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Prevention of osteopaenia by phyto-oestrogens: animal studies

Published online by Cambridge University Press:  26 October 2011

Véronique Coxam
Véronique Coxam*
Affiliation:
Groupe Ostéoporose, Unité des Maladies Métaboliques et Micronutriments, INRA Theix, F-63122 Saint Genès-Champanelle, France
*
*Corresponding author: Dr V. Coxam, fax +33 473 62 46 38, email coxam@clermont.inra.fr
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Osteoporosis has become a major public health problem. Because the biggest culprit in the process of bone loss is oestrogen deficiency, hormone replacement therapy remains the mainstay for prevention, but prophylaxis by this means is limited. Phyto-oestrogens deserve special mention because emerging data support the suggestion that these weakly oestrogenic compounds, present in plants, may prevent bone loss associated with the menopause and thus represent a potential alternative therapy for a range of hormone-dependent conditions, including postmenopausal symptoms. A substantial body of work in animal models in the past few years has provided convincing data for significant improvements in bone mass and other endpoints following feeding with soya. Thus, phyto-oestrogens appear to have potential promise for maintaining or modestly improving bone mass of human subjects when consumed at optimal dosages. However, we must appreciate the limits of the information reached before extrapolating to man and we need to gather more data before health professionals can actively advocate the increased consumption of soya. Indeed, it will be important further to characterise the physiological effects of phytooestrogens and their margins of safety.

Keywords

Phyto-oestrogensBoneAnimals
Type
Research Article
Information
British Journal of Nutrition , Volume 89 , Issue S1: Effects of Phyto-oestrogens on Bone Health: the VENUS Concerted Action , June 2003 , pp. S75 - S85
Copyright
Copyright © The Nutrition Society 2003

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