Skip to main content Accessibility help
×
Home
Hostname: page-component-59b7f5684b-569ts Total loading time: 0.408 Render date: 2022-09-30T06:18:41.884Z Has data issue: true Feature Flags: { "shouldUseShareProductTool": true, "shouldUseHypothesis": true, "isUnsiloEnabled": true, "useRatesEcommerce": false, "displayNetworkTab": true, "displayNetworkMapGraph": false, "useSa": true } hasContentIssue true

Reduced plasma half-life of radio-labelled 25-hydroxyvitamin D3 in subjects receiving a high-fibre diet

Published online by Cambridge University Press:  09 March 2007

A. J. Batchelor
Affiliation:
Gastrointestinal Research Unit, The Rayne Institute, St Thomas' Hospital, London SE1 7EH
Juliet E. Compston
Affiliation:
Gastrointestinal Research Unit, The Rayne Institute, St Thomas' Hospital, London SE1 7EH
Rights & Permissions[Opens in a new window]

Abstract

HTML view is not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. The plasma disappearance of 3H-labelled 25-hydroxyvitamin D3 (25(OH)D3) was studied in healthy volunteers on normal and high-fibre diets, using 3H-labelled tracer doses given intravenously.

2. The mean (±SEM) plasma half-life in the high-fibre-diet group was 19·2±1·7d, which was significantly shorter than in the group on normal diets (27·5±2·1 d, P < 0·02).

3. This finding suggests that a high-fibre diet leads to enhanced elimination of 25(OH)D3 by an action within the intestinal lumen. This may involve interference with an enterohepatic circulation of the metabolite, perhaps by binding of 25(OH)D3 to dietary fibre.

4. The reduced plasma half-life of 3H-labelled 25(OH)D3 associated with a high-fibre diet may explain the development of vitamin D deficiency in Asian immigrants with normal exposure to u.v. light.

Type
Papers of direct relevance to Clinical and Human Nutrition
Copyright
Copyright © The Nutrition Society 1983

References

REFERENCES

Arnaud, S. B., Goldsmith, R. S., Lambert, P. W. & Go, V. L. W. (1975). Proc. Soc. expl. Biol. Med. 46, 570.CrossRefGoogle Scholar
Avioli, L. V., Lee, S. W., McDonald, J. E., Lund, J. & DeLuca, H. F. (1967). J. clin. Invest. 46, 983.CrossRefGoogle Scholar
Bec, P. H., Bayard, F. & Louvet, J. P. (1972). Rev. Eur. Etudes Clin. Biol. 17, 793.Google Scholar
Bell, P. A. & Kodicek, E. (1969). Biochem. J. 115, 663.CrossRefGoogle Scholar
Dunnigan, M. G., Childs, W. C., Smith, C. M., McIntosh, W. B. & Ford, J. A. (1975). Scott. Med. J. 20, 217.CrossRefGoogle Scholar
Dunnigan, M. G. & Smith, C. M. (1965). Scott. Med. J. 10, 1.CrossRefGoogle Scholar
Edelstein, S., Charman, M., Lawson, D. E. M. & Kodicek, E. (1974). Clin. Sci. Mol. Med. 46, 231.Google Scholar
Ford, J. A., Colhoun, E. M., McIntosh, W. B. & Dunnigan, M. G. (1972). Br. med. J. iii, 446.CrossRefGoogle Scholar
Ford, J. A., McIntosh, W. B. & Dunnigan, M. G. (1976). Adv. expl. Med. Biol. 81, 353.Google Scholar
Gray, R. W., Weber, H. P., Dominguez, J. H. & Lemann, J. (1974). J. clin. Endocr. Metab. 39, 1045.CrossRefGoogle Scholar
Haddad, J. G. & Hahn, T. J. (1973). Nature, Lond. 244, 515.CrossRefGoogle Scholar
Haddad, J. G. & Rojanasathit, S. (1976). J. clin. Endocr. Metab. 42, 284.CrossRefGoogle Scholar
Hunt, S. P., O'Riordan, J. L. H., Windo, J. & Truswell, A. S. (1976). Br. med. J. ii, 1351.CrossRefGoogle Scholar
Mawer, E. B. (1979). Vitamin D, Basic Research and its Clinical Application, p. 553. Berlin and New York: Walter de Gruyter.Google Scholar
Mawer, E. B., Backhouse, J., Holman, C. A., Lumb, G. A. & Stanbury, S. W. (1972). Clin. Sci. 43, 413.CrossRefGoogle Scholar
Mawer, E. B., Lumb, G. A., Schaefer, K. & Stanbury, S. W. (1971). Clin. Sci. 40, 39.CrossRefGoogle Scholar
Reinhold, J. G. (1976). Lancet ii, 1132.CrossRefGoogle Scholar
Robertson, I., Kelman, A. & Dunnigan, M. G. (1977). Br. med. J. i, 229.CrossRefGoogle Scholar
Smith, J. E. & Goodman, D. S. (1971). J. clin. Invest. 50, 2159.CrossRefGoogle Scholar
Wills, M. R., Day, R. C., Phillips, J. B. & Bateman, E. C. (1972). Lancet i, 771.CrossRefGoogle Scholar
You have Access
67
Cited by

Save article to Kindle

To save this article to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Reduced plasma half-life of radio-labelled 25-hydroxyvitamin D3 in subjects receiving a high-fibre diet
Available formats
×

Save article to Dropbox

To save this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you used this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about saving content to Dropbox.

Reduced plasma half-life of radio-labelled 25-hydroxyvitamin D3 in subjects receiving a high-fibre diet
Available formats
×

Save article to Google Drive

To save this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you used this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about saving content to Google Drive.

Reduced plasma half-life of radio-labelled 25-hydroxyvitamin D3 in subjects receiving a high-fibre diet
Available formats
×
×

Reply to: Submit a response

Please enter your response.

Your details

Please enter a valid email address.

Conflicting interests

Do you have any conflicting interests? *