1Skeaff CM & Miller J (2009) Dietary fat and coronary heart disease: summary of evidence from prospective cohort and randomised controlled trials. Ann Nutr Metab 55, 173–201.
2Kris-Etherton PM, Harris WS & Appel LJ (2003) Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Arterioscler Thromb Vasc Biol 23, 20–30.
3Lichtenstein AH, Appel LJ, Brands M, et al. (2006) Summary of American Heart Association Diet and Lifestyle Recommendations revision 2006. Arterioscler Thromb Vasc Biol 26, 2186–2191.
4van Kuijk FJ, Holte LL & Dratz EA (1990) 4-Hydroxyhexenal: a lipid peroxidation product derived from oxidized docosahexaenoic acid. Biochim Biophys Acta 1043, 116–118.
5Olsen E, Vogt G, Saarem K, et al. (2005) Autoxidation of cod liver oil with tocopherol and ascorbyl palmitate. JAOCS 82, 97–103.
6Pryor WA & Porter NA (1990) Suggested mechanisms for the production of 4-hydroxy-2-nonenal from the autoxidation of polyunsaturated fatty acids. Free Radic Biol Med 8, 541–543.
7Yin H, Brooks JD, Gao L, et al. (2007) Identification of novel autoxidation products of the omega-3 fatty acid eicosapentaenoic acid in vitro and in vivo. J Biol Chem 282, 29890–29901.
8Esterbauer H, Schaur RJ & Zollner H (1991) Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic Biol Med 11, 81–128.
9Council of Europe (2008) European Pharmacopoeia, 6th ed.. Strasbourg: Council of Europe.
10Luley C, Klein B, Hanisch M, et al. (1988) Fatty acid composition and degree of peroxidation in fish oil and cod liver oil preparations. Arzneimittelforschung 38, 1783–1786.
11Shukla VK & Perkins EG (1991) The presence of oxidative polymeric materials in encapsulated fish oils. Lipids 26, 23–26.
12Fierens C & Corthout J (2007) Omega-3 fatty acid preparations – a comparative study. J Pharm Belg 62, 115–119.
13Kolanowski W (2010) Omega-3 LC PUFA contents and oxidative stability of encapsulated fish oil dietary supplements. Int J Food Prop 13, 498–511.
14Halliwell B & Chirico S (1993) Lipid peroxidation: its mechanism, measurement, and significance. Am J Clin Nutr 57, 715S–724S.
15Blomhoff R (2005) Dietary antioxidants and cardiovascular disease. Curr Opin Lipidol 16, 47–54.
16Aw TY (2005) Intestinal glutathione: determinant of mucosal peroxide transport, metabolism, and oxidative susceptibility. Toxicol Appl Pharmacol 204, 320–328.
17Wingler K, Muller C, Schmehl K, et al. (2000) Gastrointestinal glutathione peroxidase prevents transport of lipid hydroperoxides in CaCo-2 cells. Gastroenterology 119, 420–430.
18Dickinson DA & Forman HJ (2002) Cellular glutathione and thiols metabolism. Biochem Pharmacol 64, 1019–1026.
19Ursini F, Zamburlini A, Cazzolato G, et al. (1998) Postprandial plasma lipid hydroperoxides: a possible link between diet and atherosclerosis. Free Radic Biol Med 25, 250–252.
20Staprans I, Pan XM, Rapp JH, et al. (2005) The role of dietary oxidized cholesterol and oxidized fatty acids in the development of atherosclerosis. Mol Nutr Food Res 49, 1075–1082.
21Cohn JS (2002) Oxidized fat in the diet, postprandial lipaemia and cardiovascular disease. Curr Opin Lipidol 13, 19–24.
22Bowen PE & Borthakur G (2004) Postprandial lipid oxidation and cardiovascular disease risk. Curr Atheroscler Rep 6, 477–484.
23Guichardant M & Lagarde M (2009) Analysis of biomarkers from lipid peroxidation: a comparative study. Eur J Lipid Sci Technol 111, 75–82.
24Montuschi P, Barnes PJ & Roberts LJ (2004) Isoprostanes: markers and mediators of oxidative stress. FASEB J 18, 1791–1800.
25Minuz P, Fava C & Lechi A (2006) Lipid peroxidation, isoprostanes and vascular damage. Pharmacol Rep 58, 57–68.
26Pratico D, Rokach J, Lawson J, et al. (2004) F2-isoprostanes as indices of lipid peroxidation in inflammatory diseases. Chem Phys Lipids 128, 165–171.
27Pearson TA, Mensah GA, Alexander RW, et al. (2003) Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation 107, 499–511.
28Roberts LJ & Morrow JD (2000) Measurement of F(2)-isoprostanes as an index of oxidative stress in vivo. Free Radic Biol Med 28, 505–513.
29Basu S (2008) F2-isoprostanes in human health and diseases: from molecular mechanisms to clinical implications. Antioxid Redox Signal 10, 1405–1434.
30Myhrstad MC, Retterstol K, Telle-Hansen VH, et al. (2011) Effect of marine n-3 fatty acids on circulating inflammatory markers in healthy subjects and subjects with cardiovascular risk factors. Inflamm Res 60, 309–319.
31Basu A, Devaraj S & Jialal I (2006) Dietary factors that promote or retard inflammation. Arterioscler Thromb Vasc Biol 26, 995–1001.
32Higdon JV, Liu J, Du SH, et al. (2000) Supplementation of postmenopausal women with fish oil rich in eicosapentaenoic acid and docosahexaenoic acid is not associated with greater in vivo lipid peroxidation compared with oils rich in oleate and linoleate as assessed by plasma malondialdehyde and F(2)-isoprostanes. Am J Clin Nutr 72, 714–722.
33Mori TA (2004) Effect of fish and fish oil-derived omega-3 fatty acids on lipid oxidation. Redox Rep 9, 193–197.
34Nalsen C, Vessby B, Berglund L, et al. (2006) Dietary (n-3) fatty acids reduce plasma F2-isoprostanes but not prostaglandin F2alpha in healthy humans. J Nutr 136, 1222–1228.
35Long EK & Picklo MJ Sr (2010) trans-4-Hydroxy-2-hexenal, a product of n-3 fatty acid peroxidation: make some room HNE. Free Radic Biol Med 49, 1–8.
36Draper HH, Csallany AS & Hadley M (2000) Urinary aldehydes as indicators of lipid peroxidation in vivo. Free Radic Biol Med 29, 1071–1077.
37Zarkovic N (2003) 4-Hydroxynonenal as a bioactive marker of pathophysiological processes. Mol Aspects Med 24, 281–291.
38Guichardant M, Bacot S, Moliere P, et al. (2006) Hydroxy-alkenals from the peroxidation of n-3 and n-6 fatty acids and urinary metabolites. Prostaglandins Leukot Essent Fatty Acids 75, 179–182.
39Kitase A, Hino K, Furutani T, et al. (2005) In situ detection of oxidized n-3 polyunsaturated fatty acids in chronic hepatitis C: correlation with hepatic steatosis. J Gastroenterol 40, 617–624.
40Yamada S, Funada T, Shibata N, et al. (2004) Protein-bound 4-hydroxy-2-hexenal as a marker of oxidized n-3 polyunsaturated fatty acids. J Lipid Res 45, 626–634.
41Calzada C, Colas R, Guillot N, et al. (2010) Subgram daily supplementation with docosahexaenoic acid protects low-density lipoproteins from oxidation in healthy men. Atherosclerosis 208, 467–472.
42Spickett CM, Wiswedel I, Siems W, et al. (2010) Advances in methods for the determination of biologically relevant lipid peroxidation products. Free Radic Res 44, 1172–1202.
43Turner R, McLean CH & Silvers KM (2006) Are the health benefits of fish oils limited by products of oxidation? Nutr Res Rev 19, 53–62.
44Bays HE (2007) Safety considerations with omega-3 fatty acid therapy. Am J Cardiol 99, 35C–43C.
45European Food Safety Authority (2010) Scientific opinion on fish oil for human consumption. Food hygene, including rancidity. EFSA J 8, 1874.
46Maenpaa H, Heinonen OP & Manninen V (1991) Medication compliance and serum lipid changes in the Helsinki Heart Study. Br J Clin Pharmacol 32, 409–415.
47Bohn SK, Smeland S, Sakhi AK, et al. (2006) Post-radiotherapy plasma total glutathione is associated to outcome in patients with head and neck squamous cell carcinoma. Cancer Lett 238, 240–247.
48Bastani NE, Gundersen TE & Blomhoff R (2009) Determination of 8-epi PGF(2alpha) concentrations as a biomarker of oxidative stress using triple-stage liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom 23, 2885–2890.
49Luo XP, Yazdanpanah M, Bhooi N, et al. (1995) Determination of aldehydes and other lipid peroxidation products in biological samples by gas chromatography–mass spectrometry. Anal Biochem 228, 294–298.
50Panfili G, Fratianni A & Irano M (2003) Normal phase high-performance liquid chromatography method for the determination of tocopherols and tocotrienols in cereals. J Agric Food Chem 51, 3940–3944.
51Wheeler CR, Salzman JA, Elsayed NM, et al. (1990) Automated assays for superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase activity. Anal Biochem 184, 193–199.
52Bligh EG & Dyer WJ (1959) A rapid method of total lipid extraction and purification. Can J Biochem Physiol 37, 911–917.
53Olsen E, Vogt G, Veberg A, et al. (2005) Analysis of early lipid oxidation in smoked, comminuted pork or poultry sausages with spices. J Agric Food Chem 53, 7448–7457.
54Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico (1999) Dietary supplementation with n-3 polyunsaturated fatty acids and vitamin E after myocardial infarction: results of the GISSI-Prevenzione trial. Lancet 354, 447–455.
55Yokoyama M, Origasa H, Matsuzaki M, et al. (2007) Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis. Lancet 369, 1090–1098.
56Meydani M, Natiello F, Goldin B, et al. (1991) Effect of long-term fish oil supplementation on vitamin E status and lipid peroxidation in women. J Nutr 121, 484–491.
57Harats D, Dabach Y, Hollander G, et al. (1991) Fish oil ingestion in smokers and nonsmokers enhances peroxidation of plasma lipoproteins. Atherosclerosis 90, 127–139.
58Tholstrup T, Hellgren LI, Petersen M, et al. (2004) A solid dietary fat containing fish oil redistributes lipoprotein subclasses without increasing oxidative stress in men. J Nutr 134, 1051–1057.
59Ulven SM, Kirkhus B, Lamglait A, et al. (2011) Metabolic effects of krill oil are essentially similar to those of fish oil but at lower dose of EPA and DHA, in healthy volunteers. Lipids 46, 37–46.
60Balk EM, Lichtenstein AH, Chung M, et al. (2006) Effects of omega-3 fatty acids on serum markers of cardiovascular disease risk: a systematic review. Atherosclerosis 189, 19–30.
61Freese R, Dragsted LO, Loft S, et al. (2008) No effect on oxidative stress biomarkers by modified intakes of polyunsaturated fatty acids or vegetables and fruit. Eur J Clin Nutr 62, 1151–1153.
62Ravn-Haren G, Bugel S, Krath BN, et al. (2008) A short-term intervention trial with selenate, selenium-enriched yeast and selenium-enriched milk: effects on oxidative defence regulation. Br J Nutr 99, 883–892.
63Miyamoto Y, Koh YH, Park YS, et al. (2003) Oxidative stress caused by inactivation of glutathione peroxidase and adaptive responses. Biol Chem 384, 567–574.
64Awasthi YC, Yang Y, Tiwari NK, et al. (2004) Regulation of 4-hydroxynonenal-mediated signaling by glutathione S-transferases. Free Radic Biol Med 37, 607–619.
65Mabile L, Piolot A, Boulet L, et al. (2001) Moderate intake of n-3 fatty acids is associated with stable erythrocyte resistance to oxidative stress in hypertriglyceridemic subjects. Am J Clin Nutr 74, 449–456.
66Bouzidi N, Mekki K, Boukaddoum A, et al. (2010) Effects of omega-3 polyunsaturated fatty-acid supplementation on redox status in chronic renal failure patients with dyslipidemia. J Ren Nutr 20, 321–328.
67Barbosa DS, Cecchini R, El Kadri MZ, et al. (2003) Decreased oxidative stress in patients with ulcerative colitis supplemented with fish oil omega-3 fatty acids. Nutrition 19, 837–842.
68Kesavulu MM, Kameswararao B, Apparao C, et al. (2002) Effect of omega-3 fatty acids on lipid peroxidation and antioxidant enzyme status in type 2 diabetic patients. Diabetes Metab 28, 20–26.
69Kesavulu MM, Rao BK, Giri R, et al. (2001) Lipid peroxidation and antioxidant enzyme status in type 2 diabetics with coronary heart disease. Diabetes Res Clin Pract 53, 33–39.
70Cao J, Schwichtenberg KA, Hanson NQ, et al. (2006) Incorporation and clearance of omega-3 fatty acids in erythrocyte membranes and plasma phospholipids. Clin Chem 52, 2265–2272.
71Flaten H, Hostmark AT, Kierulf P, et al. (1990) Fish-oil concentrate: effects on variables related to cardiovascular disease. Am J Clin Nutr 52, 300–306.
72Harris WS & Von SC (2004) The omega-3 index: a new risk factor for death from coronary heart disease? Prev Med 39, 212–220.
73Wingler K & Brigelius-Flohe R (1999) Gastrointestinal glutathione peroxidase. Biofactors 10, 245–249.
74Chu FF, Esworthy RS & Doroshow JH (2004) Role of Se-dependent glutathione peroxidases in gastrointestinal inflammation and cancer. Free Radic Biol Med 36, 1481–1495.
75Kanazawa K & Ashida H (1998) Dietary hydroperoxides of linoleic acid decompose to aldehydes in stomach before being absorbed into the body. Biochim Biophys Acta 1393, 349–361.
76Bull AW & Bronstein JC (1990) Production of unsaturated carbonyl compounds during metabolism of hydroperoxy fatty acids by colonic homogenates. Carcinogenesis 11, 1699–1704.
77Naruszewicz M, Wozny E, Mirkiewicz E, et al. (1987) The effect of thermally oxidized soya bean oil on metabolism of chylomicrons. Increased uptake and degradation of oxidized chylomicrons in cultured mouse macrophages. Atherosclerosis 66, 45–53.
78Staprans I, Rapp JH, Pan XM, et al. (1994) Oxidized lipids in the diet are a source of oxidized lipid in chylomicrons of human serum. Arterioscler Thromb 14, 1900–1905.
79Staprans I, Hardman DA, Pan XM, et al. (1999) Effect of oxidized lipids in the diet on oxidized lipid levels in postprandial serum chylomicrons of diabetic patients. Diabetes Care 22, 300–306.
80Wallace AJ, Sutherland WH, Mann JI, et al. (2001) The effect of meals rich in thermally stressed olive and safflower oils on postprandial serum paraoxonase activity in patients with diabetes. Eur J Clin Nutr 55, 951–958.
81Sutherland WH, de Jong SA, Walker RJ, et al. (2002) Effect of meals rich in heated olive and safflower oils on oxidation of postprandial serum in healthy men. Atherosclerosis 160, 195–203.
82Sutherland WH, de Jong SA, Hessian PA, et al. (2010) Ingestion of native and thermally oxidized polyunsaturated fats acutely increases circulating numbers of endothelial microparticles. Metabolism 59, 446–453.
83Wallace JM, McCabe AJ, Robson PJ, et al. (2000) Bioavailability of n-3 polyunsaturated fatty acids (PUFA) in foods enriched with microencapsulated fish oil. Ann Nutr Metab 44, 157–162.
84Suomela JP, Ahotupa M & Kallio H (2005) Triacylglycerol oxidation in pig lipoproteins after a diet rich in oxidized sunflower seed oil. Lipids 40, 437–444.
85Suomela JP, Ahotupa M, Sjovall O, et al. (2004) Diet and lipoprotein oxidation: analysis of oxidized triacylglycerols in pig lipoproteins. Lipids 39, 639–647.
86Song JH, Fujimoto K & Miyazawa T (2000) Polyunsaturated (n-3) fatty acids susceptible to peroxidation are increased in plasma and tissue lipids of rats fed docosahexaenoic acid-containing oils. J Nutr 130, 3028–3033.