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Evolution of Sleep Complaints in Myotonic Dystrophy Type 1: A 9-Year Longitudinal Study

Published online by Cambridge University Press:  17 March 2023

Luc Laberge Open the ORCID record for Luc Laberge [Opens in a new window] ,
Alexandre Maltais ,
Julie Auclair ,
Jean Mathieu  and
Cynthia Gagnon
Luc Laberge*
Affiliation:
ÉCOBES – Recherche et transfert, Cégep de Jonquière, 2505 Rue Saint Hubert, Jonquière, Québec G7X 7W2, Canada Département des sciences de la santé, Université du Québec à Chicoutimi, 555, boul. de l’Université, Chicoutimi, Québec G7H 2B1, Canada Groupe de recherche interdisciplinaire sur les maladies neuromusculaires (GRIMN), Centre intégré universitaire de santé et de services sociaux du Saguenay–Lac-St-Jean, Québec, Canada Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Québec, Canada
Alexandre Maltais
Affiliation:
ÉCOBES – Recherche et transfert, Cégep de Jonquière, 2505 Rue Saint Hubert, Jonquière, Québec G7X 7W2, Canada
Julie Auclair
Affiliation:
ÉCOBES – Recherche et transfert, Cégep de Jonquière, 2505 Rue Saint Hubert, Jonquière, Québec G7X 7W2, Canada
Jean Mathieu
Affiliation:
Groupe de recherche interdisciplinaire sur les maladies neuromusculaires (GRIMN), Centre intégré universitaire de santé et de services sociaux du Saguenay–Lac-St-Jean, Québec, Canada
Cynthia Gagnon
Affiliation:
Groupe de recherche interdisciplinaire sur les maladies neuromusculaires (GRIMN), Centre intégré universitaire de santé et de services sociaux du Saguenay–Lac-St-Jean, Québec, Canada Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Québec, Canada
*
Corresponding author: Luc Laberge, Ph.D., ÉCOBES – Recherche et transfert, Cégep de Jonquière, 2505, rue Saint-Hubert, Jonquière, Québec G7X 7W2, Canada. Email: luclaberge@cegepjonquiere.ca
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Abstract:

The objective was to characterize the progression of sleep complaints in 115 dystrophy type 1 (DM1) patients who filled out a sleep questionnaire twice at a 9-year interval. Daytime napping (22.1% vs. 34.5%, p < 0.05), early awakenings (11.4% vs 21.1%, p < 0.05), nonrestorative sleep (39.5% vs 51.8%, p < 0.05), stimulant use (7.0% vs 19.3%, p < 0.01), breathing cessation (10.7% vs 23.2%, p < 0.01), and nighttime urination (42.5% vs 54.9%, p < 0.05) increased between Time 1 and Time 2. Sleep-related complaints are prominent and augment rapidly in DM1 patients. Physicians need to better identify and treat them to help alleviate the burden they impose on patients and their caregivers.

Résumé :

Évolution des troubles du sommeil dans la dystrophie myotonique de type 1 : une étude longitudinale de 9 ans.

L’objectif était de caractériser l’évolution des plaintes liées au sommeil chez 115 patients atteints de dystrophie myotonique de type 1 (DM1) ayant rempli un questionnaire sur le sommeil à deux reprises à 9 ans d’intervalle. La prévalence des siestes (22,1 % vs 34,5 %, p < 0,05), des réveils matinaux précoces (11,4 % vs 21,1 %, p < 0,05), du sommeil non réparateur (39,5 % vs 51,8 %, p < 0,05), de la consommation de stimulants (7,0 % vs 19,3 %, p < 0,01), des arrêts respiratoires (10,7 % vs 23,2 %, p < 0,01) et des mictions nocturnes (42,5 % vs 54,9 %, p < 0,05) a augmenté entre le temps 1 et le temps 2. Les plaintes liées au sommeil sont fréquentes et augmentent rapidement dans la DM1. Les médecins doivent mieux les identifier et les traiter pour aider à alléger le fardeau qu’ils imposent aux patients et à leurs aidants.

Keywords

Myotonic dystrophyLongitudinal studiesSleepSurveys and questionnaires
Type
Brief Communication
Information
Canadian Journal of Neurological Sciences , Volume 51 , Issue 1 , January 2024 , pp. 137 - 139
Copyright
© The Author(s), 2023. Published by Cambridge University Press on behalf of Canadian Neurological Sciences Federation.

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