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Sex differences in fat storage, fat metabolism, and the health risks from obesity: possible evolutionary origins

  • Michael L. Power (a1) (a2) and Jay Schulkin (a1) (a3)
  • DOI: http://dx.doi.org/10.1017/S0007114507853347
  • Published online: 01 May 2008
Abstract

Human beings are susceptible to sustained weight gain in the modern environment. Although both men and women can get fat, they get fat in different ways, and suffer different consequences. We review differences between men and women in the incidence of obesity, fat deposition patterns, fat metabolism, and the health consequences of obesity, and examine potential evolutionary explanations for these differences. Women generally have a larger proportion of body mass as fat, and are more likely to deposit fat subcutaneously and on their lower extremities; men are more likely to deposit fat in the abdominal region. Excess adipose tissue in the abdominal region, especially visceral fat, is associated with more health risks. Women have higher rates of reuptake of NEFA into adipose tissue; however, they also have higher rates of fat oxidation during prolonged exercise. Oestrogen appears to underlie many of these differences. Women bear higher nutrient costs during reproduction. Fat and fertility are linked in women, through leptin. Low leptin levels reduce fertility. Ovarian function of adult women is associated with their fatness at birth. In our evolutionary past food insecurity was a frequent occurrence. Women would have benefited from an increased ability to store fat in easily metabolisable depots. We suggest that the pattern of central obesity, more commonly seen in men, is not adaptive, but rather reflects the genetic drift hypothesis of human susceptibility to obesity. Female obesity, with excess adiposity in the lower extremities, reflects an exaggeration of an adaptation for female reproductive success.

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*Corresponding author: Dr Michael L. Power, fax +1 202 554 4346, email mpower@ACOG.ORG
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This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

2AA Hedley , CL Ogden , CL Johnson , MD Carroll , LR Curtin & KM Flegal (2004) Prevalence of overweight and obesity among US children, adolescents, and adults, 1999–2002. JAMA 291, 28472850.

3TR Moore (2004) Adolescent and adult obesity in women: a tidal wave just beginning. Clin Obstet Gynecol 47, 884889.

4J Hebebrand , H Wulftange , T Goerg , A Ziegler , A Hinney , N Barth , H Mayer & H Remschmidt (2000) Epidemic obesity: are genetic factors involved via increased rates of assortative mating? Int J Obesity 24, 345353.

8S Nielson , ZK Guo , M Johnson , DD Hensrud & MD Jensen (2004) Splanchic lipolysis in human obesity. J Clin Invest 113, 15821588.

9G Rodríguez , MP Samper , JL Olivares , P Ventura , LA Moreno & JM Pérez-González (2005) Skinfold measurements at birth: sex and anthropometric influence. Arch Dis Child Fetal Neonatal Ed 90, F273F275.

10Q He , M Horlick , J Thornton , J Wang , RN Pierson Jr, S Heshka & D Gallagher (2004) Sex-specific fat distribution is not linear across pubertal groups in a multiethnic study. Obes Res 12, 725733.

13P Arner (1998) Not all fat is alike. Lancet 351, 13011302.

14SB Racette , JM Hagberg , EM Evans , JO Holloszy & EP Weiss (2006) Abdominal obesity is a stronger predictor of insulin resisitance than fitness among 50–95 year olds. Diabetes Care 29, 673678.

15BH Goodpaster , S Krishnaswami , TB Harris , A Katsiaras , SB Kritchevsky , EM Simonsick , M Nevitt , P Holvoet & AB Newman (2005) Obesity, regional body fat distribution, and the metabolic syndrome in older men and women. Arch Intern Med 165, 777783.

16RE Van Pelt , EM Evans , KB Schechtman , AA Ehsani & WM Kohrt (2002) Contributions of total and regional fat mass to risk for cardiovascular disease in older women. Am J Physiol Endocrinol Metab 282, E1023E1028.

17AD Karelis , DH St-Pierre , F Conus , R Rabasa-Lhoret & ET Poehlman (2004) Metabolic and body composition factors in subgroups of obesity: what do we know? J Clin Endocrinol Metab 89, 25692575.

18A Garg (2004) Regional adiposity and insulin resistance. J Clin Endocrinol Metab 89, 42064210.

19MD Jensen (2006) Is visceral fat involved in the pathogenesis of the metabolic syndrome? Human model. Obesity 14, Suppl., 20S24S.

20S Fujioka , Y Matsuzawa , K Tokunaga & S Tarui (1987) Contribution of intra-abdominal fat accumulation to the impairment of glucose and lipid metabolism in human obesity. Metabolism 36, 5459.

21A Seppälä-Lindroos , S Vehkavaara , AM Hakkinen , T Goto , J Westerbacka , A Sovijarvi , J Halavaara & H Yki-Jarvinen (2002) Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men. J Clin Endocrinol Metab 87, 30233028.

22RN Bergman , SP Kim , KJ Catalano , IR Hsu , JD Chiu , M Kabir , K Hucking & M Ader (2006) Why visceral fat is bad: mechanisms of the metabolic syndrome. Obesity 14, Suppl., 16S19S.

23C Koutsari & MD Jensen (2006) Free fatty acid metabolism in human obesity. J Lipid Res 47, 16431650.

25R Pasquali , S Cantobelli , F Casimirri , M Capelli , L Bortoluzzi , R Flamia , AMM Labate & L Barbara (1993) The hypothalamic-pituitary-adrenal axis in obese women with different patterns of body fat distribution. J Clin Endocrinol Metab 77, 341346.

26P Deurenberg , M Deurenberg-Yap & S Guricci (2002) Asians are different from Caucasians and from each other in their body mass index/body fat per cent relationship. Obes Rev 3, 141146.

27Y-W Park , DB Allison , SB Heymsfield & D Gallagher (2001) Larger amounts of visceral adipose tissue in Asian Americans. Obes Res 9, 381387.

30TJ Tittelbach , DM Berman , BJ Nicklas , AS Ryan & AP Goldberg (2004) Racial differences in adipocyte size and relationship to the metabolic syndrome in obese women. Obes Res 12, 990998.

31N Cossrow & B Falkner (2004) Race/ethnic issues in obesity and obesity-related comorbidities. J Clin Endocrinol Metab 89, 25902594.

32S Nielsen , ZK Guo , JB Albu , S Klein , PC O'Brien & MD Jensen (2003) Energy expenditure, sex, and endogenous fuel availability in humans. J Clin Invest 111, 981988.

33SB Votruba & MD Jensen (2006) Sex-specific differences in leg fat uptake are revealed with a high-fat meal. Am J Physiol Endocrinol Metab 291, E1115E1123.

35LS Lamont (2005) Gender differences in amino acid use during endurance exercise. Nutr Rev 63, 419422.

36MJ Hamadeh , MC Devries & MA Tarnopolsky (2005) Estrogen supplementation reduces whole body leucine and carbohydrate oxidation and increases lipid oxidation in men during endurance exercise. J Clin Endocrinol Metab 90, 35923599.

37LJ Woodhouse , N Gupta , M Bhasin , AB Singh , R Ross , J Phillips & S Bhasin (2004) Dose-dependent effects of testosterone on regional adipose tissue distribution in healthy young men. J Clin Endocrinol Metab 89, 718726.

38R Singh , JN Artaza , WE Taylor , M Braga , X Yuan , NF Gonzalez-Cadavid & S Bhasin (2006) Testosterone inhibits adipogenic differentiation in 3T3-L1 cells: nuclear translocation of androgen receptor complex with β-catenin and T-cell factor 4 may bypass canonical Wnt signaling to down-regulate adipogenic transcription factors. Endocrinology 147, 141154.

39LA Anderson , PG McTernan , AH Barnett & S Kumar (2001) The effects of androgens and estrogens on preadipocyte proliferation in human adipose tissue: influence of gender and site. J Clin Endocrinol Metab 86, 50455051.

40A Tchernof , A Desmeules , C Richard , P Laberge , M Daris , J Mailloux , C Rheaume & P Dupont (2004) Ovarian hormone status and abdominal visceral adipose tissue metabolism. J Clin Endocrinol Metab 89, 34253430.

41SB Pedersen , K Kristensen , PA Hermann , JA Katzenellenbogen & B Richelsen (2004) Estrogen controls lipolysis by up-regulating α2A-adrenergic receptors directly in human adipose tissue through the estrogen receptor α. Implications for the female fat distribution. J Clin Endocrinol Metab 89, 18691878.

42S Rodriguez-Cuenca , M Monjo , AM Proenza & P Roca (2005) Depot differences in steroid receptor expression in adipose tissue: possible role of the local steroid milieu. Am J Physiol Endocrinol Metab 288, E200E207.

43B Richelsen (1986) Increased α 2- but similar β-adrenergic receptor activities in subcutaneous gluteal adipocytes from females compared with males. Eur J Clin Invest 16, 302309.

44EE Kershaw & JS Flier (2004) Adipose tissue as an endocrine organ. J Clin Endocrinol Metab 89, 25482556.

45R Andrew , DIW Phillips & BR Walker (1998) Obesity and gender influence cortisol secretion and metabolism in man. J Clin Endocrinol Metab 83, 18061809.

46E Rask , BR Walker , S Söderber , DEW Livingstone , M Eliasson , O Johnson , R Andrew & T Olsson (2002) Tissue-specific changes in peripheral cortisol metabolism in obese women: increased adipose 11β-hydroxysteroid dehydrogenase type 1 activity. J Clin Endocrinol Metab 87, 33303336.

47PM Stewart , A Boulton , S Kumar , PMS Clark & CHL Shakleton (1999) Cortisol metabolism in human obesity: impaired cortisone to cortisol conversion in subjects with central obesity. J Clin Endocrinol Metab 84, 10221027.

48E Rask , T Olsson , S Söderber , R Andrew , DEW Livingstone , O Johnson & BR Walker (2001) Tissue-specific dysregulation of cortisol metabolism in human obesity. J Clin Endocrinol Metab 86, 14181421.

49M Hallschmid , C Benedict , B Schultes , H-L Fem , J Born & W Kern (2004) Intranasal insulin reduces body fat in men but not in women. Diabetes 53, 30243029.

50DJ Clegg , CA Riedy , KA Smith , SC Benoit & SC Woods (2003) Differential sensitivity to central leptin and insulin in male and female rats. Diabetes 52, 682687.

51DJ Clegg , LM Brown , SC Woods & SC Benoit (2006) Gonadal hormones determine sensitivity to central leptin and insulin. Diabetes 55, 978987.

52J Sierra-Johnson , BD Johnson , KR Bailey & ST Turner (2004) Relationships between insulin sensitivity and measures of body fat in asymptomatic men and women. Obes Res 12, 20702077.

53FH Einstein , G Atzmon , X-M Yang , X-H Ma , M Rincon , E Rudin , R Muzumdar & N Barzilai (2005) Differential responses of visceral and subcutaneous fat depots to nutrients. Diabetes 54, 672678.

54D-M Alexe , G Syridou & ET Petridou (2006) Determinants of early life leptin levels and later life degenerative outcomes. Clin Med Res 4, 326335.

55RE Ostlund , JW Yang , S Klein & R Gingerich (1996) Relation between plasma leptin concentration and body fat, gender, diet, age, and metabolic covariates. J Clin Endocrinol Metab 81, 39093913.

56M Rosenbaum , M Nicolson , J Hirsch , SB Heymsfield , D Gallagher , F Chu & RL Leibel (1996) Effects of gender, body composition, and menopause on plasma concentrations of leptin. J Clin Endocrinol Metab 81, 34243427.

57A Kennedy , TW Gettys , P Watson , P Wallace , E Ganaway , Q Pan & WT Garvey (1997) The metabolic significance of leptin in humans: gender-based differences in relationship to adiposity, insulin sensitivity, and energy expenditure. J Clin Endocrinol Metab 82, 12931300.

58MF Saad , S Damani , RL Gingerich , MG Riad-Gabriel , A Khan , R Boyadjian , SD Jinagouda , K El-Tawil , RK Rude & V Kamdar (1997) Sexual dimorphism in plasma leptin concentration. J Clin Endocrinol Metab 82, 579584.

59X Casabiell , V Piñeiro , R Peino , M Lage , J Camiña , R Gallego , LG Vallejo , C Dieguez & FF Casanueva (1998) Gender differences in both spontaneous and stimulated leptin secretion by human omental adipose tissue in vitro: dexamethasone and estradiol stimulate leptin release in women, but not in men. J Clin Endocrinol Metab 83, 21492155.

60FF Chehab , ME Lim & R Lu (1996) Correction of the sterility defect in homozygous obese female mice by treatment with human recombinant leptin. Nat Genet 12, 318320.

61CJ Ashworth , N Hoggard , L Thomas , JG Mercer , JM Wallace & RG Lea (2000) Placental leptin. Rev Reprod 5, 1824.

62J Leperq , JC Challier , M Guerre-Millo , M Cauzac , H Vidal & S Haugel-de Mouzon (2001) Prenatal leptin production: evidence that fetal adipose tissue produces leptin. J Clin Endocrinol Metab 86, 24092413.

63MC Henson & VD Castracane (2006) Leptin in pregnancy: an update. Biol Reprod 74, 218229.

64S Aquila , M Gentile , E Middea , S Catalano , C Morelli , V Pezzi & S Andò (2005) Leptin secretion by human ejaculated spermatozoa. J Clin Endocrinol Metab 90, 47534761.

65MA McDowell , DJ Brody & JP Hughs (2007) Has age at menarche changed? Results from the National Health and Nutrition Examination Survey (NHANES) 1999–2004. J Adolescent Health 40, 227231.

66JM Lee , D Appugliese , N Kaciroti , RF Corwyn , RH Bradley & JC Lumeng (2007) Weight status in young girls and the onset of puberty. Pediatrics 119, e624e630.

67S Hauguel-de Mouzon , J Lepercq & P Catalano (2006) The known and unknown of leptin in pregnancy. Am J Obstet Gynecol 194, 15371545.

68AJ Jakimiuk , P Skalba , R Huterski , J Haczynski & DA Magoffin (2003) Leptin messenger ribonucleic acid (mRNA) content in the human placenta at term: relationship to levels of leptin in cord blood and placental weight. Gynecol Endocrinol 17, 311316.

69MC Henson & VD Castracane (2000) Leptin in pregnancy. Biol Reprod 63, 12191228.

70SR Sooranna , S Ward & R Bajoria (2001) Fetal leptin influences birth weight in twins with discordant growth. Pediatr Res 49, 667672.

71MC Henson , KF Swan , DE Edwards , GW Hoyle , J Purcell & VD Castracane (2004) Leptin receptor in fetal lung increases in late gestation in the baboon: a model for human pregnancy. Reproduction 127, 8994.

72JR Speakman (2007) A nonadaptive scenario explaining the genetic predisposition to obesity: the “predation release” hypothesis. Cell Metab 6, 511.

74M Sallmén , DP Sandler , JA Hoppin , A Blair & DD Baird (2006) Reduced fertility among overweight and obese men. Epidemiology 17, 520523.

75G Jasienska , A Ziomkiewicz , SF Lipson , I Thune & PT Ellison (2005) High ponderal index at birth predicts high estradiol levels in adult women. Am J Hum Biol 18, 133140.

76G Jasienska , I Thune & PT Ellison (2006) Fatness at birth predicts adult susceptibility to ovarian suppression: an empirical test of the Predictive Adaptive Response hypothesis. PNAS 103, 1275912762.

77ES Berk , AJ Kovera , CN Boozer , FX Pi-Sunyer & JB Albu (2006) Metabolic inflexibility in substrate use is present in African-American but not Caucasian healthy, premenopausal, nondiabetic women. J Clin Endocrinol Metab 91, 40994106.

78ME Cogswell , GS Perry , LA Schieve & WH Dietz (2001) Obesity in women of childbearing age: risks, prevention, and treatment. Prim Care Update Ob Gyns 8, 89105.

79CK Yu , TG Teoh & S Robinson (2006) Obesity in pregnancy. BJOG 113, 11171125.

80PM Catalano & HM Ehrenberg (2006) The short- and long-term implications of maternal obesity on the mother and her offspring. BJOG 113, 11261133.

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