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Immunizations and Autism: A Review of the Literature

  • Asif Doja (a1) and Wendy Roberts (a2)

Because of a temporal correlation between the first notable signs and symptoms of autism and the routine childhood vaccination schedule, many parents have become increasingly concerned regarding the possible etiologic role vaccines may play in the development of autism. In particular, some have suggested an association between the Measles-Mumps-Rubella vaccine and autism. Our literature review found very few studies supporting this theory, with the overwhelming majority showing no causal association between the Measles-Mumps-Rubella vaccine and autism. The vaccine preservative thimerosal has alternatively been hypothesized to have a possible causal role in autism. Again, no convincing evidence was found to support this claim, nor for the use of chelation therapy in autism. With decreasing uptake of immunizations in children and the inevitable occurrence of measles outbreaks, it is important that clinicians be aware of the literature concerning vaccinations and autism so that they may have informed discussions with parents and caregivers.


Plusieurs parents s’inquiètent que des vaccins puissent jouer un rôle étiologique dans le développement de l’autisme à cause d’une corrélation temporelle entre les premiers signes et symptômes décelables de l’autisme et le calendrier vaccinal. Une association entre le vaccine contre la rougeole, les oreillons et la rubéole et l‘autisme a été suggérée. Cette revue de la littérature a retrouvé peu d’études à l’appui de cette théorie, la très grande majorité des études ne démontrant pas d’association entre ce vaccine et l’autisme. On a d’autre part émis l’hypothèse d’un lien causal possible entre le thimerosal, un agent de conservation, et l’autisme. Là non plus, nous n’avons pas trouvé de données convaincantes à l’appui de cette hypothèse ou du traitement par chélation dans l’autisme. Avec la diminution du taux d’immunisation chez les enfants et l’apparition inévitable d’épidémies de rougeole, il est important que les cliniciens soient au courant de la littérapture portant sur la vaccination et l’autisme afin qu’ils puissent en discuter en connaissance de cause avec les parents et les soignants.

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Corresponding author
Division of Neurology, Children’s Hospital of Eastern Ontario, 401 Smyth Road, Ottawa, Ontario, K1H 8L1, Canada
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4. E. Fombonne Is there an epidemic of autism? Pediatrics. 2001; 107:4112.

7. PA Filipek , JA Accardo , GT Baranek , EH Cook Jr, G Dawson , B Gordon , et al.The screening and diagnosis of autistic spectrum disorders. J Aut Dev Dis. 1999; 29:43984.

8. AJ Wakefield , SH Murch , AJ Linnell , DM Casson , M Malik , M Berelowitz , et al.Ileal-lymphoid-nodular hyperplasia, nonspecific colitis, and pervasive developmental disorder in children. Lancet. 1998; 351:63741.

9. NP Thompson , SM Montgomery , RE Pounder , AJ. Wakefield Is measles vaccination a risk factor for inflammatory bowel disease? Lancet. 1995; 345:10714.

10. AJ Wakefield , A Anthony , SH Murch , M Thomson , SM Montgomery , S Davies , et al.Enterocolitis in children with developmental disorders. Am J Gastro. 2000; 95:228595.

12. AJ Wakefield , RM Pittilo , R Sim , SL Cosby , JR Stephenson , AP Dhillon , et al.Evidence of persistent measles virus infection in Chron’s disease. J Med Virol. 1993; 39:34553.

13. V Uhlman , CM Martin , O Shiels , L Pilkington , I Silva , A Killalea , et al.Potential viral pathogenic mechanism for new variant inflammatory bowel disease. Mol Pathol. 2002; 55:8490.

14. MA Afzal , E Armitage , J Begley , ML Bentley , PD Minor , S Ghosh et al.Absence of detectable measles virus genome sequence in inflammatory bowel disease tissues and peripheral blood lymphocytes. J Med Virol. 1998; 55:2439.

15. M Iizuka , H Itou , M Chiba , T Shirasaka , S Watanabe , et al.The MMR question. Lancet. 2000; 356:160.

16. VK Singh , SX Lin , E Newell , C. Nelson Abnormal measles-mumps-rubella antibodies and CNS autoimmunity in children with autism. J Biomed Sci. 2002; 9: 35964.

19. SH Murch , A Anthony , DH Casson , M Malik , M Berelowitz , AP Dhillon , et al.Retraction of an interpretation. Lancet. 2004; 363:750.

20. K Wilson , E Mills , C Ross , J McGowan , A. Jaddad Association of autistic spectrum disorder and the measles, mumps and rubella vaccine: a systematic review of current epidemiological evidence. Arch Pediatr Adolesc Med. 2003; 157:62834.

21. KM Madsen , A Hvid , M Vestergaard , D Schendel , J Wohlfahrt P Thornsen , et al.A population-based study of measles, mumps, and rubella vaccination and autism. N Engl J Med. 2002; 347:147782.

22. B Taylor , E Miller , CP Farringtom , MC Petropoulos , I Favot-Mayaud , J Li , et al.Autism and measles, mumps and rubella vaccine: no epidemiological evidence for a causal association. Lancet. 1999; 353:202629.

23. JA Kaye , MM Melero-Montes , H. Jick Mumps, measles and rubella vaccine and the incidence of autism recorded by general practioners: a time trend analysis. BMJ. 2001; 322:4603.

25. H Honda , Y Shimizu , M. Rutter No effect of MMR withdrawal on the incidence of autism: a total population study. J Child Psych Psychol. 2005; 46:57279.

26. L Smeeth , C Cook , E Fombonne , L Heavey , LC Rodrigues , PG Smith , et al.MMR vaccination and pervasive developmental disorders: a case-control study. Lancet. 2004; 364:9639.

27. A Makela , JP Nuorti , H. Petola Neurologic disorders after measles-mumps-rubella vaccination. Pediatrics. 2002; 110:95763.

28. E Fombonne , S. Chakrabart No evidence for a new variant of measles-mumps-rubella-induced autism. Pediatrics. 2001; 108:18.

29. H Petola , A Patja , P Leinikki , M Valle , I Davidkin , M. Paunio No evidence for measles, mumps, and rubella vaccine-associated inflammatory bowel disease or autism in a 14-year prospective study. Lancet. 1998; 351: 13278.

30. C Black , JA Kaye , H. Jick Relation of childhood gastrointestinal disorders to autism: nested case-control study using data from the UK General Practice Database. BMJ. 2002; 325:41921.

31. B Taylor , E Miller , R Lingam , N Andrews , A Simmons , J. Stowe Measles, mumps, and rubella vaccination and bowel problems or developmental regression in children with autism: population study. BMJ. 2002; 324:3936.

32. SK Parker , B Schwartz , J Todd , LK. Pickering Thimerosal-containing vaccines and autistic spectrum disorder: a critical review of published original data. Pediatrics. 2004; 114:793804.

36. KB Nelson , ML. Bauman Thimerosal and autism? Pediatrics. 2003; 111: 6749.

38. S Bernard , A Enayati , L Redwood , H Roger , T. Binstock Autism: a novel form of mercury poisoning. Med Hypotheses. 2001; 56:46271.

40. ME Pichichero , E Cernichiari , J Lopreiato , J. Treanor Mercury concentrations and metabolism in infants receiving vaccines containing thimerosall: a descriptive study. Lancet. 2002; 360:173741.

41. AS Holmes , MF Blaxill , BE. Haley Reduced levels of mercury in first baby haircuts of autistic children. Int J Toxicol. 2003; 22:27785.

44. A Hviid , M Stellfeld , J Wohlfahrt , M. Melbye Association between thimerosal-containing vaccines and autism. JAMA. 2003; 290:17636.

45. N Andrews , E Miller , A Grant , J Stowe , V Osborne , B. Taylor Thimerosal exposure in infants and developmental disorders: a retrospective cohort study in the United Kingdom does not support a causal association. Pediatrics. 2004; 114:58491.

46. K Madsen , M Lauritsen , C Pedersen , P Thorsen , AM Plesner , PH Anderson , et al.Thimerosal and the occurrence of autism? Negative ecological evidence from Danish population-based data. Pediatrics. 2003; 112:6046.

48. SJ James , W Slikker , S Melnyk , E New , M Pogribna , S. Jernigan Thimerosal neurotoxicity is associated with glutathione depletion: protection with glutathione precursors. Neurotoxicology. 2005; 26:18.

49. M Waly , H Olteanu , R Banerjee , SW Choi , JB Mason , BS Parker , et al. Activation of methionine synthase by insulin-like growth factor-1 and dopamine: a target for neurodevelopmental toxins and thimerosal. Mol Psych. 2004; 1-13.

58. VA Jansen , N Stollenwerk , HJ Jensen , Me Ramsay , WJ Edmunds , CJ. Rhodes Measles outbreaks in populations with declining vaccine uptake. Science. 2003; 301:804.

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Canadian Journal of Neurological Sciences
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