Skip to main content
×
Home
    • Aa
    • Aa
  • Access
  • Cited by 13
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Russell, Wendy R. Baka, Athanasia Björck, Inger Delzenne, Nathalie Gao, Dan Griffiths, Helen R. Hadjilucas, Ellie Juvonen, Kristiina Lahtinen, Sampo Lansink, Mirian Loon, Luc Van Mykkänen, Hannu östman, Elin Riccardi, Gabriele Vinoy, Sophie and Weickert, Martin O. 2016. Impact of Diet Composition on Blood Glucose Regulation. Critical Reviews in Food Science and Nutrition, Vol. 56, Issue. 4, p. 541.


    Kim, Young-Sook Woo, Jung-Yoon Han, Chang-Kyun and Chang, Il-Moo 2015. Safety Analysis of Panax Ginseng in Randomized Clinical Trials: A Systematic Review. Medicines, Vol. 2, Issue. 2, p. 106.


    Li, Ke-Ke and Gong, Xiao-Jie 2015. A review on the medicinal potential of Panax ginseng saponins in diabetes mellitus. RSC Adv., Vol. 5, Issue. 59, p. 47353.


    Smith, Imogen Williamson, Elizabeth M Putnam, Sophie Farrimond, Jonathan and Whalley, Benjamin J 2014. Effects and mechanisms of ginseng and ginsenosides on cognition. Nutrition Reviews, Vol. 72, Issue. 5, p. 319.


    Campbell, Bill Wilborn, Colin La Bounty, Paul Taylor, Lem Nelson, Mike T Greenwood, Mike Ziegenfuss, Tim N Lopez, Hector L Hoffman, Jay R Stout, Jeffrey R Schmitz, Stephen Collins, Rick Kalman, Doug S Antonio, Jose and Kreider, Richard B 2013. International Society of Sports Nutrition position stand: energy drinks. Journal of the International Society of Sports Nutrition, Vol. 10, Issue. 1, p. 1.


    Oliynyk, Sergiy and Oh, Seikwan 2013. Actoprotective effect of ginseng: improving mental and physical performance. Journal of Ginseng Research, Vol. 37, Issue. 2, p. 144.


    Shergis, Johannah L. Zhang, Anthony L. Zhou, Wenyu and Xue, Charlie C. 2013. Panax ginsengin Randomised Controlled Trials: A Systematic Review. Phytotherapy Research, Vol. 27, Issue. 7, p. 949.


    Shergis, Johannah L. Zhang, Anthony L. Zhou, Wenyu and Xue, Charlie C. 2013. Quality and Risk of Bias inPanax ginsengRandomized Controlled Trials: A Review. The American Journal of Chinese Medicine, Vol. 41, Issue. 02, p. 231.


    2013. Principles and Practice of Phytotherapy.


    Yuan, Hai-Dan Kim, Jung-Tae Kim, Sung-Hoon and Chung, Sung-Hyun 2012. Ginseng and Diabetes: The Evidences from In Vitro, Animal and Human Studies. Journal of Ginseng Research, Vol. 36, Issue. 1, p. 27.


    Xie, W. and Du, L. 2011. Diabetes is an inflammatory disease: evidence from traditional Chinese medicines. Diabetes, Obesity and Metabolism, Vol. 13, Issue. 4, p. 289.


    Xie, Weidong Zhao, Yunan and Zhang, Yaou 2011. Traditional Chinese Medicines in Treatment of Patients with Type 2 Diabetes Mellitus. Evidence-Based Complementary and Alternative Medicine, Vol. 2011, p. 1.


    Duchan, Erin Patel, Neil D. and Feucht, Cynthia 2010. Energy Drinks: A Review of Use and Safety for Athletes. The Physician and Sportsmedicine, Vol. 38, Issue. 2, p. 171.


    ×

Panax ginseng has no effect on indices of glucose regulation following acute or chronic ingestion in healthy volunteers

  • Jonathon L. Reay (a1), Andrew B. Scholey (a2), Anthea Milne (a1), J. Fenwick (a3) and David O. Kennedy (a1)
  • DOI: http://dx.doi.org/10.1017/S0007114508123418
  • Published online: 19 November 2008
Abstract

In the absence of effective pharmacotherapy for diabetes there has been an increase in the use of, and research into, alternative treatment strategies. These include exercise, dietary interventions and the use of supplements including extracts of ginseng. Two separate, placebo-controlled, double-blind, cross-over studies investigating the effects of chronic ingestion of Panax ginseng (study 1 used G115, study 2 used Cheong Kwan Jang) on glycated Hb (HbA1c; study 1, n 18; study 2, n 11), fasting plasma insulin (study 1, n 17; study 2, n 12), fasting plasma glucose and postprandial response (following breakfast) (study 1, n 23; study 2, n 14) in healthy volunteers are reported. In both studies it was found that Panax ginseng had no effect on any gluco-regulatory parameter investigated. These results are not consistent with those reported for a diabetic sample (albeit using slightly different outcomes). These results would suggest that chronic use of Panax ginseng by non-diabetic individuals will have little long-term effect on glucose regulation. The benefits to glucose regulation associated with long-term ginseng use may only be present in populations with compromised glucose control; however, further research is needed to confirm such a speculation.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Panax ginseng has no effect on indices of glucose regulation following acute or chronic ingestion in healthy volunteers
      Your Kindle email address
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Panax ginseng has no effect on indices of glucose regulation following acute or chronic ingestion in healthy volunteers
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Panax ginseng has no effect on indices of glucose regulation following acute or chronic ingestion in healthy volunteers
      Available formats
      ×
Copyright
Corresponding author
*Corresponding author: Dr Jonathon L. Reay, fax +44 191 2273190, email j.reay@unn.ac.uk
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

2RC Turner , CA Cull , V Frighi , (2000) Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49), UK Prospective Diabetes Study (UKPDS) group. JAMA 281, 20052012.

3G Roglic , N Unwin , PH Bennett , (2005) The burden of mortality attributable to diabetes. Diabetes Care 28, 21302135.

4JT Xie , YP Zhou , L Dey , (2002) Ginseng berry reduces blood glucose and body weight in db/db mice. Phytomedicine 9, 254258.

5Y Ohnishi , S Takagi , T Miura , (1996) Effects of ginseng radix on GLUT2 protein content in mouse liver in normal and epinephrine induced hypoglycaemic mice. Biol Pharm Bull 19, 12381240.

6JT Xie , CZ Wang , AB Wang , (2005) Antihyperglycemic effects of total ginsenosides from leaves and stem of panax ginseng. Acta Pharmacol Sin 26, 11041110.

7EA Sotaniemi , E Haapakoski & A Rautio (1995) Ginseng therapy in non-insulin diabetic patients. Diabetes Care 18, 13731375.

9V Vuksan , JL Sievenpiper , VYY Koo , (2000) American ginseng (Panax quinquefolius L) reduces postprandial glycemia in nondiabetic subjects and subjects with type 2 Diabetes Mellitus. Arch Int Med 160, 10091013.

12V Vuksan , MK Sung , JL Sievenpiper , (2006) Korean red ginseng (panax ginseng) improves glucose and insulin regulation in well controlled type 2 diabetes: results of a randomized, double-blind, placebo-controlled study of efficacy and safety. Nutr Metab Cardiovasc Dis 18, 4656.

13JL Reay , DO Kennedy & AB Scholey (2005) Single doses of panax ginseng (G115) reduce blood glucose levels and improve cognitive performance during sustained mental activity. J Psychopharmacol 19, 357365.

15A Dascalu , JL Sievenpiper , AL Jenkins , (2007) Five batches representative of Ontario-grown American ginseng root produce comparable reductions of postprandial gycemia in healthy individuals. Can J Physiol Pharmacol 85, 856864.

16JL Sievenpiper , JT Arnason , LA Leiter , (2002) Variable effects of American ginseng: a batch of American ginseng (Panax quinquefolius L.) with a depressed ginsenoside profile does not affect postprandial glycemia. Eur J Clin Nutr 57, 243248.

17JL Sievenpiper , JT Arnason , LA Leiter , (2003) Possible opposing effects of Asian ginseng (Panax ginseng C.A. Meyer) on glycemia: results of two acute dose escalation studies. J Am Coll Nutr 22, 524532.

20DO Kennedy & AB Scholey (2003) Ginseng: potential for the enhancement of cognitive performance and mood. Pharmacol Biochem Behav 75, 687700.

21DM Lai , YK Tu , IM Liu , (2006) Mediation of beta-endorphin by ginsenoside Rh2 to lower plasma glucose in streptozotocin-induced diabetic rats. Planta Med 72, 913.

22LC Wang , B Wang , SY Ng , (2006) Effects of ginseng saponins on beta-amyloid-induced amnesia in rats. J Ethnopharmacol 103, 103108.

23SH Chung , CG Choi & SH Park (2001) Comparisons between white ginseng radix an rootlet for antidiabetic activity and mechanism in KKAy mice. Arch Pharm Res 24, 214218.

24TP Liu , IM Liu & JT Cheng (2005) Improvement of insulin resistance by panax ginseng in fructose-rich chow-fed rats. Horm Metab Res 37, 146151.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords: