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Supplementation with DHA and the psychological functioning of young adults

  • D. Benton (a1), R. T. Donohoe (a1), D. E. Clayton (a1) (a2) and S. J. Long (a1)
Abstract

The grey matter of the brain contains high levels of the essential nutrient DHA. Although the role of DHA in the developing brain and in dementia has attracted attention, its influence on the brain of the healthy adult has been little considered. A total of 285 young adult females took 400 mg of DHA, in a double-blind, placebo-controlled trial, for 50 d. After 50 d, recently acquired information was more likely to be forgotten by those who had consumed DHA. No significant differences in mood, reaction times, vigilance or visual acuity were found.

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Corresponding author
*Corresponding author: D. Benton, email d.benton@swansea.ac.uk
References
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1Lauritzen L, Hansen HS, Jorgensen MH, et al. (2001) The essentiality of long chain n-3 fatty acids in relation to development and function of the brain and retina. Prog Lipid Res 40, 194.
2Mazza M, Pomponi M, Janiri L, et al. (2007) Omega-3 fatty acids and antioxidants in neurological and psychiatric diseases: an overview. Prog Neurol Psychopharmacol Biol Psychiatry 31, 1226.
3Henrich SC (2010) Dietary omega-3 fatty acid supplementation for optimizing neuronal structure and function. Mol Nutr Food Res 54, 447456.
4Hibbeln JR, Umhau JC, George DT, et al. (1997) Do plasma polyunsaturates predict hostility and depression? World Rev Nutr Diet 82, 175186.
5Long SJ (2011) Fatty acids depression and suicide. In Lifetime Nutritional Influences on Cognition Behaviour and Psychiatric Illness, pp. 484524 [, editor]. Oxford: Woodhead Publishing.
6Morris MC, Evans DA, Bienias JL, et al. (2003) Consumption of fish and n-3 fatty acids and risk of incident Alzheimer disease. Arch Neurol 60, 940946.
7Barberger-Gateau P, Letenneur L, Deschamps V, et al. (2002) Fish, meat, and risk of dementia: cohort study. Br Med J 325, 932933.
8Plourde M (2011) Fatty acid intake and cognitive decline. In Lifetime Nutritional Influences on Cognition Behaviour and Psychiatric Illness, pp. 525542 [, editor]. Oxford: Woodhead Publishing.
9Dullemeijer C, Durga J, Brouwer IA, et al. (2007) n-3 Fatty acid proportions in plasma and cognitive performance in older adults. Am J Clin Nutr 86, 14791485.
10Van de Rest O, Geleijnse JM, Kok FJ, et al. (2008) Effects of fish-oil supplementation on mental well-being in older subjects: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr 88, 706713.
11Kesse-Guyot E, Peneau S, Ferry M, et al. (2011) Thirteen year prospective study between fish consumption, long-chain n-3 fatty acids intakes and cognitive function. J Nutr Health Aging 15, 115120.
12Dangour AD, Allen E, Elbourne D, et al. (2010) Effect of 2-y n-3 long-chain polyunsaturated fatty acid supplementation on cognitive function in older people: a randomized, double-blind, controlled trial. Am J Clin Nutr 91, 17251732.
13Benton D (2010) Neuro-development and neuro-degeneration – are there critical stages for nutritional intervention? Nut Rev 68, Suppl. 1, S6S10.
14Rapoport SI (2003) In vivo approaches to quantifying and imaging brain arachidonic and docosahexaenoic acid metabolism. J Pediatr 143, Suppl. 4, S26S34.
15Rapoport SI (2008) Arachidonic acid and the brain. J Nutr 138, 25152520.
16Rao JS, Ertley RN, DeMar JC Jr, et al. (2007) Dietary n-3 PUFA deprivation alters expression of enzymes of the arachidonic and docosahexaenoic acid cascades in rat frontal cortex. Mol Psychiatry 12, 151157.
17Jackson PA, Reay JL, Scholey AB, et al. (2012) Docosahexaenoic acid-rich fish oil modulates the cerebral hemodynamic response to cognitive tasks in healthy young adults. Biol Psychol 89, 183190.
18Fontani G, Corradeschi F, Felici A, et al. (2005) Cognitive and physiological effects of omega-3 polyunsaturated fatty acid supplementation in healthy subjects. Eur J Clin Invest 35, 691699.
19Fontani G, Corradesch A, Felici F, et al. (2005) Blood profiles, body fat and mood state in healthy subjects on different diets supplemented with omega-3 polyunsaturated fatty acids. Eur J Clin Invest 35, 499507.
20Antypa N, Van der Does AJ, Smelt AH, et al. (2009) Omega-3 fatty acids (fish-oil) and depression-related cognition in healthy volunteers. J Psychopharmacol 23, 831840.
21Paivio A, Yuille JC & Madigan SA (1968) Concreteness imagery and meaningfulness values for 925 nouns. J Exp Psychol 76, 125.
22Jensen AR (1987) Individual differences in the Hick paradigm. In Speed of Information-processing and Intelligence, pp. 101175 [, editor]. Norwood, NJ: Ablex Publishing Corporation.
23McNair DM, Lorr M & Droppleman LF (1981) Profile of Mood States. San Diego, CA: Educational and Industrial Testing Service.
24Benton D (2007) The impact of diet on anti-social, violent and criminal behaviour. Neurosci Biobehav Rev 31, 752774.
25Hamazaki T, Sawazaki S, Itomura M, et al. (1996) The effect of docosahexaenoic acid on aggression in young adults. A placebo-controlled double-blind study. J Clin Invest 97, 11291133.
26Iribarren C, Markovitz JH, Jacobs DR Jr, et al. (2004) Dietary intake of n-3, n-6 fatty acids and fish: relationship with hostility in young adults—the CARDIA study. Eur J Clin Nutr 58, 2431.
27Kaplan JR, Manuck SB & Shively C (1991) The effects of fat and cholesterol on social behavior in monkeys. Psychosom Med 53, 634642.
28Wells AS, Read NW, Laugharne J, et al. (1998) Alterations in mood after changing to a low-fat diet. Br J Nutr 79, 2330.
29Rogers PJ, Appleton KM, Kessler D, et al. (2008) No effect of n-3 long-chain polyunsaturated fatty acid (EPA and DHA) supplementation on depressed mood and cognitive function: a randomised controlled trial. Br J Nutr 99, 421431.
30Jackson PA, Deary ME, Reay JL, et al. (2011) No effect of 12 weeks' supplementation with 1 g DHA-rich or EPA-rich fish oil on cognitive function or mood in healthy young adults aged 18–35 years. Br J Nutr 107, 12321243.
31Jensen MM, Skarsfeldt T & Høy CE (1996) Correlation between level of (n-3) polyunsaturated fatty acids in brain phospholipids and learning ability in rats. A multiple generation study. Biochim Biophys Acta 1300, 203209.
32Dalton A, Wolmarans P, Witthuhn RC, et al. (2009) A randomised control trial in schoolchildren showed improvement in cognitive function after consuming a bread spread, containing fish flour from a marine source. Prostaglandins Leukot Essent Fatty Acids 80, 143149.
33Ferrucci L, Cherubini A, Bandinelli S, et al. (2006) Relationship of plasma polyunsaturated fatty acids to circulating inflammatory markers. J Clin Endocrinol Metab 91, 439441.
34Kirby A, Woodward A, Jackson S, et al. (2010) A double-blind, placebo-controlled study investigating the effects of omega-3 supplementation in children aged 8–10 years from a mainstream school population. Res Dev Disabil 31, 718730.
35Osendarp SJ, Baghurst KI, Bryan J, et al. (2007) Effect of a 12-mo micronutrient intervention on learning and memory in well-nourished and marginally nourished school-aged children: 2 parallel, randomized, placebo-controlled studies in Australia and Indonesia. Am J Clin Nutr 86, 10821093.
36Ryan AS & Nelson EB (2008) Assessing the effect of docosahexaenoic acid on cognitive functions in healthy, preschool children: a randomized, placebo-controlled, double-blind study. Clin Pediatr (Phila) 47, 355362.
37Kennedy DO, Jackson PA, Elliott JM, et al. (2009) Cognitive and mood effects of 8 weeks' supplementation with 400 mg or 1000 mg of the omega-3 essential fatty acid docosahexaenoic acid (DHA) in healthy children aged 10–12 years. Nutr Neurosci 12, 4856.
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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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