1Parkin, J & Cohen, B (2001) An overview on the immune system. Lancet 357, 1777–1789.
2Mackay, I & Rosen, FS (2000) The immune system. Part I. N Engl J Med 343, 37–49.
3Mackay, I & Rosen, FS (2000) The immune system. Part II. N Engl J Med 343, 108–117.
4Wintergerst, ES, Maggini, S & Hornig, DH (2007) Contribution of selected vitamins and trace elements to immune function. Ann Nutr Met 51, 301–323.
5Calder, PC & Kew, S (2002) The immune system: a target for functional foods? Br J Nutr 88, Suppl. 2, S165–S177.
6Scrimshaw, NS, Taylor, CE & Gordon, JE (1968) Effects of infections on nutritional status. In Interactions of Nutrition and Infection, pp. 44–46. Geneva: World Health Organization, Monograph Series 57, .
7Calder, PC & Jackson, AA (2000) Under-nutrition, infection and immune function. Nutr Res Rev 13, 3–29.
8Stephensen, CB (2001) Vitamin A, infection, and immunity. Annu Rev Nutr 21, 167–192.
9Villamor, E & Fawzi, WW (2005) Effects of vitamin A supplementation on immune responses and correlation with nutritional outcome. Clin Microbiol Rev 18, 446–464.
10Sommer, A, Katz, J & Tarwotjo, I (1984) Increased risk of respiratory disease and diarrhea in children with preexisting mild vitamin A deficiency. Am J Clin Nutr 40, 1090–1095.
11Barreto, ML, Santos, LMP, Assis, AMO, Araujo, MP, Farenzena, GG, Santos, PA & Fiaccone, RL (1994) Effect of vitamin A supplementation on diarrhoea and acute lower-respiratory tract infections in young children in Brazil. Lancet 344, 228–231.
12Beaton, GH, Martorell, R, Aronson, KJ, Edmonston, B, McCabe, G, Ross, AC & Harvey, B (1993) .
13The Vitamin A and Pneunomia Working Group (1995) Potential interventions for the prevention on childhood pneumonia in developing countries: a meta-analysis of data from field trials to assess the impact of vitamin A supplementation on pneumonia morbidity and mortality. Bull WHO 73, 609–619.
14Semba, RD (2004) Vitamin A. In Diet and Human Immune Function, , pp. 105–131 [Hughes, DA, Darlington, LG and Bendich, A, editors]. Totowa, NJ: Humana Press.
15Ramakrishnan, U, Web, AL & Ologoudou, K (2004) Infection, immunity, and vitamins. In Handbook of Nutrition and Immunity, pp. 93–115 [Gershwin, NE, Nestel, P and Keen, CL, editors]. Totoja, NJ: Humana Press.
16Dawson, HD, Li, NQ, Deciccio, KL, Nibert, JA & Ross, AC (1999) Chronic marginal vitamin A status reduces natural killer cell number and activity and function in aging Lewis rats. J Nutr 129, 1510–1517.
17Aukrust, P, Mueller, F, Ueland, T, Svardal, A, Berge, R & Froland, SS (2000) Decreased vitamin A levels in common variable immunodeficiency: vitamin A supplementation in vivo enhances immunoglobulin production and downregulates inflammatory responses. Eur J Clin Invest 30, 252–259.
18Halevy, O, Arazi, Y, Melamed, D, Friedman, A & Sklan, D (1994) Retinoic acid receptor-alpha gene expression is modulated by dietary vitamin A and by retinoic acid in chicken T lymphocytes. J Nutr 124, 2139–2146.
19Cantorna, MT, Nashold, FE & Hayes, C (1994) In vitamin A deficiency multiple mechanism establish a regulatory T helper cell imbalance with excess Th1 and insufficient Th2 function. J Immunol 152, 1515–1522.
20Long, KZ & Santos, JL (1999) Vitamins and the regulation of the immune response. Ped Inf Dis J 18, 283–290.
21Rahman, MM, Mahalanabis, D, Alvarez, JO, Wahed, MA, Islam, MA & Habte, D (1997) Effect of early vitamin A supplementation on cell-mediated immunity in infants younger than 6 months. Am J Clin Nutr 65, 144–148.
22Semba, RD (1999) Vitamin A as “anti-infective” therapy. J Nutr 129, 783–791.
23Semba, RD (2002) Vitamin A, infection and immune function. In Nutrition and Immune Function , pp. 151–170 [Calder, PC, Field, CJ and Gill, HS, editors]. Oxford: CABI Publishing.
24Hayes, CE, Nashold, FE, Spach, KM & Pedersen, LB (2003) The immunological functions of the vitamin D endocrine system. Cell Molec Biol 49, 277–300.
25Griffin, MD, Xing, N & Kumar, R (2003) Vitamin D and its analogs as regulators of immune activities and antigen presentation. Annu Rev Nutr 23, 117–145.
26Cantorna, MT, Zhu, Y, Froicu, M & Wittke, A (2004) Vitamin D status, 1,25-dihydroxy- vitamin D3, and the immune system. Am J Clin Nutr 80, 1717S–1720S.
27Veldman, CM, Cantorna, MT & DeLuca, HF (2000) Expression of 1,25-dihydroxyvitamin D3 receptor in the immune system. Arch Biochem Biophys 374, 334–338.
28DeLuca, HF & Cantorna, MT (2001) Vitamin D: its role and uses in immunology. FASEB J 15, 2579–2585.
29Lemire, JM, Archer, DC, Beck, L & Spiegelberg, HL (1995) Immunosuppressive actions of 1,25(OH)2D3: preferential inhibition of Th1 functions. J Nutr 125, 1704S–1708S.
30Hypponen, E, Laara, E, Reunanen, A, Jarvelin, MR & Virtanen, SM (2001) Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study. Lancet 358, 1500–1503.
31The EURODIAB substudy 2 study group (1999) Vitamin D supplement in early childhood and risk for type I (insulin-dependent) diabetes mellitus. Diabetologia 42, 51–54.
32Cannell, JJ, Vieth, R, Umhau, JC, Holick, MF, Grant, WB, Madronich, S, Garland, CF & Giovannucci, E (2006) Epidemic influenza and vitamin D. Epidemiol Infec 134, 1129–1140.
33Meydani, SN, Han, SN & Wu, D (2005) Vitamin E and immune response in the aged: molecular mechanism and clinical implications. Immunol Rev 205, 269–284.
34Castle, S (2000) Clinical relevance of age-related immune dysfunction. Clin Inf Dis 31, 578–585.
35Burns, EA & Goodwin, JS (2004) Effect of aging on immune function. J Nutr Health Aging 8, 9–18.
36Miller, RA (1996) The aging immune system: primer and prospectus. Science 273, 70–74.
37Meydani, SN, Meydani, M, Blumberg, JB, Leka, LS, Siber, G, Loszewski, R, Thompson, C, Pedrosa, MC, Diamond, RD & Stollar, BD (1997) Vitamin E supplementation and in vivo immune response in healthy elderly subjects. A randomized controlled trial. J Am Med Assoc 277, 1380–1386.
38Meydani, SN, Barklund, MP, Liu, S, Miller, RA, Cannon, JG, Morow, FD, Rocklin, R & Blumberg, JB (1990) Vitamin E supplementation enhances cell-mediated immunity in healthy elderly subjects. Am J Clin Nutr 53, 557–563.
39Pallast, E, Schouten, E, de Waart, F, Fonk, H, Doekes, G, von Blomberg, B & Kok, FJ (1999) Effect of 50- and 100-mg vitamin E supplements on cellular immune function in non-institutionalized elderly persons. Am J Clin Nutr 69, 1273–1281.
40Meydani, SN, Leka, LS, Fine, BC, Dallal, GE, Keusch, GT, Singh, MF & Hamer, DH (2004) Vitamin E and respiratory tract infections in elderly nursing home residents: a randomized controlled trial. J Am Med Assoc 292, 828–836.
41Graat, JM, Schouten, EG & Kok, FJ (2002) Effect of daily vitamin E and multivitamin/multimineral supplementation on acute respiratory tract infections in elderly persons. J Am Med Assoc 288, 715–721.
42De la Fuente, M, Ferrandez, MD, Burgos, MS, Soler, A, Prieto, A & Miquel, J (1998) Immune function in aged women is improved by ingestion of vitamins C and E. Can J Physiol Pharmacol 76, 373–380.
43Park, OJ, Kim, HYP, Kim, WK, Kim, YJ & Kim, SH (2003) Effect of vitamin E supplementation on antioxidant defense systems and humoral immune response in young, middle-aged and elderly Korean women. J Nutr Sci Vitaminol 49, 94–99.
44DeWaart, FG, Portengen, L, Doekes, G, Verwaal, CJ & Kok, FJ (1997) Effect of 3 months vitamin E supplementation on indices of the cellular and humoral immune response in elderly subjects. Br J Nutr 78, 761–774.
45Hara, M, Tanaka, K & Hirota, Y (2005) Immune response to influenza vaccine in healthy adults and the elderly: association with nutritional status. Vaccine 23, 1457–1463.
46Lee, CYJ & Wan, JMF (2000) Vitamin E supplementation improves cell-mediated immunity and oxidative stress of Asian men and women. J Nutr 130, 2932–2937.
47Han, SN, Adolfsson, O, Lee, CK, Prolla, TA, Ordovas, J & Meydani, SN (2004) Vitamin E and gene expression in immune cells. Ann NY Acad Sci 1031, 96–101.
48Hughes, DA (2000) Antioxidant vitamins and immune function. In Nutrition and Immune Function, pp. 171–191 [Calder, PC, Field, CJ and Gill, HS, editors]. Wallingford: CAB International.
49Ames, BN, Shigenaga, MK & Hagen, TM (1993) Oxidants, antioxidants, and the degenerative disease of aging. Proc Natl Acad Sci USA 90, 7915–7922.
50Wintergerst, ES, Maggini, S & Hornig, DH (2006) Immune-enhancing role of vitamin C and zinc and effect on clinical conditions. Ann Nutr Met 50, 85–94.
51Anderson, R, Oosthuizen, R, Maritz, R, Theron, A & Van Rensburg, AJ (1980) The effects of increasing weekly doses of ascorbate on certain cellular and humoral immune functions in normal volunteers. Am J Clin Nutr 33, 71–76.
52Jeng, KC, Yang, CS, Siu, WY, Tsai, YS, Liao, WJ & Kuo, JS (1996) Supplementation with vitamin C and E enhances cytokine production by peripheral blood mononuclear cells in healthy adults. Am J Clin Nutr 64, 960–965.
53Haertel, C, Strunk, T, Bucsky, P & Schultz, C (2004) Effects of vitamin C on intracytoplasmic cytokine production in human whole blood monocytes and lymphocytes. Cytokine 27, 101–106.
54Johnston, CS (1991) Complement component C1q unaltered by ascorbate supplementation in healthy men and women. J Nutr Biochem 2, 499–501.
55Jacob, RA, Kelley, DS, Pianalto, FS, Swendseid, ME, Henning, SM, Zhang, JZ, Ames, BN, Fraga, CG & Peters, JH (1991) Immunocompetence and oxidant defense during ascorbate depletion of healthy men. Am J Clin Nutr 54, 1302S–1309S.
56Panush, RS, Delafuente, JC, Katz, P & Johnson, J (1982) Modulation of certain immunologic responses by vitamin C. III. Potentiation of in vitro and in vivo lymphocyte response. Int J Vitam Nutr Res 23, 35–47.
57Kennes, B, Dumont, I, Brohee, D, Hubert, C & Neve, P (1983) Effect of vitamin C supplements on cell-mediated immunity in older people. Gerontology 29, 305–310.
58Hume, R & Weyers, E (1973) Changes in leukocyte ascorbic acid during the common cold. Scot Med J 18, 3–7.
59Douglas, RM, Hemilä, H, Chalker, E & Treacy, B (2007) Vitamin C for preventing and treating the common cold. In Cochrane Database of Systematic Reviews, .
60Institute of Medicine (1998) Dietary reference intakes for thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline. Washington, D.C.: Food and Nutrition Board, Institute of Medicine, National Academy Press, , pp. 150–195.
61Leklem, JE (2001) Vitamin B6. In Handbook of Vitamins, 3rd ed, revised and expanded. , pp. 339–396 [Rucker, RB, Suttie, JW, McCormick, DB and Machlin, LJ, editors]. New York: Marcel Dekker Inc.
62Chandra, RK & Sudhakaran, L (1990) Regulation of immune responses by vitamin B6. Ann NY Acad Sci 585, 404–423.
63Rall, LC & Meydani, SN (1993) Vitamin B6 and immune competence. Nutr Rev 51, 217–225.
64Trakatellis, A, Dimitriadou, A & Trakatelli, M (1997) Pyridoxine deficiency: new approaches in immunosuppression and chemotherapy. Postgr Med J 73, 617–622.
65Ockhuizen, T, Spanhaak, S, Mares, N, Veenstra, J, Wedel, M, Mulder, J & van den Berg, H (1990) Short-term effects of marginal vitamin B deficiencies on immune parameters in healthy young volunteers. Nutr Res 10, 483–492.
66Miller, LT & Kerkvliet, NT (1990) Effect of vitamin B6 on immune competence in the elderly. Ann NY Acad Sci 587, 49–54.
67Dhur, A, Galan, P & Hercberg, S (1991) Folate status and the immune system. Progr Food Nutr Sci 15, 43–60.
68Courtemanche, C, Elson-Schwab, I, Mashiyuama, ST, Kerry, N & Ames, BN (2004) Folate deficiency inhibits the proliferation of primary human CD8+T lymphocytes in vitro. J Immunol 173, 3186–3189.
69Troen, AM, Mitchell, B, Sorensen, B, Wener, MH, Johnston, A, Wood, B, Selhub, J, McTiernan, A, Yasui, Y, Oral, E, Potter, JD & Ulrich, CM (2006) Unmetabolized folic acid in plasma is associated with reduced natural killer cell cytotoxicity among postmenopausal women. J Nutr 136, 189–194.
70Ravaglia, G, Forti, P, Maioli, F, Bastagli, L, Facchini, A, Mariani, E, Savarino, L, Sassi, S, Cucinotta, D & Lenaz, G (2000) Effect of micronutrient status on natural killer cell immune function in healthy free-living subjects aged ≧90 years. Am J Clin Nutr 71, 590–598.
71Bunout, D, Barrera, G, Hirsch, S, Gattas, V, de la Maza, MP, Haschke, F, Steenhout, P, Klassen, P, Hager, C, Avendano, M, Petermann, M & Munoz, C (2004) Effects of a nutritional supplement on the immune response and cytokine production in free-living Chilean elderly. J Parenteral Enteral Nutr 28, 348–354.
72Bailey, LB & Gregory, JF III (2006) Folate. In Present Knowledge in Nutrition, 9th ed., , pp. 278–301 [Bowman, BA and Russel, RM, editors]. Washington, DC: ILSI Press.
73Tamura, J, Kubota, K, Murakami, H, Sawamura, M, Matsushima, T, Tamura, T, Saitoh, T, Kurabayashi, H & Naruse, T (1999) Immunomodulation by vitamin B12: augmentation of CD8+T lymphocytes and natural killer (NK) cell activity in vitamin B12-deficient patients by methyl-B12 treatment. Clin Exp Immunol 116, 28–32.
74Fata, FT, Herzlich, B, Schiffman, G & Ast, AL (1996) Impaired antibody responses to pneumococcal polysaccharide in elderly patients with low serum vitamin B12 levels. Ann Intern Med 124, 299–304.
75Stabler, SP, Lindenbaum, J & Allen, RH (1997) Vitamin B12 deficiency in the elderly: current dilemmas. Am J Clin Nutr 66, 741–749.
76Arthur, JR, McKenzie, R & Beckett, GJ (2003) Selenium in the immune system. J Nutr 133, 1457S–1459S.
77Ferencik, M & Ebringer, L (2003) Modulatory effects of selenium and zinc on the immune system. Folia Microbiol 48, 417–426.
78Ryan-Harshman, M & Aldoori, W (2005) The relevance of selenium to immunity, cancer, and infectious/inflammatory diseases. Can J Diet Prac Res 66, 98–102.
79Klotz, LO, Kroencke, KD, Buchczyk, DP & Sies, H (2003) Role of copper, zinc, selenium, and tellurium in the cellular defense against oxidative and nitrosative stress. J Nutr 133, 1448S–1451S.
80Prasad, AS (2000) Effects of zinc deficiency on immune functions. J Trace Elem Exp Med 13, 1–30.
81Ibs, KH & Rink, L (2003) Zinc-altered immune function. J Nutr 133, 1452S–1456S.
82Fraker, PJ & King, LE (2004) Reprogramming of the immune system during zinc deficiency. Ann Rev Nutr 24, 277–298.
83Percival, SS (1988) Copper and immunity. Am J Clin Nutr 67, 1064S–1085S.
84Bonham, M, O'Connor, JM, Hannigan, BM & Strain, JJ (2002) The immune system as a physiological indicator of marginal copper status? Br J Nutr 87, 393–403.
85Minatel, L & Carfagnini, JC (2000) Copper deficiency and immune response in ruminants. Nutr Res 2010, 1519–1529.
86Linder, MC & Hazegh-Azam, M (1996) Copper biochemistry and molecular biology. Am J Clin Nutr 63, 797S–811S.
87Pan, YJ & Loo, G (2000) Effect of copper deficiency on oxidative DNA damage in Jurkat T-lymphocytes. Free Rad Biol Med 28, 824–830.
88Weiss, G (2004) Iron. In Diet and Human Immune Function, , pp. 203–215 [Hughes, DA, Darlington, LG and Bendich, A, editors]. Totowa, NJ: Humana Press.
89Schaible, UE & Kaufmann, SHE (2004) Iron and microbial infection. Nature Rev Microbiology 2, 946–953.
90Weiss, G (2002) Iron and immunity: a double-edged sword. Eur J Clin Invest 32, Suppl 1, 70–78.
91Oppenheimer, SJ (2001) Iron and its relation to immunity and infectious disease. J Nutr 131, 616S–635S.