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Rapid chylomicron appearance following sequential meals: effects of second meal composition

  • Kevin Evans (a1), Pertti J. Kuusela (a2), Martha L. Cruz (a2), Ingrid Wilhelmova (a2), Barbara A. Fielding (a2) and Keith N. Frayn (a2)...

Abstract

Previous studies have noted the presence of an early postprandial peak in plasma triacylglycerol concentrations following successive fat-rich meals. An earlier study has shown that the triacylglycerol in this early peak originates from a previous meal. The present study was performed to investigate the effects of different second meals on the plasma triacylglycerol response. Six healthy subjects were studied on four occasions each. At 5 h following a fat-rich breakfast they ingested one of the following in a balanced design: a fat-rich meal, a low-fat meal, water or nothing by mouth. Blood samples were taken for 2.5 h following the second meal. An early peak in chylomicron and plasma triacylglycerol concentrations was seen following both low-fat and fat-rich second meals but not following water. During studies investigating postprandial lipaemia, further meals must be avoided, even if they contain no fat, although water may be allowed.

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Copyright

Corresponding author

*Corresponding author: Dr Keith N. Frayn: fax +44(0)1865 224652, email keith.frayn@oxlip.ox.ac.uk

References

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