya, Y & Niki, R (1993) High molecular weight mucin-like glycoprotein in bovine milk. Bioscience, Biotechnology and Biochemistry 57, 666667.CrossRefGoogle Scholar
Kobata, A (1977) Milk glycoproteins and oligosaccharides The Glycoconjugates, Vol. I, 423 [Horowitz, M and Pigman, W, editors]. New York: Academic Press.Google Scholar
Korhonen, T, Valtonen, M, Parkkinen, J, Vaisanen-Rhen, V, Finne, J, Orskov, F, Orskov, I, Svenson, S & Makela, P (1985) Serotypes, hemolysin production, and receptor recognition of Escherichia coli strains associated with neonatal sepsis and meningitis. Infection and Immunity 48, 486491.CrossRefGoogle ScholarPubMed
Kuhn, R & Brossmer, R (1956) Ueber o-acetyllactaminsaure-lactose aus Kuh-Colostrum und ihre Spaltbarkeit durch Influenza virus. Chemistry Berlin 89, 20132025.CrossRefGoogle Scholar
Kulkarni, PR & Pimpale, NV (1989) Colostrum – a review. Indian Journal of Dairy Science 42, 216224.Google Scholar
Kunz, C & Rudloff, S (1993) Biological functions of oligosaccharides in human milk. Acta Paediatrica 82, 903912.CrossRefGoogle ScholarPubMed
Kunz, C, Rodriguez-Palmero, M, Berthold, K & Jensen, R (1999) Nutritional and biochemical properties of human milk, part 1; general aspects, proteins and carbohydrates. Clinics in Perinatology 26, 307333.CrossRefGoogle Scholar
McVeagh, P & Brand Miller, J (1997) Human milk oligosaccharides, only the breast. Journal of Paediatric Child Health 33, 281286.CrossRefGoogle ScholarPubMed
Messer, M, Fitzgerald, P, Merchant, J & Green, B (1987) Changes in milk carbohydrates during lactation in the eastern quoll Dasyurus viverrinus (Marsupialia). Comparative Biochemistry and Physiology B 88, 10831086.CrossRefGoogle ScholarPubMed
Montreuil, J (1994) The saga of human milk oligosaccharides New Perspectives in Infant Nutrition, pp. 311 [Renner, B, Sawatzki, G, editors] Thieme: Stuttgart.Google Scholar
Montreuil, J & Mullet, S (1960) Etude des variations des constituents glucidiques du lait de femme au cours de la lactation. Bulletin Societé de Chimie Biologique 42, 365373.Google Scholar
Neeser, J-R, Golliard, M & Vedovo, SD (1990) Quantitative determination of complex carbohydrates in bovine milk and in milk based infant formulas. Journal of Dairy Science 74, 28602871.CrossRefGoogle Scholar
Newberg, D (1999) Human milk glycoconjugates that inhibit pathogens. Current Medicinal Chemistry 5, 117127.CrossRefGoogle Scholar
Newberg, D & Neubauer, S (1995) Carbohydrates in milks, analysis, quantities, and significance Handbook of Milk Composition, pp. 273349 [Jensen, RG, editor]. New York: Academic Press.CrossRefGoogle Scholar
Parkkinen, J & Finne, J (1985) Occurrence of N-acetylglucosamine 6-phosphate in complex carbohydrates. Characterisation of a phosphorylated sialyl oligosaccharide from bovine colostrum. Journal of Biological Chemistry 260, 1097110975.CrossRefGoogle ScholarPubMed
Parkkinen, J & Finne, J (1987) Isolation of sialyl oligosaccharides and sialyl oligosaccharide phosphates from bovine colostrum and human urine. Methods in Enzymology 138, 289300.CrossRefGoogle ScholarPubMed
Parkkinen, J, Finne, J, Achtman, M, Vaisanen, V & Korhonen, T (1983) Escherichia coli strains binding neuraminyl alpha 2–3 galactosides. Biochemical and Biophysical Research Communications 111, 456461.CrossRefGoogle ScholarPubMed
Polonosky, M & Lespagnol, A (1933) Nouvelles acquisitions sur les composes glucidiques du lait de femme. Bulletin of the Society for Chemistry and Biology 15, 320349.Google Scholar
Saito, T, Itoh, T & Adachi, S (1984) Presence of two neutral disaccharides containing N-acetylhexosamine in bovine colostrum as free forms. Biochimica et Biophysica Acta 801, 147150.CrossRefGoogle ScholarPubMed
Saito, T, Itoh, T & Adachi, S (1987) Chemical structure of three neutral trisaccharides isolated from bovine colostrum. Carbohydrate Research 165, 4351.CrossRefGoogle ScholarPubMed
Sanchez-Diaz, A, Ruano, M, Lorente, F & Hueso, P (1997) A critical analysis of total sialic acid and sialoglycoconjugate content of bovine milk-based infant formulas. Journal of Pediatric Gastroenterology and Nutrition 24, 405410.Google ScholarPubMed
Schneir, M & Rafelson, M (1966) Isolation and characterisation of two structural isomers of N-acetylneuraminyl lactose from bovine colostrum. Biochimica et Biophysica Acta 130, 111.CrossRefGoogle Scholar
Schroten, H, Lethen, A & Hanisch, R (1992) Inhibition of adhesion of S-fimbriated Escherichia coli to epithelial cells by muconium and faeces of breast-fed and formula-fed newborns. Mucins are the major inhibitory component. Journal of Pediatric Gastroenterology and Nutrition 15, 150155.Google Scholar
Shimazu, M, Yamauchi, K, Miyauchi, Y, Sakurai, T, Tokugawa, K & McIlhinney, AJ (1986) HighMr glycoprotein profiles in human milk serum and fat globular membrane. Biochemical Journal 233, 725730.Google Scholar
Simon, PM, Goodee, PL, Mobasseri, A & Zopf, D (1997) Inhibition of Helicobacter pylori binding to gastrointestinal epithelial cells by sialic acid-containing oligosaccharides. Infection and Immunity 65, 750757.CrossRefGoogle ScholarPubMed
Takamizawa, K, Iwamori, M, Mutai, M & Nagai, Y (1986) Gangliosides of bovine butter milk. Isolation and characterization of a novel monosialoganglioside with a new branching structure. Journal of Biological Chemistry 261, 56255631.CrossRefGoogle ScholarPubMed
Urashima, T, Saito, T, Ohmisya, K & Shimazaki, K (1991) Structural determination of three neutral oligosaccharides in bovine (Holstein–Friesian) colostrum, including novel trisaccharide; GalNAc α1–3 Gal β1–4 Glc. Biochimica et Biophysica Acta 1073, 225229.CrossRefGoogle Scholar
Varki, A (1993) Biological roles of oligosaccharides; all of the theories are correct. Glycobiology 3, 97130.CrossRefGoogle ScholarPubMed
Veh, RW, Michalski, J, Corfield, AP, Sander-wewer, M, Dagmar, G & Schauer, R (1981) New chromatographic system for the rapid analysis and preparation of colostrum sialyl oligosaccharides. Journal of Chromatography 212, 313322.CrossRefGoogle Scholar
Yoshihama, M, Mochizuki, E, Mitsuhashi, S & Ahiko, K (1982) Studies on the application of galactosyl lactose for infant formula. III Effect of galactosyl lactose on intestinal bacterial flora of newborn infants. Yukijinushi Nyugyo Gijyutsu Kenkyushu, Hokoku 78, 3337.Google Scholar
Zopf, D & Roth, S (1996) Oligosaccharides anti-infection agents. Lancet 347, 10171021.CrossRefGoogle Scholar