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The relationship between serum fatty acids and depressive symptoms in obese adolescents

Published online by Cambridge University Press:  03 October 2022

Sandra Maria Chemin Seabra da Silva Open the ORCID record for Sandra Maria Chemin Seabra da Silva [Opens in a new window] ,
Aline de Piano Ganen ,
Deborah Cristina Landi Masquio ,
Marcus V.L. Dos Santos Quaresma ,
Debora Estadella ,
Lila Missae Oyama ,
Lian Tock ,
Marco Túlio de Mello ,
Ana Raimunda Dâmaso  and
Claudia Maria da Penha Oller do Nascimento
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Sandra Maria Chemin Seabra da Silva*
Affiliation:
Programa de Pós-Graduação Interdisciplinar em Ciências da Saúde, Universidade Federal de São Paulo, Santos, SP, Brasil Curso de Nutrição, Centro Universitário São Camilo, São Paulo, SP, Brasil
Aline de Piano Ganen
Affiliation:
Curso de Nutrição, Centro Universitário São Camilo, São Paulo, SP, Brasil Programa de Pós-Graduação em Nutrição, Universidade Federal de São Paulo, São Paulo, SP, Brasil Mestrado Profissional em Nutrição: do nascimento à adolescência, Centro Universitário São Camilo, São Paulo, SP, Brasil
Deborah Cristina Landi Masquio
Affiliation:
Curso de Nutrição, Centro Universitário São Camilo, São Paulo, SP, Brasil Programa de Pós-Graduação em Nutrição, Universidade Federal de São Paulo, São Paulo, SP, Brasil Mestrado Profissional em Nutrição: do nascimento à adolescência, Centro Universitário São Camilo, São Paulo, SP, Brasil
Marcus V.L. Dos Santos Quaresma
Affiliation:
Curso de Nutrição, Centro Universitário São Camilo, São Paulo, SP, Brasil
Debora Estadella
Affiliation:
Programa de Pós-Graduação em Nutrição, Universidade Federal de São Paulo, São Paulo, SP, Brasil Departamento de Biociências, Universidade Federal de São Paulo, Santos, SP, Brasil
Lila Missae Oyama
Affiliation:
Programa de Pós-Graduação em Nutrição, Universidade Federal de São Paulo, São Paulo, SP, Brasil Departamento de Fisiologia, Universidade Federal de São Paulo, São Paulo, SP, Brasil
Lian Tock
Affiliation:
Programa de Pós-Graduação em Nutrição, Universidade Federal de São Paulo, São Paulo, SP, Brasil
Marco Túlio de Mello
Affiliation:
Programa de Pós-Graduação em Nutrição, Universidade Federal de São Paulo, São Paulo, SP, Brasil Escola de Educação Física, Fisioterapia e Terapia Ocupacional, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brasil
Ana Raimunda Dâmaso
Affiliation:
Programa de Pós-Graduação em Nutrição, Universidade Federal de São Paulo, São Paulo, SP, Brasil
Claudia Maria da Penha Oller do Nascimento
Affiliation:
Programa de Pós-Graduação em Nutrição, Universidade Federal de São Paulo, São Paulo, SP, Brasil Departamento de Fisiologia, Universidade Federal de São Paulo, São Paulo, SP, Brasil
Danielle Arisa Caranti
Affiliation:
Programa de Pós-Graduação Interdisciplinar em Ciências da Saúde, Universidade Federal de São Paulo, Santos, SP, Brasil Departamento de Biociências, Universidade Federal de São Paulo, Santos, SP, Brasil
*
*Corresponding author: Sandra Maria Chemin Seabra da Silva, email nutri@saocamilo-sp.br
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Abstract

Depression and obesity are highly prevalent and are considered inflammatory pathologies; in addition, they are also associated with dietary patterns including types of fatty acids (FA). Changes in the FA composition in the brain are determined by changes in the content and quality of dietary and serum FA. The aim of this study was to verify the relationships between serum-free FA, inflammatory processes and depressive symptoms in obese adolescents. This was a cross-sectional study that analysed a database composed of 138 post-pubertal adolescents. Data regarding the depressive symptoms, body composition, glucose metabolism, lipid profile, FA profile, leptin concentration, as well as adiponectin, IL-A, IL-6, IL-10, TNF-α, C-reactive protein and plasminogen activator inhibitor-1 levels of the subjects were collected. A total of 54·6 % of the adolescents presented with depressive symptoms, and there were positive correlations between depressive symptoms and serum saturated fatty acids (SFA) content, body fat, and inflammatory adipokines, such as leptin, IL-6, and the leptin/adiponectin ratio. Moreover, the content of n-3 polyunsaturated fatty acids (PUFA) was negatively correlated with depressive symptoms, suggesting that eicosatrienoic acid (C20:2n6) and dihomo-γ-linolenic acid (C20:3n-6) are independently associated with depressive symptom scores and can be critical predictors of poor mental health in humans. These results point to the relationship between SFA and depressive symptoms in obese adolescents. However, longitudinal studies are needed to confirm the causality between dietary SFA and depression in obese individuals.

Keywords

Fatty acidsDepressionObesity
Type
Research Article
Information
British Journal of Nutrition , Volume 129 , Issue 12 , 28 June 2023 , pp. 2199 - 2208
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Copyright
© Universidade Federal de São Paulo, 2022. Published by Cambridge University Press on behalf of The Nutrition Society

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