Skip to main content
×
Home

Potato and high-amylose maize starches are not equivalent producers of butyrate for the colonic mucosa

  • Lucile J. M. Martin (a1) (a2) (a3), Henri J. W. Dumon (a1) (a3), Gérard Lecannu (a2) (a3) and Martine M. J. Champ (a2) (a3)
Abstract

Portal appearance of short-chain fatty acids (SCFA) produced from fermentation of three different resistant starch (RS) sources (raw potato starch, high-amylose maize starch and retrograded high-amylose maize starch) was investigated in pigs. The catheterization technique coupled with determination of portal blood flow was used to estimate SCFA uptake by the colonic mucosa. Our hypothesis was that these three RS were not equivalent butyrate providers for the colonic mucosa and that butyrate uptake would therefore be different after in vivo fermentation of each starch. The starches induced different patterns of appearance of SCFA in the portal blood; raw potato starch was the only RS source to show a significant appearance of butyrate in the portal blood. Thus, uptake of butyrate by the colonic mucosa apparently differed between starches. This finding suggests that butyrate uptake does not only depend on the flow of butyrate appearing in the lumen. Indeed, for unexplained reasons, utilization of butyrate by the colonic mucosa appeared to be less efficient when the butyrate was produced from fermentation of potato starch than when it was produced from fermentation of the other RS sources.

    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Potato and high-amylose maize starches are not equivalent producers of butyrate for the colonic mucosa
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Potato and high-amylose maize starches are not equivalent producers of butyrate for the colonic mucosa
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Potato and high-amylose maize starches are not equivalent producers of butyrate for the colonic mucosa
      Available formats
      ×
Copyright
Corresponding author
*Correspondong author:Dr Martine Champ, fax +33 2 4067 5012, email champ@nantes.inra.fr
References
Hide All
Annison G and Topping DL (1994) Nutritional role of resistant starch: chemical structurevs physiological function. Annual Review of Nutrition 14, 297320.
Argenzio RA (1982) Volatile fatty acid production and absorption from the large intestine of the pig. In Physiologie Digestive chez le Porc (Digestive Physiology of the Pig. Les Colloques de l'INRA no. 12, pp. 207215 [Laplace JP, Corring T and Rerat A, editors]. Paris: INRA.
Argenzio RA and Southworth M (1975) Sites of organic acid production and absorption in the gastrointestinal tract of the pig. American Journal of Physiology 228, 454460.
Asp NG (1992) Resistant starch. European Journal of Clinical Nutrition 46 (Suppl. 2), 148.
Bach Knudsen KE and EGudmand-Høyer (1991) Methodological aspects of in vivo methods for measuring starch digestibility: animal models In Methodological Aspects of Methods for the Measurement of Starch Digestibility. Report of a European Flair Concerted Action Workshop pp. 4057 [Gudmand-H?yer E,editor]. Copenhagen: Gentofle University Hospital.
Bingham SA (1990) Mechanisms and experimental and epidemiological evidence relating dietary fibre (non-starch polysaccharides) and starch to protection against large bowel cancer. Proceedings of the Nutrition Society 49, 153171.
Brighenti F, (1997) Simple method for quantitative analysis of short chain fatty acids in serum by gas–liquid chromatography In Plant Polysaccharides in Human Nutrition: Structure, Function, Digestive Fate and Metabolic Effects pp. 114119. [Guillon F, Andersson H, Asp NG, Bach Knudsen KE, Champ M, Robertson J and Van Loo J, editors]. Nantes, France:INRA.
Brighenti F, Casiraghi MC and Baggio C (1998) Resistant starch in the Italian diet. British Journal of Nutrition 80, 333341.
Caderni G, Luceri C, Lancioni L and Dolara P (1996) Dietary sucrose, glucose, fructose, and starches affect colonic functions in rats. Nutrition and Cancer 25, 179186.
Calvert RJ, Otsuka M and Satchithanandam S (1989) Consumption of raw potato starch alters intestinal function and colonic cell proliferation in the rat. Journal of Nutrition 119, 16101616.
Conway PL, GRGibson and GTMacfarlane (1995) Microbial ecology of the human large intestine.In Human Colonic Bacteria: Role in Nutrition, Physiology and Pathology, pp. 124 [Gibson GR and Macfarlane GT, editors]. Boca Raton, FL: CRC Press.
Cummings JH and Englyst HN (1987) Fermentation in the human large intestine and the available substrates. American Journal of Clinical Nutrition 45, 12431255.
Darcy-Vrillon B, Cherbuy C, Morel MT, Durand M and Duée PH (1996) Short-chain fatty acid and glucose metabolism in isolated pig colonocytes: modulation by NH4+. Molecular and Cellular Biochemistry 156, 145151.
Demigné C and Reacute ;meacute ; syC (1982) Influence of unrefined potato starch on cecal fermentations and volatile fatty acid absorption in rats. Journal of Nutrition 112, 22272234.
Demigné C,(1994) Short chain fatty acid and hepatic metabolism Short Chain Fatty Acids. Falk Symposium no. pp. 272282[Binder HJ, Cummings J and Soergel KH,editors]. Dordrecht, The Netherlands: Kluwer Academic Publishers.
Ellis PR, Roberts FG, Low AG and Morgan LM (1995) The effect of high-molecular-weight guar gum on net apparent insulin and gastric inhibitory polypeptide production in the growing pig: relationship to rheological changes in jejunal digesta. British Journal of Nutrition 74, 539556.
Giusi-Périer A, Fiszlewicz M and Rérat A (1989) Influence of diet composition on intestinal volatile fatty acid and nutrient absorption in unanesthetized pigs. Journal of Animal Science 67, 386402.
Hague A, Singh B and Paraskeva C (1997) Butyrate acts as survival factor for colonic epithelial cells: further fuel for the in vivo versus in vitro debate. Gastroenterology 112, 10361040.
Hylla S, Gostner A, Dusel G, Bartram H-P, Christl SU, Kasper H and Scheppach W (1998) Effects of resistant starch on the colon in healthy volunteers: possible implications for cancer prevention. American Journal of Clinical Nutrition 67, 136142.
Kristiansen E, Meyer O and Thorup I (1996) Refined carbohydrate enhancement of aberrant crypt foci (ACF) in rat colon induced by food-borne carcinogen 2-amino-3-methyl-imidazo[4,5-f]quinoline (IQ). Cancer Letters 105, 147151.
Mallett AK, Bearne CA, Young PJ, Rowland IR and Berry C (1988) Influence of starches of low digestibility on the rat caecal microflora. British Journal of Nutrition 60, 597604.
Martin LMJ, Dumon HJW and Champ MMJ (1998) Production of short chain fatty acids from resistant starch in a pig model. Journal of the Science of Food and Agriculture 77, 7180.
Mathers JC and Dawson LD (1991) Large bowel fermentation in rats eating processed potatoes. British Journal of Nutrition 66, 313329.
Noah L, Krempf M, Lecannu G, Maugère P and Champ M (2000) Bioavailability of starch and postprandial changes in splanchnic glucose metabolism in pigs. American Journal of Physiology 278, E181E188.
Perrin P; 1996 Modulation of cancer cells phenotype in rats by butyrate: application to immunotherapy and prevention for colon cancerPhD Thesis, University of Nantes, France.
Perrin P, Pierre F, Patry Y, Champ M, Berreur M, Pradal G, Bornet F, Méflah K and Ménanteau J (2000) Only fibers promoting a stable butyrate-producing colonic ecosystem decrease the rate of aberrant crypt foci in rats. Gut.(In the Press)
Rérat AA (1996) Influence of the nature of carbohydrate intake on the absorption chronology of reducing sugars and volatile fatty acids in pigs. Reproduction Nutrition Développement 36, 319.
Reacute;rat AA, Fislewicz M, Giusi A and Vaugelade P (1987) Influence of meal frequency on postprandial variations in the production and absorption of volatile fatty acids in the digestive tract of conscious pigs. Journal of Animal Science 64, 448456.
Rérat AA, Giusi-Périer A and Vaissade P (1993) Absorption balances and kinetics of nutrients and bacterial metabolites in conscious pigs after intake of maltose or maltitol-rich diets. Journal of Animal Science 71, 24732488.
Reacute;rat AA, Vaugelade P, & Villiers PA (1980) A new method for measuring the absorption of nutrients in the pig: Critical examination. In Current Concepts of Digestion and Absorption in Pigs, pp. 177214 [AG Low and Partridge IG, editors]. Ayr, UK: NIRD-HRI.
Roediger WEW,(1995) The place of short-chain fatty acids in colonocyte metabolism in health and ulcerative colitis: the impaired colonocyte barrier Physiological and Clinical Aspects of Short Chain Fatty Acids pp. 337351[Cummings JH, Rombeau JL and Sakata T, editors].Cambridge:Cambridge University Press.
Sakamoto J, Nakaji S, Sugawara K, Iwane S and Munakata A (1996) Comparison of resistant starch with cellulose diet on 1,2-dimethylhydrazine-induced colonic carcinogenesis in rats. Gastroenterology 110, 116120.
Southgate DA (1998) How much and what classes of carbohydrate reach the colon. European Journal of Cancer Prevalence 7, S81S82.
Stephen AM (1991) Starch and dietary fiber: their physiological and epidemiological interrelationships. Canadian Journal of Physiology and Pharmacology 69, 116120.
Thorup I, Meyer O and Kristiansen E (1995) Effect of potato starch, cornstarch, and sucrose on aberrant crypt foci in rats exposed to azoxymethane. Anticancer Research 15, 21012106.
Topping DL, Illman RJ, Taylor MN and McIntosh GH (1985) Effects of wheat bran and porridge oats on hepatic portal venous volatile fatty acids in the pig. Annals of Nutrition and Metabolism 29, 325331.
Van der Meulen J, Bakker GCM, Bakker JGM, de Visser H, Jongbloed AW and Everts H (1997) Effect of resistant starch on net portal-drained viscera flux of glucose, volatile fatty acids, urea, and ammonia in growing pigs. Journal of Animal Science 75, 26972704.
Yen JT, Nienaber JA, Hill DA and Pond WG (1991) Potential contribution of absorbed volatile fatty acids to whole-animal energy requirement in conscious swine. Journal of Animal Science 69, 20012012.
Young GP, McIntyre A, Albert V, Folino M, Muir JG and Gibson PR (1996) Wheat bran suppresses potato starch–potentially colorectal tumorigenesis at the aberrant crypt stage in a rat model. Gastroenterology 110, 508514.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords:

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 51 *
Loading metrics...

Abstract views

Total abstract views: 89 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 19th November 2017. This data will be updated every 24 hours.