Hostname: page-component-848d4c4894-x24gv Total loading time: 0 Render date: 2024-05-01T01:11:43.268Z Has data issue: false hasContentIssue false
  • English
  • Français

A possible control of food intake during pregnancy in the rat

Published online by Cambridge University Press:  09 March 2007

Brian Morgan  and
Myron Winick
Brian Morgan
Affiliation:
Institute of Human Nutrition, Columbia University College of Physicians and Surgeons, 701 West 168th Street, New York, New York 10032, USA
Myron Winick
Affiliation:
Institute of Human Nutrition, Columbia University College of Physicians and Surgeons, 701 West 168th Street, New York, New York 10032, USA
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. Brain hypothalamic concentrations of serotonin and norepinephrine have been implicated in the control of food intake. During pregnancy and lactation a rat dam's food consumption is increased and so a study was performed to ascertain whether this was associated with changes in the hypothalamic content of serotonin and norepinephrine.

2. In the first experiment, forty-eight Sprague Dawley rat dams were given a diet containing 250 g casein/kg adlib. After 2 weeks, eight were killed and their hypothalamic analysed for the previously-mentioned neurotransmitters. The rest were mated and continued on the diet. On each of days 7, 14 and 20 of gestation, day 14 of lactation and 2 weeks after weaning of their pups a further eight dams were killed and their hypothalami assayed as described previously. Food intake was monitored throughout the experimental period.

3. The increased food intake of the dams during gestation and lactation increased to the same extent as elevations in hypothalamic norepinephrine content and depressions in serotonin content. After lactation food intake returned to pre-pregnancy levels as did the hypothalamic levels of norepinephrine and serotonin.

4. By using the same experimental design but limiting the increase in food intake in pregnancy and lactation to half the expected amount the same changes were found in hypothalamic norepinephrine and serotonin contents.

5. The possibility of hypothalamic neurotransmitter contents controlling food intake is discussed.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 46 , Issue 1 , July 1981 , pp. 29 - 37
Copyright
Copyright © The Nutrition Society 1981

References

REFERENCES

Baile, C. A. (1974). Fedn Proc. Fedn Am. Socs exp. Biol. 33, 1166.Google Scholar
Bernhart, F. & Tomarelli, R. (1966). J. Nutr. 89, 495.CrossRefGoogle Scholar
Bizzi, A., Bonaccorsi, A., Jespersen, S., Jori, A. & Garaltini, S. (1970). In Amphetamines and Related Compounds, p. 577 [Cosia, E. and Garattini, S., editors]. New York: Raven Press.Google Scholar
Blundell, J. E. & Lesham, M. B. (1974). Eur. J. Pharmac. 28, 81.CrossRefGoogle Scholar
Bruning, J. L. & Kintz, B. L. (1968). Computational Handbook of Statistics, p. 166. Glenview, Illinois: Scott, Foresman and Co.Google Scholar
Clineschmidt, B. V., McGuffin, J. C. & Werner, A. B. (1974). Eur. J. Pharmac. 27, 313.CrossRefGoogle Scholar
Fujimori, K. & Iwamoto, T. (1974). Neuropharmacology 13, 255.CrossRefGoogle Scholar
Grossman, S. P. (1960). Science, N. Y. 132, 301.CrossRefGoogle Scholar
Jacobowitz, D. M. & Richardson, S. J. (1977). Pharmac. Biochem. Behav. 8, 515.CrossRefGoogle Scholar
Leibowitz, S. F. (1970). Proc. natn. Acad. Sci. U. S. A. 67, 1063.CrossRefGoogle Scholar
Leibowitz, S. F. (1973). In The Neurosciences: Third Study Program, p. 713 [Schmitt, F. O. and Warden, F. G., editors]. Cambridge, Mass.: MIT Press.Google Scholar
Leibowitz, S. F. (1976). In Hunger: Basic Mechanisms and Clinical Implications, p. 1 [Novin, D.Wyrwicka, W. and Bray, G., editors]. New York: Raven Press.Google Scholar
Lesham, M. B. & Blundell, J. E. (1974). J. Pharm. Pharmac. 26, 905.CrossRefGoogle Scholar
Lythe, L. D. (1977). In Nutrition and the Brain, vol. 2, p. 1 [Wurtman, R. J. and Wurtman, J. J., editors]. New York: Raven Press.Google Scholar
Maickel, R. P. & Miller, F. P. (1966). Analyt. Chem. 38, 1937.CrossRefGoogle Scholar
Porter, C. C., Totaro, J. A. & Burcin, A. (1965). J. Pharmac. Exp. Ther. 150, 17.Google Scholar
Ritter, R. C. & Epstein, A. N. (1975). Proc. natn. Acad. Sci. U. S. A. 72, 3740.CrossRefGoogle Scholar
Shoulson, I. & Chase, T. N. (1975). Clin. Pharmac. Ther. 17, 616.CrossRefGoogle Scholar
Wurtman, R. (1977). In Nutrition and the Brain, vol. 2, p. 99 [Wurtman, R. J. and Wurtman, J. J., editors]. New York: Raven Press.Google Scholar