Hostname: page-component-848d4c4894-hfldf Total loading time: 0 Render date: 2024-05-16T21:40:31.362Z Has data issue: false hasContentIssue false
  • English
  • Français

Effect of Phenytoin on Protein Binding of Valproic Acid

Published online by Cambridge University Press:  18 September 2015

J. Bruni ,
J.M. Gallo  and
B.J. Wilder
J. Bruni*
Affiliation:
Department of Neurology, College of Medicine and College of Pharmacy, University of Florida, Gainesville, Florida
J.M. Gallo
Affiliation:
Department of Neurology, College of Medicine and College of Pharmacy, University of Florida, Gainesville, Florida
B.J. Wilder
Affiliation:
Department of Neurology, College of Medicine and College of Pharmacy, University of Florida, Gainesville, Florida
*
Jones Building, Wellesley Hospital, 160 Wellesley St. East, Toronto, Ontario, M4Y 1J3, Canada
Rights & Permissions [Opens in a new window]

Summary:

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

In vitro experiments using the equilibrium dialysis technique were performed to determine the binding of valproic acid to plasma components in the absence and presence of therapeutic concentrations of phenytoin. The free fraction of valproic acid was found to be dependent on the total valproic acid concentration. Phenytoin did not influence valproic acid protein binding.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 6 , Issue 4 , November 1979 , pp. 453 - 454
Copyright
Copyright © Canadian Neurological Sciences Federation 1979

References

Bruni, J., Wilder, B.J., Willmore, L.J., Perchalski, R.J. and Villar-Real, H.J. (1978). Steady-state kinetics of valproic acid in epileptic patients. Clin. Pharmacol. Ther. 24:324–332.CrossRefGoogle ScholarPubMed
Bruni, J., Wilder, B.J., Willmore, L.J. and Barbour, B. (1979). Valproic acid and plasma levels of phenytoin. Neurology 29:904–905.CrossRefGoogle ScholarPubMed
Gallo, J.M., Bruni, J., Lee, C, Fleitman, J. and Wilder, B.J. (1979). Protein binding and salivary concentration of valproic acid in epileptic patients. Clin. Pharmacol. Ther. (In press).Google Scholar
Gugler, R. and Mueller, G. (1978). Plasma protein binding of valproic acid in healthy subjects and in subjects with renal disease. Br. J. Clin. Pharmacol. 5:441–446.CrossRefGoogle ScholarPubMed
Jordan, B.J., Shilling Ford, J.S. and Steed, K.P. (1976). Preliminary observations on the protein binding and enzyme-inducing properties of sodium valproate (Epilim). In Legg, N.J. (Editor): Clinical and Pharmacological Aspects of Sodium Valproate (Epilim) in the Treatment of Epilepsy. Tunbridge Wells, England, MCS Consultants, pp. 112–118.Google Scholar
Lecchini, S., Gatti, G., Debernardi, M.Cavaraggi, M. and Firgo, G.M. (1978). Serum protein binding of diphenyl-hydantoin in man: Interaction with sodium valproate. Il Farmaco 33:80–82.Google Scholar
Mattson, R.H., Cramer, J.A., Williamson, P.D. and Novelly, R.A. (1978). Valproic acid in epilepsy: Clinical and pharmacological effects. Ann. Neurol. 3:20–25.CrossRefGoogle ScholarPubMed
Patel, I.H. and Levy, R.H. (1979). Valproic acid binding to human serum albumin and determination of free fraction in the presence of anticonvulsants and free fatty acids. Epilepsia 20:85–90.CrossRefGoogle ScholarPubMed
Patsalos, P.N. and Lascelles, P.T. (1970). Effect of sodium valproate on plasma protein binding of diphenylhydantoin. J. Neurol. Neurosurg. Psychiatr. 40:570–574.CrossRefGoogle Scholar
Patsalos, P.N. and Lascelles, P.T. (1977). Valproate may lower serum phenytoin. Lancet 1:50–51.CrossRefGoogle ScholarPubMed
Wilder, B.J., Willmore, L.J., Bruni, J. and Villarreal, H.J. (1978). Valproic acid: Interaction with other anticonvulsant drugs. Neurology 28:892–896.CrossRefGoogle ScholarPubMed