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Sex-specific association between Chinese visceral adiposity index and hyperuricaemia among adults: a population-based cross-sectional study in Chongqing, China

Published online by Cambridge University Press:  04 April 2025

Youxing Luo ,
Rui Ding ,
Liling Chen ,
Yanqi Hu ,
Meng Xiao ,
Wenge Tang ,
Jinfu Qiu ,
Xiang Liu ,
Xianbin Ding  and
Xiaojun Tang Open the ORCID record for Xiaojun Tang [Opens in a new window]
Youxing Luo
Affiliation:
School of Public Health, Research Center for Medical and Social Development, Chongqing Medical University, Chongqing 400016, People’s Republic of China
Rui Ding
Affiliation:
First Clinical Medical College, Chongqing Medical University, Chongqing 400016, People’s Republic of China
Liling Chen
Affiliation:
Institute of Chronic Non-Communicable Disease Control and Prevention, Chongqing Center for Disease Control and Prevention, Chongqing 400707, People’s Republic of China
Yanqi Hu
Affiliation:
School of Public Health, Research Center for Medical and Social Development, Chongqing Medical University, Chongqing 400016, People’s Republic of China
Meng Xiao
Affiliation:
School of Public Health, Research Center for Medical and Social Development, Chongqing Medical University, Chongqing 400016, People’s Republic of China
Wenge Tang
Affiliation:
Institute of Chronic Non-Communicable Disease Control and Prevention, Chongqing Center for Disease Control and Prevention, Chongqing 400707, People’s Republic of China
Jinfu Qiu
Affiliation:
School of Public Health, Research Center for Medical and Social Development, Chongqing Medical University, Chongqing 400016, People’s Republic of China
Xiang Liu
Affiliation:
Department of Epidemiology and Health Statistics, West China School of Public Health, Sichuan University, Chengdu 610041, Sichuan, People’s Republic of China
Xianbin Ding*
Affiliation:
Institute of Chronic Non-Communicable Disease Control and Prevention, Chongqing Center for Disease Control and Prevention, Chongqing 400707, People’s Republic of China
Xiaojun Tang*
Affiliation:
School of Public Health, Research Center for Medical and Social Development, Chongqing Medical University, Chongqing 400016, People’s Republic of China
*
Corresponding authors: Xianbin Ding; Email: xianbinding@126.com; Xiaojun Tang; Email: tangxiaojun@cqmu.edu.cn
Corresponding authors: Xianbin Ding; Email: xianbinding@126.com; Xiaojun Tang; Email: tangxiaojun@cqmu.edu.cn
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Abstract

Research on the association between the Chinese visceral adiposity index (CVAI) and hyperuricaemia (HUA) is scarce, and whether the association differs by sex is unclear. This research aimed to explore sex-specific associations between CVAI and HUA and to compare CVAI’s predictive performance with other adiposity indices using data from 22 171 adults (30–79 years) in the China Multi-Ethnic Cohort study (Chongqing region). The prevalence of HUA was 20·9 % in men and 9·7 % in women. Multivariable logistic regression analyses were utilised to assess the adjusted OR and 95 % CI. After multivariable adjustment, CVAI was associated with HUA in men (OR Q4 v. Q1 = 3·31, 95 % CI 2·73, 4·03) and women (OR Q4 v. Q1 = 7·20, 95 % CI 5·12, 10·12). Moreover, significant interactions were observed between BMI and CVAI on HUA in both sexes (all Pinteraction < 0·001), with the strongest associations in those with BMI < 24·0 kg/m2. The OR (95 % CI) across different BMI groups (< 24·0, 24·0–27·9, ≥ 28·0 kg/m²) were 1·87 (1·63, 2·13), 1·65 (1·48, 1·85) and 1·30 (1·14, 1·49) for men and 2·76 (2·18, 3·51), 2·46 (1·98, 3·07) and 1·87 (1·47, 2·39) for women, respectively. Additionally, CVAI showed satisfactory predictive performance for HUA in women, with the largest area under the receiver operating characteristic curve of 0·735, but not in men (0·660). These findings suggest a close association between CVAI and HUA, particularly pronounced in those with BMI < 24·0 kg/m², and a stronger association in women than in men.

Keywords

Chinese visceral adiposity indexHyperuricaemiaAdiposity indicesAdultsCross-sectional study

Information

Type
Research Article
Information
British Journal of Nutrition , Volume 133 , Issue 9 , 14 May 2025 , pp. 1157 - 1166
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Copyright
© The Author(s), 2025. Published by Cambridge University Press on behalf of The Nutrition Society

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