Skip to main content
×
×
Home

Poor zinc status is associated with increased risk of insulin resistance in Spanish children

  • R. M. Ortega (a1) (a2), E. Rodríguez-Rodríguez (a2) (a3), A. Aparicio (a1) (a2), A. I. Jiménez (a2) (a4), A. M. López-Sobaler (a1) (a2), L. G. González-Rodríguez (a1) (a2) and P. Andrés (a2) (a3)...
Abstract

Zn plays a key role in the synthesis and action of insulin. The aim of the present work was to determine whether a poorer Zn status was associated with insulin resistance in a group of 357 Spanish schoolchildren. Zn intake was determined by using a 3 d food record (i.e. Sunday to Tuesday). The body weight, height and waist and hip circumferences of all subjects were recorded and fasting plasma glucose, insulin and Zn concentrations were determined. Insulin resistance was determined using the homoeostasis model assessment (HOMA) marker. Children (11·5 %) with Zn deficiency (serum Zn concentration < 10·7 μmol/l) had higher HOMA values than those with a more satisfactory Zn status (1·73 (sd 0·93)) compared with 1·38 (sd 0·90; P < 0·05). An inverse correlation was found between the HOMA value and the serum Zn concentration (r − 0·149, P < 0·05). The risk of having a greater insulin resistance value (HOMA greater than the 75th percentile) increased with age (OR 1·438; 95 % CI 1·021, 2·027) and BMI (OR 1·448; 95 % CI 1·294, 1·619) and decreased as Zn serum levels increased (OR 0·908; 95 % CI 0·835, 0·987; P < 0·001). Moreover, an inverse relationship was observed between HOMA values and Zn dietary density (r − 0·122), and the Zn intakes of male children with a HOMA value of >3·16 made a significantly smaller contribution to the coverage of those recommended (59·7 (sd 14·7) %) than observed in children with lower HOMA values (73·6 (sd 18·2) %; P < 0·05). Taking into account that Zn intake was below than that recommended in 89·4 % of the children, it would appear that increasing the intake of Zn could improve the health and nutritional status of these children, and thus contribute to diminish problems of insulin resistance.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Poor zinc status is associated with increased risk of insulin resistance in Spanish children
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Poor zinc status is associated with increased risk of insulin resistance in Spanish children
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Poor zinc status is associated with increased risk of insulin resistance in Spanish children
      Available formats
      ×
Copyright
Corresponding author
*Corresponding author: Professor R. M. Ortega, fax +34 91 394 18 10, email rortega@farm.ucm.es
References
Hide All
1 Gómez-García, A, Hernández-Salazar, E, González-Ortiz, M, et al. (2006) Effect of oral zinc administration on insulin sensitivity, leptin and androgens in obese males. Rev Med Chil 134, 279284.
2 Hashemipour, M, Kelishadi, R, Shapouri, J, et al. (2009) Effect of zinc supplementation on insulin resistance and components of the metabolic syndrome in prepubertal obese children. Hormones (Athens) 8, 279285.
3 Jansen, J, Karges, W & Rink, L (2009) Zinc and diabetes – clinical links and molecular mechanisms. J Nutr Biochem 20, 399417.
4 Wiernsperger, NF (2003) Oxidative stress as a therapeutic target in diabetes: revisiting the controversy. Diabetes Metab 29, 579585.
5 Prasad, AS (2008) Clinical, immunological, anti-inflammatory and antioxidant roles of zinc. Exp Gerontol 43, 370377.
6 Kaneto, H, Katakami, N, Matsuhisa, M, et al. (2010) Role of reactive oxygen species in the progression of type 2 diabetes and atherosclerosis. Mediators Inflamm 2010, 453892.
7 Wiernsperger, NF & Rapin, JR (2010) Trace elements in glucometabolic disorders: an update. Diabetol Metab Syndr 2, 70.
8 Rutter, GA (2010) Think zinc: new roles for zinc in the control of insulin secretion. Islets 2, 4950.
9 Sun, Q, van Dam, RM, Willet, WC, et al. (2009) Prospective study of zinc intake and risk of type 2 diabetes in women. Diabetes Care 32, 629634.
10 Artz, E & Freemark, M (2004) The pathogenesis of insulin resistance in children: metabolic complications and the roles of diet, exercise and pharmacotherapy in the prevention of type 2 diabetes. Pediatr Endocrinol Rev 1, 296309.
11 Lee, JM (2006) Insulin resistance in children and adolescents. Rev Endocr Metab Disord 7, 141147.
12 Marreiro, DN, Geloneze, B, Tambascia, MA, et al. (2006) Effect of zinc supplementation on serum leptin levels and insulin resistance of obese women. Biol Trace Elem Res 12, 109118.
13 Kelishadi, R, Hashemipour, M, Adeli, K, et al. (2010) Effect of zinc supplementation on markers of insulin resistance, oxidative stress, and inflammation among prepubescent children with metabolic syndrome. Metab Syndr Relat Disord 8, 505510.
14 World Health Organization (1995) Physical Status: The Use and Interpretation of Anthropometry. Report of the WHO Expert Committee. WHO Technical Report Series no. 854. Geneva: WHO.
15 Hernández, M, Castellet, J, Narvaiza, JL, et al. (1988) Curvas y tablas de crecimiento (Growth Charts and Tables). Instituto de Investigación sobre crecimiento y desarrollo. Faustino Orbegozo Eizaguirre. Madrid: Editorial Garsi.
16 Rolland-Cachera, MF, Deheeger, M & Bellisle, F (2001) Définition actuelle et évolution de la fréquence de l'obésité chez l'enfant (Current definition and evolution of the frequency of obesity in children). Cah Nutr Diét 36, 108112.
17 Ortega, RM, Requejo, AM & López-Sobaler, AM (2006) Questionnaires for dietetic studies and the assessment of nutritional status. In Nutriguía. Manual of Clinical Nutrition in Primary Care, pp. 456459 [Requejo, AM and Ortega, RM, editors]. Madrid: Ed. Complutense.
18 Ortega, RM, López-Sobaler, AM, Requejo, AM, et al. (2010) Food composition tables. In Food Composition. A Basic Tool for Assessing Nutritional Status, pp. 1581 [Ortega, RM, López-Sobaler, AM, Requejo, AM and Andrés, P, editors]. Madrid: Ed. Complutense.
19 Ortega, RM, Requejo, AM, Navia, B, et al. (2010) Recommended daily intakes of energy and nutrients for the Spanish population. In Food Composition. A Basic Tool for Assessing Nutritional Status, pp. 8284 [Ortega, RM, López-Sobaler, AM, Requejo, AM and Andrés, P, editors]. Madrid: Ed. Complutense.
20 Ortega, RM, López-Sobaler, AM, Andrés, P, et al. DIAL software for assessing diets and food calculations, [Ortega, RM, López-Sobaler, AM, Andrés, P, Requejo, AM, Aparicio, A and Molinero, LM, editors]. Madrid: Alce Ingeniería, S.A. http://www.alceingenieria.net/nutricion.htm (accessed 1 November 2010).
21 Food and Nutrition Board (FNB)/Institute of Medicine (IOM) (2005) Dietary Reference Intakes: Energy, Carbohidrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein and Amino Acids. Washington, DC: Institute of Medicine of the National Academies Press. www.nap.edu.
22 Ortega, RM, Requejo, AM, Andrés, P, et al. (1995) Relationship between diet composition and body mass index in a group of Spanish adolescents. Br J Nutr 74, 765773.
23 Ortega, RM, Requejo, AM & López-Sobaler, AM (2006) Activity questionnaire. In Nutriguía. Manual of Clinical Nutrition in Primary Care, p. 468 [Requejo, AM and Ortega, RM, editors]. Madrid: Ed. Complutense.
24 El Kenz, H & Bergmann, P (2004) Evaluation of immunochemiluminometric assays for the measurement of insulin and C-peptide using the ADVIA Centaur. Clin Lab 50, 171174.
25 Neese, JW, Duncan, P, Bayse, D, et al. (1976) Development and Evaluation of a Hexokinase/Glucose-6-phosphate Dehydrogenase Procedure for use as a National Glucose Reference Method. Atlanta: Center for Disease Control, GA. DHEW publication no. (CDC)77–8330.
26 Albareda, M, Rodriguez-Espinosa, J, Murugo, M, et al. (2000) Assessment of insulin sensitivity and beta-cell function from measurements in the fasting state and during an oral glucose tolerance test. Diabetologia 43, 15071511.
27 Tripathy, D, Carlsson, M, Almgren, P, et al. (2000) Insulin secretion and insulin sensitivity in relation to glucose tolerance: lessons from the Botnia Study. Diabetes 49, 975980.
28 Keskin, M, Kurtoglu, S, Kendirci, M, et al. (2005) Homeostasis model assessment is more reliable than the fasting glucose/insulin ratio and quantitative insulin sensitivity check index for assessing insulin resistance among obese children and adolescents. Pediatrics 115, 500503.
29 Smith, JC Jr, Butrimovitz, GP & Purdy, WC (1979) Direct measurement of zinc in plasma by atomic absorption spectroscopy. Clin Chem 25, 14781491.
30 Pilch, SM & Senti, FR (1984) Assessment of the Zinc Nutritional Status of the U.S. Population based on Data Collected in the Second National Health and Nutrition Examination Survey, 1976–1980. Bethesda, MD: Life Sciences Research Office, Federation of American Societies for Experimental Biology.
31 Wallach, J (2007) Interpretation of diagnostic tests. In Normal Values, pp. 325 [Wallach, J, editor]. Philadelphia, PA: Wolters Kluwer. Lippincott Williams & Wilkins.
32 Ortega, RM & Aparicio, A (2007) Problemas nutricionales actuales. Causas y consecuencias (Current nutritional problems. Causes and Consequences). In Nutrición y Alimentación en la promoción de la salud (Food and Nutrition in Health Promotion), pp. 820 [Ortega, RM, Requejo, AM and Martínez, RM, editors]. Madrid: UIMP, UIMP Comunicación.
33 Rodríguez-Rodríguez, E, Navia, B, López-Sobaler, AM, et al. (2010) Associations between abdominal fat and body mass index on vitamin D status in a group of Spanish schoolchildren. Eur J Clin Nutr 64, 461467.
34 Serra, Ll, Ribas, L, Aranceta, J, et al. (2003) Obesidad infantil y juvenil en España. Resultados del estudio enkid (1998–2000) (Childhood and adolescent obesity in Spain. Results of the enKid study (1998–2000)). Med Clin (Barc) 121, 725732.
35 Hotz, C, Peerson, JM & Brown, KH (2003) Suggested lower cutoffs of serum zinc concentrations for assessing zinc status: reanalysis of the second National Health and Nutrition Examination Survey data (1976–1980). Am J Clin Nutr 78, 756764.
36 Brown, KH, Peerson, JM, Rivera, J, et al. (2002) Effect of supplemental zinc on the growth and serum zinc concentrations of prepubertal children: a meta-analysis of randomized controlled trials. Am J Clin Nutr 75, 10621071.
37 Sayeg Porto, MA, Oliveira, HP, Cunha, AJ, et al. (2000) Linear growth and zinc supplementation in children with short stature. J Pediatr Endocrinol Metab 13, 11211128.
38 Eisenmann, JC, DuBose, KD & Donnelly, JE (2007) Fatness, fitness, and insulin sensitivity among 7- to 9-year-old children. Obesity (Silver Spring) 15, 21352144.
39 Holst-Schumacher, I, Nuñez-Rivas, H, Monge-Rojas, R, et al. (2008) Insulin resistance and impaired glucose tolerance in overweight and obese Costa Rican schoolchildren. Food Nutr Bull 29, 123131.
40 Manios, Y, Moschonis, G, Kourlaba, G, et al. (2008) Prevalence and independent predictors of insulin resistance in children from Crete, Greece: the Children Study. Diabet Med 25, 6572.
41 Hirschler, V, Maccallini, G, Karam, C, et al. (2009) Are girls more insulin-resistant than boys? Clin Biochem 42, 10511056.
42 Moran, A, Jacobs, DR Jr, Steinberger, J, et al. (2002) Association between the insulin resistance of puberty and the insulin-like growth factor-I/growth hormone axis. J Clin Endocrinol Metab 87, 48174820.
43 Lee, K, Lee, J, Bae, WK, et al. (2009) Efficacy of low-calorie, partial meal replacement diet plans on weight and abdominal fat in obese subjects with metabolic syndrome: a double-blind, randomised controlled trial of two diet plans – one high in protein and one nutritionally balanced. Int J Clin Pract 63, 195201.
44 Chiarelli, F & Marcovecchio, ML (2008) Insulin resistance and obesity in childhood. Eur J Endocrinol 159, Suppl. 1, S67S74.
45 Marreiro, DN, Fisberg, M & Cozzolino, SM (2004) Zinc nutritional status and its relationships with hyperinsulinemia in obese children and adolescents. Biol Trace Elem Res 100, 137149.
46 Gibson, RS, Hess, SY, Hotz, C, et al. (2008) Indicators of zinc status at the population level: a review of the evidence. Br J Nutr 99, Suppl. 3, S14S23.
47 Food and Nutrition Board (FNB)/Institute of Medicine (IOM) (2001) Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: Institute of Medicine of the National Academies Press. www.nap.edu.
48 Hotz, C (2007) Dietary indicators for assessing the adequacy of population zinc intakes. Food Nutr Bull 28, Suppl. 3, S430S453.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed