Hostname: page-component-76fb5796d-22dnz Total loading time: 0 Render date: 2024-04-28T16:05:57.682Z Has data issue: false hasContentIssue false

The Future: Moving from Phenotypically Defined Diseases Toward Pathophysiological Systems

Published online by Cambridge University Press:  01 March 2023

Mark R. Keezer
Affiliation:
Centre de recherche du Centre Hospitalier de l’Université de Montréal (CRCHUM), Montréal, Québec, H2X 0A9, Canada Stichting Epilepsie Instellingen Nederland (SEIN), Heemstede 2103SW, The Netherlands
Prisca R. Bauer
Affiliation:
Department of Psychosomatic Medicine and Psychotherapy, University Medical Center Freiburg, University of Freiburg, 79104, Germany
Josemir W. Sander*
Affiliation:
Stichting Epilepsie Instellingen Nederland (SEIN), Heemstede 2103SW, The Netherlands UCL Queen Square Institute of Neurology, London WC1N 3BG, & Chalfont Centre for Epilepsy, Chalfont St Peter, SL9 0RJ, UK Neurology Department, West of China Hospital, Sichuan University, Chengdu 61004, China
*
Corresponding author: Ley Sander, Box 29, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK. Email: l.sander@ucl.ac.uk

Abstract

Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Type
Commentary
Copyright
© The Author(s), 2023. Published by Cambridge University Press on behalf of Canadian Neurological Sciences Federation

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Price, BH, Adams, RD, Coyle, JT. Neurology and psychiatry: closing the great divide. Neurology. 2000;54:814.CrossRefGoogle ScholarPubMed
Dubois, B, Feldman, HH, Jacova, C, et al. Advancing research diagnostic criteria for Alzheimer’s disease: the IWG-2 criteria. Lancet Neurol. 2014;13:61429.CrossRefGoogle ScholarPubMed
Scheffer, IE, Berkovic, S, Capovilla, G, et al. ILAE classification of the epilepsies: position paper of the ILAE Commission for Classification and Terminology. Epilepsia. 2017;58:51221.CrossRefGoogle ScholarPubMed
Woodcock, T, Morganti-Kossmann, MC. The role of markers of inflammation in traumatic brain injury. Front Neurol. 2013;4.CrossRefGoogle Scholar
De Haan, S. An enactive approach to psychiatry. Philos Psychiatr Psychol. 2020;27:325.CrossRefGoogle Scholar
Kirmayer, LJ, Gómez-Carrillo, A. Agency, embodiment and enactment in psychosomatic theory and practice. Med Humanit. 2019;45:16982.CrossRefGoogle ScholarPubMed
Shinnar, S, Bello, JA, Chan, S, et al. MRI abnormalities following febrile status epilepticus in children: the FEBSTAT study. Neurology. 2012;79:8717.CrossRefGoogle ScholarPubMed
Cacabelos, R. Epigenetics of brain disorders: the paradigm of Alzheimer’s disease. J Alzheimers Dis Parkinsonism. 2016;6:21610460 1000229.10.4172/2161-0460.1000229CrossRefGoogle Scholar
Olsson, T, Barcellos, LF, Alfredsson, L. Interactions between genetic, lifestyle and environmental risk factors for multiple sclerosis. Nat Rev Neurol. 2017;13:2536.CrossRefGoogle ScholarPubMed