Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Home
  • Home
Article
  • Cited by 14

  • Access

Reducing exercise-induced muscular injury in kendo athletes with supplementation of coenzyme Q10

  • Michihiro Kon (a1), Kai Tanabe (a1), Takayuki Akimoto (a2), Fuminori Kimura (a1), Yuko Tanimura (a1), Kazuhiro Shimizu (a1), Tadashi Okamoto (a3) and Ichiro Kono (a1)...

Abstract

Intensive physical exercise may cause muscular injury and increase oxidative stress. The purpose of this study was to examine the effect of an antioxidant, coenzyme Q10 (CoQ10), on muscular injury and oxidative stress during exercise training. Eighteen male students, all elite Japanese kendo athletes, were randomly assigned to either a CoQ10 group (n 10) or a placebo group (n 8) in a double-blind manner. Subjects in the CoQ10 group took 300 mg CoQ10 per d for 20 d, while subjects in the placebo group took the same dosage of a placebo. All subjects practised kendo 5·5 h per d for 6 d during the experimental period. Blood samples were taken 2 weeks before, during (1 d, 3 d, 5 d) and 1 week after the training. Serum creatine kinase (CK) activity and myoglobin (Mb) concentration significantly increased in both groups (at 3 d and 5 d). Serum CK (at 3 d), Mb (at 3 d) and lipid peroxide (at 3 d and 5 d) of the CoQ10 group were lower than those of the placebo group. The leucocyte counts in the placebo group significantly increased (at 3 d) and neutrophils significantly increased in both groups (at 3 d and 5 d). Serum scavenging activity against superoxide anion did not change in either group. These results indicate that CoQ10 supplementation reduced exercise-induced muscular injury in athletes.

  • View HTML

      • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Reducing exercise-induced muscular injury in kendo athletes with supplementation of coenzyme Q10
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Reducing exercise-induced muscular injury in kendo athletes with supplementation of coenzyme Q10
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Reducing exercise-induced muscular injury in kendo athletes with supplementation of coenzyme Q10
      Available formats
      ×

Copyright

COPYRIGHT: © The Authors 2008

Corresponding author

*Corresponding author: Dr Ichiro Kono, fax +81 29 853 2656, email kono@taiiku.tsukuba.ac.jp

References

Hide All
1Turunen, M, Olsson, J & Dallner, G (2004) Metabolism and function of coenzyme Q. Biochim Biophys Acta 1660, 171–199.
2Ernster, L & Dallner, G (1995) Biochemical, physiological and medical aspects of ubiquinone function. Biochim Biophys Acta 1271, 195–204.
3Forsmark-Andree, P, Dallner, G & Ernster, L (1995) Endogenous ubiquinol prevents protein modification accompanying lipid peroxidation in beef heart submitochondrial particles. Free Radic Biol Med 19, 749–757.
4Kagan, V, Serbinova, E & Packer, L (1990) Antioxidant effects of ubiquinones in microsomes and mitochondria are mediated by tocopherol recycling. Biochem Biophys Res Commun 169, 851–857.
5Lass, A & Sohal, RS (1998) Electron transport-linked ubiquinone-dependent recycling of alpha-tocopherol inhibits autooxidation of mitochondrial membranes. Arch Biochem Biophys 352, 229–236.
6Mohr, D, Bowry, VW & Stocker, R (1992) Dietary supplementation with coenzyme Q10 results in increased levels of ubiquinol-10 within circulating lipoproteins and increased resistance of human low-density lipoprotein to the initiation of lipid peroxidation. Biochim Biophys Acta 1126, 247–254.
7Weber, C, Bysted, A & Holmer, G (1996) The coenzyme Q10 content of the average Danish diet. Int J Vitam Res 67, 123–129.
8Hosoe, K, Kitano, M, Kishida, H, Kubo, H, Fujii, K & Kitahara, M (2007) Study on safety and bioavailability of ubiquinol (Kaneka QH) after single and 4-week multiple oral administration to healthy volunteers. Regul Toxicol Pharmacol 47, 19–28.
9Sjodin, B, Hellsten Westing, Y & Apple, FS (1990) Biochemical mechanisms for oxygen free radical formation during exercise. Sports Med 10, 236–254.
10McArdle, A, van der Meulen, JH, Catapano, M, Symons, MC, Faulkner, JA & Jackson, MJ (1999) Free radical activity following contraction-induced injury to the extensor digitorum longus muscles of rats. Free Radic Biol Med 26, 1085–1091.
11Peake, J, Nosaka, K & Suzuki, K (2005) Characterization of inflammatory responses to eccentric exercise in humans. Exerc Immunol Rev 11, 64–85.
12Finaud, J, Lac, G & Filaire, E (2006) Oxidative stress: relationship with exercise and training. Sports Med 36, 327–358.
13Radak, Z, Pucsok, J, Mecseki, S, Csont, T & Ferdinandy, P (1999) Muscle soreness-induced reduction in force generation is accompanied by increased nitric oxide content and DNA damage in human skeletal muscle. Free Radic Biol Med 26, 1059–1063.
14Banerjee, AK, Mandal, A, Chanda, D & Chakraborti, S (2003) Oxidant, antioxidant and physical exercise. Mol Cell Biochem 253, 307–312.
15Kumar, CT, Reddy, VK, Prasad, M, Thyagaraju, K & Reddanna, P (1992) Dietary supplementation of vitamin E protects heart tissue from exercise-induced oxidant stress. Mol Cell Biochem 111, 109–115.
16Mastaloudis, A, Morrow, JD, Hopkins, DW, Devaraj, S & Traber, MG (2004) Antioxidant supplementation prevents exercise-induced lipid peroxidation, but not inflammation, in ultramarathon runners. Free Radic Biol Med 36, 1329–1341.
17Shimomura, Y, Suzuki, M, Sugiyama, S, Hanaki, Y & Ozawa, T (1991) Protective effect of coenzyme Q10 on exercise-induced muscular injury. Biochem Biophys Res Commun 176, 349–355.
18Okamoto, T, Kubota, N, Takahata, K, Takahashi, T, Goshima, K & Kishi, T (1995) Protective effect of coenzyme Q10 on cultured skeletal muscle cell injury induced by continuous electric field stimulation. Biochem Biophys Res Commun 216, 1006–1012.
19Imai, H, Hayashi, T, Negawa, T, Nakamura, K, Tomida, M, Koda, K, Tajima, T, Koda, Y, Suda, K & Era, S (2002) Strenuous exercise-induced change in redox state of human serum albumin during intensive kendo training. Jpn J Physiol 52, 135–140.
20Kon, M, Kimura, F, Tanimura, Y, Shimizu, K & Kono, I (2006) The influence of coenzyme Q10 ingestion on hemolysis in college kendo athletes at a training camp. Sport Sciences 3, 78–84.
21Kon, M, Nakamura, K, Natsui, H, Kimura, F, Lee, H, Akama, T & Kono, I (2006) Changes in serum haptoglobin in college kendo athletes at a training camp. Res J Budo 39, 1–8.
22Dill, DB & Costill, DL (1974) Calculation of percentage changes in volumes of blood, plasma, and red cells in dehydration. J Appl Physiol 37, 247–248.
23Ikematsu, H, Nakamura, K, Harashima, S, Fujii, K & Fukutomi, N (2006) Safety assessment of coenzyme Q10 (Kaneka Q10) in healthy subjects: a double-blind, randomized, placebo-controlled trial. Regul Toxicol Pharmacol 44, 212–218.
24Tanabe, K, Masuda, K, Hirayama, A, Nagase, S, Kono, I & Kuno, S (2006) Effect of spontaneous exercise on antioxidant capacity in rat muscles determined by electron spin resonance. Acta Physiol (Oxf) 186, 119–125.
25Kwong, LK, Kamzalov, S, Rebrin, I, Bayne, AC, Jana, CK, Morris, P, Forster, MJ & Sohal, RS (2002) Effects of coenzyme Q (10) administration on its tissue concentrations, mitochondrial oxidant generation, and oxidative stress in the rat. Free Radic Biol Med 33, 627–638.
26Koutedakis, Y, Raafat, A, Sharp, NC, Rosmarin, MN, Beard, MJ & Robbins, SW (1993) Serum enzyme activities in individuals with different levels of physical fitness. J Sports Med Phys Fitness 33, 252–257.
27Peake, JM, Suzuki, K, Wilson, G, Hordern, M, Nosaka, K, Mackinnon, L & Coombes, JS (2005) Exercise-induced muscle damage, plasma cytokines, and markers of neutrophil activation. Med Sci Sports Exerc 37, 737–745.
28Kaikkonen, J, Kosonen, L, Nyyssonen, K, Porkkala-Sarataho, E, Salonen, R, Korpela, H & Salonen, JT (1998) Effect of combined coenzyme Q10 and d-alpha-tocopheryl acetate supplementation on exercise-induced lipid peroxidation and muscular damage: a placebo-controlled double-blind study in marathon runners. Free Radic Res 29, 85–92.
29Kambara, N, Takagi, K, Satake, T, Sugiyama, S & Ozawa, T (1983) Mechanism responsible for endotoxin-induced lung microsomal dysfunction in rats. Lung 161, 361–368.
30Nagai, S, Miyazaki, Y, Ogawa, K, Satake, T, Sugiyama, S & Ozawa, T (1985) The effect of Coenzyme Q10 on reperfusion injury in canine myocardium. J Mol Cell Cardiol 17, 873–884.
31Bello, RI, Gomez-Diaz, C, Buron, MI, Alcain, FJ, Navas, P & Villalba, JM (2005) Enhanced anti-oxidant protection of liver membranes in long-lived rats fed on a coenzyme Q10-supplemented diet. Exp Gerontol 40, 694–706.
32Jackson, MJ, Edwards, RH & Symons, MC (1985) Electron spin resonance studies of intact mammalian skeletal muscle. Biochim Biophys Acta 847, 185–190.
33Moncada, S & Higgs, A (1993) The L-arginine-nitric oxide pathway. N Engl J Med 329, 2002–2012.
34Cheeseman, KH & Slater, TF (1993) An introduction to free radical biochemistry. Br Med Bull 49, 481–493.
35Ji, LL (1999) Antioxidants and oxidative stress in exercise. Proc Soc Exp Biol Med 222, 283–292.
36Close, GL, Ashton, T, Cable, T, Doran, D, Noyes, C, McArdle, F & MacLaren, DP (2005) Effects of dietary carbohydrate on delayed onset muscle soreness and reactive oxygen species after contraction induced muscle damage. Br J Sports Med 39, 948–953.
37Kon, M, Tanabe, K, Lee, H, Kimura, F, Akimoto, T & Kono, I (2007) Eccentric muscle contractions induce greater oxidative stress than concentric contractions in skeletal muscle. Appl Physiol Nutr Metab 32, 273–281.
38Dlugosz, A, Kuzniar, J, Sawicka, E, Marchewka, Z, Lembas-Bogaczyk, J, Sajewicz, W & Boratynska, M (2004) Oxidative stress and coenzyme Q10 supplementation in renal transplant recipients. Int Urol Nephrol 36, 253–258.
39Zhou, M, Zhi, Q, Tang, Y, Yu, D & Han, J (1999) Effects of coenzyme Q10 on myocardial protection during cardiac valve replacement and scavenging free radical activity in vitro. J Cardiovasc Surg (Torino) 40, 355–361.

Keywords

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed