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Cerebral Glucose Metabolism in Parkinson’s Disease

Published online by Cambridge University Press:  18 September 2015

W.R.W. Martin ,
J.H. Beckman ,
D.B. Calne ,
M.J. Adam ,
R. Harrop ,
J.G. Rogers ,
T.J. Ruth ,
C.I. Sayre  and
B.D. Pate
J.H. Beckman
Affiliation:
Division of Neurology, Health Sciences Centre Hospital, and the UBC/TRIUMF Program on Positron Emission Tomography, University of British Columbia, Vancouver, B.C.
D.B. Calne
Affiliation:
Division of Neurology, Health Sciences Centre Hospital, and the UBC/TRIUMF Program on Positron Emission Tomography, University of British Columbia, Vancouver, B.C.
M.J. Adam
Affiliation:
Division of Neurology, Health Sciences Centre Hospital, and the UBC/TRIUMF Program on Positron Emission Tomography, University of British Columbia, Vancouver, B.C.
R. Harrop
Affiliation:
Division of Neurology, Health Sciences Centre Hospital, and the UBC/TRIUMF Program on Positron Emission Tomography, University of British Columbia, Vancouver, B.C.
J.G. Rogers
Affiliation:
Division of Neurology, Health Sciences Centre Hospital, and the UBC/TRIUMF Program on Positron Emission Tomography, University of British Columbia, Vancouver, B.C.
T.J. Ruth
Affiliation:
Division of Neurology, Health Sciences Centre Hospital, and the UBC/TRIUMF Program on Positron Emission Tomography, University of British Columbia, Vancouver, B.C.
C.I. Sayre
Affiliation:
Division of Neurology, Health Sciences Centre Hospital, and the UBC/TRIUMF Program on Positron Emission Tomography, University of British Columbia, Vancouver, B.C.
B.D. Pate
Affiliation:
Division of Neurology, Health Sciences Centre Hospital, and the UBC/TRIUMF Program on Positron Emission Tomography, University of British Columbia, Vancouver, B.C.
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Abstract

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Local cerebral glucose utilization was measured in patients with predominantly unilateral Parkinson’s disease using 18F-2-fluoro-deoxyglucose and positron emission tomography. Preliminary results indicate the presence of asymmetric metabolic rates in the inferior basal ganglia. The structure comprising the largest portion of basal ganglia at this level is globus pallidus. These findings are consistent with metabolic studies on animals with unilateral nigrostriatal lesions in which pallidal hypermetabolism on the lesioned side has been demonstrated. Increased pallidal activity is likely secondary to a loss of inhibitory dopaminergic input to the striatum from substantia nigra.

Type
5. Positron Emission Tomography in Parkinson’s Disease
Information
Canadian Journal of Neurological Sciences , Volume 11 , Issue S1: Current Concepts and Controversies in Parkinson’s Disease , February 1984 , pp. 169 - 173
Copyright
Copyright © Canadian Neurological Sciences Federation 1984

References

Adam, MJ (1982) A rapid, stereoselective, high yielding synthesis of 2-deoxy-2-fluor-D-hexopyranoses: reaction of glycals with acetyl hypofluorite. J. Chem. Soc. Chem. Commun. 730.Google Scholar
Binder, GA, Haughton, VM, Ho, K-C (1979) Computed Tomogaphy of the Brain in Axial, Coronal, and Sagittal Planes. Little, Brown and Company: Boston.Google Scholar
Brooks, RA (1982) Alternative formula for glucose utilization using labeled deoxyglucose, J. Nucl. Med. 23: 538–539.Google ScholarPubMed
Fahn, S (1976) Biochemistry of the basal ganglia. Adv. Neurol. 14: 59–89.Google ScholarPubMed
Ferron, A, DesRosiers, MH, de Montigny, C, Bosler, O, Reader, TA, Descarries, L (1979) Effects of unilateral destruction of the nigrostriatal dopamine system on local cerebral glucose utilization in adult rat. Soc. Neurosci. Abstr. 5: 70.Google Scholar
Garnett, ES, Firnau, G, Nahmias, C (1982) Dopamine visualized in the basal ganglia of living man. Nature 305: 137–138.CrossRefGoogle Scholar
Hanaway, J, Scott, WR, Strother, CM (1980) Atlas of the Human Brain and the Orbit for Computed Tomography. Warren H. Green Inc.: St. Louis, Missouri.Google Scholar
Hornykiewicz, O (1972) Neurochemistry of parkinsonism. In: Handbook of Neurochemistry 7, Lajtha, A., ed., pp. 465–501, Plenum Press: New York.Google Scholar
Kozlowski, M, Marshall, JF (1980) Plasticity of [14C]2-deoxy-D-glucose incorporation into neostriatum and related structures in response to dopamine neuron damage and apomorphine replacement. Brain Res. 197: 167–183.CrossRefGoogle ScholarPubMed
Leenders, K, Wolfson, L, Gibbs, J, Wise, R, Jones, T, Legg, N (1983) Regional cerebral blood flow and oxygen metabolism in Parkinson’s disease and their response to L-dopa. J. Cereb. Blood Flow and Metabol. 3 (Suppl. 1): S488–S489.Google Scholar
Mata, M, Fink, DJ, Gainers, H, Smith, CB, Davidsen, L, Savaki, H, Schwartz, WJ, Sokoloff, L (1980) Activity-dependent energy metabolism in rat posterior pituitary primarily reflects sodium pump activity. J. Neurochem. 34: 213–215.CrossRefGoogle ScholarPubMed
Phelps, ME, Huang, SC, Hoffman, EJ, Selin, C, Sokoloff, I, Kuhl, DE (1979) Tomographic measurement of local cerebral glucose metabolic rate in humans with (F-18)2-fluoro-2-deoxy-D-glucose: validation of method. Ann. Neurol. 6: 371–388.CrossRefGoogle ScholarPubMed
Sagar, SM, Snodgrass, SR (1980) Effects of substantia nigra lesions on forebrain 2-deoxyglucose retention in the rat. Brain Res. 185: 335–348.CrossRefGoogle ScholarPubMed
Schwartz, WJ, Sharp, FR, Gunn, RH, Evarts, EV (1976) Lesions of ascending dopaminergic pathways decrease forebrain glucose utilization. Nature 261: 155–157.CrossRefGoogle Scholar
Siggins, GR, Hoffer, BJ, Bloom, FE, Ungerstedt, U (1976) Cytochemical and electrophysiological studies of dopamine in the caudate nucleus. In: Yahr, M.D. (Ed.), Research Communications: Association for Research in Nervous and Mental Disease (The Basal Ganglia), Vol. 55, Raven Press: New York, pp. 227–247.Google Scholar
Sokoloff, L, Reivich, M, Kennedy, C, Des Rosiers, MH, Patlak, CS, Pettigrew, KD, Sakurada, O, Shinohara, M (1977) The [MC]deoxy-glucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized albino rat. J. Neurochem. 28: 897–916.CrossRefGoogle Scholar
Ungerstedt, U (1971) Stereotaxic mapping of monomine pathways in the rat brain. Acta. Physiol. Scand. 367 (Suppl.): 1–48.CrossRefGoogle Scholar
Wagner, HN, Burns, HD, Dannals, RF, Wong, DF, Langstrom, B, Duelfer, T, Frost, JJ, Ravert, HT, Links, , Rosenblood, SB, Lukas, SE, Kramer, AV, Kuhar, MJ (1983) Imaging dopamine receptors in the human brain by positron tomography. Science 221: 1264–1266.CrossRefGoogle ScholarPubMed
Wooten, GF, Collins, RC (1983) Effects of dopaminergic stimulation on functional brain metabolism in rats with unilateral substantia nigra lesions. Brain Res. 263: 267–275.CrossRefGoogle ScholarPubMed
Wooten, GF, Collins, RC (1981) Metabolic effects of unilateral lesions of the substantia nigra. J. Neurosci. 1: 285–291.CrossRefGoogle ScholarPubMed