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Resting energy expenditure is not increased in mildly hyperglycaemic obese diabetic patients

Published online by Cambridge University Press:  08 March 2007

M. Ryan ,
A. Sallé ,
G. Guilloteau ,
M. Genaitay ,
M. B. E. Livingstone  and
P. Ritz
M. Ryan
Affiliation:
Department of Diabetes and Nutrition, CHU Angers F-49033, France NICHE, University of Ulster, Coleraine, Northern Ireland
A. Sallé
Affiliation:
Department of Diabetes and Nutrition, CHU Angers F-49033, France
G. Guilloteau
Affiliation:
Department of Diabetes and Nutrition, CHU Angers F-49033, France
M. Genaitay
Affiliation:
Department of Diabetes and Nutrition, CHU Angers F-49033, France
M. B. E. Livingstone
Affiliation:
NICHE, University of Ulster, Coleraine, Northern Ireland
P. Ritz*
Affiliation:
Department of Diabetes and Nutrition, CHU Angers F-49033, France
*
*Corresponding author: Professor P. Ritz, fax +33 241 354 969, email patrick.ritz@wanadoo.fr
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Abstract

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Resting energy expenditure (REE) is believed to be increased in type 2 diabetes, an increase that is associated with deteriorating glucose tolerance during its development. Meanwhile, insulin resistance, a state linked to obesity and observed in all type 2 diabetic patients, is associated with reduced REE. Our aim was to compare REE in obese patients with and without diabetes. REE, body composition (total body water, density, percentage fat and fat-free mass: 3-compartment model) and metabolic control were assessed in fifty obese Caucasian patients with diabetes (glycated haemoglobin level 7·6 (sd 1·5) %) and fifty obese patients who were non-diabetic. Despite being more overweight and younger, obese non-diabetic patients had an absolute REE (7·73 (sd 1·44) v. 8·12 (sd 1·37) MJ; P=0·17) and percentage fat-free mass similar to those of obese diabetic patients. Even when adjusted for differences in body composition, REE remained similar in both groups. Furthermore, REE (absolute and adjusted) was unaffected by both glucose level and control (glycated haemoglobin), with fat-free mass being the only determinant of REE. We conclude that REE is not necessarily increased by the presence of diabetes in obese people.

Keywords

Resting energy expenditureObesityDiabetesFat-free mass
Type
Research Article
Information
British Journal of Nutrition , Volume 96 , Issue 5 , November 2006 , pp. 945 - 948
Copyright
Copyright © The Nutrition Society 2006

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