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Down Syndrome Cell Adhesion Molecule , Mother of Innovations

  • Brian E. Chen (a1)
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Abstract
Copyright
This is an open access article, distributed under the terms of the creative commons attribution licence (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Corresponding author
Correspondence to: Brian Chen, Centre for Research in Neuroscience, Research Institute of the McGill University Health Centre, Montreal General Hospital, 1650 Cedar Ave, L7-224, Montréal, Québec, H3G 1A4, Canada. Email: brian.chen@mcgill.ca
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4. JP Ioannidis . More time for research: fund people not projects. Nature. 2011;477:529-531.

7. D Schmucker , BE Chen . Dscam and DSCAM: complex genes in simple animals, complex animals yet simple genes. Genes Dev. 2009;23:147-156.

8. D Schmucker , JG Flanagan . Generation of recognition diversity in the nervous system. Neuron. 2004;44:219-222.

10. ML Montesinos . Roles for DSCAM and DSCAML1 in central nervous system development and disease. Adv Neurobiol. 2014;8:249-270.

11. Y Kise , D Schmucker . Role of self-avoidance in neuronal wiring. Curr Opin Neurobiol. 2013;23:983-989.

12. SL Zipursky , WB Grueber . The molecular basis of self-avoidance. Annu Rev Neurosci. 2013;36:547-568.

14. AD Chipman , DE Ferrier , C Brena , et al. The first myriapod genome sequence reveals conservative arthropod gene content and genome organisation in the centipede Strigamia maritima. PLoS Biol. 2014;12:e1002005.

15. A Alves-Sampaio , JA Troca-Marin , ML Montesinos . NMDA-mediated regulation of DSCAM dendritic local translation is lost in a mouse model of Down’s syndrome. J Neurosci. 2010;30:13537-13548.

16. GM Barlow , XN Chen , ZY Shi , et al. Down syndrome congenital heart disease: a narrowed region and a candidate gene. Genet Med. 2001;3:91-101.

19. V Brown , P Jin , S Ceman , et al. Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome. Cell. 2001;107:477-487.

20. JC Darnell , SJ Van Driesche , C Zhang , et al. FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism. Cell. 2011;146:247-261.

21. V Cvetkovska , AD Hibbert , F Emran , BE Chen . Overexpression of Down syndrome cell adhesion molecule impairs precise synaptic targeting. Nat Neurosci. 2013;16:677-682.

23. I Kays , V Cvetkovska , BE Chen . Structural and functional analysis of single neurons to correlate synaptic connectivity with grooming behavior. Nat Protocols. 2014;9:1-10.

24. TR Grossman , A Gamliel , RJ Wessells , et al. Over-expression of DSCAM and COL6A2 cooperatively generates congenital heart defects. PLoS Genet. 2011;7:e1002344.

25. G Barlow , B Micales , X Chen , GE Lyons , J Korenberg . Mammalian DSCAMs: roles in the development of the spinal cord, cortex, and cerebellum? Biochem Biophys Res Commun. 2002;293:881-891.

26. N Spruston . Pyramidal neurons: dendritic structure and synaptic integration. Nat Rev Neurosci. 2008;9(3):206-221.

27. P Somogyi , T Klausberger . Defined types of cortical interneurone structure space and spike timing in the hippocampus. J Physiol. 2005;562:9-26.

29. R Suciu , E Aydin , BE Chen . GeneDig: a web application for accessing genomic and bioinformatics knowledge. BMC Bioinformatics. 2015;16:16.

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Canadian Journal of Neurological Sciences
  • ISSN: 0317-1671
  • EISSN: 2057-0155
  • URL: /core/journals/canadian-journal-of-neurological-sciences
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