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Cognitive Function in Nigerians with Newly Diagnosed Epilepsy

Published online by Cambridge University Press:  04 August 2016

Olubunmi Ogunrin ,
B. Adamolekun ,
A. O. Ogunniyi  and
A. P. Aldenkamp
Olubunmi Ogunrin
Affiliation:
Department of Medicine, University of Benin, Benin-city, Nigeria
B. Adamolekun*
Affiliation:
Department of Neurology, S.I.U School of Medicine, Springfield, IL, USA
A. O. Ogunniyi
Affiliation:
Department of Medicine, University College Hospital, Ibadan, Nigeria
A. P. Aldenkamp
Affiliation:
Department of Behavioural Sciences and Psychological Services, Epilepsy Centrum Kempenhaeghe, Heeze, The Netherlands
*
2255, S. Koke Mill Rd, Springfield, IL62707 USA
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Abstract:

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Objective:

The objective of this study was to evaluate the pattern of cognitive disturbances in Nigerian Africans with newly diagnosed epilepsy, prior to onset of drug therapy.

Methods:

A total of 60 consecutive patients (mean age 31.6 ± 17.4, range 14 - 55 years) presenting with a clinical diagnosis of epilepsy were recruited for the study. Sixty healthy volunteers without a history of epilepsy and who were age-, sex- and level of education matched with the epileptic patients, were recruited as controls. The administration of cognitive tests was done with the FePsy computerized neuropsychological test battery. The tests administered were the visual and auditory reaction times, the continuous performance test and the recognition memory tests to assess mental speed, attention and memory respectively. The means of the cognitive performances of the epileptic patients and controls were statistically compared.

Results:

Epileptic patients performed worse than the controls across the spectrum of cognitive tasks assessed (P = 0.00001; P < 0.025), with the exception of the β parameter (response bias) of the vigilance test (P = 0.488; P> 0.025).

Conclusions:

The cognitive impairments of short-term memory, psychomotor speed and sustained attention observed in this study are similar to those reported in the literature for patients with epilepsy. The results of this study will be useful in the counseling of patients on their educational, social and vocational needs.

Type
Original Article
Information
Canadian Journal of Neurological Sciences , Volume 27 , Issue 2 , May 2000 , pp. 148 - 151
Copyright
Copyright © The Canadian Journal of Neurological 2000

References

REFERENCES

1. Aldenkamp, AP, Vermeilen, J. Phenytoin and carbamazepine: differential effects on cognitive function. Seizure 1995;4:95–104.CrossRefGoogle ScholarPubMed
2. Alphert, WCJ and Aldenkamp, AP. Neuropsychological assessment of cognitive functioning in children with epilepsy. Epilepsia 1990; 31 (suppl. 4): S35–S40.Google Scholar
3. Aikia, M, Kalviainen, R, Riekkinen, PJ. Verbal learning and memory in newly diagnosed partial epilepsy. Epilepsy Research 1995;22 (2): 157–164.CrossRefGoogle ScholarPubMed
4. Prevey, ML, Richard, CD, Cramer, JA, et al. Complex partial and secondary generalized seizure patients: cognitive functioning prior to treatment with antiepileptic medication. Epilepsy Research 1998;30:1–9.Google Scholar
5. Trimble, MR. Anticonvulsant drugs, mood and cognitive function. In: Trimble, MR and Reynolds, EH, eds. Epilepsy, behaviour and cognitive function. Chichester: John Wiley and Sons. 1987;135–145.Google ScholarPubMed
6. Osuntokun, BO, Adeuja, AO, Nottidge, VA, et al. Prevalence of the epilepsies in Nigeria Africans: a community-based study. Epilepsia 1987;28(3):272–279.CrossRefGoogle ScholarPubMed
7. Ogunniyi, A, Osuntokun, BO, Adeuja, AO, et al. Risk factors for epilepsy: case-control study in Nigerians. Epilepsia 1987;28(3): 280–285.CrossRefGoogle ScholarPubMed
8. Lansell, H, Mivsky, AF. Attention in focal and centrencephalic epilepsy. Exp Neurol 1964;9: 463–469.CrossRefGoogle Scholar
9. Commission on Classification and Terminology, International League against Epilepsy. Proposed revisions of clinical and electro-encephalographic classification of epileptic seizures. Epilepsia 1981;22:480–501.Google Scholar
10. Moerland, MC, Aldenkamp, AP, Alpherts, WCJ. Computerized psychological testing in epilepsy. In: Moarse, FJ, Mulder, LJM, Syouw, WPB and Aldenkamp, AP. Computers in Psychology, Methods, Instrumentation and Psychodiagnostics. Lisse, USA: Swets and Zertlinger, 1988:157–164.Google Scholar
11. Louiseau, P, Strube, E, Signoret, J. Memory and Epilepsy. In: Epilepsy, Behavior and Cognitive Function. Chichester: John Wiley and Sons, 1987:165–176.Google Scholar