Aasen, G, Fagertun, H & Halse, J (2006) Body composition analysis by dual X-ray absorptiometry: in vivo and in vitro comparison of three different fan-beam systems. Scand J Clin Lab Invest 66, 659–666.
Akahoshi, A, Goto, Y, Murao, K, Miyazaki, T, Yamasaki, M, Nonaka, M, Yamada, K & Sugano, M (2002) Conjugated linoleic acid reduces body fats and cytokine levels of mice. Biosci Biotech Biochem 66, 916–920.
Albers, R, van der Wielen, R, Brink, E, Hendriks, H, Dorovska-Taran, V & Mohede, I (2003) Effects of cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid (CLA) isomers on immune function in healthy men. Eur J Clin Nutr 57, 595–603.
Atkinson, R (1999) Conjugated linoleic acid for altering body composition and treating obesity In , pp. 348–353 [Yurawecz, M, Mossoba, M, Kramer, J, Pariza, M and Nelson, G, editors]. Champaign, IL: AOCS Press.
Bassaganya-Riera, J, Pogranichniy, RM, Jobgen, SC, Halbur, PG, Yoon, KJ, O'Shea, M, Mohede, I & Hontecillas, R (2003) Conjugated linoleic acid ameliorates viral infectivity in a pig model of virally induced immunosuppression. J Nutr 133, 3204–3214.
Bassaganya-Riera, J, Reynolds, K, Martino-Catt, S, Cui, YZ, Hennighausen, L, Gonzalez, F, Rohrer, J, Benninghoff, AU & Hontecillas, R (2004) Activation of PPAR gamma and delta by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease. Gastroenterology 127, 777–791.
Basu, S, Riserus, U, Turpeinen, A & Vessby, B (2000 a) Conjugated linoleic acid induces lipid peroxidation in men with abdominal obesity. Clin Sci (Lond) 99, 511–516.
Basu, S, Smedman, A & Vessby, B (2000 b) Conjugated linoleic acid induces lipid peroxidation in humans. FEBS Lett 468, 33–36.
Belury, M, Mahon, A & Banni, S (2003) The conjugated linoleic acid (CLA) isomer, t10c12-CLA, is inversely associated with changes in body weight and serum leptin in subjects with type 2 diabetes mellitus. J Nutr 133, 257S–260S.
Berven, G, Bye, A, Hals, O, Blankson, H, Fagertun, H, Thom, E, Wadstein, J & Gudmundsen, O (2000) Safety of conjugated linoleic acid (CLA) in overweight or obese human volunteers. Eur J Lipid Sci Technol 102, 455–462.
Bhattacharya, A, Rahman, MM, Sun, DX, Lawrence, R, Mejia, W, McCarter, R, O'Shea, M & Fernandes, G (2005) The combination of dietary conjugated linoleic acid and treadmill exercise lowers gain in body fat mass and enhances lean body mass in high fat-fed male Balb/C mice. J Nutr 135, 1124–1130.
Blankson, H, Stakkestad, J, Fagertun, H, Thom, E, Wadstein, J & Gudmundsen, O (2000) Conjugated linoleic acid reduces body fat mass in overweight and obese humans. J Nutr 130, 2943–2948.
Cook, M, Miller, C, Park, Y & Pariza, M (1993) Immune modulation by altered nutrient metabolism: nutritional control of immune-induced growth depression. Poult Sci 72, 1301–1305.
Corino, C, Mourot, J, Magni, S, Pastorelli, G & Rosi, F (2002) Influence of dietary conjugated linoleic acid on growth, meat quality, lipogenesis, plasma leptin and physiological variables of lipid metabolism in rabbits. J Anim Sci 80, 1020–1028.
Cox, KL, Burke, V, Morton, AR, Beilin, LJ & Pudley, IB (2003) The independent and combined effect of 16 weeks of vigorous exercise and energy restriction on body mass and composition in free-living overweight men – a randomized controlled trial. Metabolism 52, 107–115.
Cunningham, D, Harrison, L & Shultz, T (1997) Proliferative responses of normal human mammary and MCF-7 breast cancer cells to linoleic acid, conjugated linoleic acid and eicosanoid synthesis inhibitors in culture. Anticancer Res 17, 197–203.
DeLany, J, Blohm, F, Truett, A, Scimeca, J & West, D (1999) Conjugated linoleic acid rapidly reduces body fat content in mice without affecting energy intake. Am J Physiol 276, R1172–R1179.
Dugan, M, Aalhus, J, Schaefer, A & Kramer, J (1997) The effects of conjugated linoleic acid on fat to lean repartitioning and feed conversion in pigs. Can J Anim Sci 77, 723–725.
Evans, M, Geigerman, C, Cook, J, Curtis, L, Kuebler, B & McIntosh, M (2000) Conjugated linoleic acid suppresses triglyceride accumulation and induces apoptosis in 3T3-L1 preadipocytes. Lipids 35, 899–910.
Eyjolfson, V, Spriet, LL & Dyck, DJ (2004) Conjugated linoleic acid improves insulin sensitivity in young, sedentary humans. Med Sci Sport Exercise 36, 814–820.
Gaullier, J-M, Berven, G, Blankson, H & Gudmundsen, O (2002) Clinical trial results support a preference for using CLA preparations enriched with two isomers rather than four isomers in human studies. Lipids 37, 1019–1025.
Gaullier, JM, Halse, J, Høye, K, Kristiansen, K, Fagertun, H, Vik, H & Gudmundsen, O (2004) Conjugated linoleic acid (CLA) supplementation for one year reduces body fat mass in healthy, overweight humans. Am J Clin Nutr 79, 1118–1125.
Gaullier, JM, Halse, J, Høye, K, Kristiansen, K, Fagertun, H, Vik, H & Gudmundsen, O (2005) Supplementation with conjugated linoleic acid for 24 months is well tolerated by and reduces body fat mass in healthy, overweight humans. J Nutr 135, 778–784.
Gavino, V, Gavino, G, Leblanc, M & Tuchweber, B (2000) An isomeric mixture of conjugated linoleic acids but not pure cis-9, trans-11-octadecadienoic acid affects body weight gain and plasma lipids in hamsters. J Nutr 130, 27–29.
Glickman, SG, Marn, CS, Supiano, MA & Dengel, DR (2004) Validity and reliability of dual-energy X-ray absorptiometry for the assessment of abdominal adiposity. J Appl Physiol 97, 509–514.
Granlud, L, Juvet, L, Pedersen, J & Nebb, H (2003) Trans 10, cis 12 conjugated linoleic acid prevents triacylglycerol accumulation in adipocytes by acting as a PPARgamma modulator. J Lipid Res 44, 1441–1452.
Hall, TR & Young, TB (1989) A validation study of body fat distribution as determined by self-measurement of waist and hip circumference. Int J Obes 13, 801–807.
Hara, M, Saikawa, T, Kurokawa, M, Sakata, T & Yoshimatsu, H (2004) Leg fat percentage correlates negatively with coronary atherosclerosis. Circ J 68, 1173–1178.
Houseknecht, K, Vanden Heuvel, J, Moya-Camarena, S, Portocarrero, C, Peck, L, Nickel, K & Belury, M (1998) Dietary conjugated linoleic acid normalizes impaired glucose tolerance in the Zucker diabetic fatty fa/fa rat. Biochem Biophys Res Commun 244, 678–682.
Ip, C, Singh, M, Thompson, H & Scimeca, J (1994) Conjugated linoleic acid suppresses mammary carcinogenesis and proliferative activity of the mammary gland in the rat. Cancer Res 54, 1212–1215.
Kallen, CB & Lazar, MA (1996) Antidiabetic thiazolidinediones inhibit leptin ob gene expression in 3T3-L1 adipocytes. Proc Natl Acad Sci USA 93, 5793–5796.
Kirchengast, S, Gruber, D, Sator, M, Knogler, W & Huber, J (1998) The impact of nutritional status on body fat distribution patterns in pre- and postmenopausal females. J Biosoc Sci 30, 145–154.
Kreider, R, Ferreira, M, Greenwood, M, Wilson, M & Almada, A (2002) Effects of conjugated linoleic acid supplementation during resistance-training on body composition, bone density, strength, and selected hematological markers. J Strength Cond Res 3, 325–334.
Lee, K, Kritchevsky, D & Pariza, M (1994) Conjugated linoleic acid and atherosclerosis in rabbits. Atherosclerosis 108, 19–25.
Liew, C, Schut, H, Chin, S, Pariza, M & Dashwood, R (1995) Protection of conjugated linoleic acids against 2-amino-3-methylimidazo[4,5-f]quinoline-induced colon carcinogenesis in the F344 rat: a study of inhibitory mechanisms. Carcinogenesis 16, 3037–3043.
Lowery, L, Appicelli, P & Lemon, P (1998) Conjugated linoleic acid enhances muscle size and strength gains in novice bodybuilders. (Abstract 1038). Med Sci Sports Exerc 30, 182.
Miller, C, Park, Y, Pariza, M & Cook, M (1994) Feeding conjugated linoleic acid. Biochem Biophys Res Commun 198, 1107–1112.
Moloney, F, Yeow, TP, Mullen, A, Nolan, JJ & Roche, HM (2004) Conjugated linoleic acid supplementation, insulin sensitivity, and lipoprotein metabolism in patients with type 2 diabetes mellitus. Am J Clin Nutr 80, 887–895.
Mueller, WH & Joos, SK (1985) Android (centralized) obesity and somatotypes in men: association with mesomorphy. Ann Hum Biol 12, 377–381.
Nes, M, Andersen, L, Solovoll, K, Sandstad, B, Hustvedt, B, Løvø, A & Drevon, C (1992) Accuracy of a quantitative food frequency questionnaire applied in elderly Norwegian women. Eur J Clin Nutr 46, 809–821.
Nicolosi, R, Rogers, E, Kritchevsky, D, Scimeca, J & Huth, P (1997) Dietary conjugated linoleic acid reduces plasma lipoproteins and early aortic atherosclerosis in hypercholesterolemic hamsters. Artery 22, 266–277.
Noone, E, Roche, H, Nugent, A & Gibney, M (2002) The effect of dietary supplementation using isomeric blends of conjugated linoleic acid on lipid metabolism in healthy human subjects. Br J Nutr 88, 243–251.
Ostrowska, E, Suster, D, Muralitharan, M, Cross, RF, Leury, BJ, Bauman, DE & Dunshea, FR (2003) Conjugated linoleic acid decreases fat accretion in pigs: evaluation by dual-energy X-ray absorptiometry. Br J Nutr 89, 219–229.
Park, Y, Albright, K, Storkson, J, Liu, W, Cook, M & Pariza, M (1999) Changes in body composition in mice during feeding and withdrawal of conjugated linoleic acid. Lipids 34, 243–248.
Park, Y & Pariza, M (2001) Lipoxygenase inhibitors inhibit heparin-releasable lipoprotein lipase activity in 3T3-L1 adipocytes and enhance body fat reduction in mice by conjugated linoleic acid. Biochim Biophys Acta 1534, 27–33.
Rahman, S, Wang, Y, Han, S, Cha, J, Fukuda, N, Yotsumoto, H & Yanagita, T (2001) Effects of short-term administration of conjugated linoleic acid on lipid metabolism in white and brown adipose tissues of starved/refed Otsuka Long-Evans Tokushima Fatty rats. Food Res Int 34, 515–520.
Ramakers, JD, Plat, J, Sebedio, JL & Mensink, RP (2005) Effects of the individual isomers cis-9, trans-11 vs. trans-10,cis-12 of conjugated linoleic acid (CLA) on inflammation parameters in moderately overweight subjects with LDL-phenotype B. Lipids 40, 909–918.
Reaven, G (2005) All obese individuals are not created equal: insulin resistance is the major determinant of cardiovascular disease in overweight/obese individuals. Diab Vasc Dis Res 2, 105–112.
Riserus, U, Arner, P, Brismar, K & Vessby, B (2002 a) Treatment with dietary trans10cis12 conjugated linoleic acid causes isomer-specific insulin resistance in obese men with the metabolic syndrome. Diabetes Care 25, 1516–1521.
Riserus, U, Basu, S, Jovinge, S, Fredrikson, G, Arnlov, J & Vessby, B (2002 b) Supplementation with conjugated linoleic acid causes isomer-dependent oxidative stress and elevated C-reactive protein: a potential link to fatty acid-induced insulin resistance. Circulation 106, 1925–1929.
Riserus, U, Berglund, L & Vessby, B (2001) Conjugated linoleic acid (CLA) reduced abdominal adipose tissue in obese middle-aged men with signs of the metabolic syndrome: a randomised controlled trial. Int J Obes Relat Metab Disord 25, 1129–1135.
Riserus, U, Vessby, B, Arner, P & Zethelius, B (2004 a) Supplementation with trans10cis12-conjugated linoleic acid induces hyperproinsulinaemia in obese men: close association with impaired insulin sensitivity. Diabetologia 47, 1016–1019.
Riserus, U, Vessby, B, Arnlov, J & Basu, S (2004 b) Effects of cis-9,trans-11 conjugated linoleic acid supplementation on insulin sensitivity, lipid peroxidation, and proinflammatory markers in obese men. Am J Clin Nutr 80, 279–283.
Salamone, LM, Fuerst, T, Visser, M, Kern, M, Lang, T, Dockrell, M, Cauley, JA, Nevitt, M, Tylavsky, F & Lohman, T (2000) Measurement of fat mass using DEXA: a validation study in elderly adults. J Appl Physiol 89, 345–352.
Schonberg, S & Krokan, H (1995) The inhibitory effect of conjugated dienoic derivatives (CLA) of linoleic acid on the growth of human tumor cell lines is in part due to increased lipid peroxidation. Anticancer Res 15, 1241–1246.
Song, HJ, Grant, I, Rotondo, D, Mohede, I, Sattar, N, Heys, SD & Wahle, KW (2005) Effect of CLA supplementation on immune function in young healthy volunteers. Eur J Clin Nutr 59, 508–517.
Soriano, JM, Ioannidou, E, Wang, J, Thornton, JC, Horlick, MN, Gallagher, D, Heymsfield, SB & Pierson, RN (2004) Pencil-beam vs fan-beam dual-energy X-ray absorptiometry comparison across four systems: body composition and bone mineral. J Clin Densitom 7, 281–289.
Szymczyk, B, Pisulewski, P, Szczurek, W & Hanczakowski, P (2001) Effects of conjugated linoleic acid on growth performance, feed conversion efficiency, and subsequent carcass quality in broiler chickens. Br J Nutr 85, 465–473.
Terpstra, A (2001) Differences between humans and mice in efficacy of the body fat lowering effect of conjugated linoleic acid: role of metabolic rate. J Nutr 131, 2067–2068.
Thom, E, Wadstein, J & Gudmundsen, O (2001) Conjugated linoleic acid reduces body fat in healthy exercising humans. J Int Med Res 29, 392–396.
Tricon, S, Burdge, GC, Kew, S, Banerjee, T, Russell, JJ, Grimble, RF, Williams, CM, Calder, PC & Yaqoob, P (2004) Effects of cis-9,trans-11 and trans-10,cis-12 conjugated linoleic acid on immune cell function in healthy humans. Am J Clin Nutr 80, 1626–1633.
Tylavsky, FA, Lohman, TG, Dockrell, M, Lang, T, Schoeller, DA, Wan, JY, Fuerst, T, Cauley, JA, Nevitt, M & Harris, TB (2003) Comparison of the effectiveness of 2 dual-energy X-ray absorptiometers with that of total body water and computed tomography in assessing changes in body composition during weight change. Am J Clin Nutr 77, 356–363.
Vessby, B & Smedman, A (1999) Conjugated linoleic acid (CLA) reduces the body fat content in humans. Abstract Section, Chemistry and Physics of Lipids 101, 141–213. .
Wallner, SJ, Luschnigg, N, Schnedl, WJ, Lahousen, T, Sudi, K, Crailsheim, K, Möller, R, Taifet, E & Horejsi, R (2004) Body fat distribution of overweight females with a history of weight cycling. Int J Obes Relat Metab Disord 28, 1143–1148.
Wargent, E, Sennit, MV, Stocker, C, et al. (2005) Prolonged treatment of genetically obese mice with conjugated linoleic acid improves glucose tolerance and lowers plasma insulin concentration: possible involvement of PPAR activation. Lipids Health Dis 4, 3.
West, D, DeLany, J, Camet, P, Blohm, F, Truett, A & Scimeca, J (1998) Effects of conjugated linoleic acid on body fat and energy metabolism in the mouse. Am J Physiol 275, R667–R672.
Whigham, LD, O'Shea, M, Mohede, ICM, Walaski, HP & Atkinson, RL (2004) Safety profile of conjugated linoleic acid in a 12-month trial in obese humans. Food Chem Toxicol 42, 1701–1709.
Wong, M, Chew, B, Wong, T, Hosick, H, Boylston, T & Shultz, T (1997) Effects of dietary conjugated linoleic acid on lymphocyte function and growth of mammary tumors in mice. Anticancer Res 17, 987–993.
Woodhouse, LJ, Gupta, N, Bhasin, M, Singh, AB, Ross, R, Phillips, J & Bhasin, S (2004) Dose-dependent effects of testosterone on regional adipose tissue distribution in healthy young men. J Clin Endocrinol Metab 89, 718–726.
Yusuf, S, Hawken, S, Ounpuu, S, et al. (2005) Obesity and the risk of myocardial infarction in 27,000 participants from 52 countries: a case-control study. Lancet 366, 1640–1649.
Zachwieja, JJ, Ezell, DM, Cline, AD, Ricketts, JC, Vicknair, PC, Schorle, SM & Ryan, DH (2001) Short-term dietary energy restriction reduces lean body mass but not performance in physically active men and women. Int J Sports Med 22, 310–316.
Zambell, K, Keim, N, Van Loan, M, Gale, B, Benito, P, Kelley, D & Nelson, G (2000) Conjugated linoleic acid supplementation in humans: effects on body composition and energy expenditure. Lipids 35, 777–782.
Zu, H & Schut, H (1992) Inhibition of 2-amino-3-methylimidazo[4,5-f]quinoline-DNA adduct formation in CDF1 mice by heat-altered derivatives of linoleic acid. Food Chem Toxicol 30, 9–16.