Skip to main content
×
Home
    • Aa
    • Aa
  • Access
  • Cited by 2
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Kaore, Shilpa N. and Kaore, Navinchandra M. 2014. Biomarkers in Toxicology.


    Reisinger, Kostan W. de Vaan, Loes Kramer, Boris W. Wolfs, Tim G.A.M. van Heurn, L.W. Ernest and Derikx, Joep P.M. 2014. Breast-Feeding Improves Gut Maturation Compared With Formula Feeding in Preterm Babies. Journal of Pediatric Gastroenterology and Nutrition, Vol. 59, Issue. 6, p. 720.


    ×

Urinary citrulline in very low birth weight preterm infants receiving intravenous nutrition

  • Aurélie Bourdon (a1) (a2), Carole Rougé (a1) (a2), Arnaud Legrand (a3), Clotilde Des Robert (a1) (a2) (a3), Hugues Piloquet (a1) (a2), Michel Vodovar (a4), Marcel Voyer (a4), Jean-Christophe Rozé (a1) (a2) (a3) and Dominique Darmaun (a1) (a2)
  • DOI: http://dx.doi.org/10.1017/S0007114511006660
  • Published online: 12 December 2011
Abstract

As gut immaturity precludes full enteral feeding, very low birth weight (VLBW) preterm infants receive parenteral nutrition (PN) during the first few weeks of life. Weaning VLBW infants off PN, however, is a top priority since PN is associated with a high risk of complications. The decision making is purely empirical, as there is currently no suitable index of gastrointestinal (GI) maturity. Plasma citrulline concentration is considered an index of GI function in conditions such as short-bowel syndrome and coeliac disease in adults. To identify the factors determining urinary citrulline excretion, and determine whether urinary citrulline excretion could be used as a non-invasive index of GI tolerance to enteral feeding, nutritional intake and urinary citrulline were monitored bi-weekly in forty-seven preterm infants < 1500 g (interquartiles 880–1320 g), during their stay in the Neonatology unit. Median urinary citrulline was 24·7 μmol/mmol creatinine (14·5–38·6 μmol/mmol creatinine). No relationship was observed with the percentage of energy tolerated enterally. In multivariate regression analysis, weak correlations were found with post-conceptional age (P = 0·001), parenteral amino acid supply (P = 0·001) and the daily volume of enteral mixture administered (P = 0·043). A significant correlation was found with urinary nitrite+nitrate excretion (r 0·47; P < 0·001). We conclude that in preterm infants: (1) one of the major determinants of urinary citrulline may be the biosynthesis of citrulline from arginine by NO-synthase; (2) urinary citrulline cannot be used to predict GI tolerance. This is consistent with the observations that, in neonatal gut, citrulline is converted to arginine in situ rather than exported towards the kidneys as observed in adults.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Urinary citrulline in very low birth weight preterm infants receiving intravenous nutrition
      Your Kindle email address
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      Urinary citrulline in very low birth weight preterm infants receiving intravenous nutrition
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      Urinary citrulline in very low birth weight preterm infants receiving intravenous nutrition
      Available formats
      ×
Copyright
Corresponding author
*Corresponding author: D. Darmaun, fax +33 2 53 48 20 03, email ddarmaun@chu-nantes.fr
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

1EC Eichenwald & AR Stark (2008) Management and outcomes of very low birth weight. N Engl J Med 358, 17001711.

2M De Curtis & J Rigo (2004) Extrauterine growth restriction in very-low-birth weight infants. Acta Paediatr 93, 15631568.

3E Curis , I Nicolis & C Moinard (2005) Almost all about citrulline in mammals. Amino Acids 29, 177205.

5MC Van de Poll , GC Lighthart-Melis , PG Boelens , (2007) Intestinal and hepatic metabolism of glutamine and citrulline in humans. J Physiol 581, 819827.

6P Crenn , C Coudray-Lucas , F Thuillier , (2000) Postabsorptive plasma citrulline concentration is a marker of absorptive enterocyte mass and intestinal failure in humans. Gastroenterology 119, 14961505.

7P Crenn , K Vahedi , A Lavergne-Slove , (2003) Plasma citrulline: a marker of enterocyte mass in villous atrophy-associated small bowel disease. Gastroenterology 124, 12101219.

8PA Pappas , AG Tzakis , JM Saudubray , (2004) Trends in serum citrulline and acute rejection among recipients of small bowel transplants. Transplant Proc 36, 345347.

9JM Rhoads , E Plunkett , J Galanko , (2005) Serum citrulline levels correlate with enteral tolerance and bowel length in infants with short bowel syndrome. J Pediatr 146, 542547.

10C Tomlinson , M Rafii , RO Ball , (2011) Arginine can be synthesized from enteral proline in healthy adult humans. J Nutr 141, 14321436.

11C Tomlinson , M Rafii , M Sgro , (2011) Arginine is synthesized from proline, not glutamate, in enterally fed human preterm neonates. Pediatr Res 69, 4650.

13C Rougé , H Piloquet , MJ Butel , (2009) Oral supplementation with probiotics in very low birth weight preterm infants: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr 89, 18281835.

17G Wu , LA Jaeger , FW Bazer , (2004) Arginine deficiency in preterm infants: biochemical mechanisms and nutritional implications. J Nutr Biochem 15, 447451.

20CY Yeung , HC Lee , SP Lin , (2006) Negative effect of heat sterilization on the free amino acid concentrations in infant formula. Eur J Clin Nutr 60, 131141.

22L Castillo , L Beaumier , AM Ajami , (1996) Whole body nitric oxide synthesis in healthy men determined from [15N] arginine-to-[15N] citrulline labeling. Proc Natl Acad Sci U S A 93, 1146011465.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords: