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Prevalence and haemopoietic effects of low serum vitamin B12 levels in geriatric medical patients

  • David J. Stott (a1), Peter Langhorne (a2), Anne Hendry (a2), Pamela J Mckay (a3), Tessa Holyoake (a3), Jon Macdonald (a2) and Norman Lucie (a3)
  • DOI: http://dx.doi.org/10.1079/BJN19970118
  • Published online: 01 March 2007
Abstract

The clinical significance of low serum vitamin B12 levels in elderly people is controversial. We aimed to document the prevalence of a low serum vitamin B12 (<175pmol/l) in patients referred to a geriatric medical unit, and to determine whether haemopoiesis is commonly affected in elderly patients with low serum vitamin B12. We studied prospectively 472 consecutive referrals to a geriatric medical unit; fifty-six (13%) had a low serum vitamin B12 level, of whom nineteen (34%) of the fifty-six also had evidence of Fe deficiency (serum ferritin<45ng/ml). Low vitamin B12 was associated with a raised mean erythrocyte volume (MCV; mean 96·0 (SD 6·7) fl), compared with a control group (91·7 (SD 6·0) fl; P=0·001). However, only thirteen (23%) of the fifty-six patients with a low vitamin Blz had an MCV≥100 fl. Mean haemoglobin (Hb) levels were not significantly reduced in those with a low vitamin B12. In a subsequent study the haematological response to intramuscular hydroxocobalamin was examined in thirty-four patients with a low serum vitamin B12. Treatment resulted in a significant fall in MCV and rise in Hb; these effects could be detected both in those patients with an initially normal full blood count (change in MCV -1·2 (SD 1·2); Hb + 0·5 (SD 0·6); P<0·01) and in those with macrocytosis and/or anaemia (-9·1 (SD 11·8); + 0·8 (SD 1·2); P<0·05). A low serum vitamin B12 is common in geriatric medical patients. This is usually associated with an upset in erythropoiesis, although the abnormalities are often subtle and may not be apparent on inspection of the full blood count. Elderly patients with serum vitamin B12<175pmol/l should be assumed to have vitamin deficiency even if their full blood count is normal.

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B. B. Anderson (1964). Investigations into the Euglena method for the assay of the vitamin B12 in serum. Journal of Clinical Pathology 17, 1421.

H. I. Atrah & R. J. Davidson (1988). Iron deficiency in pernicious anaemia: a neglected diagnosis. Postgraduate Medical Journal 64, 110111.

H. Basun , L. Fratiglioni & B. Winblad (1994). Cobalamin levels are not reduced in Alzheimer's Disease: results from a population-based study. Journal of the American Geriatrics Society 42, 132136.

R. Carmel & D. S. Karnaze (1985). The deoxyuridine suppression test identifies subtle cobalamin deficiency in patients without typical megaloblastic anaemia Journal of the American Medical Association 253, 12841287.

R. Carmel , J. M. Weiner & C. S. Johnson (1987 b). Iron deficiency occurs frequently in patients with pernicious anemia. Journal of the American Medical Association 257, 10811083.

G. Casale , C. Bonora , A. Migliavacca , I. E. Zurita & P. de Nicola (1981). Serum ferritin and ageing. Age and Ageing 10, 119122.

G. H. Guyatt , C. Patterson , M. Ali , J. Singer , M. Levine , I. Turpie & R. Meyer (1990). Diagnosis of iron-deficiency anemia in the elderly. American Journal of Medicine 88, 205209.

L. A. Harker , R. Ross , S. I. Slichter & C. R. Scott (1976). Homocystine-induced arteriosclerosis: the role of endothelial cell injury and platelet response in its genesis. Journal of Clinical Investigation 58, 731741.

A. V. Hoffbrand , B. F. A. Newcombe & D. L. Mollin (1966). Method of assay of red cell folate activity and the value of the assay as a test for folate deficiency. Journal of Clinical Pathology 19, 1728.

T. L. Holyoake , D. J. Stott , P. J. McKay , A. Hendry , J. B. MacDonald & N. P. Lucie (1993). Use of plasma ferritin level to diagnose iron deficiency in elderly patients. Journal of Clinical Pathology 46, 857860.

D. Hughes , R. C. Elwood , N. K. Shinton & R. J. Wrighton (1970). Clinical trial of the effect of vitamin B12 in elderly subjects with low serum B12 levels. British Medical Journal 2, 458460.

S. S. Kang , P. W. Wong & M. R. Malinow (1992). Hyperhomocyst(e)inemia as a risk factor for occlusive vascular disease. Annual Review of Nutrition 12, 279298.

D. S. Karnaze & R. Carmel (1990). Neurologic and evoked potential abnormalities in subtle cobalamin deficiency states, including those without anaemia and with normal absorption of free cobalamin. Archives of Neurology 47, 10081012.

M. O. Kristensen , N. C. Gulmann , J. E. J. Christensen , K. Ostergaard & K. Rasmussen (1993). Serum cobalamin and methylmalonic acid in Alzheimer dementia. Acta Neurologica Scandinavica 87, 475481.

P. Langhorne , A. Hendry , J. B. MacDonald , P. MacKay , T. Holyoake , N. Lucie & D. J. Stott (1992). Screening for vitamin B12 and folate deficiency in geriatric medical patients. Age and Ageing 21 Suppl. 2, 15 Abstr.

J. Lindenbaum , E. B. Healton , D. G. Savage , J. C. M. Brust , T. J. Garrett , E. R. Podell , P. D. Marcell , S. P. Stabler & R. H. Allen (1988). Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis. New England Journal of Medicine 318, 17201728.

R. F. Logan , A. Elwis , M. J. Forrest & A. C. Lawrence (1989). Mechanisms of vitamin B12 deficiency in elderly inpatients. Age and Ageing 18, 410.

K. S. Mattila , V. Kuusela , T. T. Pelliniemi , A. Rajamaki , H. L. Kaihola & K. Juva (1986). Haematological laboratory findings in the elderly: influence of age and sex. Scandinavian Journal of Clinical and Laboratory Investigation 46, 411415.

P. J. McKay , D. J. Stott , T. Holyoake , A. Hendry , J. B. MacDonald & N. P. Lucie (1993). Use of the erythrogram in the diagnosis of iron deficiency in elderly patients. Acta Haematologica 89, 169173.

J. Mosbech (1952). Incidence of pernicious anaemia. Acta Medica Scandinavica 141, 433439.

L. C. Pennypacker , R. H. Allen , J. P. Kelly , L. M. Matthews , T. Grigsby , K. Kaye , J. Lindenbaum & S. P. Stabler (1992). High prevalence of cobalamin deficiency in elderly outpatients. Journal of the American Geriatrics Society 40, 11971204.

A. Tefferi & R. K. Pruthi (1994). The biochemical basis of cobalamin deficiency. Mayo Clinic Proceedings 69, 181186.

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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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