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Detection of S-100β Protein in Plasma and Urine After a Mild Traumatic Brain Injury

  • Natalie Le Sage (a1) (a2), Pier-Alexandre Tardif (a1), Jérôme Frenette (a1) (a3), Marcel Émond (a1) (a2) (a4), Jean-Marc Chauny (a5) (a6), Lynne Moore (a1), Patrick Archambault (a2) (a3) (a7), Jeffrey Perry (a8) and Antoine Boulanger-Piette (a3)...

Abstract:

This study assessed whether S-100β protein could be measured in urine when detectable in plasma after a mild traumatic brain injury (mTBI). Clinical data, plasma and urine samples were collected for the 46 adult patients prospectively enrolled in the emergency department (ED) of a Level 1 trauma center. S-100β protein concentrations were analysed using ELISA. S-100β protein was detectable in 91% and 71% of plasma and urine samples, but values were not correlated (r = 0.002). Urine sampling would have been a non-invasive procedure, but it does not appear to be useful in the ED during the acute phase after an mTBI.

Détection de la protéine S-100β dans le plasma et l’urine à la suite d’un traumatisme cranio-cérébral léger (TCCL). Cette étude a cherché à évaluer dans quelle mesure la teneur en protéine S-100β peut être mesurée dans l’urine après avoir été détectée dans le plasma, et ce, à la suite d’un TCCL. Des données cliniques ainsi que des échantillons de plasma et d’urine ont alors été collectés chez quarante-six patients adultes recrutés de façon prospective dans le service d’urgence d’un centre tertiaire de traumatologie. La teneur en protéine S-100β a été analysée au moyen de la méthode immuno-enzymatique ELISA. La protéine S-100β s’est avérée détectable dans respectivement 91 % et 71 % des échantillons de plasma et d’urine. Cela dit, les valeurs obtenues ne sont pas apparues corrélées (r = 0,002). Le fait de recourir à des échantillons d’urine aurait pu représenter une procédure non-invasive ; cependant, elle ne semble pas utile dans un service d’urgence lors de la phase aigüe consécutive à un TCCL.

Copyright

Corresponding author

Correspondence to: Natalie Le Sage, CHU de Québec - Université Laval Research Center, Université Laval, 1401, 18e rue, Québec, QC G1J 1Z4, Canada. Email: natalie.lesage@fmed.ulaval.ca

References

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Keywords

Detection of S-100β Protein in Plasma and Urine After a Mild Traumatic Brain Injury

  • Natalie Le Sage (a1) (a2), Pier-Alexandre Tardif (a1), Jérôme Frenette (a1) (a3), Marcel Émond (a1) (a2) (a4), Jean-Marc Chauny (a5) (a6), Lynne Moore (a1), Patrick Archambault (a2) (a3) (a7), Jeffrey Perry (a8) and Antoine Boulanger-Piette (a3)...

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