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Autoimmune Inflammatory Myopathy after Treatment with Ipilimumab

Published online by Cambridge University Press:  02 December 2014

Gary Hunter*
Department of Neurology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
Chris Voll
Department of Neurology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
Christopher A. Robinson
Department of Pathology and Laboratory Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
Royal University Hospital, Dept of Neurology, 103 Hospital Drive, Saskatoon, Saskatchewan, S7N 0W8, Canada
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Brief Communications
Copyright © The Canadian Journal of Neurological 2009


1. Cranmer, LD, Hersh, E. The role of the CTLA4 blockade in the treatment of malignant melanoma. Cancer Invest. 2007;25(7): 61331.Google Scholar
2. Attia, P, Phan, GQ, Maker, AV, Robinson, MR, Quezado, MM, Yang, JC, et al. Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic Tlymphocyte antigen-4. J Clin Oncol. 2005;23(25):604353.CrossRefGoogle ScholarPubMed
3. Ribas, A, Camacho, LH, Lopez-Berestein, G, Pavlov, D, Bulanhagui, CA, Millham, R, et al. Antitumor activity in melanoma and antiself responses in a phase I trial with the anti-cytotoxic T lymphocyte-associated antigen 4 monoclonal antibody CP-675,206. J Clin Oncol. 2005;23(35):896877.CrossRefGoogle Scholar
4. Tchekmedyian, S, Glasby, J, Korman, A, Keler, T, Deo, Y, Davis, T. MDX-010 (human anti-CTLA-4): a phase I trial in malignant melanoma. [abstract] Proc Am Soc Clin Oncol. 2002; 2:56.Google Scholar
5. Phan, GQ, Haworth, LR, Duray, PH, Davis, TA, Rosenberg, SA. Blockade of CTLA-4 with MDX-010 in humans can induce both autoimmunity and cancer regression. [abstract] Proc Am Soc Clin Oncol. 2003; 22: 3424.Google Scholar
6. Maker, AV, Phan, GQ, Attia, P, Yang, JC, Sherry, RM, Topalian, SL, et al. Tumor regression and autoimmunity in patients treated with cytotoxic T lymphocyteassociated antigen 4 blockade and interleukin 2: a phase I/II study. Ann Surg Oncol. 2005, 12(12), 100516.CrossRefGoogle ScholarPubMed
7. Weber, J. Review: Anti-CTLA-4 Antibody Ipilimumab: case studies of clinical response and immune-related adverse events. The Oncologist. 2007;12:86472.CrossRefGoogle ScholarPubMed
8. Beck, KE, Blansfield, JA, Tran, KQ, Feldman, AL, Hughes, MS, Royal, RE, et al. Enterocolitis in patients with cancer after antibody blockade of cytotoxic T-lymphocyte associated antigen 4. J Clin Oncol. 2006;24:22839.Google Scholar
9. Colucci, F, Bergman, ML, Penha-Goncalves, C, Cilio, CM, Holmberg, D. Apoptosis resistance of nonobese diabetic peripheral lymphocytes linked to the Idd5 diabetes susceptibility region. Proc Natl Acad Sci USA. 1997;94:86704.Google Scholar
10. Greve, B, Vijayakrishnan, L, Kubal, A, Sobel, RA, Peterson, LB, Wicker, LS, et al. The diabetes susceptibility locus Idd5.1 on mouse chromosome 1 regulates ICOS expression and modulates murine experimental autoimmune encephalomyelitis. J Immunol. 2004;73:15763.CrossRefGoogle Scholar
11. Ueda, H, Howson, JM, Esposito, L. Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature. 2003;423:50611.CrossRefGoogle ScholarPubMed
12. Wang, HB, Shi, FD, Li, H, Chambers, BJ, Link, H, Ljunggren, HG. Anti-CTLA-4 antibody treatment triggers determinant spreading and enhances murine myasthenia gravis. J Immunol. 2001;166 (10):64306.CrossRefGoogle ScholarPubMed