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Plasma phospholipid fatty acids and CHD in older men: Whitehall study of London civil servants

  • Robert Clarke (a1), Martin Shipley (a2), Jane Armitage (a1), Rory Collins (a1) and William Harris (a3)
  • DOI:
  • Published online: 24 December 2008

Dietary fatty acids (FA) are the major determinants of blood lipids, and measurements of plasma phospholipid FA (PL-FA) composition that reflect the dietary intake of FA may provide insights into the relationships between diet and CHD. We assessed CHD mortality associations with PL-FA (SFA, PUFA and MUFA) levels measured in a nested case–control study of 116 cases of CHD death and 239 controls that were frequency-matched for age and employment grade. The participants had plasma levels of total cholesterol, LDL-cholesterol (LDL-C), HDL-cholesterol, apo B and apo A1, C-reactive protein (CRP) and fibrinogen recorded. SFA levels were significantly positively correlated with total cholesterol, LDL-C, apo B, CRP protein and fibrinogen. By contrast, phospholipid-PUFA were inversely associated with CRP, but not with any of the lipids. A higher SFA content (top v. bottom quarter) was associated with a 2-fold higher risk of CHD (OR and 95 % CI: OR 2·12; 95 % CI: 1·13, 3·99), and an equivalent difference in PUFA was associated with a halving in CHD risk (OR 0·49; 95 % CI: 0·26, 0·94), but MUFA was unrelated to CHD risk. These associations were substantially attenuated, after additional adjustment for lipids and inflammatory markers. Higher levels of saturated fat and lower levels of polyunsaturated fats were each associated with a higher risk of CHD in elderly men, and these associations were partly explained by their effects on blood lipids and biomarkers of inflammation.

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*Corresponding author: Dr Robert Clarke, fax +44 1865 743985, email
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1R Clarke , C Frost , R Collins , (1997) Dietary lipids and blood cholesterol: a quantitative meta-analysis of the metabolic ward studies. Br Med J 314, 112117.

3FB Hu , MJ Stampfer , JE Manson , (1997) Dietary fat intake and the risk of coronary heart disease in women. N Engl J Med 337, 14911499.

4AH Lichtenstein , LJ Appel & M Brands , (2006) Summary of American heart association diet and lifestyle recommendations revision. Arterioscler Thromb Vasc Biol 26, 21862191.

5PL Zock , RP Mensink , J Harryvan , (1997) Fatty acids in serum cholesteryl esters as quantitative biomarkers of dietary intake in humans. Am J Epidemiol 145, 11141122.

7R Clarke , JR Emberson , S Parish , (2007) Cholesterol fractions and apolipoprotiens are strong predictors of heart disease mortality in older men. Arch Intern Med 167, 13731378.

9R Clarke , E Breeze , P Sherliker , (1998) Design, objectives and lessons from a 25 year follow-up re-survey of survivors in the Whitehall study of London civil servants. J Epidemiol Community Health 52, 364369.

10R Clarke , E Breeze , L Youngman , (2000) Re-survey of the Whitehall study of London civil servants: changes in risk factors for cardiovascular disease during 29 years of follow-up. J Cardiovasc Risk 7, 251257.

11S Clark , LD Youngman , A Palmer , (2003) Stability of plasma analytes after delayed separation of whole blood: implications for epidemiological studies. Int J Epidemiol 32, 125130.

13WS Harris & C von Shacky (2004) The omega-3 index: a new risk factor death from coronary heart disease. Prev Med 39, 212220.

14R Peto , MC Pike , P Armitage , (1977) Design and analysis of randomized controlled trials requiring prolonged observations of each patient. Analysis and examples. Br J Cancer 35, 139.

15JL Schafer (1997) Analysis of Incomplete Multivariate Data. London: Chapman & Hall.

16DE Laaksonen , K Nyyssönen , L Niskanen , (2005) Prediction of cardiovascular mortality in middle-aged men by dietary and serum linoleic and polyunsaturated fatty acids. Arch Intern Med 165, 193199.

17FB Hu & WC Willett (2002) Optimal diets for prevention of coronary heart disease. JAMA 288, 25692578.

19E Guallar , CH Hennekens , FM Sacks , (1995) A prospective study of plasma fish oil levels and incidence of myocardial infarction in US male physicians. J Am Coll Cardiol 25, 387394.

20RN Lemaitre , IB King , TE Raghunathan , (2002) Cell membrane trans-fatty acids and the risk of primary cardiac arrest. Circulation 105, 697701.

21WS Harris , WC Poston & CK Haddock (2007) Tissue n-3 and n-6 fatty acids and risk for coronary heart disease events. Atherosclerosis 193, 110.

23R Clarke & S Lewington (2006) Trans fatty acids and coronary heart disease: food labels should list these as well as cholesterol and saturated fat. BMJ 333, 214.

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British Journal of Nutrition
  • ISSN: 0007-1145
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