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Supplementation with a juice powder concentrate and exercise decrease oxidation and inflammation, and improve the microcirculation in obese women: randomised controlled trial data

  • Manfred Lamprecht (a1) (a2), Georg Obermayer (a1) (a2), Kurt Steinbauer (a3), Gerhard Cvirn (a1), Lidija Hofmann (a4), Gerhard Ledinski (a1), Joachim F. Greilberger (a1) (a5) and Seth Hallstroem (a1)...
Abstract

Obesity and sedentary lifestyle are associated with increased oxidative stress, inflammation and vessel dysfunction. Previous research has shown that an encapsulated fruit/berry/vegetable juice powder (FBV) supplement or controlled exercise training improve the markers of redox biology, low-grade inflammation and circulation. The aim of the present study was to assess the effects of 8 weeks of supplementation with FBV or placebo, and a single bout of controlled walking on the markers of oxidation, inflammation and skin capillary microcirculation in forty-two obese pre-menopausal women (41 (sd 5) years, non-smokers and BMI 34·5 (sd 3·8) kg/m2) using a randomised, double-blind, placebo-controlled design. All assessments were made before and after 8 weeks of capsule supplementation, and pre- and post-30 min of controlled treadmill walking at 70 % of VO2max. Venous blood was collected for the determination of carbonyl proteins (CP), oxidised LDL (ox-LDL), total oxidation status (TOS) of lipids, malondialdehyde, TNF-α and IL-6. Capillary blood flow, O2 saturation of Hb (SO2Hb) and the relative concentration of Hb (rHb) were assessed at a 2 mm skin depth. Following 8 weeks of supplementation, compared with placebo, the FBV group had a significant (P< 0·05) reduction in CP, ox-LDL, TOS and TNF-α, and a significant increase in blood flow, SO2Hb and rHb. Independent of supplementation, moderate exercise significantly increased blood flow and rHb, with a trend towards increased SO2Hb. Compared with placebo, 8 weeks of supplementation with FBV decreased the markers of systemic oxidation and inflammation. Both FBV supplementation and a single walking bout improved the markers of the microcirculation in these obese women.

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      Supplementation with a juice powder concentrate and exercise decrease oxidation and inflammation, and improve the microcirculation in obese women: randomised controlled trial data
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      Supplementation with a juice powder concentrate and exercise decrease oxidation and inflammation, and improve the microcirculation in obese women: randomised controlled trial data
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The online version of this article is published within an Open Access environment subject to the conditions of the Creative Commons Attribution licence < http://creativecommons.org/licenses/by/3.0/>.
Corresponding author
*Corresponding author: Dr M. Lamprecht, fax +43 3163809610, email manfred.lamprecht@medunigraz.at
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1 GCM Bakker , MJ vanErk , L Pellis , et al. (2010) An antiinflammatory dietary mix modulates inflammation and oxidative and metabolic stress in overweight men: a nutrigenomics approach. Am J Clin Nutr 91, 10441059.

2 K Fujita , H Nishizawa , T Funahashi , et al. (2006) Systemic oxidative stress is associated with visceral fat accumulation and the metabolic syndrome. Circ J 70, 14371442.

3 LG Kraemer-Aguiar , CM Laflor & E Bouskela (2008) Skin microcirculatory dysfunction is already present in normoglycemic subjects with metabolic syndrome. Metabolism 57, 17401746.

4 JN Fain (2006) Release of interleukins and other inflammatory cytokines by human adipose tissue is enhanced in obesity and primarily due to the nonfat cells. Vitam Horm 74, 443477.

5 DT Smith , LJ Carr , C Dorozynski , et al. (2009) Internet-delivered lifestyle physical activity intervention: limited inflammation and antioxidant capacity efficacy in overweight adults. J Appl Physiol 106, 4956.

6 EA Francischetti , E Tibirica , EG da Silva , et al. (2001) Skin capillary density and microvascular reactivity in obese subjects with and without metabolic syndrome. Microvasc Res 81, 325330.

9 EM Holt , LM Steffen , A Moran , et al. (2009) Fruit and vegetable consumption and its relation to markers of inflammation and oxidative stress in adolescents. J Am Diet Assoc 109, 414421.

12 S DeSpirt , H Sies , H Tronnier , et al. (2012) An encapsulated fruit and vegetable juice concentrate increases skin microcirculation in healthy women. Skin Pharmacol Physiol 25, 28.

14 AMW Petersen & BK Pedersen (2005) The anti-inflammatory effect of exercise. J Appl Physiol 98, 11541162.

15 L Pasqualini , G Schillaci , S Innocente , et al. (2010) Lifestyle intervention improves microvascular reactivity and increases serum adiponectin in overweight hypertensive patients. Nutr Metab Cardiovasc Dis 20, 8792.

16 GA Tew , JM Saxton & GJ Hodges (2012) Exercise training and the control of skin blood flow in older adults. J Nutr Health Aging 16, 237241.

19 DH Alamdari , E Kostidou , K Palets , et al. (2005) High sensitivity enzyme-linked immunosorbent assay (ELISA) method for measuring protein carbonyl in samples with low amounts of protein. Free Radic Biol Med 39, 13621367.

20 J Pilz , I Meinekea & CH Gleitera (2000) Measurement of free and bound malondialdehyde in plasma by high-performance liquid chromatography as the 2,4-dinitrophenyl-hydrazine derivative. J Chromatogr B Biomed Sci Appl 742, 315325.

21 A Stirban , S Nandrean , C Götting , et al. (2010) Effects of n-3 fatty acids on macro- and microvascular function in subjects with type 2 diabetes mellitus. Am J Clin Nutr 91, 808813.

24 M Lamprecht , K Oettl , G Schwaberger , et al. (2009) Protein modification responds to exercise intensity and antioxidant supplementation. Med Sci Sports Exerc 41, 155163.

25 AH Goldfarb , RS Garten , C Cho , et al. (2011) Effects of a fruit/berry/vegetable supplement on muscle function and oxidative stress. Med Sci Sports Exerc 43, 501508.

26 RJ Bloomer , AH Goldfarb & MJ McKenzie (2006) Oxidative stress response to aerobic exercise: comparison of antioxidant supplements. Med Sci Sports Exerc 38, 10981105.

27 JA Canas , L Damaso , A Altomare , et al. (2012) Insulin resistance and adiposity in relation to serum β-carotene levels. J Pediatr 161, 5864.

29European Food Safety Authority; EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) (2011) Guidance on the scientific requirements for health claims related to antioxidants, oxidative damage and cardiovascular health. EFSA J 9, 2474.

30 MS Linna , P Borg , K Kukkonen-Harjula , et al. (2007) Successful weight maintenance preserves lower levels of oxidized LDL achieved by weight reduction in obese men. Int J Obes (Lond) 31, 245253.

31 C Meisinger , J Baumert , N Khuseyinova , et al. (2005) Plasma oxidized low-density lipoprotein, a strong predictor for acute coronary heart disease events in apparently healthy, middle-aged men from the general population. Circulation 112, 651657.

32 OT Njajou , AM Kanaya , P Holvoet , et al. (2009) Association between oxidized LDL, obesity and type 2 diabetes in a population-based cohort, the health aging and body composition study. Diabetes Metab Res Rev 25, 733739.

33 T Vasankari , M Fogelholm , K Kukkonen-Harjula , et al. (2001) Reduced oxidized low-density lipoprotein after weight reduction in obese premenopausal women. Int J Obes Relat Metab Disord 25, 205211.

34 TJ Vasankari , UM Kujala , TM Vasankari , et al. (1998) Reduced oxidized LDL levels after a 10-month exercise program. Med Sci Sports Exerc 30, 14961501.

35 C Novembrino , G Cighetti , R DeGiuseppe , et al. (2011) Effects of encapsulated fruit and vegetable juice powder concentrates on oxidative status in heavy smokers. J Am Coll Nutr 30, 4956.

36 Y Tomino , S Hagiwara & T Gohda (2011) AGE–RAGE interaction and oxidative stress in obesity-related renal dysfunction. Kidney Int 80, 133135.

38 M Lamprecht , P Hofmann , JF Greilberger , et al. (2009) Increased lipid peroxidation in trained men after 2 weeks of antioxidant supplementation. Int J Sport Nutr Exerc Metab 19, 385399.

39 H Esterbauer , RJ Schaur & H Zollner (1991) Chemistry and biochemistry of 4-hydroxynonenal, malondialdehyde and related aldehydes. Free Radic Biol Med 11, 81128.

40 GS Hotamisligil (1999) Mechanisms of TNF-alpha-induced insulin resistance. Exp Clin Endocrinol Diabetes 107, 119125.

41 GS Hotamisligil , P Peraldi , A Budavari , et al. (1996) IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance. Science 271, 665668.

42 CR Bruce & DJ Dyck (2004) Cytokine regulation of skeletal muscle fatty acid metabolism: effect of interleukin-6 and tumor necrosis factor-α. Am J Physiol Endocrinol Metab 287, E616E621.

43 GS Hotamisligil , NS Shargill & BM Spiegelman (1993) Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259, 8791.

45 Y Jin , X Cui , U Singh , et al. (2010) Systematic inflammatory load in humans is suppressed by consumption of two formulations of dried, encapsulated juice concentrate. Mol Nutr Food Res 54, 15061514.

46 LH Clerk , MA Vincent , LA Hahn , et al. (2006) Obesity blunts insulin-mediated microvascular recruitment in human forearm muscle. Diabetes 55, 14361442.

47 AM Jonk , AJ Houben , RT DeJongh , et al. (2007) Microvascular dysfunction in obesity: a potential mechanism in the pathogenesis of obesity-associated insulin resistance and hypertension. Physiology (Bethesda) 22, 252260.

48 GD Plotnick , MC Corretti , RA Vogel , et al. (2003) Effect of supplemental phytonutrients on impairment of the flow-mediated brachial artery vasoactivity after a single high-fat meal. J Am Coll Cardiol 41, 17441749.

49 SJ Bailey , P Winyard , A Vanhatalo , et al. (2009) Dietary nitrate supplementation reduces the O2 cost of low-intensity exercise and enhances tolerance to high-intensity exercise in humans. J Appl Physiol 107, 11441155.

51 A Matsumoto , Y Hirai , S Momomura , et al. (1994) Increased nitric oxide production during exercise. Lancet 343, 849850.

53 M Lamprecht , JF Greilberger , G Schwaberger , et al. (2008) Single bouts of exercise affects albumin redox state and carbonyl groups on plasma protein of trained men in a workload-dependent manner. J Appl Physiol 104, 16111617.

54 DS Young (1987) Implementation of SI units for clinical laboratory tables – style specifications and conversion tables. Ann Intern Med 106, 114129.

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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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