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Phytosterols: to be or not to be toxic; that is the question

  • Gérard Lizard (a1)
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*Corresponding author: Dr Gérard Lizard, fax +33 380 39 62 50, email Gerard.Lizard@u_bourgogne.fr
References
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1Von Bergmann, K, Sudhop, T & Lütjohann, D (2005) Cholesterol and plant sterol absorption: recent insights. Am J Cardiol 96, Suppl. 1, 10D14D.
2Glueck, CJ, Speirs, J, Tracy, T, Streicher, P, Illig, E & Vandegrift, J (1991) Relationships of serum plant sterols (phytosterols) and cholesterol in 595 hypercholesterolemic subjects, and familial aggregation of phytosterols, cholesterol, and premature coronary heart disease in hypercholesterolemic probands and their first-degree relatives. Metabolism 38, 136140.
3Sudhop, T, Gottwald, BM & von Bergmann, K (2002) Serum plant sterols as a potential risk factor for coronary heart disease. Metabolism 51, 15191521.
4Weihrauch, JL & Gardner, JM (1978) Sterol content of foods of plant origin. J Am Diet Assoc 73, 3947.
5Plat, J & Mensik, RP (2002) Increased intestinal ABCA1 expression contributes to the decrease in cholesterol absorption after plant stanol consumption. FASEB J 16, 12481253.
6Sudhop, T, Lütjohann, D & von Bergmann, K (2005) Sterol transporters: targets of natural sterols and new lipid lowering drugs. Pharmacol Ther 15, 333341.
7Adcox, C, Boyd, L, Oehrl, L, Allen, J & Fenner, G (2001) Comparative effects of phytosterol oxides and cholesterol oxides in cultured macrophage-derived cell lines. J Agric Food Chem 49, 20902095.
8De Jong, A, Plat, J & Mensink, RP (2003) Metabolic effects of plant sterols and stanols (review). J Nutr Biochem 14, 362369.
9Rubis, B, Paszel, A, Kaczmarek, M, Rudzinska, M, Jelen, H & Rybczynska, M (2008) Beneficial or harmful influence of phytosterols on human cells? Br J Nutr 99, 000000.
10Maguire, L, Konoplyannikov, M, Ford, A, Maguire, AR & O'Brien, NM (2003) Comparison of the cytotoxic effects of β-sitosterol oxides and a cholesterol oxide, 7β-hydroxycholsterol, in cultured mammalian cells. Br J Nutr 90, 767775.
11Heinemann, T, Axtmann, G & von Bergmann, K (1993) Comparison of intestinal absorption of cholesterol with different plant sterols in man. Eur J Clin Invest 23, 827831.
12Boberg, KM, Pettersen, KS & Prydz, H (1991) Toxicity of sitosterol to human umbilical vein endothelial cells in vitro. Scand J Clin Lab Invest 51, 509516.
13Heistad, DD, Armstrong, ML, Marcus, ML, Piergors, DJ & Mark, AL (1984) Augmented responses to vasoconstrictor stimuli in hypercholesterolemic and atherosclerotic monkey. Circ Res 54, 711718.
14Jayakody, L, Senaratne, M, Thomson, A & Kappagoda, T (1987) Endothelium-dependent relaxation in experimental atherosclerosis in the rabbit. Circ Res 60, 251264.
15Celermajer, DS, Sorensen, KE, Bull, C, Robinson, J & Deanfield, JE (1994) Endothelium-dependent dilatation in the systemic arteries of asymptomtic subjects relates to coronary risk factors and their interaction. J Am Coll Cardiol 24, 14681474.
16Biasi, F, Leonarduzzi, G, Vizio, B, Zanetti, D, Sevanian, A, Sottero, B, Verde, V, Zingaro, B, Chiarpotto, E & Poli, G (2004) Oxysterol mixtures prevent pro-apoptotic effects of 7-ketocholesterol in macrophages: implications for proatherogenic gene modulation. FASEB J 18, 693695.
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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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