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Periodic fluctuations of gut regulatory peptides in phase with the duodenal migrating myoelectric complex in preruminant calves: effect of different sources of dietary protein

Published online by Cambridge University Press:  09 March 2007

Romuald Zabielski ,
Claude Dardillat ,
Isabelle Le Huërou-Luron ,
Christine Bernard ,
Jean Alain Chayvialle  and
Paul Guilloteau
Romuald Zabielski
Affiliation:
Laboratoire du Jeune Ruminant, INRA, 65 rue de St Brieuc, 35042 Rennes, France Department of Animal Physiology, Warsaw Agricultural University, 02-787 Warsaw, Poland
Claude Dardillat
Affiliation:
Station de Recherches sur la Nutrition des Herbivores, INRA, Theix, 63122 Saint-Genès-Champanelle, France
Isabelle Le Huërou-Luron
Affiliation:
Laboratoire du Jeune Ruminant, INRA, 65 rue de St Brieuc, 35042 Rennes, France
Christine Bernard
Affiliation:
INSERM U45, Hôpital Edouard Herriot, 69374 Lyon, France
Jean Alain Chayvialle
Affiliation:
INSERM U45, Hôpital Edouard Herriot, 69374 Lyon, France
Paul Guilloteau*
Affiliation:
Laboratoire du Jeune Ruminant, INRA, 65 rue de St Brieuc, 35042 Rennes, France
*
*Corresponding author:Dr Paul Guilloteau, fax +33 2 99 28 53 70, email guilloteau@roazhon.inra.fr
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Abstract

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Four preruminant calves with implanted electrodes in the duodenum and a catheter in the external jugular vein were used for investigation of plasma gut regulatory peptide profiles during different phases of migrating myoelectric complex (MMC) in the small intestine. The effects of different dietary proteins on the rhythmic activity of gut peptides and gastrointestinal motility were compared. In particular, the effects of skimmed-milk protein (retaining physiological patterns of abomasal clotting, and abomaso-intestinal digesta flow) v. fish protein (devoid of clotting activity and modifying the digesta flow) were studied. In calves fed on the milk diet, plasma concentrations of pancreatic polypeptide, motilin, secretin, cholecystokinin (CCK) and somatostatin, but not vasoactive intestinal polypeptide or gastrin, fluctuated in phase with the duodenal MMC in the preprandial period. Feeding transiently affected the intestinal MMC and abolished the peptide fluctuations in a specimen-specific manner. In contrast, calves fed on the fish-protein diet showed more profound changes in intestinal MMC. In these animals the MMC-related fluctuations were significant only for plasma CCK. In conclusion, the source of dietary protein has an impact on the physiological endocrine function of the small intestine. Observed fluctuations of plasma gut regulatory peptides seem to be secondary to duodenal motility cycles.

Keywords

Gut peptidesDuodenumMyoelectrical activityDietary protein
Type
Animal Nutrition
Information
British Journal of Nutrition , Volume 79 , Issue 3 , March 1998 , pp. 287 - 296
Copyright
Copyright © The Nutrition Society 1998

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