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Study of potential cardioprotective effects of Ganoderma lucidum (Lingzhi): results of a controlled human intervention trial

  • Tanya T. W. Chu (a1), Iris F. F. Benzie (a2), Christopher W. K. Lam (a3), Benny S. P. Fok (a1), Kenneth K. C. Lee (a4) and Brian Tomlinson (a1)...

Abstract

Previous studies have suggested that Lingzhi (Ganoderma lucidum) has antioxidant effects and possibly beneficial effects on blood pressure, plasma lipids and glucose, but these have not been confirmed in subjects with mild hypertension or hyperlipidaemia. The objective of the present study was to assess the cardiovascular, metabolic, antioxidant and immunomodulatory responses to therapy with Lingzhi in patients with borderline elevations of blood pressure and/or cholesterol in a controlled cross-over trial. A total of twenty-six patients received 1·44 g Lingzhi daily or matching placebo for 12 weeks in a randomised, double-blind, cross-over study with placebo-controlled run-in and cross-over periods. Body weight, blood pressure, metabolic parameters, urine catecholamines and cortisol, antioxidant status and lymphocyte subsets were measured after each period. Lingzhi was well tolerated and data from twenty-three evaluable subjects showed no changes in BMI or blood pressure when treated with Lingzhi or placebo. Plasma insulin and homeostasis model assessment-insulin resistance were lower after treatment with Lingzhi than after placebo. TAG decreased and HDL-cholesterol increased with Lingzhi but not with placebo in the first treatment period, but significant carry-over effects prevented complete analysis of these parameters. Urine catecholamines and cortisol, plasma antioxidant status and blood lymphocyte subsets showed no significant differences across treatments. Results indicate that Lingzhi might have mild antidiabetic effects and potentially improve the dyslipidaemia of diabetes, as shown previously in some animal studies. Further studies are desirable in patients with hyperglycaemia.

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Corresponding author

*Corresponding author: Professor B. Tomlinson, fax +852 2632 3139, email btomlinson@cuhk.edu.hk

References

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1 Yuen, JW & Gohel, MD (2005) Anticancer effects of Ganoderma lucidum: a review of scientific evidence. Nutr Cancer 53, 1117.
2 Boh, B, Berovic, M, Zhang, J, et al. (2007) Ganoderma lucidum and its pharmaceutically active compounds. Biotechnol Annu Rev 13, 265301.
3 Shiao, MS (2003) Natural products of the medicinal fungus Ganoderma lucidum: occurrence, biological activities, and pharmacological functions. Chem Rec 3, 172180.
4 Komoda, Y, Shimizu, M, Sonoda, Y, et al. (1989) Ganoderic acid and its derivatives as cholesterol synthesis inhibitors. Chem Pharm Bull (Tokyo) 37, 531533.
5 Lee, SY & Rhee, HM (1990) Cardiovascular effects of mycelium extract of Ganoderma lucidum: inhibition of sympathetic outflow as a mechanism of its hypotensive action. Chem Pharm Bull (Tokyo) 38, 13591364.
6 Lee, JM, Kwon, H, Jeong, H, et al. (2001) Inhibition of lipid peroxidation and oxidative DNA damage by Ganoderma lucidum. Phytother Res 15, 245249.
7 Zhu, M, Chang, Q, Wong, LK, et al. (1999) Triterpene antioxidants from Ganoderma lucidum. Phytother Res 13, 529531.
8 Lai, KN, Chan, LY, Tang, SC, et al. (2006) Ganoderma extract prevents albumin-induced oxidative damage and chemokines synthesis in cultured human proximal tubular epithelial cells. Nephrol Dial Transplant 21, 11881197.
9 Hikino, H, Konno, C, Mirin, Y, et al. (1985) Isolation and hypoglycemic activity of ganoderans A and B, glycans of Ganoderma lucidum fruit bodies 1. Planta Med 51, 339340.
10 Zhang, HN & Lin, ZB (2004) Hypoglycemic effect of Ganoderma lucidum polysaccharides. Acta Pharmacol Sin 25, 191195.
11 Seto, SW, Lam, TY, Tam, HL, et al. (2009) Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db) mice. Phytomedicine 16, 426436.
12 Wachtel-Galor, S, Szeto, YT, Tomlinson, B, et al. (2004) Ganoderma lucidum (‘Lingzhi’); acute and short-term biomarker response to supplementation. Int J Food Sci Nutr 55, 7583.
13 Wachtel-Galor, S, Tomlinson, B & Benzie, IF (2004) Ganoderma lucidum (‘Lingzhi’), a Chinese medicinal mushroom: biomarker responses in a controlled human supplementation study. Br J Nutr 91, 263269.
14 Stewart, PM (2003) Tissue-specific Cushing's syndrome, 11beta-hydroxysteroid dehydrogenases and the redefinition of corticosteroid hormone action. Eur J Endocrinol 149, 163168.
15 Heaney, AP, Ferguson, T, Sheridan, B, et al. (1995) Cortisol excretion in essential hypertension. J Hum Hypertens 9, 947951.
16 Csabi, GY, Juricskay, S & Molnar, D (2000) Urinary cortisol to cortisone metabolites in hypertensive obese children. J Endocrinol Invest 23, 435439.
17 van Uum, SH, Lenders, JW & Hermus, AR (2004) Cortisol, 11beta-hydroxysteroid dehydrogenases, and hypertension. Semin Vasc Med 4, 121128.
18 Benzie, IF & Strain, JJ (1996) The ferric reducing ability of plasma (FRAP) as a measure of ‘antioxidant power’: the FRAP assay. Anal Biochem 239, 7076.
19 Benzie, IF, Chung, W & Tomlinson, B (1999) Simultaneous measurement of allantoin and urate in plasma: analytical evaluation and potential clinical application in oxidant:antioxidant balance studies. Clin Chem 45, 901904.
20 Thurnham, DI, Davies, JA, Crump, BJ, et al. (1986) The use of different lipids to express serum tocopherol:lipid ratios for the measurement of vitamin E status. Ann Clin Biochem 23, 514520.
21 Taylor, RL, Machacek, D & Singh, RJ (2002) Validation of a high-throughput liquid chromatography-tandem mass spectrometry method for urinary cortisol and cortisone. Clin Chem 48, 15111519.
22 Schwartz, SL (2006) Diabetes and dyslipidaemia. Diabetes Obes Metab 8, 355364.
23 Kobayashi, K, Forte, TM, Taniguchi, S, et al. (2000) The db/db mouse, a model for diabetic dyslipidemia: molecular characterization and effects of Western diet feeding. Metabolism 49, 2231.
24 de Vries-van der Weij, J, Zadelaar, S, Toet, K, et al. (2009) Human CETP aggravates atherosclerosis by increasing VLDL-cholesterol rather than by decreasing HDL-cholesterol in APOE*3-Leiden mice. Atherosclerosis 206, 153158.
25 MacLean, PS, Bower, JF, Vadlamudi, S, et al. (2003) Cholesteryl ester transfer protein expression prevents diet-induced atherosclerotic lesions in male db/db mice. Arterioscler Thromb Vasc Biol 23, 14121415.
26 Tam, LS, Tomlinson, B, Chu, TT, et al. (2007) Impact of TNF inhibition on insulin resistance and lipids levels in patients with rheumatoid arthritis. Clin Rheumatol 26, 14951498.
27 Tchernof, A, Lamarche, B, Prud'Homme, D, et al. (1996) The dense LDL phenotype. Association with plasma lipoprotein levels, visceral obesity, and hyperinsulinemia in men. Diabetes Care 19, 629637.
28 Wang, SY, Hsu, ML, Hsu, HC, et al. (1997) The anti-tumor effect of Ganoderma lucidum is mediated by cytokines released from activated macrophages and T lymphocytes. Int J Cancer 70, 699705.
29 Li, EK, Tam, LS, Wong, CK, et al. (2007) Safety and efficacy of Ganoderma lucidum (lingzhi) and San Miao San supplementation in patients with rheumatoid arthritis: a double-blind, randomized, placebo-controlled pilot trial. Arthritis Rheum 57, 11431150.
30 Xi Bao, Y, Kwok Wong, C, Kwok Ming Li, E, et al. (2006) Immunomodulatory effects of lingzhi and san-miao-san supplementation on patients with rheumatoid arthritis. Immunopharmacol Immunotoxicol 28, 197200.
31 Lam, FF, Ko, IW, Ng, ES, et al. (2008) Analgesic and anti-arthritic effects of Lingzhi and San Miao San supplementation in a rat model of arthritis induced by Freund's complete adjuvant. J Ethnopharmacol 120, 4450.
32 Wicks, SM, Tong, R, Wang, CZ, et al. (2007) Safety and tolerability of Ganoderma lucidum in healthy subjects: a double-blind randomized placebo-controlled trial. Am J Chin Med 35, 407414.
33 Armanini, D, Fiore, C, Mattarello, MJ, et al. (2002) History of the endocrine effects of licorice. Exp Clin Endocrinol Diabetes 110, 257261.
34 Sigurjonsdottir, HA, Manhem, K, Axelson, M, et al. (2003) Subjects with essential hypertension are more sensitive to the inhibition of 11 beta-HSD by liquorice. J Hum Hypertens 17, 125131.
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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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