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Bauer, Paige V. Hamr, Sophie C. and Duca, Frank A. 2016. Regulation of energy balance by a gut–brain axis and involvement of the gut microbiota. Cellular and Molecular Life Sciences, Vol. 73, Issue. 4, p. 737.
Ferrer, Isidro Garcia-Esparcia, Paula Carmona, Margarita Carro, Eva Aronica, Eleonora Kovacs, Gabor G. Grison, Alice and Gustincich, Stefano 2016. Olfactory Receptors in Non-Chemosensory Organs: The Nervous System in Health and Disease. Frontiers in Aging Neuroscience, Vol. 8,
Glendinning, John I. 2016. Do low-calorie sweeteners promote weight gain in rodents?. Physiology & Behavior, Vol. 164, p. 509.
Martinez, Kristina B. Pierre, Joseph F. and Chang, Eugene B. 2016. The Gut Microbiota. Gastroenterology Clinics of North America, Vol. 45, Issue. 4, p. 601.
Neiers, Fabrice Canivenc-Lavier, Marie-Chantal and Briand, Loïc 2016. What Does Diabetes “Taste” Like?. Current Diabetes Reports, Vol. 16, Issue. 6,
Nettleton, Jodi E. Reimer, Raylene A. and Shearer, Jane 2016. Reshaping the gut microbiota: Impact of low calorie sweeteners and the link to insulin resistance?. Physiology & Behavior, Vol. 164, p. 488.
Ojeda, Patricia Bobe, Alexandria Dolan, Kyle Leone, Vanessa and Martinez, Kristina 2016. Nutritional modulation of gut microbiota — the impact on metabolic disease pathophysiology. The Journal of Nutritional Biochemistry, Vol. 28, p. 191.
Sherwin, Eoin Sandhu, Kiran V. Dinan, Timothy G. and Cryan, John F. 2016. May the Force Be With You: The Light and Dark Sides of the Microbiota–Gut–Brain Axis in Neuropsychiatry. CNS Drugs, Vol. 30, Issue. 11, p. 1019.
Calvo, Sara Santa-Cruz and Egan, Josephine M. 2015. The endocrinology of taste receptors. Nature Reviews Endocrinology, Vol. 11, Issue. 4, p. 213.
Ciullo, Dana L. and Dotson, Cedrick D. 2015. Using Animal Models to Determine the Role of Gustatory Neural Input in the Control of Ingestive Behavior and the Maintenance of Body Weight. Chemosensory Perception, Vol. 8, Issue. 2, p. 61.
Mayer, Emeran A. Tillisch, Kirsten and Gupta, Arpana 2015. Gut/brain axis and the microbiota. Journal of Clinical Investigation, Vol. 125, Issue. 3, p. 926.
Mazzoni, Maurizio Bonaldo, Alessio Gatta, Pier Paolo Vallorani, Claudia Latorre, Rocco Canova, Marco and Clavenzani, Paolo 2015. α-Transducin and α-gustducin immunoreactive cells in the stomach of common sole (Solea solea) fed with mussel meal. Fish Physiology and Biochemistry, Vol. 41, Issue. 3, p. 603.
Sanmiguel, Claudia Gupta, Arpana and Mayer, Emeran A. 2015. Gut Microbiome and Obesity: A Plausible Explanation for Obesity. Current Obesity Reports, Vol. 4, Issue. 2, p. 250.
Wang, Chun-Wen Huang, Yu-Chuan Chan, Fang-Na Su, Shih-Chieh Kuo, Yu-Han Huang, Shu-Fen Hung, Mei-Whey Lin, Hang-Chin Chang, Wen-Liang and Chang, Tsu-Chung 2015. A gut microbial metabolite of ginsenosides, compound K, induces intestinal glucose absorption and Na+/glucose cotransporter 1 gene expression through activation of cAMP response element binding protein. Molecular Nutrition & Food Research, Vol. 59, Issue. 4, p. 670.
Alcock, Joe Maley, Carlo C. and Aktipis, C. Athena 2014. Is eating behavior manipulated by the gastrointestinal microbiota? Evolutionary pressures and potential mechanisms. BioEssays, Vol. 36, Issue. 10, p. 940.
Araújo, João Ricardo Martel, Fátima and Keating, Elisa 2014. Exposure to non-nutritive sweeteners during pregnancy and lactation: Impact in programming of metabolic diseases in the progeny later in life. Reproductive Toxicology, Vol. 49, p. 196.
Behrens, Maik Prandi, Simone and Meyerhof, Wolfgang 2014. Taste and Smell.
Duca, F. A. and Lam, T. K. T. 2014. Gut microbiota, nutrient sensing and energy balance. Diabetes, Obesity and Metabolism, Vol. 16, Issue. S1, p. 68.
The chemosensory components shared by both lingual and intestinal epithelium play a critical role in food consumption and the regulation of intestinal functions. In addition to nutrient signals, other luminal contents, including micro-organisms, are important in signalling across the gastrointestinal mucosa and initiating changes in digestive functions. A potential role of gut microbiota in influencing food intake, energy homeostasis and weight gain has been suggested. However, whether gut microbiota modulates the expression of nutrient-responsive receptors and transporters, leading to altered food consumption, is unknown. Thus, we examined the preference for nutritive (sucrose) and non-nutritive (saccharin) sweet solutions in germ-free (GF, C57BL/6J) mice compared with conventional (CV, C57BL/6J) control mice using a two-bottle preference test. Then, we quantified mRNA and protein expression of the sweet signalling protein type 1 taste receptor 3 (T1R3) and α-gustducin and Na glucose luminal transporter-1 (SGLT-1) of the intestinal epithelium of both CV and GF mice. Additionally, we measured gene expression of T1R2, T1R3 and α-gustducin in the lingual epithelium. We found that, while the preference for sucrose was similar between the groups, GF mice consumed more of the high concentration (8 %) of sucrose solution than CV mice. There was no difference in either the intake of or the preference for saccharin. GF mice expressed significantly more T1R3 and SGLT-1 mRNA and protein in the intestinal epithelium compared with CV mice; however, lingual taste receptor mRNA expression was similar between the groups. We conclude that the absence of intestinal microbiota alters the expression of sweet taste receptors and GLUT in the proximal small intestine, which is associated with increased consumption of nutritive sweet solutions.
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