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Panax ginseng has no effect on indices of glucose regulation following acute or chronic ingestion in healthy volunteers

  • Jonathon L. Reay (a1), Andrew B. Scholey (a2), Anthea Milne (a1), J. Fenwick (a3) and David O. Kennedy (a1)...
Abstract

In the absence of effective pharmacotherapy for diabetes there has been an increase in the use of, and research into, alternative treatment strategies. These include exercise, dietary interventions and the use of supplements including extracts of ginseng. Two separate, placebo-controlled, double-blind, cross-over studies investigating the effects of chronic ingestion of Panax ginseng (study 1 used G115, study 2 used Cheong Kwan Jang) on glycated Hb (HbA1c; study 1, n 18; study 2, n 11), fasting plasma insulin (study 1, n 17; study 2, n 12), fasting plasma glucose and postprandial response (following breakfast) (study 1, n 23; study 2, n 14) in healthy volunteers are reported. In both studies it was found that Panax ginseng had no effect on any gluco-regulatory parameter investigated. These results are not consistent with those reported for a diabetic sample (albeit using slightly different outcomes). These results would suggest that chronic use of Panax ginseng by non-diabetic individuals will have little long-term effect on glucose regulation. The benefits to glucose regulation associated with long-term ginseng use may only be present in populations with compromised glucose control; however, further research is needed to confirm such a speculation.

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Corresponding author
*Corresponding author: Dr Jonathon L. Reay, fax +44 191 2273190, email j.reay@unn.ac.uk
References
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1Mokdad AH, Ford ES, Bowman BA, et al. (2003) Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. JAMA 289, 7679.
2Turner RC, Cull CA, Frighi V, et al. (2000) Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49), UK Prospective Diabetes Study (UKPDS) group. JAMA 281, 20052012.
3Roglic G, Unwin N, Bennett PH, et al. (2005) The burden of mortality attributable to diabetes. Diabetes Care 28, 21302135.
4Xie JT, Zhou YP, Dey L, et al. (2002) Ginseng berry reduces blood glucose and body weight in db/db mice. Phytomedicine 9, 254258.
5Ohnishi Y, Takagi S, Miura T, et al. (1996) Effects of ginseng radix on GLUT2 protein content in mouse liver in normal and epinephrine induced hypoglycaemic mice. Biol Pharm Bull 19, 12381240.
6Xie JT, Wang CZ, Wang AB, et al. (2005) Antihyperglycemic effects of total ginsenosides from leaves and stem of panax ginseng. Acta Pharmacol Sin 26, 11041110.
7Sotaniemi EA, Haapakoski E & Rautio A (1995) Ginseng therapy in non-insulin diabetic patients. Diabetes Care 18, 13731375.
8Tetsutani T, Yamamura M, Yamaguchi T, et al. (2000) Can red ginseng control blood glucose in diabetic patients. Ginseng Rev 28, 4447.
9Vuksan V, Sievenpiper JL, Koo VYY, et al. (2000) American ginseng (Panax quinquefolius L) reduces postprandial glycemia in nondiabetic subjects and subjects with type 2 Diabetes Mellitus. Arch Int Med 160, 10091013.
10Vuksan V, Xu Z & Jenkins AL (2000) American ginseng improves long term glycaemic control in type two diabetes: double blind placebo controlled crossover trial. Diabetes 49, Suppl. 1, A95, (abstract).
11Vuksan V, Sievenpiper JL, Wong J, et al. (2001) American ginseng (Panax quinquefolius L.) attenuates postprandial glycemia in a time-dependent but not dose-dependent manner in healthy individuals. Am J Clin Nutr 73, 753758.
12Vuksan V, Sung MK, Sievenpiper JL, et al. (2006) Korean red ginseng (panax ginseng) improves glucose and insulin regulation in well controlled type 2 diabetes: results of a randomized, double-blind, placebo-controlled study of efficacy and safety. Nutr Metab Cardiovasc Dis 18, 4656.
13Reay JL, Kennedy DO & Scholey AB (2005) Single doses of panax ginseng (G115) reduce blood glucose levels and improve cognitive performance during sustained mental activity. J Psychopharmacol 19, 357365.
14Reay JL, Kennedy DO & Scholey AB (2006) The glycaemic effect of single doses of panax ginseng (G115) in young healthy volunteers. Br J Nutr 96, 639642.
15Dascalu A, Sievenpiper JL, Jenkins AL, et al. (2007) Five batches representative of Ontario-grown American ginseng root produce comparable reductions of postprandial gycemia in healthy individuals. Can J Physiol Pharmacol 85, 856864.
16Sievenpiper JL, Arnason JT, Leiter LA, et al. (2002) Variable effects of American ginseng: a batch of American ginseng (Panax quinquefolius L.) with a depressed ginsenoside profile does not affect postprandial glycemia. Eur J Clin Nutr 57, 243248.
17Sievenpiper JL, Arnason JT, Leiter LA, et al. (2003) Possible opposing effects of Asian ginseng (Panax ginseng C.A. Meyer) on glycemia: results of two acute dose escalation studies. J Am Coll Nutr 22, 524532.
18Sotaniemi EA, Haapakoski E & Rautio A (1995) Ginseng therapy in non-insulin diabetic patients. Diabetes Care 18, 13731375.
19Price CP & Koller PU (1988) A multicentre study of the new Reflotron system for the measurement of urea, glucose, triacylglycerols, cholesterol, gamma-glutamyltransferase and haemoglobin. J Clin Chem Clin Biochem 26, 233250.
20Kennedy DO & Scholey AB (2003) Ginseng: potential for the enhancement of cognitive performance and mood. Pharmacol Biochem Behav 75, 687700.
21Lai DM, Tu YK, Liu IM, et al. (2006) Mediation of beta-endorphin by ginsenoside Rh2 to lower plasma glucose in streptozotocin-induced diabetic rats. Planta Med 72, 913.
22Wang LC, Wang B, Ng SY, et al. (2006) Effects of ginseng saponins on beta-amyloid-induced amnesia in rats. J Ethnopharmacol 103, 103108.
23Chung SH, Choi CG & Park SH (2001) Comparisons between white ginseng radix an rootlet for antidiabetic activity and mechanism in KKAy mice. Arch Pharm Res 24, 214218.
24Liu TP, Liu IM & Cheng JT (2005) Improvement of insulin resistance by panax ginseng in fructose-rich chow-fed rats. Horm Metab Res 37, 146151.
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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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