Hostname: page-component-8448b6f56d-xtgtn Total loading time: 0 Render date: 2024-04-15T23:58:38.415Z Has data issue: false hasContentIssue false
  • English
  • Français

Relationship between body collagen and urinary hydroxyproline excretion in young rats fed on a low-protein or low-calorie diet

Published online by Cambridge University Press:  09 March 2007

A. Anasuya  and
B. S. Narasinga Rao
A. Anasuya
Affiliation:
Nutrition Research Laboratories, Indian Council of Medical Research, Jamai-Osmania, Hyderabad-7, India
B. S. Narasinga Rao
Affiliation:
Nutrition Research Laboratories, Indian Council of Medical Research, Jamai-Osmania, Hyderabad-7, India
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. Hydroxyproline was determined in urine, carcass, and skin of young rats fed on low-protein and low-calorie diets.

2. Protein and calorie deprivation in young rats resulted in a marked fall in the soluble as well as insoluble collagen content of the skin.

3. The collagen content of the carcass (excluding skin) was slightly greater in the deficient rats than in the weanling rats, but very much lower than in the well-fed rats.

4. In rats subjected to protein and calorie deficiency, urinary hydroxyproline was markedly reduced. In these rats, most of the reduction in urinary hydroxyproline was observed within 1 week of feeding the deficient diet. Protein deficiency had affected urinary excretion of hydroxyproline more severely than calorie deficiency.

5. The reduction of urinary hydroxyproline in the deficient animals can be attributed to decreased turnover rate of their body collagen. This apparent decrease in turnover rate is explained as being due to an increase in the proportion of collagen of slow turnover in these animals.

6. Protein and calorie deficiency had also resulted in the depletion of non-collagen nitrogen of both carcass and skin.

Type
Research Article
Information
British Journal of Nutrition , Volume 24 , Issue 1 , March 1970 , pp. 97 - 107
Copyright
Copyright © The Nutrition Society 1970

References

Anasuya, A. & Narasinga Rao, B. S. (1966). Indian J. med. Res. 54, 849.Google Scholar
Cabak, V., Dickerson, J. W. T. & Widdowson, E. M. (1963). Br. J. Nutr. 17, 601.CrossRefGoogle Scholar
Clark, L. C. Jr & Thompson, H. L. (1949). Analyt. Chem. 21, 1218.Google Scholar
Halliday, D. (1967). Clin. Sci. 33, 365.Google Scholar
Jasin, H. E., Fink, C. W., Wise, W. & Ziff, M. (1962). J. clin. Invest. 41, 1928.CrossRefGoogle Scholar
Laitinen, O. (1967). Acta endocr. Copenh. Suppl. no. 120, p. 24.Google Scholar
Lindstedt, S. & Prockop, D. J. (1961). J. biol. Chem. 236, 1399.CrossRefGoogle Scholar
McCance, R. A. (1960). Br. J. Nutr. 14, 59.CrossRefGoogle Scholar
Picou, D., Alleyne, G. A. O. & Seakins, A. (1965). Clin. Sci. 29, 517.Google Scholar
Picou, D., Halliday, D. & Garrow, J. S. (1966). Clin. Sci. 30, 345.Google Scholar
Prockop, D. J. (1964). J. clin. Invest. 43, 453.Google Scholar
Prockop, D. J. & Udenfriend, S. (1960). Analyt. Biochem. 1, 228.Google Scholar
Vasantha, L. (1970). Am. J. clin. Nutr. (In the Press.)Google Scholar
Waterlow, J. C. & Stephen, J. M. I. (1966). Br. J. Nutr. 20, 461.Google Scholar
Whitehead, R. G. (1965). Lancet ii, 567.CrossRefGoogle Scholar
Widdowson, E. M. & Whitehead, R. G. (1966). Nature, Lond. 212, 683.CrossRefGoogle Scholar
Ziff, M., Kibrick, A., Dresner, E. & Gribetz, H. J. (1956). J. clin. Invest. 35, 579.Google Scholar