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Resveratrol, a new biomarker of moderate wine intake?

Published online by Cambridge University Press:  01 January 2009

Raul Zamora-Ros
Affiliation:
Nutrition and Food Science Department-Xarta, INSA, AGL2006-14228-C03-02/01 and INGENIO-CONSOLIDER Program, Fun-c-food CSD2007-063, Pharmacy School, University of Barcelona, Av. Joan XXIII, s/n 08028Barcelona, Spain Fax +34 93 403 59 31
Rosa M. Lamuela-Raventós
Affiliation:
Nutrition and Food Science Department-Xarta, INSA, AGL2006-14228-C03-02/01 and INGENIO-CONSOLIDER Program, Fun-c-food CSD2007-063, Pharmacy School, University of Barcelona, Av. Joan XXIII, s/n 08028Barcelona, Spain Fax +34 93 403 59 31
Ramón Estruch
Affiliation:
2Department of Internal Medicine, Hospital Clínic, Barcelona, Institut d'Investigació Biomèdica August Pi i Sunyer (IDIBAPS), University of Barcelona, 08036 Barcelona, SpainCIBER 06/03: Fisiopatología de la Obesidad y la Nutrición, Instituto de Salud Carlos III
Cristina Andres-Lacueva*
Affiliation:
Nutrition and Food Science Department-Xarta, INSA, AGL2006-14228-C03-02/01 and INGENIO-CONSOLIDER Program, Fun-c-food CSD2007-063, Pharmacy School, University of Barcelona, Av. Joan XXIII, s/n 08028Barcelona, Spain Fax +34 93 403 59 31
*
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Extract

In a recent study published in the British Journal of Nutrition, Spencer et al.(1) reviewed the strengths and the limitations of the biomarkers of dietary polyphenol intake, since nutritional biomarkers may be a better measure of dietary exposure than self-reported dietary data.

Type
Letter to the Editor
Copyright
Copyright © The Authors 2008

In a recent study published in the British Journal of Nutrition, Spencer et al. (Reference Spencer, Abd El Mohsen, Minihane and Mathers1) reviewed the strengths and the limitations of the biomarkers of dietary polyphenol intake, since nutritional biomarkers may be a better measure of dietary exposure than self-reported dietary data. These authors identified the criteria that must be considered in the development of such biomarkers as the following: (i) robust methodology; (ii) sensitivity; (iii) specificity; (iv) bioavailability. Different polyphenols were reviewed as potential biomarkers by the authors; we suggest that resveratrol should also be considered. We analysed resveratrol metabolites as potential biomarkers of wine consumption in two randomised cross-over trials and a cohort study(Reference Zamora-Ros, Urpí-Sardà, Lamuela-Raventós, Estruch, Vázquez-Agell, Serrano-Martínez, Jaeger and Andres-Lacueva2). Using a cut-off of 90 nmol/g, we were able to use urinary total resveratrol metabolite concentration to differentiate wine consumers from abstainers with a sensitivity of 72 % (60–84 %) and a specificity of 94 % (87–100 %). In these trials, urinary resveratrol was specific, as wine has been reported as the most important source of dietary resveratrol (98·4 %)(Reference Zamora-Ros, Andres-Lacueva and Lamuela-Raventós3), has an adequate half-life and provided a good correlation between these measured values and the dietary data reported (r 0·654; P < 0·001). In addition, there is a robust analytical technique(Reference Urpí-Sardà, Jáuregui, Lamuela-Raventós, Jaeger, Miksits, Covas and Andres-Lacueva4, Reference Urpi-Sarda, Zamora-Ros, Lamuela-Raventos, Cherubini, Jauregui, de la Torre, Covas, Estruch, Jaeger and Andres-Lacueva5) using LC-MS-MS to determine urinary resveratrol metabolites and their pharmacokinetic parameters have been recently studied by Boocock et al. (Reference Boocock, Faust and Patel6).

Taking these points into consideration, we want to propose urinary resveratrol metabolites as a biomarker of grape product consumption; this would be a new nutritional biomarker which accomplish and fulfil the criteria of Spencer et al. (Reference Spencer, Abd El Mohsen, Minihane and Mathers1).

We declare no conflict of interest.

References

1Spencer, JPE, Abd El Mohsen, MM, Minihane, A-M & Mathers, JC (2008) Biomarkers of the intake of dietary polyphenols: strengths, limitations and application in nutrition research. Br J Nutr 99, 1222.CrossRefGoogle ScholarPubMed
2Zamora-Ros, R, Urpí-Sardà, M, Lamuela-Raventós, RM, Estruch, R, Vázquez-Agell, M, Serrano-Martínez, M, Jaeger, W & Andres-Lacueva, C (2006) Diagnostic performance of urinary resveratrol metabolites as a biomarker of moderate wine consumption. Clin Chem 52, 13731380.CrossRefGoogle ScholarPubMed
3Zamora-Ros, R, Andres-Lacueva, C, Lamuela-Raventós, RM, et al. (2007) Concentrations of resveratrol and derivatives in foods and estimation of dietary intake in a Spanish population: European Prospective Investigation into Cancer and Nutrition (EPIC)-Spain cohort. Br J Nutr doi:10.1017/S0007114507882997.Google Scholar
4Urpí-Sardà, M, Jáuregui, O, Lamuela-Raventós, RM, Jaeger, W, Miksits, M, Covas, MI & Andres-Lacueva, C (2005) Uptake of diet resveratrol into the human low density lipoprotein. Identification and quantification of resveratrol metabolites by liquid chromatography coupled with tandem mass spectrometry. Anal Chem 77, 31493155.CrossRefGoogle ScholarPubMed
5Urpi-Sarda, M, Zamora-Ros, R, Lamuela-Raventos, R, Cherubini, A, Jauregui, O, de la Torre, R, Covas, MI, Estruch, R, Jaeger, W & Andres-Lacueva, C (2006) Rapid and highly sensitive method to characterize the metabolism of resveratrol in humans. Clin Chem 53, 292299.CrossRefGoogle Scholar
6Boocock, DJ, Faust, GE, Patel, KR, et al. (2007) Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent. Cancer Epidemiol Biomarkers Prev 16, 12461252.CrossRefGoogle ScholarPubMed
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