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Postprandial glycaemic, lipaemic and haemostatic responses to ingestion of rapidly and slowly digested starches in healthy young women

  • Louisa J. Ells (a1), Chris J. Seal (a2), Bernd Kettlitz (a3), Wendy Bal (a1) and John C. Mathers (a1)...
Abstract

The objective of the present study was to investigate the postprandial metabolism of two starches with contrasting rates of hydrolysis in vitro. Characterized using the Englyst method of in vitro starch classification, C*Set 06 598 contained predominantly rapidly digestible starch and C*Gel 04 201 contained predominantly slowly digestible starch. Each test starch, naturally enriched with 13C, was fed to ten healthy female volunteers as part of a moderate fat test meal (containing 75 g test starch and 21 g fat), in a double-blind randomized crossover design. The metabolic response to each starch was measured after an overnight fast, in an acute 6 h study, before and after 14 d of daily consumption of 75 g test starch. During each acute study, blood samples were taken at 15 min intervals for the first 2 h and at 30 min intervals for the remaining 4 h. Breath 13CO2 enrichment was measured at the same time points and indirect calorimetry was performed for 20 min every 40 min immediately before and throughout the study. Significantly more rapid, greater changes in postprandial plasma glucose, NEFA and serum insulin concentrations were observed after consumption of the rapidly digestible starch. Breath 13CO2 output over the first 3–4 h rose rapidly then began to decline following consumption of the rapidly digestible starch, but plateaued for the slowly digestible starch. The 14 d adaptation period did not affect any of the glycaemic or lipaemic variables but there was a reduction in postprandial plasminogen activator inhibitor-1 concentrations. These data confirm that starches characterized as predominantly rapidly digestible versus slowly digestible by the Englyst procedure provoke distinctly different patterns of metabolism postprandially.

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Corresponding author
*Corresponding author: Dr L. J. Ells, fax +44 (0)1642 384105, email L.Ells@tees.ac.uk
References
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Abate N (2000) Obesity and cardiovascular disease. Pathogenetic role of the metabolic syndrome and therapeutic implications. J Diabet Comp 14, 154174.
Achour L, Flouie B & Briet F (1997) Metabolic effects of digestible and partially indigestible cornstarch: a study in the absorptive and postabsorptive periods in healthy humans. Am J Clin Nutr 66, 11511159.
Argiles JM, Lopez-Soriano FJ (2001) Insulin and cancer (review). Int J Oncol 18, 683687.
Bastard JP, Pieroni L & Hainque B (2000) Relationship between plasma Plasminogen activator inhibitor 1 and insulin resistance. Diabetes Metab Res Rev 16, 192201.
Bingham SA & Cummings JH (1983) The use of 4-aminobenzoic acid as a marker to validate the completeness of 24h urine collection in man. Clin Sci 64, 629635.
Bingham SA & Cummings JH (1985) Urine nitrogen as an independent validatory measure of dietary intake: a study of nitrogen balance in individuals consuming their normal diet. Am J Clin Nutr 42, 12761289.
Bornet FRJ, Fontvielle A-M, Rizkalla S, et al. (1989) Insulin and glycaemic responses in healthy humans to native starches processed in different ways; correlation with in vitro α-amylase hydrolysis. Am J Clin Nutr 50, 315323.
Carroll MF & Schade DS (2003) Timing of antioxidant vitamin ingestion alters postprandial proatherogenic serum markers. Circulation 108, 2431.
Champ M, Martin L, Noah L & Gratus M (1999) Analytical methods for resistant starch. In Complex Carbohydrates in Foods, pp. 169187 [Chol SS, Prosky L and Dreher M, editors]. New York: Marcel Dekker.
Collier GR, Greenberg GR, Wolever TMS & Jenkins DJA (1988) The acute effect of fat on insulin secretion. J Clin Endocrinol Metab 66, 323326.
Collier G, McLean A & O'Dea K (1984) Effect of co-ingestion of fat on the metabolic responses to slowly and rapidly absorbed carbohydrates. Diabetologia 26, 5054.
Corring T (1980) The adaptation of digestive enzymes to the diet: its physiological significance. Reprod Nutr Dev 20, 4B, 12171235.
Daly ME, Vale C, Littlefield A, Alberti KGMM & Mathers JC (2000) Acute fuel selection in response to high-sucrose and high-starch meals in healthy men. Am J Clin Nutr 71, 15161524.
Daly ME, Vale C, Walker M, Littlefield A, Alberti KGMM & Mathers JC (1998) Acute effects on insulin sensitivity and diurnal metabolic profiles of a high-sucrose compared with a high-starch diet. Am J Clin Nutr 67, 11861196.
Department of Health (1991) Dietary Reference Values for Food Energy and Nutrients for the United Kingdom. Report on Health and Social Subjects no. 55. London: HMSO.
Englyst HN, Kingman SM & Cummings JH (1992) Classification and measurement of nutritionally important starch fractions. Eur J Clin Nutr 46, Suppl. 2S33S50.
Englyst HN, Kingman SM, Geoffrey JH & Cummings JH (1996) Measurement of resistant starch in vitro and in vivo. Br J Nutr 75, 749755.
Englyst HN, Veenstra J & Hudson GJ (1996) Measurement of rapidly available glucose (RAG) in plant foods: a potential in vitro predictor of the glycaemic response. Br J Nutr 73, 327337.
Englyst KN, Englyst HN, Hudson GJ, Cole TJ & Cummings JH (1999) Rapidly available glucose in foods: an in vitro measurement that reflects the glycaemic response. Am J Clin Nutr 69, 448454.
Englyst KN, Hudson GJ & Englyst HN (2000) Starch analysis in food. In Encyclopaedia of Analytical Chemistry, pp. 42464262 [Meyers RA, editor]. Chichester: John Wiley & Sons.
Facchini FS, Hua NW, Reaven GM & Stoohs RA (2000) Hyperinsulinemia: the missing link among oxidative stress and age-related diseases? Free Radic Biol Med 29, 13021306.
FAO/WHO (1998) Carbohydrates in Human Nutrition. Report of a Joint FAO/WHO Report, Rome, 14–18 April 1997, paper 66. Rome: FAO.
Ferraris RP (2001) Dietary and developmental regulation of intestinal sugar transport. Biochem J 360, part 2 265276.
Flint A, Koller BK & Raben A (2004) The use of glycaemic index tables to predict glycaemic index of composite breakfast meals. Br J Nutr 91, 979989.
Flores CA, Brannon PM, Bustamante SA, et al. (1988) Effect of diet on intestinal and pancreatic enzyme activities in the pig. J Pediatr Gastroenterol Nutr 7, 914921.
Foster-Powell K & Brand-Miller J (1995) International tables of glycaemic index. Am J Clin Nutr 62, 871S893S.
Frayn KN (1998) Non-esterified fatty acid metabolism and postprandial lipaemia. Atherosclerosis 141, Suppl. 1S41S46.
Holm J & Bjorck I (1992) Bioavailability of starch in various wheat-based bread products: evaluation of metabolic responses in healthy subjects and rate and extent of in vitro starch digestion. Am J Clin Nutr 55, 420429.
Itoh K, Imai K & Masuda T (1999) Relationship between serum total cholesterol level and nutritional status in Japanese young female. Nutr Res 19, 11451152.
Ivey FM, Womack CJ, Kulaputana O, Dobrovovolny CL, Wiley LA & Macko RF (2003) A single bout of walking exercise enhances endogenous fibrinolysis in stroke patients. Med Sci Sports Exerc 35, 193198.
Jarvi AE, Karlstrom BE, Granfeldt YE, Bjorck IE, Asp N-G & Vessby BOH (1999) Improved glycaemic control and lipid profile and normalized fibrinolytic activity on a low-glycaemic index diet in type 2 diabetic patients. Diabetes Care 22, 1018.
Jenkins DJA, Kendall CW & Augustin LS (2002) Glycaemic index: overview of implication in health and disease. Am J Clin Nutr 76, 226S273S.
Jenkins DJA, Wolever TMS & Taylor RH (1981) Glycaemic index of foods: a physiological basis for carbohydrate exchange. Am J Clin Nutr 34, 362366.
Kohler HP (2002) Insulin resistance syndrome: interaction with coagulation and fibrinolysis. Swiss Med Wkly 132, 241252.
Mathers JC & Daly ME (1998) Dietary carbohydrate and insulin sensitivity. Curr Opin Clin Nutr Metab Care 1, 553557.
Mathers JC & Daly ME (2001) Food polysaccharides, glucose absorption and insulin sensitivity. In Advanced Dietary Fibre Technology, pp. 186196 [McCleary DBV and Prosky L, editors]. Oxford: Blackwell Science.
Nelson M, Atkinson M & Meyer J (1997) A Photographic Atlas of Food Portion Sizes. London: MAFF Publications.
Normand S, Khalfallah Y & Louche-Pelissier C (2001) Influence of dietary fat on postprandial glucose metabolism (exogenous and endogenous) using intrinsically 13 C-enriched durum wheat. Br J Nutr 86, 311.
Normand S, Rachiaudi C, Khalfallah Y, Guilluy R, Mornex R, Riou JP, et al. (1992) 13C appearance in plasma glucose and breath CO2 during feeding with naturally 13C-enriched starch food in normal humans. Am J Clin Nutr 55, 430435.
Rankinen T, Vaisanen S, Penttila I & Rauramaa R (1995) Acute dynamic exercise increases fibrinolytic activity. Thromb Haemost 73, 281286.
Rauramaa R, Vaisanen S, Penttila I & Rankinen T (1994) Inverse relationship between dietary starch intake and plasma fibrinogen in middle-aged men. Nutr Metab Cardiovasc Dis 4, 192196.
Raynaud E, Perez-Martin A, Brun JF, Aissa-Benhaddad A, Fedou C & Mercier J (2000) Relationships between fibrinogen and insulin resistance. Atherosclerosis 150, 365370.
Reaven GM (1995) Pathophysiology of insulin resistance in human disease. Physiol Rev 75, 473486.
Sanders TAB, de Grassi T, Acharya J, Miller GJ & Humphries SE (2004) Postprandial variations in fibrinolytic activity in middle-aged men are modulated by Plasminogen activator inhibitor I 4G-675/5G genotype but not by the fat content of a meal. Am J Clin Nutr 79, 577581.
Seal CJ, Daly ME, Thomas LC, Bal W, Birkett AM, Jeffcoat R & Mathers JC (2003) Postprandial carbohydrate metabolism in healthy subjects and those with type 2 diabetes fed starches with slow and rapid hydrolysis rates determined in vitro. Br J Nutr 90, 853864.
Taiz L & Zeiger E (1991) Plant Physiology, pp. 234–224. Redwood City, CA: Benjamin/Cummings Publishing Co.
Vonk RJ, Hagedoorn RE, De Graaff R, et al. (2000) Digestion of so-called resistant starch sources in the human small intestine. Am J Clin Nutr 72, 432438.
Wallace TM & Matthews DR (2002) The assessment of insulin resistance in man. Diabet Med 19, 527534.
Wolever TMS (2000) Dietary carbohydrates and insulin action in humans. Br J Nutr 83, S97S102.
Yoshikawa T, Yoshikazu N, Doi C, Makino T & Nomura K (2001) Insulin resistance in patients with cancer: relationships with tumor site, tumor stage, body-weight loss, acute-phase response, and energy expenditure. Nutrition 17, 590593.
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British Journal of Nutrition
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