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The Impact of Fatigue on Patients with Multiple Sclerosis

Published online by Cambridge University Press:  18 September 2015

John D. Fisk*
Affiliation:
Department of Psychology, Camp Hill Medical Centre, Dalhousie University Department of Psychiatry, Dalhousie University Department of Psychology, Dalhousie University Department of Medicine, Dalhousie University
Amanda Pontefract
Affiliation:
Department of Psychiatry, Dalhousie University
Paul G. Ritvo
Affiliation:
Department of Psychology, Camp Hill Medical Centre, Dalhousie University Department of Psychiatry, Dalhousie University Department of Psychology, Dalhousie University
Catherine J. Archibald
Affiliation:
Department of Psychology, Dalhousie University
T.J. Murray
Affiliation:
Department of Medicine, Dalhousie University
*
Department of Psychology, Camp Hill Medical Centre, 1763 Robie Street, Halifax, Nova Scotia, Canada B3H 3G2
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Abstract:

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Although fatigue is recognized as a symptom of MS, there have been insufficient methods for evaluating this symptom. We administered the Fatigue Impact Scale to 85 MS patients and 20 hypertensive patients. Neurologic impairment, mental health, and general health status were also assessed. MS patients reported significantly higher fatigue impact than hypertensive patients. Most MS patients reported fatigue as either their worst (14%), or one of their worst (55%) symptoms. Disease classification and neurologic impairment had little bearing on Fatigue Impact Scale scores in the MS sample. The best predictive models for mental health and general health status in the MS sample both included the Fatigue Impact Scale as a significant factor. This study demonstrates that: 1) fatigue is a very prevalent and severe problem in MS, 2) fatigue impact cannot be predicted by clinical measures of neurologic impairment, 3) fatigue has a significant effect on the mental health and general health status of MS patients.

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Articles
Copyright
Copyright © Canadian Neurological Sciences Federation 1994

References

1.Kurtzke, JF. Rating neurologic impairment in multiple sclerosis: an Expanded Disability Status Scale (EDSS). Neurology 1983; 33: 14441452.Google Scholar
2.Murray, TJ. Amantadine therapy for fatigue in multiple sclerosis. Can J Neurol Sci 1985; 12: 251254.Google Scholar
3.Krupp, LB, Alvarez, LA, LaRocca, NG, Scheinberg, LC. Fatigue in multiple sclerosis. Arch Neurol 1988; 45: 435437.CrossRefGoogle ScholarPubMed
4.Freal, JE, Kraft, GH, Coryell, JK. Symptomatic fatigue in multiple sclerosis. Arch Phys Med Rehabil 1984; 65: 135138.Google ScholarPubMed
5. The Canadian Research Group. A randomized controlled trial of amantadine in fatigue associated with multiple sclerosis. Can J Neurol Sci 1987; 14: 273278.CrossRefGoogle Scholar
6.Cohen, RA, Fisher, M. Amantadine treatment of fatigue associated with multiple sclerosis. Arch Neurol 1989; 46: 676680.CrossRefGoogle ScholarPubMed
7.Sandroni, P, Walker, C, Starr, A. “Fatigue” in patients with multiple sclerosis. Arch Neurol 1992; 49: 517524.CrossRefGoogle ScholarPubMed
8.Krupp, LB, LaRocca, NG, Muir-Nab, J, Steinberg AD. The Fatigue Severity Scale: application to patients with multiple sclerosis and systemic lupus erythematosus. Arch Neurol 1989; 46: 11211123.CrossRefGoogle ScholarPubMed
9.Guyatt, GH, Van Zanten, SJOV, Feeny, DH, Patrick, DL. Measuring quality of life in clinical trials: a taxonomy and review. Can Med Assoc J 1989; 140: 14411448.Google ScholarPubMed
10.Ritvo, PG, Fisk, JD, Archibald, CJ, et al. A model of mental health in patients with multiple sclerosis. Can Psychol 1992 33(2a): 391.Google Scholar
11.McNair, D, Lorr, M, Droppleman, L . EDITS Manual for the Profile of Mood States. San Diego, CA: Educational and Industrial Testing Service, 1971.Google Scholar
12.American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders-Revised. Washington, DC: American Psychiatric Association, 1987.Google Scholar
13.Minden, SL, Schiffer, RB. Affective disorders in multiple sclerosis:review and recommendations for clinical research. Arch Neurol 1990; 47:98104.CrossRefGoogle ScholarPubMed
14.Kurtzke, JF . Multiple sclerosis: what's in a name? Neurology 1988; 38: 309316.Google Scholar
15.Monks, J. Experiencing symptoms in chronic illness: fatigue in mul-tiple sclerosis. Int Disabil Stud 1989; 11: 7883.CrossRefGoogle Scholar
16.Pollard, WE, Bobbitt, RA, Bergner, M, et al. The Sickness Impact Profile: reliability of a health status measure. Med Care 1976; 14: 146155.CrossRefGoogle ScholarPubMed
17.Read, JL, Quinn, R, Hoefer, MA. Measuring overall health: an evalu-ation of three important approaches. J Chron Dis 1987; 40: 7s-21s.CrossRefGoogle Scholar
18.Veit, C, Ware, J Jr. The structure of psychological distress and well-being in general populations. J Consult Clin Psychol 1983; 51: 730742.CrossRefGoogle ScholarPubMed
19.Bergner, M, Bobbitt, RA, Carter, WB, Gilson, BS. The Sickness Impact Profile: development and final revision of a health status measure. Med Care 1981; 19: 787805.CrossRefGoogle ScholarPubMed
20.Busenbark, KL, Nash, J, Nash, S, Hubble, JP, Koller, WC. Is essential tremor benign? Neurology 1991; 41: 19821983.CrossRefGoogle Scholar
21.Follick, MJ, Smith, TW, Ahern, DK. The Sickness Impact Profile: a global measure of disability in chronic low back pain. Pain 1985; 21: 6776.CrossRefGoogle ScholarPubMed
22.Klonoff, PS, Snow, WG, Costa, LD. Quality of life in patients 2 to 4 years after closed head injury. Neurosurgery 1986; 19: 735743.CrossRefGoogle ScholarPubMed
23.Prigatano, GP, Wright, EC, Levin, D. Quality of life and its predictors in patients with mild hypoxemia and chronic obstructive pulmonary disease. Arch Intern Med 1984; 144: 16131619.CrossRefGoogle ScholarPubMed
24.Bell, M, Bombardier, C, Tugwell, P. Measurement of functional status, quality of life, and utility in rheumatoid arthritis. Arthritis Rheum 1990; 33: 591601.CrossRefGoogle ScholarPubMed
25.Monroe, SM. Assessment of life events: retrospective versus concurrent strategies. Arch Gen Psychiatry 1982; 39: 606610.CrossRefGoogle Scholar
26.Russell, D, Peplau, LA, Cutrona, CE. The Revised UCLA Loneliness Scale: concurrent and discriminant validity evidence. J Pers Soc Psychol 1980; 39: 472480.CrossRefGoogle ScholarPubMed
27.Davies, AR, Sherbourne, CD, Peterson, JR, Ware, JE. Scoring Manual: Adult Health Status and Patient Satisfaction Measures Used In RAND Health Insurance Experiment. Bethesda, MD: Department of Health and Human Services, 1988.Google Scholar
28.Ware, JE, Manning, WG Jr, Duan, N, Wells, KB, Newhouse, JP. Health status and the use of outpatient mental health services. Am Psychol 1984; 39: 10901100.CrossRefGoogle ScholarPubMed
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