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B.2 Time from symptom onset and number of health care encounters prior to diagnosis of cerebral venous thrombosis

Published online by Cambridge University Press:  24 May 2024

T Field
Affiliation:
(Vancouver)
LW Zhou
Affiliation:
(Vancouver)
V Dizonno
Affiliation:
(Vancouver)*
M Almekhlafi
Affiliation:
(Calgary)
F Bala
Affiliation:
(Tours)
B Graham
Affiliation:
(Saskatoon)
LA Sposato
Affiliation:
(London)
J Mandzia
Affiliation:
(London)
G Medvedev
Affiliation:
(Vancouver)
B Buck
Affiliation:
(Edmonton)
MI Boulos
Affiliation:
(Toronto)
A Tkach
Affiliation:
(Kelowna)
A Pikula
Affiliation:
(Toronto)
D Blacquiere
Affiliation:
(Ottawa)
K Perera
Affiliation:
(Hamilton)
C Odier
Affiliation:
(Montreal)
MD Hill
Affiliation:
(Calgary)
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Abstract

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Background: Cerebral venous thrombosis (CVT)most commonly affects younger women. Diagnosis may be delayed due to its distinct presentation and demographic profile compared to other stroke types. Methods: We examined delays to diagnosis of CVT in the SECRET randomized trial and TOP-SECRET parallel registry. Adults diagnosed with symptomatic CVT within <14 days were included. We examined time to diagnosis and number of health care encounters prior to diagnosis and associations with demographics, clinical and radiologic features and functional and patient-reported outcomes (PROMS) at days 180&365. Results: Of 103 participants, 68.9% were female; median age was 45 (IQR 31.0-61.0). Median time from symptom onset to diagnosis was 4 (1-8) days. Diagnosis on first presentation to medical attention was made in 60.2%. The difference in time to diagnosis for single versus multiple presentations was on the order of days (3[1-7] vs. 5[2-11.75], p=0.16). Women were likelier to have multiple presentations (OR 2.53; 95% CI1.00-6.39; p=0.05) and longer median times to diagnosis (5[2-8]days vs. 2[1-4.5] days; p=0.005). However, this was not associated with absolute or change in functional, or any patient reported, outcome measures (PROMs) at days 180&365. Conclusions: Diagnosis of CVT was commonly delayed; women were likelier to have multiple presentations. We found no association between delayed diagnosis and outcomes.

Type
Abstracts
Copyright
© The Author(s), 2024. Published by Cambridge University Press on behalf of Canadian Neurological Sciences Federation