Skip to main content
×
Home
    • Aa
    • Aa

The whey fermentation product malleable protein matrix decreases TAG concentrations in patients with the metabolic syndrome: a randomised placebo-controlled trial

  • Ioanna Gouni-Berthold (a1), Dominik M. Schulte (a1), Wilhelm Krone (a1), Jean-François Lapointe (a2), Pierre Lemieux (a2), Hans-Georg Predel (a3) and Heiner K. Berthold (a4) (a5)...
Abstract

Animal and human studies suggest that a malleable protein matrix (MPM) from whey decreases plasma lipid concentrations and may positively influence other components of the metabolic syndrome such as glucose metabolism and blood pressure (BP). The primary objective of this double-blind, multi-centre trial was to investigate the effects of a low-fat yoghurt supplemented with whey MPM on fasting TAG concentrations in patients with the metabolic syndrome. A total of 197 patients were randomised to receive MPM or a matching placebo yoghurt identical in protein content (15 g/d). Patients were treated during 3 months with two daily servings of 150 g yoghurt each to compare changes from baseline in efficacy variables. MPM treatment resulted in a significantly larger reduction of TAG concentrations in comparison to placebo (relative change − 16 %, P = 0·004). The difference was even more pronounced in subjects with elevated fasting TAG ( ≥ 200 mg/dl) at baseline ( − 18 %, P = 0·005). The relative treatment difference in fasting plasma glucose was − 7·1 mg/dl (P = 0·089). This effect was also more pronounced in subjects with impaired fasting glucose at baseline ( − 11 mg/dl, P = 0·03). In patients with hypertension, the relative treatment difference in systolic BP reached − 5·9 mmHg (P = 0·054). The relative treatment difference in body weight was − 1·7 kg (P = 0·015). The most common adverse events were gastrointestinal in nature. Conclusions from the present study are that consumption of a low-fat yoghurt supplemented with whey MPM twice a day over 3 months significantly reduces fasting TAG concentrations in patients with the metabolic syndrome and improves multiple other cardiovascular risk factors.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      The whey fermentation product malleable protein matrix decreases TAG concentrations in patients with the metabolic syndrome: a randomised placebo-controlled trial
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Dropbox account. Find out more about sending content to Dropbox.

      The whey fermentation product malleable protein matrix decreases TAG concentrations in patients with the metabolic syndrome: a randomised placebo-controlled trial
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your Google Drive account. Find out more about sending content to Google Drive.

      The whey fermentation product malleable protein matrix decreases TAG concentrations in patients with the metabolic syndrome: a randomised placebo-controlled trial
      Available formats
      ×
Copyright
Corresponding author
*Corresponding author: Professor I. Gouni-Berthold, fax +49 221 478 86937, email ioanna.berthold@uni-koeln.de
Linked references
Hide All

This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

2Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (2001) Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA 285, 24862497.

4 A Galassi , K Reynolds & J He (2006) Metabolic syndrome and risk of cardiovascular disease: a meta-analysis. Am J Med 119, 812819.

6 I Rudkowska & PJ Jones (2007) Functional foods for the prevention and treatment of cardiovascular diseases: cholesterol and beyond. Expert Rev Cardiovasc Ther 5, 477490.

7 HG Shertzer , SE Woods , M Krishan , (2011) Dietary whey protein lowers the risk for metabolic disease in mice fed a high-fat diet. J Nutr 141, 582587.

8 S Pal , V Ellis & S Ho (2010) Acute effects of whey protein isolate on cardiovascular risk factors in overweight, post-menopausal women. Atherosclerosis 212, 339344.

10 M Bortolotti , E Maiolo , M Corazza , (2011) Effects of a whey protein supplementation on intrahepatocellular lipids in obese female patients. Clin Nutr 30, 494498.

12 J Beaulieu , R Dubuc , N Beaudet , (2007) Immunomodulation by a malleable matrix composed of fermented whey proteins and lactic acid bacteria. J Med Food 10, 6772.

13 J Beaulieu , C Dupont & P Lemieux (2007) Anti-inflammatory potential of a malleable matrix composed of fermented whey proteins and lactic acid bacteria in an atopic dermatitis model. J Inflamm (Lond) 4, 6.

15 J Beaulieu , E Millette , E Trottier , (2010) Regulatory function of a malleable protein matrix as a novel fermented whey product on features defining the metabolic syndrome. J Med Food 13, 509519.

16 HK Berthold , DM Schulte , JF Lapointe , (2011) The whey fermentation product malleable protein matrix decreases triglyceride concentrations in subjects with hypercholesterolemia: a randomized placebo-controlled trial. J Dairy Sci 94, 589601.

17 SM Grundy , JI Cleeman , SR Daniels , (2005) Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 112, 27352752.

19 AV Chobanian , GL Bakris , HR Black , (2003) The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA 289, 25602572.

20 I Gouni-Berthold & W Krone (2005) Hypertriglyceridemia – why, when and how should it be treated? Z Kardiol 94, 731739.

21 SM Grundy , JI Cleeman , CN Merz , (2004) Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines. Arterioscler Thromb Vasc Biol 24, e149e161.

22 SM Grundy (1999) Hypertriglyceridemia, insulin resistance, and the metabolic syndrome. Am J Cardiol 83, 25F29F.

23 H Bays (2008) Rationale for prescription omega-3-acid ethyl ester therapy for hypertriglyceridemia: a primer for clinicians. Drugs Today (Barc) 44, 205246.

24 JW Anderson , BM Johnstone & ME Cook-Newell (1995) Meta-analysis of the effects of soy protein intake on serum lipids. N Engl J Med 333, 276282.

25 JW Anderson (2000) Dietary fiber prevents carbohydrate-induced hypertriglyceridemia. Curr Atheroscler Rep 2, 536541.

26 G AbouRjaili , N Shtaynberg , R Wetz , (2010) Current concepts in triglyceride metabolism, pathophysiology, and treatment. Metabolism 59, 12101220.

27 LK Nies , AA Cymbala , SL Kasten , (2006) Complementary and alternative therapies for the management of dyslipidemia. Ann Pharmacother 40, 19841992.

28 TJ Wang , P Gona , MG Larson , (2007) Multiple biomarkers and the risk of incident hypertension. Hypertension 49, 432438.

29 P Libby & J Plutzky (2007) Inflammation in diabetes mellitus: role of peroxisome proliferator-activated receptor-alpha and peroxisome proliferator-activated receptor-gamma agonists. Am J Cardiol 99, 27B40B.

31 Q Chen & RA Reimer (2009) Dairy protein and leucine alter GLP-1 release and mRNA of genes involved in intestinal lipid metabolism in vitro. Nutrition 25, 340349.

32 S Nagaoka , Y Kanamaru , Y Kuzuya , (1992) Comparative studies on the serum cholesterol lowering action of whey protein and soybean protein in rats. Biosci Biotechnol Biochem 56, 14841485.

34 DR Jacobs Jr, MD Gross & LC Tapsell (2009) Food synergy: an operational concept for understanding nutrition. Am J Clin Nutr 89, 1543S1548S.

35 S Nagaoka , Y Kanamaru & Y Kuzuya (1991) Effects of whey protein and casein on the plasma and liver lipids in rats. Agric Biol Chem 55, 813818.

38 M Kawase , H Hashimoto , M Hosoda , (2000) Effect of administration of fermented milk containing whey protein concentrate to rats and healthy men on serum lipids and blood pressure. J Dairy Sci 83, 255263.

41 G Schaafsma , WJ Meuling , DW van , (1998) Effects of a milk product, fermented by Lactobacillus acidophilus and with fructo-oligosaccharides added, on blood lipids in male volunteers. Eur J Clin Nutr 52, 436440.

43 JZ Xiao , S Kondo , N Takahashi , (2003) Effects of milk products fermented by Bifidobacterium longum on blood lipids in rats and healthy adult male volunteers. J Dairy Sci 86, 24522461.

44 HM Lakka , DE Laaksonen , TA Lakka , (2002) The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. JAMA 288, 27092716.

45 S Mottillo , KB Filion , J Genest , (2010) The metabolic syndrome and cardiovascular risk a systematic review and meta-analysis. J Am Coll Cardiol 56, 11131132.

48 SM Grundy , HB Brewer Jr, JI Cleeman , (2004) Definition of metabolic syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Circulation 109, 433438.

49 ES Ford , WH Giles & WH Dietz (2002) Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA 287, 356359.

50 SM Grundy , JI Cleeman , SR Daniels , (2006) Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute scientific statement. Curr Opin Cardiol 21, 16.

51 P Gaede , H Lund-Andersen , HH Parving , (2008) Effect of a multifactorial intervention on mortality in type 2 diabetes. N Engl J Med 358, 580591.

52 M Coutinho , HC Gerstein , Y Wang , (1999) The relationship between glucose and incident cardiovascular events. A metaregression analysis of published data from 20 studies of 95,783 individuals followed for 12·4 years. Diabetes Care 22, 233240.

53 SC Ho , YM Chen , JL Woo , (2001) Association between simple anthropometric indices and cardiovascular risk factors. Int J Obes Relat Metab Disord 25, 16891697.

54 A Onat , GS Avci , MM Barlan , (2004) Measures of abdominal obesity assessed for visceral adiposity and relation to coronary risk. Int J Obes Relat Metab Disord 28, 10181025.

56 W Aekplakorn , V Kosulwat & P Suriyawongpaisal (2006) Obesity indices and cardiovascular risk factors in Thai adults. Int J Obes (Lond) 30, 17821790.

57 DC Henderson , X Fan , B Sharma , (2009) Waist circumference is the best anthropometric predictor for insulin resistance in nondiabetic patients with schizophrenia treated with clozapine but not olanzapine. J Psychiatr Pract 15, 251261.

58 K Diepvens , D Haberer & M Westerterp-Plantenga (2008) Different proteins and biopeptides differently affect satiety and anorexigenic/orexigenic hormones in healthy humans. Int J Obes (Lond) 32, 510518.

59 PW Wilson , WB Kannel , H Silbershatz , (1999) Clustering of metabolic factors and coronary heart disease. Arch Intern Med 159, 11041109.

60 Y Gerber , R Dankner , A Chetrit , (2005) The role of risk factor time trends in the steep decline of CHD mortality between two Israeli cohort studies. Prev Med 41, 8591.

61 B Angelin , B Leijd , R Hultcrantz , (1990) Increased turnover of very low density lipoprotein triglyceride during treatment with cholestyramine in familial hypercholesterolaemia. J Intern Med 227, 201206.

62 GC Major , JP Chaput , M Ledoux , (2008) Recent developments in calcium-related obesity research. Obes Rev 9, 428445.

63 HK Berthold , S Unverdorben , R Degenhardt , (2006) Effect of policosanol on lipid levels among patients with hypercholesterolemia or combined hyperlipidemia: a randomized controlled trial. JAMA 295, 22622269.

Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

British Journal of Nutrition
  • ISSN: 0007-1145
  • EISSN: 1475-2662
  • URL: /core/journals/british-journal-of-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords:

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 3
Total number of PDF views: 52 *
Loading metrics...

Abstract views

Total abstract views: 98 *
Loading metrics...

* Views captured on Cambridge Core between September 2016 - 25th May 2017. This data will be updated every 24 hours.