Chen, Yu-Wen Scutaru, Tabita Timeea Ghetu, Nicolae Carasevici, Eugen Lupascu, Cristian Dumitru Ferariu, Dan Pieptu, Dragos Coman, Corneliu-George and Danciu, Mihai 2017. The Effects of Adipose-Derived Stem Cell–Differentiated Adipocytes on Skin Burn Wound Healing in Rats. Journal of Burn Care & Research, Vol. 38, Issue. 1, p. 1.
Urai, Tamae Haryanto, Mukai, Kanae Matsushita, Tatsuhiko Asano, Kimi Nakajima, Yukari Okuwa, Mayumi Sugama, Junko and Nakatani, Toshio 2016. The Relationship between Cutaneous Wounds Made on Obese Mice or Those with Decreased Body Weight and Serum Leptin Level. Health, Vol. 08, Issue. 11, p. 1015.
Uzêda-e-Silva, Virgínia Dias Rodriguez, Tania Tavares Rocha, Isadora Almeida Rios Xavier, Flávia Calo Aquino dos Santos, Jean Nunes Cury, Patrícia Ramos and Ramalho, Luciana Maria Pedreira 2016. Laser phototherapy improves early stage of cutaneous wound healing of rats under hyperlipidic diet. Lasers in Medical Science, Vol. 31, Issue. 7, p. 1363.
Bandeira, Luana Graziella Bortolot, Beatriz Salari Cecatto, Matheus Jorand Monte-Alto-Costa, Andréa Romana-Souza, Bruna and Platten, Michael 2015. Exogenous Tryptophan Promotes Cutaneous Wound Healing of Chronically Stressed Mice through Inhibition of TNF-α and IDO Activation. PLOS ONE, Vol. 10, Issue. 6, p. e0128439.
Szczęsny, Wojciech Szczepanek, Joanna Tretyn, Andrzej Dąbrowiecki, Stanisław Szmytkowski, Jakub and Polak, Juliusz 2015. An analysis of the expression of collagen I and III genes in the fascia of obese patients. Journal of Surgical Research, Vol. 195, Issue. 2, p. 475.
Assis de Brito, Thatiana L. Monte-Alto-Costa, Andréa and Romana-Souza, Bruna 2014. Propranolol impairs the closure of pressure ulcers in mice. Life Sciences, Vol. 100, Issue. 2, p. 138.
Cantatore, Matteo Ferrari, Roberta Boracchi, Patrizia Gobbetti, Matteo Travetti, Olga Ravasio, Giuliano Giudice, Chiara Di Giancamillo, Mauro Grieco, Valeria and Stefanello, Damiano 2014. Factors Influencing Wound Healing Complications After Wide Excision of Injection Site Sarcomas of the Trunk of Cats. Veterinary Surgery, Vol. 43, Issue. 7, p. 783.
Pence, Brandt D. and Woods, Jeffrey A. 2014. Exercise, Obesity, and Cutaneous Wound Healing: Evidence from Rodent and Human Studies. Advances in Wound Care, Vol. 3, Issue. 1, p. 71.
Romana-Souza, Bruna Assis de Brito, Thatiana L. Pereira, Gabriela R. and Monte-Alto-Costa, Andréa 2014. Gonadal hormones differently modulate cutaneous wound healing of chronically stressed mice. Brain, Behavior, and Immunity, Vol. 36, p. 101.
Sawada, Naoki Jiang, Aihua Takizawa, Fumihiko Safdar, Adeel Manika, Andre Tesmenitsky, Yevgenia Kang, Kyu-Tae Bischoff, Joyce Kalwa, Hermann Sartoretto, Juliano L. Kamei, Yasutomi Benjamin, Laura E. Watada, Hirotaka Ogawa, Yoshihiro Higashikuni, Yasutomi Kessinger, Chase W. Jaffer, Farouc A. Michel, Thomas Sata, Masataka Croce, Kevin Tanaka, Rica and Arany, Zolt 2014. Endothelial PGC-1α Mediates Vascular Dysfunction in Diabetes. Cell Metabolism, Vol. 19, Issue. 2, p. 246.
de-Sá-Earp, Ana P. do Nascimento, Adriana P. Carneiro, Sueli C. Porto, Luís C. and Monte-Alto-Costa, Andréa 2013. Dermal Dendritic Cell Population and Blood Vessels Are Diminished in the Skin of Systemic Sclerosis Patients. The American Journal of Dermatopathology, Vol. 35, Issue. 4, p. 438.
Marinho, Polyana Cury Neto-Ferreira, Rodrigo and José de Carvalho, Jorge 2013. Evaluation of Therapeutic Intervention with a Natural Product in Cutaneous Wound Healing: The Use of Capybara Oil. Evidence-Based Complementary and Alternative Medicine, Vol. 2013, p. 1.
Negrão, Rita Costa, Raquel Duarte, Delfim Gomes, Tiago Taveira Coelho, Pedro Guimarães, João T. Guardão, Luísa Azevedo, Isabel and Soares, Raquel 2012. Xanthohumol-supplemented beer modulates angiogenesis and inflammation in a skin wound healing model. Involvement of local adipocytes. Journal of Cellular Biochemistry, Vol. 113, Issue. 1, p. 100.
PENCE, BRANDT D. DIPIETRO, LUISA A. and WOODS, JEFFREY A. 2012. Exercise Speeds Cutaneous Wound Healing in High-Fat Diet-Induced Obese Mice. Medicine & Science in Sports & Exercise, Vol. 44, Issue. 10, p. 1846.
Al-Mulla, Fahd Leibovich, Samuel J. Francis, Issam M. and Bitar, Milad S. 2011. Impaired TGF-β signaling and a defect in resolution of inflammation contribute to delayed wound healing in a female rat model of type 2 diabetes. Molecular BioSystems, Vol. 7, Issue. 11, p. 3006.
Paulino do Nascimento, Adriana and Monte-Alto-Costa, Andréa 2011. Both obesity-prone and obesity-resistant rats present delayed cutaneous wound healing. British Journal of Nutrition, Vol. 106, Issue. 04, p. 603.
Xing, Liyu Culbertson, Eric J. Wen, Yuan Robson, Martin C. and Franz, Michael George 2011. Impaired Laparotomy Wound Healing in Obese Rats. Obesity Surgery, Vol. 21, Issue. 12, p. 1937.
Otranto, Marcela Do Nascimento, Adriana Paulino and Monte-Alto-Costa, Andréa 2010. Effects of supplementation with different edible oils on cutaneous wound healing. Wound Repair and Regeneration, Vol. 18, Issue. 6, p. 629.
Romana-Souza, Bruna Otranto, Marcela Vieira, Andreza M. Filgueiras, Cláudio C. Fierro, Iolanda M. and Monte-Alto-Costa, Andréa 2010. Rotational stress-induced increase in epinephrine levels delays cutaneous wound healing in mice. Brain, Behavior, and Immunity, Vol. 24, Issue. 3, p. 427.
Romana-Souza, B and Monte-Alto-Costa, A 2010. Simultaneous blockade of alpha and beta adrenoceptors impairs cutaneous wound healing in rats. Journal of the European Academy of Dermatology and Venereology, Vol. 24, Issue. 3, p. 349.
Prolonged wound healing is a complication that contributes to morbidity and mortality. Overweight people regularly undergo surgery and trauma, and often develop chronic wounds, but the effects of the adipose tissue excess on cutaneous wound healing are not well understood. This study tested the hypothesis that overweight induced by a high-fat diet impairs rat cutaneous wound healing. Male Wistar rats were fed with either a high-fat or a standard (control) diet. After 15 weeks, an excisional lesion was done and the animals were killed 21 d later. Wound contraction and re-epithelialization, blood pressure, glucose and retroperitoneal fat were evaluated. After killing, lesion and adjacent normal skin were formol-fixed and paraffin-embedded. Inflammatory infiltrate, myofibroblasts, collagen fibres and cellular proliferation were analysed and blood vessels were evaluated using stereological methods. There was no difference in blood pressure and glucose, but retroperitoneal fat increased in the high-fat diet group. Animals fed with the high-fat diet presented delayed wound contraction and re-epithelialization. It was found that 21 d after wounding, overweight induced by a high-fat diet increased the inflammatory infiltrate and delayed myofibroblastic differentiation, collagen deposition, epithelial and connective tissue cell proliferation, and angiogenesis. These findings support the hypothesis that a high-fat diet exerts negative effects on rat cutaneous wound healing, due mainly to the prolongation of the inflammatory phase.
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