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Traditionally living populations in East Africa have a mean serum 25-hydroxyvitamin D concentration of 115 nmol/l

  • Martine F. Luxwolda (a1), Remko S. Kuipers (a1), Ido P. Kema (a1), D. A. Janneke Dijck-Brouwer (a1) and Frits A. J. Muskiet (a1)...
Abstract

Cutaneous synthesis of vitamin D by exposure to UVB is the principal source of vitamin D in the human body. Our current clothing habits and reduced time spent outdoors put us at risk of many insufficiency-related diseases that are associated with calcaemic and non-calcaemic functions of vitamin D. Populations with traditional lifestyles having lifelong, year-round exposure to tropical sunlight might provide us with information on optimal vitamin D status from an evolutionary perspective. We measured the sum of serum 25-hydroxyvitamin D2 and D3 (25(OH)D) concentrations of thirty-five pastoral Maasai (34 (sd 10) years, 43 % male) and twenty-five Hadzabe hunter–gatherers (35 (sd 12) years, 84 % male) living in Tanzania. They have skin type VI, have a moderate degree of clothing, spend the major part of the day outdoors, but avoid direct exposure to sunlight when possible. Their 25(OH)D concentrations were measured by liquid chromatography–MS/MS. The mean serum 25(OH)D concentrations of Maasai and Hadzabe were 119 (range 58–167) and 109 (range 71–171) nmol/l, respectively. These concentrations were not related to age, sex or BMI. People with traditional lifestyles, living in the cradle of mankind, have a mean circulating 25(OH)D concentration of 115 nmol/l. Whether this concentration is optimal under the conditions of the current Western lifestyle is uncertain, and should as a possible target be investigated with concomitant appreciation of other important factors in Ca homeostasis that we have changed since the agricultural revolution.

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Corresponding author
*Corresponding author: M. F. Luxwolda, fax +31 50 361 2290, email m.luxwolda@umcg.nl
References
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1Nesse RM & Williams GC (1994) Why We Get Sick. The New Science of Darwinian Medicine. New York: Times Books, Random House.
2Eaton SB & Konner M (1985) Paleolithic nutrition. A consideration of its nature and current implications. N Engl J Med 312, 283289.
3Cordain L, Eaton SB, Sebastian A, et al. (2005) Origins and evolution of the Western diet: health implications for the 21st century. Am J Clin Nutr 81, 341354.
4Egger G & Dixon J (2009) Obesity and chronic disease: always offender or often just accomplice? Br J Nutr 102, 12381242.
5Norman AW & Bouillon R (2010) Vitamin D nutritional policy needs a vision for the future. Exp Biol Med (Maywood) 235, 10341045.
6Stringer C (2000) Palaeoanthropology. Coasting out of Africa. Nature 405, 2425, 27.
7Jablonski NG & Chaplin G (2000) The evolution of human skin coloration. J Hum Evol 39, 57106.
8Holick MF (2007) Vitamin D deficiency. N Engl J Med 357, 266281.
9Vieth R (2006) What is the optimal vitamin D status for health? Prog Biophys Mol Biol 92, 2632.
10Coast E (2002) Maasai socioeconomic conditions: a cross-border comparison. Hum Ecol 30, 79105.
11Biss K, Ho KJ, Mikkelson B, et al. (1971) Some unique biologic characteristics of the Masai of East Africa. N Engl J Med 284, 694699.
12Marlowe FW (2004) Mate preferences among Hadza hunter-gatherers. Hum Nat 15, 365376.
13Marlowe F (2002) Why the Hadza are still hunter-gatherers. In Ethnicity, Hunter-Gatherers, and the “Other”: Association or Assimilation in Africa, pp. 247275 [, editor]. Washington, DC: Smithsonian Institution Press.
14de Jong WH, Graham KS, van der Molen JC, et al. (2007) Plasma free metanephrine measurement using automated online solid-phase extraction HPLC tandem mass spectrometry. Clin Chem 53, 16841693.
15Maunsell Z, Wright DJ & Rainbow SJ (2005) Routine isotope-dilution liquid chromatography-tandem mass spectrometry assay for simultaneous measurement of the 25-hydroxy metabolites of vitamins D2 and D3. Clin Chem 51, 16831690.
16Health Council of the Netherlands (2008) Towards as adequate intake of vitamin D. The Hague, publication no. 2008/15. http://www.gezondheidsraad.nl/sites/default/files/200815c.pdf.
17Henry HL, Bouillon R, Norman AW, et al. (2010) 14th Vitamin D Workshop consensus on vitamin D nutritional guidelines. J Steroid Biochem Mol Biol 121, 46.
18Ross AC, Abrams SA & Aloia JF, et al. (2011) Dietary reference intakes for calcium and vitamin D. http://www.iom.edu/Reports/2010/Dietary-Reference-Intakes-for-Calcium-and-Vitamin-D.aspx (accessed accessed 23 May 2011).
19Taylor SN, Wagner CL & Hollis BW (2008) Vitamin D supplementation during lactation to support infant and mother. J Am Coll Nutr 27, 690701.
20Heaney RP (2005) The vitamin D requirement in health and disease. J Steroid Biochem Mol Biol 97, 1319.
21Vieth R (1999) Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. Am J Clin Nutr 69, 842856.
22Zittermann A (2003) Vitamin D in preventive medicine: are we ignoring the evidence? Br J Nutr 89, 552572.
23Hathcock JN, Shao A, Vieth R, et al. (2007) Risk assessment for vitamin D. Am J Clin Nutr 85, 618.
24Haddad JG & Chyu KJ (1971) Competitive protein-binding radioassay for 25-hydroxycholecalciferol. J Clin Endocrinol Metab 33, 992995.
25Hollis BW, Wagner CL, Drezner MK, et al. (2007) Circulating vitamin D3 and 25-hydroxyvitamin D in humans: an important tool to define adequate nutritional vitamin D status. J Steroid Biochem Mol Biol 103, 631634.
26Bischoff-Ferrari HA, Shao A, Dawson-Hughes B, et al. (2010) Benefit-risk assessment of vitamin D supplementation. Osteoporos Int 21, 11211132.
27Jackson RD, LaCroix AZ, Gass M, et al. (2006) Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med 354, 669683.
28Bolland MJ, Grey A, Avenell A, et al. (2011) Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women's Health Initiative limited access dataset and meta-analysis. BMJ 342, d2040.
29Nielsen FH (2010) Magnesium, inflammation, and obesity in chronic disease. Nutr Rev 68, 333340.
30Vermeer C & Braam L (2001) Role of K vitamins in the regulation of tissue calcification. J Bone Miner Metab 19, 201206.
31Schurgers LJ, Cranenburg EC & Vermeer C (2008) Matrix Gla-protein: the calcification inhibitor in need of vitamin K. Thromb Haemost 100, 593603.
32Frassetto LA, Morris RC Jr, Sellmeyer DE, et al. (2008) Adverse effects of sodium chloride on bone in the aging human population resulting from habitual consumption of typical American diets. J Nutr 138, 419S422S.
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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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