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UK Food Standards Agency Workshop Report: the effects of the dietary n-6:n-3 fatty acid ratio on cardiovascular health

  • John C. Stanley (a1) (a2), Rachel L. Elsom (a3), Philip C. Calder (a4), Bruce A. Griffin (a5), William S. Harris (a6), Susan A. Jebb (a7), Julie A. Lovegrove (a8), Carmel S. Moore (a7), Rudolph A. Riemersma (a9) and Tom A. B. Sanders (a10)...
Abstract

This report summarises a workshop convened by the UK Food Standards Agency (FSA) on 11 September 2006 to review the results of three FSA-funded studies and other recent research on effects of the dietary n-6:n-3 fatty acid ratio on cardiovascular health. The objective of this workshop was to reach a clear conclusion on whether or not it was worth funding any further research in this area. On the basis of this review of the experimental evidence and on theoretical grounds, it was concluded that the n-6:n-3 fatty acid ratio is not a useful concept and that it distracts attention away from increasing absolute intakes of long-chain n-3 fatty acids which have been shown to have beneficial effects on cardiovascular health. Other markers of fatty acid intake, that more closely relate to physiological function, may be more useful.

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Corresponding author
*Corresponding author: Dr J. C. Stanley, fax+44 1865 279911, email john.stanley@trinity.oxford.ac.uk
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1 WS Harris (2006) The omega-6/omega-3 fatty acid ratio and cardiovascular disease risk: uses and abuses. Curr Atheroscler Rep 8, 453459.

4 D Mozaffarian , A Ascherio , FB Hu , MJ Stampfer , WC Willett , DS Siscovick & EB Rimm (2005) Interplay between different polyunsaturated fatty acids and risk of coronary heart disease in men. Circulation 111, 157164.

5 A Ascherio , EB Rimm , EL Giovannucci , D Spiegelman , M Stampfer & WC Willett (1996) Dietary fat and risk of coronary heart disease in men: cohort follow up study in the United States. BMJ 313, 8490.

6 FB Hu , MJ Stampfer , JE Manson , E Rimm , GA Colditz , BA Rosner , CH Hennekens & WC Willett (1997) Dietary fat and risk of coronary heart disease in women. N Eng J Med 337, 14911499.

7 RB Shekelle , AM Shryock , O Paul , M Lepper , J Stamler , S Liu & WJ Raynor Jr (1981) Diet, serum cholesterol and death from coronary heart disease. N Eng J Med 304, 6570.

9 P Leren (1970) The Oslo diet-heart study. Eleven-year report. Circulation 42, 935942.

10 O Turpeinen , MJ Karvonen , M Pekkarinen , M Miettinen , R Elosuo & E Paavilainen (1979) Dietary prevention of coronary heart disease: the Finnish Mental Hospital Study. Int J Epidemiol 8, 99118.

13 TA Lennie , ML Chung , DL Habash & DK Moser (2005) Dietary fat intake and proinflammatory cytokine levels in patients with heart failure. J Cardiac Failure 11, 613618.

14 T Pischon , SE Hankinson , GS Hotamisligil , N Rifai , WC Willett & EB Rimm (2003) Habitual dietary intake of n-3 and n-6 fatty acids in relation to inflammatory markers among US men and women. Circulation 108, 155160.

15 L Ferrucci , A Cherubini , S Bandinelli , B Bartali , A Corsi , F Lauretani , A Martin , C Andres-Lacueva , U Senin & JM Guralnik (2006) Relationship of plasma polyunsaturated fatty acids to circulating inflammatory markers. J Clin Endocrinol Metab 91, 439446.

16 WS Harris , B Assaad & WC Poston (2006) Tissue omega-6/omega-3 fatty acid ratio and risk for coronary heart disease. Am J Cardiol 98, 19i26i.

20 PC Calder (2004) n-3 Fatty acids and cardiovascular disease: evidence explained and mechanisms explored. Clin Sci 107, 111.

21 PM Kris-Etherton , WS Harris & LJ Appel American Heart Association. Nutrition Committee (2002) Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation 106, 27472757.

25 DS Kelley , GJ Nelson , JE Love , LB Branch , PC Taylor , PC Schmidt , BE Mackey & JM Iacono (1993) Dietary α-linolenic acid alters tissue fatty acid composition, but not blood lipids, lipoproteins or coagulation status in humans. Lipids 28, 533537.

28 WE Lands (2003) Diet could prevent many diseases. Lipids 38, 317321.

29 WS Harris & C von Schacky (2004) The omega-3 index: a new risk factor for death from coronary heart disease? Prev Med 39, 212220.

33 T Tillin , N Forouhi , DG Johnston , PM McKeigue , N Chaturvedi & IF Godsland (2005) Metabolic syndrome and coronary heart disease in South Asians, African-Caribbeans and white Europeans: a UK population based cross-sectional study. Diabetologia 48, 649656.

35 AM Minihane , LM Brady , SS Lovegrove , SV Lesauvage , CM Williams & JA Lovegrove (2005) Lack of effect of dietary n-6:n-3 PUFA ratio on plasma lipid and markers of insulin response in Indian Asians. Eur J Nutr 44, 2632.

39 WE Lands , B Libelt , A Morris , NC Kramer , TE Prewitt , P Bowen , D Schmeisser , MH Davidson & JH Burns (1992) Maintenance of lower proportions of (n-6) eicosanoid precursors in phospholipids of human plasma in response to added dietary (n-3) fatty acids. Biochim Biophys Acta 1180, 147162.

41 CS Moore , SP Bryant , GD Mishra , JD Krebs , LM Browning , GJ Miller & SA Jebb (2006) Oily fish reduces plasma triacylglycerols: a primary prevention study in overweight men and women. Nutrition 22, 10121024.

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British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
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