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Familial Occurrence of Complex Regional Pain Syndrome

Published online by Cambridge University Press:  02 December 2014

Peyman Shirani ,
Ali Jawaid ,
Paolo Moretti ,
Elham Lahijani ,
Alicia R. Salamone ,
Paul E. Schulz  and
Everton A. Edmondson
Peyman Shirani
Affiliation:
Department of Neurology, Baylor College of Medicine
Ali Jawaid
Affiliation:
Department of Neurology, Baylor College of Medicine
Paolo Moretti
Affiliation:
Department of Neurology, Baylor College of Medicine
Elham Lahijani
Affiliation:
Interventional Neurology, Inc., Houston, Texas, USA
Alicia R. Salamone
Affiliation:
Department of Neurology, Baylor College of Medicine
Paul E. Schulz
Affiliation:
Department of Neurology, Baylor College of Medicine Department of Neurology, The Methodist Hospital
Everton A. Edmondson*
Affiliation:
Department of Neurology, The Methodist Hospital Interventional Neurology, Inc., Houston, Texas, USA
*
The Methodist Hospital, 6560 Fannin St., Suite 2202, Houston, Texas, 77030, USA.
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Abstract

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Background:

The etiology of complex regional pain syndrome (CRPS) is unknown. Different environmental and genetic factors have been postulated to contribute to CRPS.

Methods:

We reviewed the clinical data from a cohort of 69 patients with CRPS. Four families were identified with two or more members affected with CRPS yielding a total of nine patients. Six more patients reported the presence of pain symptoms in their family members, however; this could not be clinically confirmed.

Results:

The case histories of the nine individuals with ‘familial’ CRPS suggested a younger age at onset and more frequent history of migraine versus the non-familial patients. A pattern of inheritance could not be ascertained.

Conclusion:

This data supports the hypothesis that CRPS can be familial and hence may have a genetic basis in some families. Larger studies will be needed to ascertain clearer patterns of inheritance and to determine whether the clinical features of ‘familial’ CRPS are the same as the sporadic form.

Type
Original Article
Information
Canadian Journal of Neurological Sciences , Volume 37 , Issue 3 , May 2010 , pp. 389 - 394
Copyright
Copyright © The Canadian Journal of Neurological 2010

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